CMS121 onye na-emepụta ntụ ntụ CAS No.: 1353224-53-9 98.0% ịdị ọcha min. maka ihe mgbakwunye
Ngwa ngwaahịa
| Aha ngwaahịa | CMS121 |
| Aha ọzọ | CMS-121; 1,2-Benzenediol,4-[4- (cyclopentyloxy) -2-quinolinyl] -; 4- (4- (cyclopentyloxy) quinolin-2-yl) benzene-1,2-diol (CMS121); ACC, AcetylCoenzymeACarboxylase, ọrịa, neuroprotective, igbochi, mgbochi mkpali, mitochondrial, Alzheimer's, antioxidant, acetylation, inhibitor, H3K9, Acetyl-CoACarboxylase, CMS121, dementia, ACC1, CMS-121 |
| CAS Mba. | 1353224-53-9 |
| Usoro ihe omimi | C20H19NO3 |
| Ibu arọ molekụla | 321.37 |
| Ịdị ọcha | 98.0% |
| Ọdịdị | Ntụ ntụ edo edo dị ọkụ |
| Ngwa | Ihe mgbakwunye nri nri |
Ntinye ngwaahịa
4- (4- (cyclopentyloxy) quinolin-2-yl) benzene-1,2-diol bụ ihe a na-akpọkwa CMS121. Mgbagwoju anya nhazi nke ogige ahụ na-egosi na ọ nwere ike ịnwe akụrụngwa pụrụ iche yana ojiji enwere ike. Iji ghọta mkpa ọ dị, ọ na-enyere aka ịchọpụta otu ndị na-arụ ọrụ na-eweta na nyochaa mmetụta ha nwere ike ime. Ọnụnọ nke mgbanaka quinoline na-egosi na ogige ahụ nwere ike ịdị na-arụ ọrụ nke ndụ. A na-ama ụmụ irighiri ihe ndị sitere na Quinoline maka ihe ndị dị ndụ ha dị iche iche, gụnyere ihe na-egbu egbu na mgbochi mkpali. Mgbakwunye nke otu cyclopentyloxy nwere ike inye aka na solubility nke ogige ma ọ bụ kwalite ọrụ ndu ya site na mmetụta dị egwu. N'ime ọmụmụ ihe na mkpụrụ ndụ HT22, CMS-121 egosipụtawo mmetụta neuroprotective dị ịrịba ama, na-echebe mkpụrụ ndụ ndị a nke ọma site na ischemia na mmebi oxidative. Ọzọkwa, CMS-121 nwere mmetụta mgbochi mkpali dị ịrịba ama, na-egosi ikike ọ nwere imezi nzaghachi mkpali. Site n'ime nke a, CMS-121 nwere ike ibelata mbufụt na anụ ahụ na akụkụ dị iche iche. CMS-121 nwere ọrụ ọgwụ siri ike dị ka onye na-egbochi acetyl-CoA carboxylase 1 (ACC1). Mmetụta mgbochi ya nwere ike na ACC1 na-eme ka ọ bụrụ onyinye na-ekwe nkwa.
Njirimara
(1) Ịdị ọcha dị elu: CMS-121 nwere ike nweta ngwaahịa dị ọcha site na usoro mmepụta ihe a nụchara anụcha. Ịdị ọcha dị elu pụtara bioavailability ka mma yana mmeghachi omume ọjọọ dị ole na ole.
(2) Nchekwa: Nchekwa dị elu, mmeghachi omume ọjọọ ole na ole.
(3) Nkwụsi ike: CMS-121 nwere ezigbo nkwụsi ike ma nwee ike ịnọgide na-arụ ọrụ ya na mmetụta ya n'okpuru ebe dị iche iche na ọnọdụ nchekwa.
Ngwa
CMS-121 bụ ihe nrụpụta quinolone na ọnụ na-arụ ọrụ acetyl-CoA carboxylase 1 (ACC1) inhibitor nwere akụrụngwa ọgwụ na-ekwe nkwa. Emere nyocha sara mbara iji nyochaa uru CMS-121 nwere ike na mpaghara dị iche iche, gụnyere neuroprotection, mmetụta mgbochi mkpali, ọrụ antioxidant, na mmetụta ya na akara ndị metụtara ịka nká.
