7,8-Dihydroxyflavone (7,8-DHF) bụ flavonoid sitere n'okike nke na-egosi nkwa n'ọtụtụ akụkụ ahụike. Ọ bụrụ na ị nwere mmasị na ihe mgbakwunye eke ma ọ bụ ihe oriri ndị nwere ike ịkwado ahụike ụbụrụ, ọnọdụ uche, na ọdịmma zuru oke, 7,8-DHF nwere ike ịba uru inyocha. Ntụ ntụ 7,8-Dihydroxyflavone nke Suzhou Myland nyere nwere nọmba CAS nke 38183-03-8 na ịdị ọcha nke ruru 98%. Ngwaahịa a agafeela njikwa mma siri ike ma na-agbaso ụkpụrụ mba ụwa, na-ahụ na arụmọrụ na nchekwa nke ngwaahịa ahụ. , dabara adaba maka nyocha sayensị, mmepe ọgwụ, mmepụta ngwaahịa nlekọta ahụike na mpaghara ndị ọzọ, na-enye gị nhọrọ a pụrụ ịdabere na ya.
7,8-Dihydroxyflavone (7,8-DHF)bụ ihe dị ụkọ nke flavonoid nke na-apụta n'okike. Achọpụtala ya na Astragalus pumila, Primula grandifolia na Hubei crabapple. Apụtala dị ka ihe na-ekwe nkwa nootropic. O gosipụtala ọtụtụ mmetụta neuropharmacological na ọmụmụ ihe tupu a mụọ ọgwụ.
Flavonoids bụ otu n'ime ihe ndị mejupụtara polyphenolic dị na mkpụrụ osisi dị iche iche, akwụkwọ nri, na ihe ndị ọzọ sitere na osisi. N'afọ ndị na-adịbeghị anya, a na-elebara ha anya nke ọma n'ihi ihe ndị na-egbochi ọrịa kansa, ihe ndị na-egbochi mbufụt, na ihe ndị na-echebe akwara ozi.
A chọpụtala na ihe ndị a nwere mmetụta bara uru n'ụbụrụ, gụnyere ime ka ọrụ nghọta dịkwuo mma na igbochi ọrịa neurodegenerative. 7,8-DHF bụ otu n'ime ihe ndị kacha pụta ìhè na-enweta nlebara anya dị ka nootropic. A mụọla ya maka mmetụta ya nwere ike inwe na ọnọdụ uche, ncheta, mmụta, nchekasị, na ọrụ ọgụgụ isi ndị ọzọ.
A na-eche na mmetụta akwara nke 7,8-DHF na-akpata site na mmekọrịta ya na ndị nnata kpọmkwem. A chọpụtala na ọ bụ TrkA, ihe nnata nke na-etinye aka na mgbaàmà nke ihe na-eme ka akwara too ma dị mkpa maka ndụ na ịdị ọcha nke akwara.
7,8-DHF na-arụ ọrụ site n'ịhazi ngosipụta nke ọtụtụ ndị nnata, gụnyere glutamate receptor subunits na BDNF. Ọ na-emetụtakwa nhazi synapse, metabolism ike, na mwepụta nke acetylcholine n'akụkụ ụfọdụ nke ụbụrụ.
Tinyere nke a, a maara osteoporosis dị ka "onye na-egbu ahụ nkịtị" nke ahụ mmadụ, na-eyi ahụike nke ndị agadi na ndị agadi egwu nke ukwuu, ọkachasị ụmụ nwanyị mgbe ha menopause gasịrị. N'ọnọdụ anụ ahụ nkịtị, nhazi ọkpụkpụ na-adị n'ọnọdụ kwesịrị ekwesị; mana mgbe enwere enweghị nguzozi n'etiti nhazi ọkpụkpụ nke osteoblast na mwepụ ọkpụkpụ nke osteoclast, na ọnụọgụ ọkpụkpụ e guzobere ezughị iji kwado oke ọkpụkpụ a na-amịkọrọ, oke ọkpụkpụ ga-ebelata. , a na-ebibi obere nhazi nke anụ ahụ ọkpụkpụ, na-akpata osteoporosis.
