5-Amino-1-methylquinolinium iodide(NNMTi) Nọmba CAS:42464-96-0 98.0% ịdị ọcha nkeji | onye nrụpụta ihe mgbakwunye
Usoro Ngwaahịa
| Aha ngwaahịa | 5-Amino-1-methylquinolinium iodide(NNMTi) |
| Aha ọzọ | NNMTi5-AMINO-1-METHYLQUINOLIN-1-IUM IODIDE 5-amino-1-methylquinolinium iodide 5-Amino-1-methylquinolin-1-iumiodide 1-methylquinolin-1-ium-5-amine; ayodid 5-Amino-1-methyl-1-quinolinium Iodide 5-Amino-1-mq iodide |
| Nọmba CAS | 42464-96-0 |
| Usoro molekụla | C10H11IN2 |
| Ibu molekụla | 286.11 |
| Ịdị ọcha | 98.0% |
| Ọdịdị | Agba aja aja ruo ọbara ọbara siri ike |
| Nkwakọ ngwaahịa | 1kg/akpa, 25kg/gbọmgbọm |
| Ngwa | Ihe Mgbakwunye Nri Ihe Ndị A Na-anaghị Ewu |
Okwu mmeghe ngwaahịa
A chọpụtala na enzyme cytosolic nicotinamide N-methyltransferase (NNMT) na-achịkwa ọkwa nke ihe ndị na-ebute nicotinamide dị mkpa maka biosynthesis NAD+, ya mere ọ na-arụ ọrụ dị mkpa n'ịchịkwa ụzọ mgbapụta NAD+ na metabolism cellular. A na-egosipụta NNMT na akwara ọkpụkpụ, ngosipụta ya na-abawanye nwayọ nwayọ ka anụ ahụ akwara na-aka nká. Ihe dị mkpa bụ na NNMT bụ akụkụ dị mkpa nke mbinye aka nke mkpụrụ ndụ sarcopenic, oke ngosipụta ya nwere ike ibute mbelata dị ukwuu na ọkwa NAD+ na mbelata na oke akwara, ike, na ọrụ nke na-eso ịka nká. Ọgwụgwọ nke òké ndị meworo agadi na obere molekul NNMT inhibitor (NNMTi) mere ka mmụba, njikọta, na ikike mmeghari nke muSCs dịkwuo mma, si otú a na-eme ka arụmọrụ ọrụ nke akwara ọkpụkpụ dịkwuo mma. E nwetara nsonaazụ ndị yiri ya na vitro site na iji mkpụrụ ndụ C2C12, nke yiri nnọọ muSCs, ebe ọgwụgwọ NNMTi kwalitere ọdịiche myoblast ma kwado mgbanwe metabolic na metabolites cellular metụtara ụzọ mgbapụta NAD +.
NNMTi bụ enzyme a na-egosipụta oke n'oge agadi akwara ọkpụkpụ ma jikọtara ya na mmebi nke ụzọ NAD+, ọrụ sirtuin1 na-adịghị mma, na mmụba nke mkpụrụ ndụ akwara. NNMT bụ enzyme metabolic nke na-eme ka methylation nke nicotinamide (NAM) dị ike site na iji S-adenosylmethionine (SAM) zuru ụwa ọnụ, na-ejikọ ọnọdụ metabolic nke mkpụrụ ndụ na nguzozi methylation na ọkwa NAD+ dị n'ime sel. NNMT na-egosipụta nke ukwuu n'ime imeju na anụ ahụ adipose, yana n'ọnọdụ ọrịa nke mmụba nke ọchịchọ metabolic, dị ka ụfọdụ ọrịa imeju abụba na ọrịa shuga. NNMT na-etinye aka na usoro dị iche iche, gụnyere mgbanwe mkpụrụ ndụ embrayo na-eto eto, myogenesis, na mgbanwe epithelial na neuromesenchymal na ọrịa kansa dị iche iche. A na-achịkwa ngosipụta NNMT n'ụzọ anụ ahụ na nke dị n'ọnọdụ kama site na usoro iwu zuru ebe niile.
atụmatụ
(1) Ịdị ọcha dị elu: NNMTi nwere ike inweta ngwaahịa dị ọcha dị elu site na usoro mmepụta dị mma. Ịdị ọcha dị elu pụtara nnweta bioavailability ka mma.
(2) Nledo: NNMTi na-elekwasị anya kpọmkwem na enzyme NNMT ma nwee ike igbochi ọrụ ya nke ọma, si otú a na-emetụta ụzọ metabolic nke nicotinamide.
(3) Ịkwụsi ike: NNMTi nwere ezigbo nkwụsi ike ma nwee ike ịnọgide na-arụ ọrụ na mmetụta ya n'okpuru gburugburu ebe obibi na ọnọdụ nchekwa dị iche iche.
(4)Olileanya mmepe: N'ihi njirimara dị iche iche nke NNMTi, mmepe ya enwetala nlebara anya zuru oke ma nwee nnukwu nyocha na atụmanya itinye n'ọrụ.
Ngwa
NNMTi (CAS 42464-96-0) bụ ihe na-egbochi nicotinamide N-methyltransferase (NNMT), ihe na-egbochi myoblast dị ike (IC50=1.2 μM) nke nicotinamide N-methyltransferase (NNMT) nke na-akwalite mgbanwe myoblast. NNMTi na-ejikọ nke ọma na ihe fọdụrụ na NNMT substrate na-ejikọ ebe. NNMTi na-akwalite mgbanwe myoblast in vitro ma na-eme ka njikọ mkpụrụ ndụ akwara na mmeghari ohuru dịkwuo mma n'ime òké ndị meworo agadi. NNMT bụ enzyme cytosolic biotransformation dị mkpa nke na-akwalite N-methylation nke endogenous na exogenous xenobiotics. Ma e jiri ya tụnyere nnọchi nri dị nro naanị, ọgwụgwọ NNMTi yana nnọchi nri dị nro na-eme ka mmụba na mfu abụba ahụ dịkwuo elu, mụbaa oke ahụ dum na oke ibu ahụ, belata ibu anụ ahụ epididymal ọcha adipose imeju, belata itinye abụba imeju, na imeziwanye steatosis imeju. Na mgbakwunye, NNMTi nwere ike ịbawanye ike ma kwalite ikike mmeghari nke akwara meworo agadi, nke nwere ike ịba uru maka ọgwụgwọ sarcopenia.
