RU58841 onye na-emepụta ntụ ntụ CAS No.: 154992-24-2 99.0% ịdị ọcha min. maka ihe mgbakwunye
Ngwa ngwaahịa
| Aha ngwaahịa | 4-[3- (4-Hydroxybutyl) -4,4-dimethyl-2,5-dioxo-1-imidazolidinyl]-2- (trifluoromethyl) benzonitrile |
| Aha ọzọ | RU58841 |
| CAS Mba. | 154992-24-2 |
| Usoro ihe omimi | C17H18F3N3O3 |
| Ibu arọ molekụla | 369.34 |
| Ịdị ọcha | 99.0% |
| Ọdịdị | ọcha ntụ ntụ |
| Nkwakọ ngwaahịa | 1kg/akpa |
| Ngwa | Too ntutu isi |
Ntinye ngwaahịa
RU58841 (nke a makwaara dị ka RU-58841) bụ ngwakọta, RU58841 na-asọmpi dihydrotestosterone iji mee ka ọkwa DHT dị n'ime oke nkịtị, si otú ahụ na-achịkwa usoro ntutu isi. Ọ na-akpali ntụgharị nke ntutu isi ọhụrụ n'ime ntutu isi anagen site na ịbanye na oge anagen. Ikwenye oge follicle mebiri emebi ka ọ laghachi azụ n'oge uto na-enyere mkpụrụ ndụ aka ịgbake. Ọ na-eme ka ọbara na-eruba na follicles mebiri emebi ma na-enyere ha aka ịmaliteghachi. N'aka nke ọzọ, RU58841 (RU-58841) na-arụ ọrụ site na ijikọta ndị na-anabata androgen na ntutu isi. Ya mere, androgens enweghị ohere ijikọ wee malite mmeghachi omume nke androgenetic alopecia wee malite usoro a na-akpọ miniaturization. E gosiputara na ọ ga-akwụsị ozi ntutu isi a n'ime obodo ka uto ntutu isi wee gaa n'ihu.
Njirimara
(1) Nwere ike igbochi ntutu isi: RU58841 bụ ihe mgbochi homonụ pụrụ iche, nke nwere ike igbochi njikọta nke androgen na sel follicle ntutu isi, si otú ahụ belata ohere nke ntutu isi.
(2) Ntinye dị mma: RU58841 nwere obere ihe dị arọ, nhazi dị mfe, ma dị mfe ịnweta. Ọ nwere ike banye ngwa ngwa banye n'ime ahụ wee rụọ ọrụ n'ime obere oge.
(3) Nhọrọ dị elu na androgen: RU58841 nwere ike igbochi ọrụ nke androgen na-enweghị emetụta homonụ ndị ọzọ.
(4) Ogologo oge nke ime ihe: RU58841 nwere ogologo ndụ ọkara ndụ n'ime ahụ, nwere ike na-egbochi mmetụta nke androgen, na oge dị irè nwere ike ịdị ogologo oge 48 awa.
(5) Ịdị ọcha dị elu: Site na mmịpụta eke na usoro nrụpụta dị mma, mmepe nke RU58841 nwere ike nweta ngwaahịa dị ọcha.
Ngwa
N'ime nyocha na nyocha ụlọ ọgwụ, RU58841 egosila na ọ na-eme ka ọnụọgụ mkpụrụ ndụ na-amụba n'ime mkpụrụ ndụ stromal, na-amụba ụba nke cell na mpụta akwụkwọ mgbọrọgwụ ma na-amụba dayameta ntutu isi na njupụta ntutu, ya mere RU58841 bụ ọgwụ nyocha maka ọgwụgwọ nke androgenetic alopecia. Ụkpụrụ ọrụ bụ isi bụ igbochi njikọ DHT na AR nke ntutu isi, nke a na-ejikarị agwọ ọrịa ntutu na ntutu isi.