7,8-Dihydroxyflavone (7,8-DHF) bụ flavonoid sitere na osisi nke nwere ike iṅomi ọrụ nke ihe na-akpata neurotrophic (BDNF) nke ụbụrụ, kpalite mmụba nke ndị na-anabata TrkB ma mee ka mkpụrụ ndụ ihe mgbaàmà ya dị n'okpuru rụọ ọrụ. Ọmụmụ ihe egosila na BDNF nwere ike ịkwalite ọdịiche osteoblast na ịkwaga ma mee ka ọgwụgwọ mgbawa dịkwuo ngwa ngwa.
7,8-DHF nwere ike ịkwalite mmụba na ọdịiche nke osteoblasts site na mmekọrịta na TrkB na ịgbalite ụzọ mgbaàmà Wnt/β-catenin, ma nwee ike igbochi mmepụta nke osteoclasts site na ibelata ihe ntụgharị c-fos; na mgbakwunye, 7,8-DHF nwere ike imeziwanye ụdị osteoporosis na oke ovariectomized.
Nhazi na ihe onwunwe nke 7,8-dihydroxyflavone
O nwere otu hydroxyl abụọ dị na mgbanaka benzene na otu otu hydroxyl dị na mgbanaka pyrrolone. Ka anyị leba anya nke ọma na nhazi kemịkalụ nke 7,8-dihydroxyflavone:
Usoro molekul nke 7,8-DHF bụ C15H10O5, nke na-egosi na o nwere atọm carbon iri na ise, atọm hydrogen iri, na atọm oxygen ise.
7,8-Dihydroxyflavone bụ kristal siri ike odo odo nke nwere oke molekul nke 286.24 g/mol. Ọ na-agbaze ntakịrị na mmiri n'ihi ọtụtụ otu hydroxyl nke nwere ike ijikọ hydrogen na molekul mmiri.
7,8-DHF usoro ihe omume: iwu BDNF na ọrụ nnabata Trkb
N'ihe gbasara usoro ọrụ, a maara 7,8-DHF iji kwalite mmepụta nke BDNF (ihe na-akpata neurotrophic nke ụbụrụ) site na ijikọ na ma mee ka onye nnata ya bụ TrkB rụọ ọrụ. Na-enweghị ike itinye uche nke ukwuu, nke a na-eduga n'ọtụtụ ọrụ sel nke bara uru n'ịnọgide na-arụ ọrụ neuronal kwesịrị ekwesị na ịkwalite neurogenesis.
Ka anyị leba anya nke ọma n'ụdị ọrụ 7,8-DHF bụ isi n'okpuru.
Ihe na-akpata neurotrophic nke ụbụrụ (BDNF) na ọrụ ya na neuroplasticity
Site na nchọpụta na ngosipụta neurotrophic factor (BDNF) nke sitere na ụbụrụ na-ebelata n'ọrịa neurodegenerative, ọkachasị ọrịa Alzheimer (AD), mkpa ọ dị n'ịnọgide na ime ka ahụike ụbụrụ ka mma na-apụta ìhè.
BDNF dị oke mkpa maka ọrụ dị iche iche nke akwara ozi ebe ọ na-akwalite nnyefe synaptic, synaptogenesis, na plasticity synaptic site na mgbaàmà site na ndị nnata TrkB. Nke a na-eme ka ụzọ mgbaàmà BDNF-TrkB bụrụ ihe mgbaru ọsọ dị mma maka mmepe nke ọgwụgwọ ebumnuche iji lụso ọrịa neurodegenerative ọgụ.
Nnyocha ndị e mere n'oge na-adịbeghị anya enyochaala uru dị na obere molekul TrkB agonist 7,8-dihydroxyflavone (7,8-DHF) n'ibelata mmetụta mbụ nke ọrịa metụtara AD. N'ọmụmụ ihe gbasara ụdị òké 5xFAD nke AD, a gwọrọ òké na 7,8-DHF ruo ọnwa abụọ malite na otu ọnwa.
Nsonaazụ nke nyocha a na-ekpughe ike ọgwụgwọ nke 7,8-DHF n'ịgwọ mgbanwe neurochemical metụtara AD na ihe nrịbama ọrịa. Ihe pụrụ iche bụ na ọgwụgwọ 7,8-DHF mere ka mbelata nke ihe e ji kpuchie cortical Aβ plaque, nke bụ isi ihe dị mkpa nke AD.
