Lemairamin (WGX-50) onye na-emepụta ntụ ntụ CAS No.: 29946-61-0 98.0% ịdị ọcha min.maka ihe mgbakwunye
Ngwa ngwaahịa
| Aha ngwaahịa | Lemairamin |
| Aha ọzọ | 2-Propenamide, N-[2- (3,4-dimethoxyphenyl) ethyl] -3-phenyl-, (2E) -; Lemairamin (WGX-50) |
| CAS Mba. | 29946-61-0 |
| Usoro ihe omimi | C19H21NO3 |
| Ibu molekụla | 311.37 |
| Ịdị ọcha | 98.0% |
| Ọdịdị | Na-acha ọcha na-acha ọcha ntụ ntụ |
| Ngwa | Ihe mgbakwunye nri nri |
Ntinye ngwaahịa
Lemairamin ma ọ bụ Wgx50 bụ ngwakọta okike ewepụtara na ose chili nke gosipụtara nsonaazụ na-ekwe nkwa igbochi ọrịa Alzheimer.Nnyocha achọpụtala na ọ nwere ike igbochi Aβ-induced neuronal apoptosis, belata neuronal calcium toxicity, ma belata mkpokọta Aβ oligomer na ụbụrụ ụbụrụ.Na mgbakwunye, egosiri wgx50 ka ọ kwalite arụmọrụ ọgụgụ isi na ụmụ oke.Nnyocha na-egosi na wgx50 nwere ikike igbochi mgbakọ protein-protein n'etiti ụmụ irighiri ihe amyloid.N'ozuzu, wgx50 nwere ikike igbochi ọrịa Alzheimer ma nwee ike ịnye ụzọ ọhụrụ maka ịmepụta ọgwụ na-elekwasị anya Aβ oligomers.Tụkwasị na nke ahụ, WGX-50 na-egosipụta ọrụ mgbochi mkpali dị ịrịba ama, nke na-eme ka ọ bụrụ onye na-ekwe nkwa maka ọgwụgwọ ọrịa ndị na-egbuke egbuke.A chọpụtala na WGX-50 nwere mmetụta dị ukwuu na akpụkpọ ahụ, dị ka ibelata wrinkles na ime ka akpụkpọ ahụ dịkwuo mma.Na mgbakwunye na ogige ndị sitere n'okike ewepụtara na osisi Zanthoxylum bungeanum, enwere ugbu a ọtụtụ ogige synthetic nke a na-eji na ngwa dị iche iche ma dabara adaba maka ahịa.
Njirimara
(1) Ịdị ọcha dị elu: Lemairamin nwere ike nweta ngwaahịa dị ọcha site na mmịpụta eke na imezi usoro mmepụta ihe.Ịdị ọcha dị elu pụtara bioavailability ka mma yana mmeghachi omume ọjọọ dị ole na ole.
(2) Nchekwa: Nchekwa dị elu, mmeghachi omume ọjọọ ole na ole, enweghị mmeghachi omume ọjọọ doro anya ọbụna na iji ogologo oge.
(3) Nkwụsi ike: Lemairamin nwere ezigbo nkwụsi ike ma nwee ike ịnọgide na-arụ ọrụ ya na mmetụta ya n'okpuru ebe dị iche iche na ọnọdụ nchekwa.
(4) Ọ dị mfe ịnweta: Lemairamin nwere ike ịmịnye ahụ mmadụ ngwa ngwa ma kesaa ya na anụ ahụ na akụkụ dị iche iche.
Ngwa
Lemairamin bụ ngwakọta amide ewepụtara na ogbugbo nke osisi Zanthoxylum bungeanum.A na-eji ya eme ihe ugbu a dị ka ihe mgbakwunye nri, ọ na-arụkwa ọrụ dị ka agonist nke alpha7 nicotinic acetylcholine receptor (α7nAChR), nke na-ebelata neuroinflammation na ọrịa Alzheimer, na kpamkpam synthetic.Wgx50 egosiwo na-agba ume na ọmụmụ preclinical, gụnyere igbochi Aβ-induced neuronal neuronal. apoptosis, ibelata neuronal calcium toxicity, ibelata mkpokọta Aβ oligomer na cerebral cortex, na imeziwanye arụmọrụ ọgụgụ isi na ụmụ oke.
