Agomelatine ntụ ntụ emeputa CAS No .: 138112-76-2 99% ịdị ọcha min. maka ihe mgbakwunye
Video ngwaahịa
Ngwa ngwaahịa
| Aha ngwaahịa | Agomelatine |
| Aha ọzọ | N-[2- (7-Methoxy-1-naphthyl) ethyl] acetamide; N-[2- (7methoxynaphthalen-1-yl) ethyl] acetamide |
| CAS Mba. | 138112-76-2 |
| Usoro ihe omimi | C15H17NO2 |
| Ibu arọ molekụla | 243.3082 |
| Ịdị ọcha | 99.0% |
| Ọdịdị | Ọcha ntụ ntụ |
| Nkwakọ ngwaahịa | 1kg/bag 25kg /drum |
| Ngwa | Ngwa ngwaahịa ahụike |
Ntinye ngwaahịa
Ebu ụzọ malite Agomelatine na Europe na 2009 ma kwadoro ugbu a maka ojiji na ihe karịrị mba 70. N'adịghị ka antidepressants ọdịnala, agomelatine na-arụ ọrụ site n'ịchụso melatonin na ndị na-anabata serotonin na ụbụrụ. Site n'ime ihe dị ka agonist na ndị na-anabata melatonin, agomelatine na-enyere aka ịhazi usoro ihi ụra na-akụghasị nke na-ejikọtakarị na ịda mbà n'obi. Usoro a abụghị naanị na-enyere aka melite ogo ihi ụra kamakwa ọ na-enye aka weghachi usoro ụda circadian eke. Na mgbakwunye, agomelatine na-eme dị ka onye na-emegide ya na ụfọdụ ndị na-anabata serotonin (5-HT2C receptors). Omume abụọ a pụrụ iche na-eme ka ọnụnọ nke serotonin dị n'ụbụrụ, onye na-ahụ maka nhazi ọnọdụ. Site n'ịhazi ọkwa serotonin, agomelatine nwere ike rụọ ọrụ dị ka ọgwụ mgbochi ịda mbà n'obi dị irè, na-ebelata mgbaàmà dị ka mwute, enweghị mmasị, mmetụta nke obi amamikpe ma ọ bụ abaghị uru. Na mgbakwunye, agomelatine nwere ike inye uru ndị ọzọ. Nnyocha na-egosi na ọ nwere ike inye aka melite ọrụ ọgụgụ isi Nnyocha na-egosipụta ikike ya ịkwalite ebe nchekwa, nlebara anya, na ọrụ ndị isi, na-eme ka ọ bụrụ ebe na-akpali akpali maka nchọpụta n'ọdịnihu.
Njirimara
(1) Ịdị ọcha dị elu: Agomelatine nwere ike nweta ngwaahịa dị ọcha site na nhazi usoro mmepụta ihe. Ịdị ọcha dị elu pụtara bioavailability ka mma yana mmeghachi omume ọjọọ dị ole na ole.
(2) Nchekwa: Nchekwa dị elu, mmeghachi omume ọjọọ ole na ole.
(3) Nkwụsi ike: Agomelatine nwere ezigbo nkwụsi ike ma nwee ike ịnọgide na-arụ ọrụ ya na mmetụta ya n'okpuru ebe dị iche iche na ọnọdụ nchekwa.
Ngwa
Agomelatine bụ antidepressant na melatonin antagonist. Ọ na-ebelata mgbaàmà ịda mbà n'obi site n'ịchịkwa melatonin MT1 ndị na-anabata ya (na-ebelata akara ngosi cortical) na ndị na-anabata MT2 (circadian sleep rhythm) na ọkwa serotonin. A na-ewere ya n'abalị, ọ na-eṅomi usoro ụda nke melatonin ma nwee ike melite ogo ụra nke ọma. Usoro ọrụ ya na-agbaji site na usoro mgbasa ozi monoamine ọdịnala. Ọ na-arụ ọrụ ndị na-anabata melatonin MT1 na MT2 ma na-emegide ndị na-anabata 5-HT2C. Na-eme ka ihi ụra dịkwuo mma, na-eweghachi usoro ndu ndu, ma nwee mmetụta antidepressant; N'etiti ha, site na mmegide 5-HT2C ndị na-anabata ya na akpụkpọ anụ postsynaptik, ọ nwere ike ịbawanye ntọhapụ nke DA na NE na prefrontal cortex, na-enwe mmetụta antidepressant. Mgbe MT agonism na 5-HT2C receptor antagonism na-ebikọ ọnụ, enwere ike ịmepụta mmetụta synergistic pụrụ iche, na-akwalite ntọhapụ nke DA na NE na mpaghara ụbụrụ PFC, na-eme ka mmetụta antidepressant dịkwuo ike. Na mgbakwunye, agomelatine nwere ike ịkwalite ntọhapụ nke ụbụrụ neurotrophic nke ụbụrụ na-enweta na PFC ma gbochie ntọhapụ nke glutamate na-akpata nrụgide na mpaghara ụbụrụ amygdala.