Ọzọkwa, ọ na-echebe akwara cortical site na mbelata na mgbagwoju anya nke dendritic arbor, na-enyere aka ịnọgide na-enwe nhazi akwara niile. Agbanyeghị, ọ metụtaghị njupụta ọkpụkpụ azụ dendritic nke ukwuu.
Dịka Aytan, Nurgul na ndị ọzọ si kwuo, ọgwụgwọ ahụ gosikwara mmetụta nchebe akwara na hippocampus, na-egbochi mmụba nke ihe ndị nwere choline ma na-ebelata mfu glutamate.
Ụzọ mgbaama onye nnata Tropomyosin kinase B (Trkb)
Na 2010, otu Prọfesọ Ye Keqiang nke Mahadum Emory kọrọ maka oge mbụ na akwụkwọ akụkọ Proceedings of the National Academy of Sciences (PNAS) na enwere ike iji 7,8-DHF dị ka obere molekul agonist nke tropomyosin receptor kinase B (TrkB), nke nwere ike ime ka ọrụ nke ihe na-akpata neurotrophic nke ụbụrụ (BDNF) na-eme ka ụzọ mgbaàmà dị n'okpuru TrkB rụọ ọrụ, dị ka MAPK/ERK, PI3K/Akt na PKC. Ọzọkwa, ọmụmụ ihe ndị sochirinụ chọpụtara na 7,8-DHF nwere ike ibelata oke ibu nke oke abụba na-akpata na oke nwanyị site na ịgbalite akwara ọkpụkpụ TrkB, na-egosi nnukwu ọdịiche nwoke na nwanyị.
Ihe na-akpata neurotrophic nke ụbụrụ (BDNF) nwere ike ịkwalite nhazi osteoblast, ịkwaga na ọgwụgwọ mgbawa. BDNF bụ onye otu ezinụlọ neurotrophic factor ma na-achịkwa ọtụtụ usoro ihe ndị dị ndụ site na ijikọ na transmembrane receptor tyrosine kinase B (TrkB). Agbanyeghị, mgbaàmà TrkB nke BDNF kpatara dị obere na nkeji 10 ma ruo n'ọkwa kachasị elu na nkeji 60. Agbanyeghị, BDNF nwere obere ọkara ndụ ma ọ nweghị ike ịgafe ihe mgbochi ọbara-ụbụrụ ngwa ngwa.
7,8-dihydroxyflavone (7,8-DHF) bụ flavonoid sitere na osisi nke nwere ike imeri oke BDNF dị n'elu ma achọpụtara ya dị ka mimetic BDNF na-arụ ọrụ ma ugbu a, a na-ejikwa ya na sistemụ biochemical na cell dị iche iche. E gosipụtara na ọ nwere ike ịkpalite mgbanwe TrkB ma mee ka mkpụrụ ndụ ihe mgbaàmà ya dị n'okpuru rụọ ọrụ.
Onye nnata tropomyosin nke na-anabata kinase B (TrkB) na-arụ ọrụ dị mkpa n'igbochi mmetụta nke BDNF na akwara ozi. Dịka onye nnata tyrosine kinase transmembrane, TrkB bụ onye nnata bụ isi maka BDNF ma na-amalite usoro ihe omume mgbaàmà dị iche iche na sel mgbe ejikọtara ya na ihe ndị na-akpata neurotrophic.
BDNF na-eme ka TrkB rụọ ọrụ iji kpalite ọtụtụ ụzọ dị mkpa n'ime ahụ, gụnyere phosphatidylinositol 3-kinase (PI3K)-Akt, mitogen-activated protein kinase (MAPK)-extracellular signal-regulated kinase (ERK), na phospholipase Cγ (PLCγ)-protein kinase C (PKC). Ụzọ ndị a ọ bụla na-enye aka na akụkụ dị iche iche nke ọrụ neuronal na ọdịmma.
