Onye na-emepụta ntụ ntụ CMS121 Nọmba CAS: 1353224-53-9 98.0% ịdị ọcha nkeji maka ihe mgbakwunye
Usoro Ngwaahịa
| Aha ngwaahịa | CMS121 |
| Aha ọzọ | CMS-121; 1,2-Benzenediol,4-[4-(cyclopentyloxy)-2-quinolinyl]-; 4-(4-(cyclopentyloxy)quinolin-2-yl)benzene-1,2-diol(CMS121); ACC,AcetylCoenzymeACarboxylase,ọrịa,neuroprotective,inhibiting,ant-inflammatory,mitochondria,Alzheimer's,antioxidative,acetylation,Inhibitor,H3K9,Acetyl-CoACarboxylase,CMS121,dementia,ACC1,CMS-121 |
| Nọmba CAS | 1353224-53-9 |
| Usoro molekụla | C20H19NO3 |
| Ibu molekụla | 321.37 |
| Ịdị ọcha | 98.0% |
| Ọdịdị | Ntụ ntụ odo dị mfe |
| Ngwa | Ihe Mgbakwunye Nri Ihe Ndị A Na-anaghị Ewu |
Okwu mmeghe ngwaahịa
4-(4-(cyclopentyloxy)quinolin-2-yl)benzene-1,2-diol bụ ihe mejupụtara nke a na-akpọkwa CMS121. Mgbagwoju anya nke ihe mejupụtara ya na-egosi na o nwere ike inwe ihe pụrụ iche na ojiji nwere ike. Iji ghọta mkpa ọ dị, ọ na-enyere aka ịchọpụta otu ọrụ dị na ya ma nyochaa mmetụta ha nwere ike inwe. Ọnụnọ nke mgbanaka quinoline na-egosi na ihe mejupụtara ya nwere ike ịdị na-arụ ọrụ na bayoloji. A maara molekul sitere na Quinoline maka ihe dị iche iche dị na bayoloji, gụnyere ọrụ nje bacteria na mgbochi mkpali. Njikọ nke otu cyclopentyloxy nwere ike itinye aka na mgbaze nke ihe mejupụtara ahụ ma ọ bụ melite ọrụ bayoloji ya site na mmetụta steric. Na ọmụmụ ihe gbasara mkpụrụ ndụ HT22, CMS-121 egosila mmetụta dị mkpa na-echebe neuroprotective, na-echebe mkpụrụ ndụ ndị a nke ọma site na ischemia na mmebi oxidative. Ọzọkwa, CMS-121 nwere ihe mgbochi mkpali dị mkpa, na-egosi ikike ya ịhazi nzaghachi mkpali. Site n'ime nke a, CMS-121 nwere ike ibelata mbufụt na anụ ahụ na akụkụ dị iche iche. CMS-121 nwere ọrụ ọgwụ siri ike dịka ihe na-egbochi acetyl-CoA carboxylase 1 (ACC1). Mmetụta mgbochi ya dị ike na ACC1 na-eme ka ọ bụrụ ihe na-ekwe nkwa.
atụmatụ
(1) Ịdị ọcha dị elu: CMS-121 nwere ike inweta ngwaahịa dị ọcha dị elu site na usoro mmepụta dị mma. Ịdị ọcha dị elu pụtara nnweta bioavailability ka mma na obere mmeghachi omume ọjọọ.
(2) Nchekwa: Nchekwa dị elu, obere mmeghachi omume ọjọọ.
(3) Ịkwụsi ike: CMS-121 nwere ezigbo nkwụsi ike ma nwee ike ịnọgide na-arụ ọrụ na mmetụta ya n'okpuru gburugburu ebe obibi na ọnọdụ nchekwa dị iche iche.
Ngwa
CMS-121 bụ ihe na-egbochi quinolone na acetyl-CoA carboxylase 1 (ACC1) nke na-arụ ọrụ n'ọnụ, nke nwere nnukwu ihe ndị na-enye aka na ọgwụ. Emeela nnyocha sara mbara iji nyochaa uru CMS-121 nwere ike ịba n'ọtụtụ ebe, gụnyere nchekwa neuroprotection, mmetụta mgbochi mkpali, ọrụ antioxidant, na mmetụta ya na ihe nrịbama metụtara ịka nká dị mma.
