BAM15A CAS Nke:210302-02-6 Mee ka akwara gị sie ike ma belata abụba.
Usoro Ngwaahịa
| Aha ngwaahịa | BAM15A |
| Aha ọzọ | N5,N6-Bis(2-Chlorophenyl)-[1,2,5]oxadiazolo[3,4-b]pyrazine-5,6-diamine |
| Nọmba CAS | 210302-02-6 |
| Usoro molekụla | C16H10Cl2N6O |
| Ibu molekụla | 373.2 |
| Ịdị ọcha | 98% |
| Ọdịdị | Ntụ ntụ na-acha ọcha ruo na ntụ ntụ odo dị mfe |
| Nkwakọ ngwaahịa | 1kg/akpa, 25kg/gbọmgbọm |
| Ngwa | Ihe Mgbakwunye Nri Ihe Ndị A Na-anaghị Ewu |
Okwu mmeghe ngwaahịa
BAM15A bụ ihe na-eme ka mitochondrial dị ọhụrụ. Dịka ezigbo ihe na-egbochi proton mitochondrial, ọ na-achịkwa proton gradient n'ofe akpụkpọ ahụ mitochondrial dị n'ime, na-eme ka metabolism ike nke ahụ dịkwuo mma ma na-eme ka mmebi oxidative eke nke abụba dịkwuo ngwa ngwa, na-enweghị mmetụta nke oke akwara ma ọ bụ agụụ nkịtị.
Nnyocha tupu a mụọ ọgwụ egosila na ihe a na-enyere aka ime ka afọ gbapụta, mee ka insulin dịkwuo mma, belata mkpokọta abụba imeju ma belata mmeghachi omume mkpali sistemụ. Ọ nwere bioavailability ọnụ nke ruru 67% ma nwee obere ihe onwunwe yana nchekwa dị elu. N'adịghị ka ihe ndị yiri ya na omenala, ọ naghị ebute oke okpomọkụ ahụ ma ọ bụ mmebi sel, na-eme ka ọ bụrụ ihe oriri dị mma maka ijikwa ibu na ịchịkwa metabolism.
atụmatụ
(1) Ịdị ọcha dị elu: BAM15Anwere ike imepụta ngwaahịa dị ọcha site na usoro mmepụta dị mma. Ịdị ọcha dị elu pụtara nnweta bioavailability ka mma.
(2) Usoro nkewapụ njikọ dị irè: Dịka onye na-ebu proton mitochondrial, ọ na-emebi usoro proton nke akpụkpọ ahụ mitochondrial dị n'ime, na-akwalite mgbanwe nke ike oxidative site na ihe oriri gaa na ike okpomọkụ karịa ATP, na-eme ka oriri ike dịkwuo mma nke ukwuu
(3) Mbelata abụba dị mma na mmezi metabolic: Na nnwale anụmanụ, bioavailability nke ọnụ ruru 67%, na-ebelata abụba ahụ site na ihe karịrị 20% na-ebelata oke akwara, na-emetụta agụụ ma ọ bụ okpomọkụ ahụ, ebe ọ na-eme ka mmetụta insulin dịkwuo mma, na-ebelata imeju abụba na mbufụt.
(4) Uru dị ala nke nsí: Ma e jiri ya tụnyere ihe ndị na-eme ka njikọ dị n'etiti ha dị iche iche, ọ dịghị ihe egwu nke nnukwu ahụ ọkụ ma ọ bụ nsí cytotoxicity. Enweghị mmebi akụkụ ahụ ma ọ bụ mmetụta ọjọọ nke akwara ozi..
Ngwa
1. Mbelata abụba na mmezi metabolism: Site na njikọta mitochondrial, ọ na-ebelata abụba ahụ nke ukwuu (n'ụdị anụmanụ, abụba ahụ na-ebelata ihe karịrị 20%), n'otu oge ahụ na-ebelata shuga dị n'ọbara, iguzogide insulin, na mkpokọta abụba imeju, na-enweghị mmetụta agụụ ma ọ bụ oke akwara;
2. Mgbochi ịka nká: Mee ka akwara dịkwuo mma (site na 8%) na ike (site na 40%) n'anụmanụ ndị meworo agadi, belata abụba ma gbochie mbufụt na-adịghị ala ala, ma lụso oke ibu nke na-akpata ọrịa myogenic ọgụ.
3. Ọgwụ mgbochi mbufụt: Na-ebelata ohere nke mmerụ ahụ akụrụ dị oke njọ nke sepsis kpatara (AKI), ma na-ebelata mmeghachi omume mkpali sistemụ site na igbochi mmepụta ROS mitochondrial na mwepụta mtDNA.
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