Ụzọ PI3K-Akt dị oke mkpa maka ịkwalite ndụ akwara ozi na igbochi apoptosis. BDNF-TrkB signaling na-eme ka ụzọ a dịkwuo mma iji mee ka ndụ sel dịkwuo mma site na igbochi ihe ndị na-akwado apoptosis na ịkpalite ihe ndị na-egbochi apoptosis, si otú a na-ahụ na echekwara akwara ozi dị mma.
N'aka nke ọzọ, ụzọ MAPK-ERK na-arụ ọrụ dị mkpa na nhazi na mmụba nke akwara ozi. BDNF-TrkB signaling na-akwalite mkpali nke ụzọ MAPK-ERK, nke na-akwado ntozu okè na nhazi nke akwara ozi na njikọta ha na netwọkụ akwara ozi dị adị.
Ụzọ PLCγ-PKC dị oke mkpa maka ịchịkwa ike synaptic, usoro dị mkpa nke mmụta na ncheta. BDNF-TrkB signaling na-agbanwe ọrụ nke ụzọ a, na-eduga na mgbanwe na ike synaptic na njikọ.
Mgbanwe a na-akwalite mgbanwe na nhazigharị nke sekit akwara dịka nzaghachi nye ahụmịhe ọhụrụ na mkpali gburugburu ebe obibi.
Njirimara nchekwa akwara
Nnyocha na-egosi na flavonoid a na-echebe akwara ozi site na nrụgide oxidative na apoptosis (ọnwụ mkpụrụ ndụ emebere). Nrụgide oxidative bụ ihe dị mkpa na ọrịa neurodegenerative dị ka ọrịa Alzheimer na Parkinson. Site na iwepụ radicals efu na ibelata mmebi oxidative, 7,8-DHF nwere ike inye aka chebe iguzosi ike n'ezi ihe na ọrụ neuronal.
N'ọmụmụ anụmanụ, egosila na 7,8-DHF na-eme ka ọrụ nghọta na ebe nchekwa dịkwuo mma. Dịka ọmụmaatụ, n'ihe atụ nke ọrịa Alzheimer, egosila na 7,8-DHF na-eme ka synaptic plasticity dịkwuo mma, nke dị oke mkpa maka mmụta na ebe nchekwa.
Mmetụta mgbochi mkpali
Tinyere ihe ndị na-echebe akwara ozi ya, 7,8-dihydroxyflavone nwekwara mmetụta mgbochi mbufụt. Mbufụt ogologo oge bụ ihe a na-ahụkarị n'ọtụtụ ọrịa, gụnyere ọrịa neurodegenerative. Site n'ịgbanwe ụzọ mkpali, 7,8-DHF nwere ike inye aka belata mbufụt neurodegeneration, nke na-ejikọkarị ya na mbelata nghọta.
Njirimara antioxidant: Nchacha ROS na lipid peroxidation
7,8-DHF nwere ihe ndị na-egbochi ọrịa dịka ihe akaebe ya si dị site n'ike ya nke ịchụpụ ụdị oxygen reactive (ROS) ma belata lipid peroxidation. Mmetụta ndị a na-enye aka na mmetụta neuroprotective ya site na ibelata mmebi na nsogbu neuronal nke nrụgide oxidative kpatara.
Nnyocha egosila na 7,8-DHF na-egbochi mmepụta nke cytokines pro-inflammatory ma na-ebelata ọrụ nke microglia, mkpụrụ ndụ na-alụso ọrịa ọgụ na sistemụ akwara etiti. Mmetụta mgbochi mbufụt a abụghị naanị na-echebe neurons kamakwa ọ na-emepụta gburugburu ebe dị mma maka ọrụ nghọta.
Ebe ọ bụ na 7,8-dihydroxyflavone nwere ike iji ya n'ọtụtụ ebe ahụike na ọgwụ. Ụfọdụ n'ime ngwa ndị a ma ama gụnyere:
Njikọta na Iweghachite Ebe Nchekwa
A chọpụtala na 7,8-DHF na-eme ka nchekwa na inwetaghachi ihe dị n'ime ọtụtụ ọrụ mmụta na ebe nchekwa dabere na hippocampal na ụdị oke. Nchọpụta ndị a na-egosi na 7,8-DHF nwere ike ịbụ nootropic na-ekwe nkwa maka imeziwanye ọrụ ebe nchekwa n'ime ndị nwere ahụike na ndị nwere nsogbu ncheta.
