Agomelatine ntụ ntụ emeputa CAS No .: 138112-76-2 99% ịdị ọcha min.maka ihe mgbakwunye
Ngwa ngwaahịa
| Aha ngwaahịa | Agomelatine |
| Aha ọzọ | N-[2- (7-Methoxy-1-naphthyl) ethyl] acetamide; N-[2- (7methoxynaphthalen-1-yl) ethyl] acetamide |
| CAS Mba. | 138112-76-2 |
| Usoro ihe omimi | C15H17NO2 |
| Ibu molekụla | 243.3082 |
| Ịdị ọcha | 99.0% |
| Ọdịdị | Ọcha ntụ ntụ |
| Nkwakọ ngwaahịa | 1kg/bag 25kg /drum |
| Ngwa | Ngwa ngwaahịa ahụike |
Ntinye ngwaahịa
Agomelatine bụ ụdị antidepressant ọhụrụ.Usoro ọrụ ya na-agbaji site na usoro mgbasa ozi monoamine ọdịnala.Ọ na-arụ ọrụ ndị na-anabata melatonin, MT1 na MT2, ma na-emegide ndị na-anabata 5-HT2C.Ọ nwere ike melite ogo ihi ụra ma weghachi usoro ndu ndu mgbe ọ na-enwe mmetụta antidepressant;N'etiti ha, site na imegide onye na-anabata 5-HT2C nke akpụkpọ ahụ postsynaptik, ọ nwere ike ịbawanye ntọhapụ nke DA na NE na prefrontal cortex ma rụọ ọrụ antidepressant.Mgbe MT agonism na 5-HT2C receptor antagonism dị n'otu oge ahụ, enwere ike ịmepụta mmetụta synergistic pụrụ iche iji kwalite ntọhapụ nke DA na NE na mpaghara ụbụrụ PFC, na-eme ka mmetụta antidepressant dịkwuo ike.Na mgbakwunye, agomelatine nwekwara ike ịkwalite ntọhapụ nke ụbụrụ neurotrophic nke ụbụrụ na-enweta na PFC ma gbochie ntọhapụ nke glutamate na-akpata nrụgide na mpaghara ụbụrụ amygdala.
Njirimara
(1) Usoro abụọ: Ọ bụghị naanị na ọ nwere ike ịhazi ntọhapụ nke melatonin, kamakwa ịhazi ntọhapụ nke 5-hydroxytryptamine na norepinephrine, si otú ahụ na-ekere òkè n'ịhazi ọnọdụ, ụra, mgbu na ihe ndị ọzọ.
(2) Mmelite nke ihi ụra: Agomelatine bụ nke nwere ike ime ka ehighị ụra nke ọma na-eme ka ụra ghara ịrahụ ụra ma ọ bụ coma.
(3) Meziwanye ọrụ ọgụgụ isi: Agomelatine nwere ike imeziwanye ọrụ ọgụgụ isi site na imeziwanye neuroplasticity na hippocampus.
(4) Nchekwa dị elu: E jiri ya tụnyere ndị ọzọ antidepressants, ọgwụ ahụ nwere mmetụta dị ntakịrị mgbe ọ na-agwọ ịda mbà n'obi, ọ gaghị emetụta ọrụ mmekọahụ na ibu ahụ.
Ngwa
Agomelatine bụ maka antidepressant nke bụkwa melatonin antagonist.Ọ na-ebelata mgbaàmà ịda mbà n'obi site n'ịgbanwe ọkwa nke melatonin MT1 ndị na-anabata ya (iji belata akara ngosi cortical) na ndị na-anabata MT2 (na circadian rhythms nke ụra) na serotonin.A na-ewere ya n'abalị iji ṅomie ụda anụ ahụ nke ntọhapụ nke melatonin, ọ nwere ike ime ka ụra dịkwuo mma.
