RU58841 onye na-emepụta ntụ ntụ CAS Nọmba: 154992-24-2 99.0% ịdị ọcha nkeji maka ihe mgbakwunye
Usoro Ngwaahịa
| Aha ngwaahịa | 4-[3-(4-Hydroxybutyl)-4,4-dimethyl-2,5-dioxo-1-imidazolidinyl]-2-(trifluoromethyl)benzonitrile |
| Aha ọzọ | RU58841 |
| Nọmba CAS | 154992-24-2 |
| Usoro molekụla | C17H18F3N3O3 |
| Ibu molekụla | 369.34 |
| Ịdị ọcha | 99.0% |
| Ọdịdị | ntụ ntụ ọcha |
| Nkwakọ ngwaahịa | 1kg/akpa |
| Ngwa | Too ntutu isi |
Okwu mmeghe ngwaahịa
RU58841 (a makwaara dịka RU-58841) bụ ihe mejupụtara ya, RU58841 na-asọmpi na dihydrotestosterone iji mee ka ọkwa DHT dị n'ime oke nkịtị, si otú a na-achịkwa usoro uto ntutu. Ọ na-akpali mgbanwe nke follicles ntutu ọhụrụ ka ọ bụrụ follicles ntutu anagen site na ịbanye na usoro anagen. Inye follicles mebiri emebi oge ịlaghachi na usoro uto nkịtị na-enyere mkpụrụ ndụ aka ịgbake. Ọ na-emekwa ka ọbara na-eruba na follicles mebiri emebi ma na-enyere ha aka ịmaliteghachi. N'aka nke ọzọ, RU58841 (RU-58841) na-arụ ọrụ site na ijikọ na ndị na-anabata androgen na follicles ntutu. Ya mere, androgens enweghị ohere ijikọ ma malite mmeghachi omume nke androgenetic alopecia ma malite usoro a na-akpọ miniaturization. Egosila na ọ na-egbochi ozi mfu ntutu a n'ógbè ka uto ntutu nkịtị wee nwee ike ịga n'ihu.
atụmatụ
(1) Nwere ike igbochi ntutu isi ịda: RU58841 bụ ọgwụ pụrụ iche nke na-egbochi homonụ, nke nwere ike igbochi njikọta nke sel follicle ntutu isi androgen na isi, si otú a na-ebelata ohere nke ntutu isi ịda.
(2) Ọ na-amịkọrọ nke ọma: RU58841 nwere obere ibu molekul, nhazi ya dị mfe, ọ dịkwa mfe ịmịkọrọ. Ọ nwere ike ịbanye n'ahụ ngwa ngwa ma malite ịrụ ọrụ n'ime obere oge.
(3) Nnukwu nhọrọ na androgen: RU58841 nwere ike igbochi ọrụ androgen n'enweghị mmetụta na homonụ ndị ọzọ.
(4) Ogologo oge ọrụ: RU58841 nwere ọkara ndụ ogologo n'ahụ, ọ nwere ike igbochi mmetụta nke androgen mgbe niile, oge dị irè nwekwara ike ịdịru awa 48.
(5) Ịdị ọcha dị elu: Site na mwepụta eke na usoro nrụpụta dị mma, mmepe nke RU58841 nwere ike nweta ngwaahịa dị ọcha dị elu.
Ngwa
N'ime nnyocha na nnwale ahụike, egosila na RU58841 na-eme ka ọnụego mmụgharị mkpụrụ ndụ dịkwuo elu na mkpụrụ ndụ stromal, na-eme ka mmụba mkpụrụ ndụ dịkwuo elu na mkpụrụ ndụ mgbọrọgwụ mpụta ma na-eme ka dayameta ntutu na njupụta ntutu dịkwuo elu, yabụ RU58841 bụ ọgwụ nyocha maka ọgwụgwọ nke alopecia androgenic. Isi ihe na-arụ ọrụ bụ igbochi njikọta nke DHT na AR nke follicles ntutu, nke a na-ejikarị agwọ nsogbu ntutu isi na ntutu isi.
