1-Methylnicotinamide Chloride CAS Nke:1005-24-9
Usoro Ngwaahịa
| Aha ngwaahịa | 1-Methylnicotinamide chloride |
| Aha ọzọ | N-Methylnicotinamide chloride; NMN-Cl; 1-MNA chloride；3-carbamoyl-1-methyl-pyridinium chloride |
| Nọmba CAS | 1005-24-9 |
| Usoro molekụla | C7H9N2OCl |
| Ibu molekụla | 172.61 |
| Ịdị ọcha | 98.5% |
| Ọdịdị | Ọcha - ọcha na-adịghị ọcha, ihe siri ike kristalntụ ntụ |
| Nkwakọ ngwaahịa | 1kg/akpa; 25kg/gbamgbam |
| Ngwa | chemicalennwalemihe ngosi ụlọ elu |
Okwu mmeghe ngwaahịa
1-Methylnicotinamide chloride bụ ihe e ji methylated nke nicotinamide mee, nke a na-ahụ site na nhazi nnu ammonium nke quaternary kwụsiri ike. Ọ na-eje ozi dị ka ihe dị mkpa n'ịmụ banyere metabolism nicotinamide. Mmiri na-agbaze nke ọma na nkwụsi ike kemịkalụ ya na-eme ka ọ dabara adaba dị ka ihe mejupụtara ngwaọrụ maka nyocha biochemical.
1-MNA bụ ihe sitere n'okike n'ahụ mmadụ, na-arụ ọrụ dị ka ihe nkịtị sitere na metabolism niacin. Dịka ihe dị n'etiti ụzọ metabolic a, a na-ejikwa aldehyde oxidase na-ahazi 1-MNA iji mepụta metabolites ndị dị n'okpuru ala dịka N-methyl-2-pyridone-5-carboxamide (2PY) na N-methyl-4-pyridone-3-carboxamide (4PY), nke a na-emesịa apụta site na sistemụ mmamịrị.
1-Methylnicotinamide chloride bụ ihe e ji methylated nke nicotinamide mee, nke a na-ahụ site na nhazi nnu ammonium nke quaternary kwụsiri ike. Ọ na-eje ozi dị ka ihe dị mkpa n'ịmụ banyere metabolism nicotinamide. Mmiri na-agbaze nke ọma na nkwụsi ike kemịkalụ ya na-eme ka ọ dabara adaba dị ka ihe mejupụtara ngwaọrụ maka nyocha biochemical.
1-MNA bụ ihe sitere n'okike n'ahụ mmadụ, na-arụ ọrụ dị ka ihe nkịtị sitere na metabolism niacin. Dịka ihe dị n'etiti ụzọ metabolic a, a na-ejikwa aldehyde oxidase na-ahazi 1-MNA iji mepụta metabolites ndị dị n'okpuru ala dịka N-methyl-2-pyridone-5-carboxamide (2PY) na N-methyl-4-pyridone-3-carboxamide (4PY), nke a na-emesịa apụta site na sistemụ mmamịrị.
atụmatụ
(1) Mmiri na-agbaze: Ọ na-agbaze ngwa ngwa na mmiri na ihe ndị na-agbaze ihe ndị dị ndụ.
(2) Ịkwụsi ike: Ọ na-adị mma n'ọnọdụ okpomọkụ ụlọ mana ọ chọrọ nchekwa n'ebe mmiri na-anaghị eru.
(3) Nchekwa: Njikọ Mba Yuropu emeela nyocha sayensị nke 1-MNA dị ka ihe oriri ọhụrụ. Dịka Iwu EU (EC) Nke 258/97 si dị, a na-ahụ 1-MNA dị mma maka oriri, yana oke oriri okenye kwa ụbọchị nke 58 mg, nke a na-atụ aro ya karịsịa maka iji na mgbakwunye nri.
Ngwa
1-Methylnicotinamide chloride (nke a kpọrọ MNC) bụ ihe e ji methylated mee nke nicotinamide. Enwere ike ịchọpụta 1-MNA site na usoro dịka high-performance liquid chromatography (HPLC) na enzyme-linked immunosorbent assay (ELISA). Ọ na-egosi ike maka ojiji n'ime ngalaba nri na ahụike. N'ụlọ ọrụ nri, ọ nwere ike ịrụ ọrụ dị ka antioxidant iji belata oxidation lipid ma chekwaa ịdị mma nri. N'ihi njirimara ya, ọ nwekwara ike ịrụ ọrụ dị ka ihe na-arụ ọrụ na nri ndị nwere nri siri ike. Ọzọkwa, 1-MNA na-egosi ọrụ na nhazi metabolic na mmezi nke ọnọdụ physiological, na-enye ya uru maka mmepe na nri bara uru na ihe mgbakwunye nri na-eburu nkwupụta ahụike.
Nnyocha EU kwubiri na iri 58 mg nke 1-MNA kwa ụbọchị site na ihe mgbakwunye nri agaghị ebute nsonaazụ ahụike na-adịghị mma n'ahụ mmadụ, a tinyekwara ya na katalọgụ nri ọhụrụ nke EU.
Dịka ihe dị mkpa gbasara molekul na ntụaka bioactive, 1-methylnicotinamide chloride nwere ohere sara mbara maka ojiji na nyocha sayensị, mmepe ọgwụ, na ụlọ ọrụ mgbakwunye nri. Nyocha nchekwa ya nke ọma na ọrụ dị iche iche nke ihe ndị dị ndụ na-eme ka ọ bụrụ isiokwu bara uru maka nyocha na akụkụ maka ojiji dị iche iche.