Njikarị Synaptic: ike ogologo oge na ịda mbà n'obi
Dịka ekwuru na mbụ, egosila na 7,8-DHF na-agbanwe ike synaptic site n'ịkwalite LTP na ibelata LTD na hippocampus. A na-eche na mmetụta ndị a na-akwalite site na ike ya ime ka ndị na-anabata TrkB rụọ ọrụ ma mechaa melite ụzọ mgbaama BDNF.
Mgbanwe a nke synaptic plasticity na-enye aka na mmelite na ọrụ nghọta nke a hụrụ mgbe nchịkwa 7,8-DHF gasịrị.
Mmezi nghọta
Dịka ekwuru na mbụ, 7,8-DHF na-egosi ike ime ka ọrụ ọgụgụ isi na ebe nchekwa dịkwuo mma. Nke a na-eme ka ọ bụrụ ihe mgbakwunye maka imeziwanye arụmọrụ uche, ọkachasị n'etiti ndị agadi ma ọ bụ ndị nwere mbelata ọgụgụ isi.
Ntinye, Nkesa, Mmebi ahụ, na Mwepụ (ADME): 7,8-DHF nwere ihe ndị dị mma maka ọgwụ, gụnyere ịmịnye ngwa ngwa, nkesa sara mbara, na ịmịnye ụbụrụ nke ọma. Imeju na-eme ka ọ gbazee nke ọma, ọtụtụ ihe mejupụtara ya na-apụta n'ime nsị ma na-apụta obere n'ime mmamịrị.
Ihe mgbochi ọbara na ụbụrụ na-adịgide adịgide na ikike nke anụ ahụ ụbụrụ. Otu n'ime ihe ndị bụ isi dị mkpa 7,8-DHFbụ ikike ya ịgafe ihe mgbochi ụbụrụ ọbara (BBB) ma banye n'ime anụ ahụ ụbụrụ, nke dị oke mkpa maka arụmọrụ ya dị ka nootropic.
Nkọwa Nchekwa Tupu Ọgwụ - Ọmụmụ Ihe Ndị Na-egbu Mgbu Na-adịghị Adịgide na Ndị Na-adịghị Adịgide: Ọmụmụ ihe gbasara nchekwa tupu ọgwụ gosiri na 7,8-DHF nwere profaịlụ nchekwa dị mma, na-enweghị mmetụta ọjọọ dị ukwuu a hụrụ na ọmụmụ ihe ndị na-egbu mgbu na ndị na-adịghị ala ala na oke. Agbanyeghị, a chọrọ nyocha nchekwa ọzọ, gụnyere ọmụmụ ihe gbasara anụmanụ dị elu na ndị mmadụ, iji chọpụta nchekwa ya maka ojiji ahụike.
Ọ bụ ezie na ọmụmụ ihe tupu oge eruo egosila na 7,8-DHF nwere njirimara nchekwa dị mma, mana a ka maara mmetụta ọjọọ ndị nwere ike inwe n'ahụ mmadụ. Dịka ọ dị na ihe ọ bụla ọzọ, a ga-akpachara anya ma nyochaa mmetụta ọjọọ ndị nwere ike inwe mgbe a na-enyocha ojiji ya n'ahụ mmadụ.
Dabere na usoro 7,8-DHF si arụ ọrụ na mmetụta ya na ndị na-anabata TrkB, ụfọdụ mmetụta ọjọọ nwere ike ịdị na 7,8-DHF nwere ike ịgụnye:
Isi ọwụwa: Mmelite BDNF na TrkB na-achịkwa ọrụ akwara ozi na mkpali; ojiji nke 7,8-DHF nwere ike ibute isi ọwụwa n'ime ụfọdụ ndị mmadụ.
Enweghị ike ihi ụra: Mmụba ọrụ akwara ozi na ike synaptic nwere ike imetụta usoro ụra, nke nwere ike ibute enweghị ike ihi ụra ma ọ bụ nsogbu ụra.
