Oleoylethanolamide (OEA) onye na-emepụta ntụ ntụ CAS No.: 111-58-0 98%,85% ịdị ọcha min. maka ihe mgbakwunye
Ngwa ngwaahịa
| Aha ngwaahịa | Oleoyl ethanolamide |
| Aha ọzọ | N-oleoyl ethanolamine; N- (2-hydroxyethyl) -, (Z) -9-Octadecenamide |
| CAS Mba. | 111-58-0 |
| Usoro ihe omimi | C20H39NO2 |
| Ibu arọ molekụla | 325.53 |
| Ịdị ọcha | 98.0%, 85.0% |
| Ọdịdị | Ntụ ntụ kristal dị ọcha |
| Nkwakọ ngwaahịa | 1kg / akpa, 25kg / drum |
| Ngwa | Mgbu mgbu, mgbochi mkpali |
Ntinye ngwaahịa
Oleoylethanolamide bụ ihe nke abụọ amide mejupụtara lipophilic oleic acid na hydrophilic ethanolamine. Oleoylethanolamide bụkwa mkpụrụ ndụ lipid na-emekarị n'anụmanụ na anụ ahụ osisi ndị ọzọ. Ọ na-anọkarị n'anụmanụ na anụ ahụ osisi dịka ntụ koko, soybean, na akị, mana ọdịnaya ya dị oke ala. Naanị mgbe mgbanwe gburugburu ebe obibi na-agbanwe ma ọ bụ nri na-akpali akpali, anụ ahụ sel nke anụ ahụ naanị mgbe ahụ ka a ga-emepụta ọtụtụ ihe a.
N'ebe okpomọkụ dị n'ime ụlọ, Oleoylethanolamide bụ ihe siri ike na-acha ọcha nke na-agbaze ihe dịka 50 ° C. Ọ na-agbaze ngwa ngwa na ihe mgbaze mmanya na-egbu egbu dị ka methanol na ethanol, ọ na-adịkwa mfe karị n'ime ihe mgbaze na-abụghị polar dị ka n-hexane na ether, na mmiri na-adịghị ike. OEA bụ molekul amphiphilic ejiri ọdịnala eme ihe dị ka ihe ncha na ncha na ụlọ ọrụ kemịkalụ. Otú ọ dị, nnyocha ndị ọzọ chọpụtara na OEA nwere ike ije ozi dị ka ihe na-egosi lipid molecule na gut-ụbụrụ axis ma gosipụta usoro ihe omume dị ndụ n'ime ahụ, gụnyere: ịchịkwa agụụ, melite metabolism lipid, ịkwalite ebe nchekwa na cognition na ọrụ ndị ọzọ. N'ime ha, ọrụ Oleoylethanolamide nke ịchịkwa agụụ na imeziwanye metabolism lipid enwetala nlebara anya kacha.
Oleoylethanolamide nwere ike ịhazi oriri nri na ume homeostasis site na ịgbalite peroxisome proliferator-activated receptor-α. Tụkwasị na nke ahụ, Oleoylethanolamide na-egosipụta ọrụ ndị ọzọ metụtara ahụike, gụnyere ịmegharị ọrụ ntụgharị na ụzọ akara ngosi lysosomal-na-nuklear jikọtara ya na ụkpụrụ ogologo ndụ na-echebe akwara ndị na-achịkwa àgwà ịda mbà n'obi. Nnyocha na-egosikwa na Oleoylethanolamide nwere ike inwe mmetụta neuroprotective. N'ụdị anụmanụ, a chọpụtala na ọ na-ebelata mmebi site na ọrịa strok na mmerụ ahụ ụbụrụ. A na-ekwu na mmetụta nchịkwa nke Oleoylethanolamide na-ejikọta ya na PPARA, nke na-eme ka onye na-anabata retinoid X (RXR) na-eme ka ọ rụọ ọrụ dị ka ihe na-eme ka ọ bụrụ ihe na-emepụta ihe na-etinye aka na ike homeostasis, metabolism lipid, autophagy, na mbufụt. mgbada lekwasịrị anya.
Njirimara
(1) Ịdị ọcha dị elu: OEA nwere ike nweta ngwaahịa dị ọcha site na nhazi usoro mmepụta ihe. Ịdị ọcha dị elu pụtara bioavailability ka mma yana mmeghachi omume ọjọọ dị ole na ole.
(2) Nchekwa: E gosila na OEA dị mma maka ahụ mmadụ.
(3) Nkwụsi ike: OEA nwere ezigbo nkwụsi ike ma nwee ike ịnọgide na-arụ ọrụ ya na mmetụta ya n'okpuru ebe dị iche iche na ọnọdụ nchekwa.
(4) Ọ dị mfe ịnabata: Ahụ mmadụ nwere ike itinye OEA ngwa ngwa wee kesaa ya na anụ ahụ na akụkụ ahụ dị iche iche.
Ngwa
Oleoylethanolamide bụ egbugbere ọnụ ethanolamide sitere n'okike ejiri dị ka nhazi nri nri na onye na-achịkwa ịdị arọ ahụ n'ụdị ụdị vertebrate dị iche iche. Ọ bụ metabolite nke oleic acid a kpụrụ n'ime obere eriri afọ mmadụ. Oleylethanolamide (OEA) bụ molekul na-achịkwa metabolism lipid na ume homeostasis. Ọ na-arapara na ndị na-anabata PPAR Alpha ma na-enyere aka ịchịkwa ihe anọ: agụụ, abụba anụ ahụ, cholesterol na ibu. PPAR Alpha na-anọchi anya peroxide proliferator-activated receptor alpha, na bioactive lipid amide oleoylethanolamide (OEA) nwere ihe dị iche iche nke homeostatic pụrụ iche, gụnyere ọrụ mgbochi mkpali, mgbanwe mmeghachi omume mgbochi, na mmetụta antioxidant.
