Onye na-emepụta ntụ ntụ Lemairamin (WGX-50) Nọmba CAS: 29946-61-0 98.0% ịdị ọcha nkeji maka ihe mgbakwunye
Vidiyo Ngwaahịa
Usoro Ngwaahịa
| Aha ngwaahịa | Lemairamin |
| Aha ọzọ | 2-Propenamide, N-[2-(3,4-dimethoxyphenyl)ethyl]-3-phenyl-, (2E)-; Lemairamin (WGX-50) |
| Nọmba CAS | 29946-61-0 |
| Usoro molekụla | C19H21NO3 |
| Ibu molekụla | 311.37 |
| Ịdị ọcha | 98.0% |
| Ọdịdị | Ntụ ntụ ọcha ruo na ntụ ọcha na-acha ọcha |
| Ngwa | Ihe Mgbakwunye Nri Ihe Ndị A Na-anaghị Ewu |
Okwu mmeghe ngwaahịa
Lemairamin ma ọ bụ Wgx50 bụ ihe e ji aka mee nke e si na ose chili wepụta nke gosiri na ọ ga-ekwe omume igbochi ọrịa Alzheimer. Nnyocha achọpụtala na ọ nwere ike igbochi apoptosis neuronal nke Aβ kpatara, belata nsí calcium neuronal, ma belata mkpokọta Aβ oligomers na cerebral cortex. Na mgbakwunye, egosila na wgx50 na-eme ka arụmọrụ nghọta dịkwuo mma na òké. Nnyocha na-egosi na wgx50 nwere ike igbochi njikọ protein-protein n'etiti molekul amyloid. N'ozuzu, wgx50 nwere ike igbochi ọrịa Alzheimer ma nwee ike inye ụzọ ọhụrụ maka mmepe nke ọgwụ ndị na-elekwasị anya na Aβ oligomers. Na mgbakwunye, WGX-50 na-egosipụta ọrụ mgbochi mkpali dị ukwuu, nke na-eme ka ọ bụrụ onye a ga-atụ anya ya maka ọgwụgwọ nke ọrịa mkpali. Achọpụtala na WGX-50 nwere mmetụta dị ukwuu na akpụkpọ ahụ, dị ka ibelata wrinkles na imeziwanye njupụta akpụkpọ ahụ. Na mgbakwunye na ihe ndị sitere n'okike ewepụtara na osisi Zanthoxylum bungeanum, enwere ọtụtụ ihe ndị e ji emepụta ihe nke a na-eji eme ihe dị iche iche ma dabara adaba maka ahịa.
atụmatụ
(1) Ịdị ọcha dị elu: Lemairamin nwere ike inweta ngwaahịa dị ọcha dị elu site na mwepụta na imeziwanye usoro mmepụta. Ịdị ọcha dị elu pụtara nnweta bioavailability ka mma na obere mmeghachi omume ọjọọ.
(2) Nchekwa: Nchekwa dị elu, obere mmeghachi omume ọjọọ, enweghị mmeghachi omume ọjọọ doro anya ọbụlagodi na ojiji ogologo oge.
(3) Ịkwụsi Ike: Lemairamin nwere ezigbo nkwụsi ike ma nwee ike ịnọgide na-arụ ọrụ na mmetụta ya n'okpuru gburugburu ebe obibi na ọnọdụ nchekwa dị iche iche.
(4) Ọ dị mfe ịmịkọrọ: Ahụ mmadụ nwere ike ịmịkọrọ Lemairamin ngwa ngwa ma kesaa ya na anụ ahụ na akụkụ ahụ dị iche iche.
Ngwa
Lemairamin bụ ihe mejupụtara amide nke a na-ewepụta site n'ogwe osisi Zanthoxylum bungeanum. A na-eji ya ugbu a dị ka ihe mgbakwunye nri, ọ na-arụkwa ọrụ dị ka ihe na-akwalite nnabata alpha7 nicotinic acetylcholine (α7nAChR), nke na-ebelata mbufụt neuroinflammation na ọrịa Alzheimer, ma bụrụ nke ejiri aka mee kpamkpam. Wgx50 egosila nsonaazụ na-agba ume na ọmụmụ ihe tupu oge eruo, gụnyere igbochi apoptosis neuronal nke Aβ kpatara, ibelata nsí calcium neuronal, ibelata mkpokọta nke Aβ oligomers na cerebral cortex, na imeziwanye arụmọrụ nghọta na òké.
