Onye na-emepụta ntụ ntụ Oleoylethanolamide (OEA) Nọmba CAS: 111-58-0 98%, 85% ịdị ọcha nkeji maka ihe mgbakwunye
Usoro Ngwaahịa
| Aha ngwaahịa | Oleoyl ethanolamide |
| Aha ọzọ | N-oleoyl ethanolamine; N-(2-hydroxyethyl)-,(Z)-9-Octadecenamide |
| Nọmba CAS | 111-58-0 |
| Usoro molekụla | C20H39NO2 |
| Ibu molekụla | 325.53 |
| Ịdị ọcha | 98.0% ,85.0% |
| Ọdịdị | Ntụ ntụ kristal ọcha dị mma |
| Nkwakọ ngwaahịa | 1kg/akpa, 25kg/gbamgbam |
| Ngwa | Mgbu mgbu, mgbochi mkpali |
Okwu mmeghe ngwaahịa
Oleoylethanolamide bụ ngwakọta amide nke abụọ nke mejupụtara lipophilic oleic acid na hydrophilic ethanolamine. Oleoylethanolamide bụkwa molekul lipid na-apụta n'okike n'anụmanụ na osisi ndị ọzọ. Ọ dị n'ọtụtụ ebe n'anụmanụ na osisi dịka ntụ koko, soybean, na mkpụrụ, mana ọdịnaya ya dị obere nke ukwuu. Naanị mgbe gburugburu ebe obibi dị n'èzí gbanwere ma ọ bụ kpalite nri, anụ ahụ dị n'ime ahụ ka a ga-emepụta ihe a karịa.
N'okpomọkụ ụlọ, Oleoylethanolamide bụ ihe siri ike ọcha nwere ebe agbaze ihe dị ka 50°C. Ọ na-agbaze ngwa ngwa na ihe mgbaze mmanya dịka methanol na ethanol, ọ na-agbaze ngwa ngwa na ihe mgbaze na-abụghị polar dị ka n-hexane na ether, ọ naghịkwa agbaze na mmiri. OEA bụ molekul amphiphilic nke a na-ejikarị eme ihe dị ka surfactant na sachaa ihe na ụlọ ọrụ kemịkalụ. Agbanyeghị, nnyocha ndị ọzọ chọpụtara na OEA nwere ike ije ozi dị ka molekul mgbaàmà lipid na axis eriri afọ ma gosipụta usoro ihe omume bayoloji n'ahụ, gụnyere: ijikwa agụụ, imeziwanye metabolism lipid, imeziwanye ncheta na nghọta na ọrụ ndị ọzọ. N'ime ha, ọrụ Oleoylethanolamide nke ijikwa agụụ na imeziwanye metabolism lipid enwetawo nlebara anya kachasị.
Oleoylethanolamide nwere ike ịchịkwa oriri na homeostasis nke nri na ike site na ịgbalite receptor-α nke peroxisome proliferator na-arụ ọrụ. Na mgbakwunye, Oleoylethanolamide na-egosipụta ọrụ ndị ọzọ metụtara ahụike, gụnyere ịhazi ọrụ mgbanwe na ụzọ mgbaàmà lysosomal-to-nuclear nke metụtara nhazi ogologo oge na ichekwa akwara ndị na-achịkwa omume ịda mbà n'obi. Nnyocha na-atụkwa aro na Oleoylethanolamide nwere ike inwe mmetụta neuroprotective. Na ụdị anụmanụ, achọpụtala na ọ na-ebelata mmebi sitere na strok na mmerụ ahụ ụbụrụ. A na-akọwa mmetụta nchịkwa nke Oleoylethanolamide na njikọ ya na PPARα, nke na-ebelata na retinoid X receptor (RXR) ma na-eme ka ọ rụọ ọrụ dị ka ihe ntụgharị siri ike nke metụtara njikọta ike homeostasis, metabolism lipid, autophagy, na mbufụt. ihe mgbaru ọsọ ala.
atụmatụ
(1) Ịdị ọcha dị elu: OEA nwere ike nweta ngwaahịa dị ọcha dị elu site na usoro mmepụta dị mma. Ịdị ọcha dị elu pụtara nnweta bioavailability ka mma na obere mmeghachi omume ọjọọ.
(2) Nchekwa: A chọpụtala na OEA dị mma maka ahụ mmadụ.
(3) Ịkwụsi Ike: OEA nwere ezigbo nkwụsi ike ma nwee ike ịnọgide na-arụ ọrụ na mmetụta ya n'okpuru gburugburu ebe obibi na ọnọdụ nchekwa dị iche iche.
(4) Ọ dị mfe ịmịkọrọ: Ahụ mmadụ nwere ike ịmịkọrọ OEA ngwa ngwa ma kesaa ya na anụ ahụ na akụkụ ahụ dị iche iche.
Ngwa
Oleoylethanolamide bụ lipid ethanolamide eke nke a na-eji dị ka nhazi nri na njikwa ibu ahụ n'ọtụtụ ụdị vertebrate. Ọ bụ metabolite nke oleic acid nke e mepụtara n'ime obere eriri afọ mmadụ. Oleylethanolamide (OEA) bụ molekul nke na-achịkwa metabolism lipid na homeostasis ike. Ọ na-arapara na ndị na-anabata PPAR Alpha ma na-enyere aka ijikwa ihe anọ: agụụ, abụba ahụ, cholesterol na ibu. PPAR Alpha na-anọchite anya peroxide proliferator-activated receptor alpha, bioactive lipid amide oleoylethanolamide (OEA) nwekwara ọtụtụ ihe pụrụ iche homeostatic, gụnyere ọrụ mgbochi mkpali, modulation response response, na mmetụta antioxidant.
