SLU-PP-332 Nọmba CAS: 303760-60-3
Usoro Ngwaahịa
| Aha ngwaahịa | SLU-PP-332 |
| Aha ọzọ | SLU-PP-332； (E)-4-Hydroxy-N′(Naphthalen-2-Ylmethylene)Benzohydrazide;4-Hydroxybenzoic acid 2-(2-naphthalenylmethylene)hydrazide; |
| Nọmba CAS | 303760-60-3 |
| Usoro molekụla | C18H14N2O2 |
| Ibu molekụla | 290.32 |
| Ịdị ọcha | 98% |
| Ọdịdị | Ntụ ntụ ọcha ma ọ bụ nke na-acha ọcha |
| Nkwakọ ngwaahịa | 1kg/akpa, 25kg/gbọmgbọm |
| Ngwa | Ihe Mgbakwunye Nri Ihe Ndị A Na-anaghị Ewu |
Okwu mmeghe ngwaahịa
SLU-PP-332 bụ obere molekul ọhụrụ nke na-arụ ọrụ dị ka agonist nke perifollicle estrogen receptor (ERR), nke na-elekwasị anya na ERRα, ERRβ, na ERRγ, yana mmetụta mkpali kachasị ike na ERRα (EC₅₀=98 nM). Ngwakọta a na-eme ka ụzọ mgbaama ERR rụọ ọrụ site n'iṅomi usoro nhazi metabolic nke mmega ahụ, si otú a na-agbanwe metabolism ike, ọrụ mitochondrial, na ntachi obi akwara.
atụmatụ
(1) Usoro ọrụ: mee ka ERRα/β/γ rụọ ọrụ, mee ka oxidation nke abụba (FAO) na mkpụrụ ndụ ihe nketa metụtara iku ume mitochondrial dịkwuo mma, kwalite mmebi abụba maka inye ike, belata mkpokọta abụba, melite ọrụ mitochondrial nke akwara ọkpụkpụ, melite ikike oxidation na ntachi obi, dịka mmetụta nke ọzụzụ aerobic.
(2) Mmega ahụ: a) Mmetụta nke ihe nlereanya anụmanụ: Òké buru ibu: mgbe ụbọchị 28 nke ọgwụ gasịrị, ibu ahụ belatara site na 12%, abụba imeju, cholesterol, na triglycerides belatara nke ukwuu; òké nkịtị: oge ịgba ọsọ mụbara site na 70%, anya mụbara site na 45%, na-enweghị mmetụta agụụ ma ọ bụ mmegharị afọ ofufo. b) Nchekwa: ahụghị mmetụta ọjọọ dị njọ na ọmụmụ ihe tupu a mụọ ọgwụ.
(3) Njirimara anụ ahụ na kemịkalụ: ọcha ruo ọcha siri ike, na-agbaze na DMSO4 (75 mg/mL) na ethanol, nke anaghị agbaze na mmiri; a ga-echekwa ya n'ọchịchịrị.
Ngwa
SLU-PP-332 na-enweta mbelata abụba na nhazi glucose ọbara site n'ịkwalite oxidation abụba na imeziwanye mmetụta insulin; ọ na-eme ka ọrịa imeju abụba na-abụghị mmanya na-aba n'anya (NAFLD) ka mma, na-ebelata ọdịnaya abụba imeju; na-enye nkwado metabolic maka ndị na-enweghị ike ịme mmega ahụ, na-enwe oke akwara na ọrụ; na-ebelata mbelata akwara n'oge usoro mbelata abụba; ma nwee nnukwu atụmanya n'akụkụ mbelata abụba, imeziwanye ntachi obi, na imeziwanye metabolism.
