Onye na-emepụta ntụ ntụ Agomelatine CAS Nọmba: 138112-76-2 99% ịdị ọcha nkeji maka ihe mgbakwunye
Vidiyo Ngwaahịa
Usoro Ngwaahịa
| Aha ngwaahịa | Agomelatin |
| Aha ọzọ | N-[2-(7-Methoxy-1-naphthyl)ethyl]acetamide;N-[2-(7methoxynaphthalen-1-yl)ethyl]acetamide |
| Nọmba CAS | 138112-76-2 |
| Usoro molekụla | C15H17NO2 |
| Ibu molekụla | 243.3082 |
| Ịdị ọcha | 99.0% |
| Ọdịdị | Ntụ ntụ ọcha |
| Nkwakọ ngwaahịa | 1kg/akpa 25kg/mgba |
| Ngwa | Ngwaahịa ahụike |
Okwu mmeghe ngwaahịa
A malitere Agomelatine na Yuropu na 2009 ma ugbu a a kwadoro ya maka ojiji na ihe karịrị mba 70. N'adịghị ka ọgwụ mgbochi ọgwụ ọdịnala, agomelatine na-arụ ọrụ site n'ịchọta ndị na-anabata melatonin na serotonin n'ụbụrụ. Site n'ịrụ ọrụ dị ka onye na-egbochi ndị na-anabata melatonin, agomelatine na-enyere aka ịhazi usoro ụra na-adịghị mma nke a na-ejikarị eme ihe na ịda mbà n'obi. Usoro a abụghị naanị na-enyere aka imeziwanye ịdị mma ụra kamakwa ọ na-enyere aka weghachite usoro circadian eke. Na mgbakwunye, agomelatine na-arụ ọrụ dị ka onye na-emegide ụfọdụ ndị na-anabata serotonin (ndị na-anabata 5-HT2C). Omume abụọ a pụrụ iche na-eme ka serotonin dị n'ụbụrụ dịkwuo mma, onye na-ahụ maka neurotransmitter nke na-ahụ maka ịchịkwa ọnọdụ. Site n'ịchịkwa ọkwa serotonin, agomelatine nwere ike ịrụ ọrụ dị ka ọgwụ mgbochi ọgwụ dị irè, na-ebelata ihe mgbaàmà dị ka mwute, enweghị mmasị, mmetụta nke ikpe ọmụma ma ọ bụ enweghị uru. Na mgbakwunye, agomelatine nwere ike inye uru ndị ọzọ. Nnyocha na-egosi na ọ nwere ike inye aka melite ọrụ nghọta. Nnyocha na-egosi ikike ya imeziwanye ncheta, nlebara anya, na ọrụ nchịkwa, na-eme ka ọ bụrụ ebe na-atọ ụtọ maka nyocha n'ọdịnihu.
atụmatụ
(1) Ịdị ọcha dị elu: Agomelatine nwere ike inweta ngwaahịa dị ọcha dị elu site na usoro mmepụta dị mma. Ịdị ọcha dị elu pụtara nnweta bioavailability ka mma na obere mmeghachi omume ọjọọ.
(2) Nchekwa: Nchekwa dị elu, obere mmeghachi omume ọjọọ.
(3) Ịkwụsi Ike: Agomelatine nwere ezigbo nkwụsi ike ma nwee ike ịnọgide na-arụ ọrụ na mmetụta ya n'okpuru gburugburu ebe obibi na ọnọdụ nchekwa dị iche iche.
Ngwa
Agomelatine bụ ọgwụ na-egbochi ịda mbà n'obi na ọgwụ na-egbochi melatonin. Ọ na-ebelata ihe mgbaàmà ịda mbà n'obi site n'ịchịkwa ndị na-anabata melatonin MT1 (na-ebelata ihe mgbaàmà mkpu cortical) na ndị na-anabata MT2 (usoro ụra circadian) na ọkwa serotonin. A na-aṅụ ya n'abalị, ọ na-eṅomi usoro okike nke ntọhapụ melatonin ma nwee ike ime ka ịdị mma ụra ka mma nke ukwuu. Usoro ọrụ ya na-agbaji site na sistemụ nnyefe monoamine ọdịnala. Ọ na-eme ka ndị na-anabata melatonin MT1 na MT2 rụọ ọrụ ma na-emegide ndị na-anabata 5-HT2C. Na-eme ka ịdị mma ụra ka mma, na-eweghachi usoro ndu, ma nwee mmetụta ọgwụ na-egbochi ịda mbà n'obi; n'ime ha, site n'ịlụso ndị na-anabata 5-HT2C ọgụ na akpụkpọ ahụ postsynaptic, ọ nwere ike ịbawanye ntọhapụ nke DA na NE na cortex prefrontal, na-eme mmetụta ọgwụ na-egbochi ịda mbà n'obi. Mgbe MT agonism na 5-HT2C receptor antagonism na-emekọ ihe ọnụ, enwere ike ịmepụta mmetụta synergistic pụrụ iche, na-akwalite ntọhapụ nke DA na NE karịa na mpaghara ụbụrụ PFC, na-eme ka mmetụta ọgwụ na-egbochi ịda mbà n'obi ka mma. Tinyere nke ahụ, agomelatine nwere ike ịkwalite mwepụta nke ihe na-akpata neurotrophic nke sitere na ụbụrụ na PFC ma gbochie mwepụta glutamate nke nrụgide kpatara na mpaghara ụbụrụ amygdala.
