Onye na-emepụta ntụ ntụ PRL-8-53 Nọmba CAS: 51352-87-5 98% ịdị ọcha nkeji maka ihe mgbakwunye
Usoro Ngwaahịa
| Aha ngwaahịa | PRL-8-53 |
| Aha ọzọ | Methyl 3-(2-(benzyl(Methyl)aMino)ethyl)benzoate hydrochloride；Asịd Benzoic, 3-[2-[methyl(phenylmethyl)amino]ethyl]-, methyl ester, hydrochloride (1:1)；Methyl 3-{2-[benzyl(methyl)amino]ethyl}benzoate hydrochloride (1:1) |
| Nọmba CAS | 51352-87-5 |
| Usoro molekụla | C18H22ClNO2 |
| Ibu molekụla | 319.83 |
| Ịdị ọcha | 98.0% |
| Ọdịdị | Ntụ ntụ ọcha |
| Nkwakọ ngwaahịa | 1 kg kwa akpa 25kg kwa drum |
| Ngwa | nootropic |
Okwu mmeghe ngwaahịa
PRL-8-53, nke a makwaara dị ka methyl 3-(2-(benzyl(methyl)amino)ethyl)benzoate, bụ ihe mejupụtara nootropic sịntetik nke a na-eche na ọ na-eme ka nnyefe cholinergic dịkwuo mma ma na-achịkwa ọkwa dopamine n'ụbụrụ. Omume ndị a na-enye aka na mmetụta ya nwere ike ime ka ọgụgụ isi dịkwuo mma, si otú a na-eme ka nhazi ncheta dịkwuo mma, na-ejide ya, na-enwetaghachi ya. Ọtụtụ ọmụmụ ihe gbasara anụmanụ na ụmụ mmadụ akọpụtala nsonaazụ dị mma maka ihe ndị na-eme ka ncheta dịkwuo mma. N'ọmụmụ ihe nnwale nke abụọ-kpuru ìsì, nke a na-achịkwa placebo, ndị natara otu dose nke PRL-8-53 gosipụtara ikike ncheta okwu ka mma ma e jiri ya tụnyere otu placebo. Nchọpụta ndị a kpaliri mmasị na nyocha ọzọ na ikike nke ogige ahụ. Ọmụmụ ihe ọzọ na oke gosiri na inye PRL-8-53 mere ka ikike ha ịmụta ihe dịkwuo mma n'ọrụ mmiri maze. Oke ndị a na-agwọ PRL-8-53 nwere ike ịchọta ikpo okwu zoro ezo nke ọma karịa njikwa, na-egosi ikike nke ogige ahụ dị ka ihe na-eme ka ncheta dịkwuo mma.
atụmatụ
(1) Ịdị ọcha dị elu: PRL-8-53 nwere ike inweta ngwaahịa dị ọcha dị elu site na usoro mmepụta dị mma. Ịdị ọcha dị elu pụtara nnweta bioavailability ka mma na obere mmeghachi omume ọjọọ.
(2) Nchekwa: Nchekwa dị elu, obere mmeghachi omume ọjọọ, enweghị mmeghachi omume ọjọọ doro anya.
(3) Ịkwụsi ike: PRL-8-53 nwere ezigbo nkwụsi ike ma nwee ike ịnọgide na-arụ ọrụ na mmetụta ya n'okpuru gburugburu ebe obibi na ọnọdụ nchekwa dị iche iche.
Ngwa
Dịka ụdị mgbakwunye ọhụrụ nke mgbakwunye mmụba nghọta, PRL-8-53 na-eme ka ebe nchekwa dị mkpụmkpụ na ebe nchekwa ọrụ ka mma, ebe ọ na-eme ka ikike mmụta na ọsọ inweta nkà dịkwuo mma, na-enyere aka imeziwanye mmụta na arụmọrụ ọrụ. Nnyocha na-egosi na PRL-8-53 nwere ike ịkwalite uto na mmeghari nke neurons n'ụbụrụ. PRL-8-53 nwere ike ime ka ọsọ nke ụbụrụ na-ahazi ozi dịkwuo elu, na-enye ndị mmadụ ohere imezu ọrụ ma mee mkpebi ngwa ngwa. Ọ bụ ezie na e jiri ya tụnyere ihe ndị ọzọ na-adịghị ahụkebe. Agbanyeghị, nnyocha na PRL-8-53 pere mpe, mana nnyocha dị ugbu a na-egosi na ọ nwere ike imeziwanye ikike ncheta na nghọta.
