O-304 CAS Nke:1261289-04-6 Mee ka akwara gị sie ike ma belata abụba.
Usoro Ngwaahịa
| Aha ngwaahịa | O-304 |
| Aha ọzọ | 4-Chloro-N-[2-[(4-chlorophenyl)methyl]-2,3-dihydro-3-oxo-1,2,4-thiadiazol-5-yl]benzamide |
| Nọmba CAS | 1261289-04-6 |
| Usoro molekụla | C16H11Cl2N3O2S |
| Ibu molekụla | 380.25 |
| Ịdị ọcha | 98% |
| Ọdịdị | Ntụ ntụ ọcha ruo na ntụ ọcha na-acha ọcha |
| Nkwakọ ngwaahịa | 1kg/akpa, 25kg/gbọmgbọm |
| Ngwa | Ihe Mgbakwunye Nri Ihe Ndị A Na-anaghị Ewu |
Okwu mmeghe ngwaahịa
O-304 bụ obere ihe na-eme ka AMPK rụọ ọrụ nke na-eme ka ọrụ AMPK ka mma site na igbochi dephosphorylation nke AMPK phosphorylated (pAMPK), si otú a na-eme ka ọkwa pAMPK dịkwuo elu n'ebelataghị mkpokọta adenosine triphosphate (ATP) n'ime sel. O nwere ọtụtụ usoro ọrụ, gụnyere imeziwanye metabolism glucose, ibelata iguzogide insulin, na ichekwa sistemu obi.
atụmatụ
(1) Ịdị ọcha dị elu: A na-emepụta O-304 site na usoro nrụpụta dị mma, na-enweta ịdị ọcha dị elu nke ngwaahịa. Ịdị ọcha dị elu pụtara nnweta bioavailability ka mma.
(2) Ọrụ Bayọlọji:O-304 bụ ihe na-eme ka AMPK (AMP-activated protein kinase) rụọ ọrụ nke ọma n'ọnụ. Ọ na-eme ka ọrụ AMPK ka mma site n'igbochi dephosphorylation nke pAMPK.
Ngwa
1. Mmelite AMPK: O-304 na-eme ka ọrụ AMPK dịkwuo elu site na igbochi usoro dephosphorylation nke AMPK phosphorylated (pAMPK), si otú a na-achịkwa nguzozi nke metabolism ike.
2. Imeziwanye usoro nhazi glucose: N'ọmụmụ anụmanụ, dose nke 100 mg/kg nke O-304 nyere aka mee ka glucose ọbara na insulin dị n'ọbara na-adị ngwa ngwa na plasma, na-ebelata ibu arọ metabolic nke nri nwere abụba dị elu kpatara nke ukwuu, na igbochi mgbanwe glucose ọbara na mmụba insulin na-adịghị mma nke enweghị nhazi nri na-akpata.
3. Pnhazi nke elasticity nke arịa ọbara:O-304 na-enyere aka ịnọgide na-enwe ọbara mgbali elu n'ọkwa dị mma, na-ebelata nrụgide na arịa ọbara, ma na-enye nchebe ogologo oge, dị nro maka sistemu obi na ụbụrụ, na-akwado nkwụsi ike mmetụta uche na ike na-adịgide adịgide.
4.Ịkwalite ntorobịa na-adịgide adịgide:O-304 na-elekwasị anya kpọmkwem n'ụzọ mgbaama AMPK-mTOR, na-achịkwa usoro nke autophagy cellular n'ụzọ amamihe dị na ya, na-akwalite catabolism nke protein ndị meworo agadi na lipids na-adịghị mma, ma na-edobe gburugburu sel dị ọcha ma na-egbuke egbuke, si otú a na-egbu oge ịka nká nke cell.
