5-Amino-1-methylquinolinium chloride CAS Nọmba:42464-96-0 98.0% ịdị ọcha nkeji | onye nrụpụta ihe mgbakwunye
Usoro Ngwaahịa
| Aha ngwaahịa | 5-Amino-1-methylquinolinium chloride(5-amino-1MQ) |
| Aha ọzọ | 5-amino-1MQ5-Amino-1-mq klorid 5-Amino-1-methylquinolinium chloride 5-Amino-1-methylquinolin-1-ium chloride 5-AMINO-1-METHYLQUINOLIN-1-IUM CHLOEIDE 5-Amino-1-methyl-1-quinolinium chloride |
| Nọmba CAS | 42464-96-0 |
| Usoro molekụla | C₁₀H₁₁ClN₂ |
| Ibu molekụla | 194.6 |
| Ịdị ọcha | 98% |
| Ọdịdị | Agba aja aja ruo ọbara ọbara siri ike |
| Nkwakọ ngwaahịa | 1kg/akpa, 25kg/gbọmgbọm |
| Ngwa | Ihe Mgbakwunye Nri Ihe Ndị A Na-anaghị Ewu |
Okwu mmeghe ngwaahịa
5-Amino-1-methylquinolinium chloride bụ enzyme a na-egosipụta oke n'oge agadi akwara ọkpụkpụ ma jikọtara ya na ndozi nke mmebi ụzọ NAD+, ọrụ sirtuin1 na-adịghị mma, na mmụba nke mkpụrụ ndụ akwara. 5-Amino-1-methylquinolinium chloride na-akwalite mgbanwe myoblast na vitro ma na-eme ka njikọ na imeghari nke mkpụrụ ndụ akwara dịkwuo mma n'ime òké ndị meworo agadi. 5-Amino-1-methylquinolinium chloride bụkwa ihe na-egbochi nicotinamide N-methyltransferase (NNMT), na-ejikọ nke ọma na ihe fọdụrụ na NNMT substrate njikọ saịtị. 5-Amino-1-methylquinolinium chloride na-akwalite mgbanwe myoblast na vitro ma na-eme ka njikọ na mmeghari nke mkpụrụ ndụ akwara dịkwuo mma n'ime òké ndị meworo agadi. N'ime ha, achọpụtala enzyme cytosolic nicotinamide N-methyltransferase (NNMT) ọhụrụ iji chịkwaa ọkwa nke ihe ndị na-ebute nicotinamide dị mkpa maka biosynthesis NAD+, ya mere ọ na-arụ ọrụ dị mkpa n'ịchịkwa ụzọ nzọpụta NAD+ na metabolism sel.
5-Amino-1-Methylquinolinium Chloride na-arụ ọrụ n'ime microbiome gị iji belata abụba abụba ma nyere gị aka ifelata. Mgbe mkpụrụ ndụ abụba ndị ọzọ na-agbakọta, ahụ gị na-emepụta enzyme a maara dị ka NNMT (nicotinamide N-methyltransferase). Ka NNMT na-abawanye, otú ahụ ka ahụ gị na-eme ka mbufụt dịkwuo elu ma na-echekwa abụba. 5-Amino-1-Methylquinolinium Chloride na-egbochi NNMT, na-ekwe ka ahụ gị daa oke ibu.
atụmatụ
(1) Ịdị ọcha dị elu: 5-Amino-1-methylquinolinium chloride nwere ike inweta ngwaahịa dị ọcha dị elu site na usoro mmepụta emelitere. Ịdị ọcha dị elu pụtara nnweta bioavailability ka mma.
(2) Nlebara anya: 5-Amino-1-methylquinolinium chloride na-elekwasị anya kpọmkwem na enzyme NNMT ma nwee ike igbochi ọrụ ya nke ọma, si otú a na-emetụta ụzọ metabolic nke nicotinamide.
(3) Ịkwụsi ike: 5-Amino-1-methylquinolinium chloride nwere ezigbo nkwụsi ike ma nwee ike ịnọgide na-arụ ọrụ na mmetụta ya n'okpuru gburugburu ebe obibi na ọnọdụ nchekwa dị iche iche.
(4) Olileanya mmepe: N'ihi njirimara dị iche iche nke 5-Amino-1-methylquinolinium chloride, mmepe ya enwetala nlebara anya zuru oke ma nwee nnukwu nyocha na atụmanya ojiji.
Ngwa
5-Amino-1-methylquinolinium chloride bụ ihe na-egbochi nicotinamide N-methyltransferase (NNMT) nke na-akwalite mgbanwe myoblast. Enwere ike iji 5-Amino-1-methylquinolinium chloride dị ka ihe mgbakwunye iji nyere aka belata ibu na abụba ma melite abụba imeju.