Nsogbu afọ: Dịka ọtụtụ ihe ndị na-arụ ọrụ n'ime ahụ, 7,8-DHF nwere ike ibute nsogbu afọ, dịka ọgbụgbọ, agbọ agbọ, ma ọ bụ afọ ọsịsa n'ime ụfọdụ ndị mmadụ.
Ọ dị mkpa ịmara na a ga-amụkwu banyere mmetụta ndị a nwere ike ịkpata n'oge nnwale ahụike. N'ihi ikike ya ịgbanwe akara ngosi BDNF na mkpali nke onye nnata TrkB, a kwesịkwara ịkpachara anya mgbe a na-ejikọta 7,8-DHF na ọgwụ ndị ọzọ na-elekwasị anya n'ụzọ ndị a ma ọ bụ nwee usoro ọrụ yiri ya.
Dịka ihe dị mkpa, 7,8-Dihydroxyflavone adọtala ọtụtụ mmasị n'ihi ọrụ ya pụrụ iche na ihe ndị dị ndụ. Maka ndị nchọpụta sayensị na ụlọ ọrụ, ọ dị mkpa ịchọta ntụ ntụ 7,8-Dihydroxyflavone dị elu. Ntụ ntụ 7,8-Dihydroxyflavone nke Suzhou Myland nyere nwere nọmba CAS nke 38183-03-8 na ịdị ọcha nke ruru 98%. Ngwaahịa a agafeela njikwa mma siri ike ma na-agbaso ụkpụrụ mba ụwa, na-ahụ na arụmọrụ na nchekwa nke ngwaahịa ahụ. , nke dabara adaba maka nyocha sayensị, mmepe ọgwụ, mmepụta ngwaahịa nlekọta ahụike na mpaghara ndị ọzọ, na-enye gị nhọrọ a pụrụ ịdabere na ya.
Ntụkwasị obi ịdị mma
Anyị maara na ịdị mma nke ngwaahịa anyị na-emetụta kpọmkwem nyocha na nsonaazụ ngwa nke ndị ahịa anyị. Ya mere, Suzhou Myland na-agbaso ụkpụrụ GMP (Ezi Omume Mmepụta) na asambodo ISO n'oge usoro mmepụta iji hụ na ngwaahịa ọ bụla kwụsiri ike ma kwụsie ike. Na mgbakwunye, ndị otu R&D anyị na-aga n'ihu na-eme ihe ọhụrụ teknụzụ ma na-agba mbọ ịnọgide na-emeziwanye mma na arụmọrụ ngwaahịa.
Ndị ọrụ nlekọta ndị ahịa
Suzhou Myland anaghị enye naanị ngwaahịa dị elu, kamakwa ọ na-elebara mkpa ndị ahịa anya. Anyị nwere ndị otu nkwado teknụzụ ọkachamara nwere ike inye ndị ahịa aro ojiji ngwaahịa na nduzi teknụzụ iji nyere ndị ahịa aka inweta nsonaazụ ka mma na nyocha na itinye n'ọrụ. Ma ọ bụ obere nnwale ma ọ bụ mmepụta buru ibu, anyị nwere ike inye azịza dị mfe iji gboo mkpa nke ndị ahịa dị iche iche.
Otu esi enweta ntụ ntụ 7,8-Dihydroxyflavone
Ọ bụrụ na ị na-achọ ntụ ntụ 7,8-Dihydroxyflavone dị elu, Suzhou Myland bụ nhọrọ kacha mma gị. Ị nwere ike ịkpọtụrụ anyị site na:
Weebụsaịtị gọọmentị: Gaa na weebụsaịtị gọọmentị nke Suzhou Myland iji mụtakwuo maka ozi ngwaahịa na nkwado teknụzụ.
Ndụmọdụ n'ịntanetị: Gwa ndị otu ọrụ nlekọta ndị ahịa anyị okwu ozugbo site na ọrụ ndụmọdụ n'ịntanetị nke weebụsaịtị ahụ nyere iji nweta ozi ngwaahịa na nkọwapụta ịchọrọ.
Kpọtụrụ anyị na ekwentị: Kpọọ nọmba ekwentị anyị ka anyị na ndị ọrụ ahịa ọkachamara kparịta ụka ma nweta ozi zuru ezu gbasara ngwaahịa na aro ịzụrụ ihe.
Ajụjụ Email: I nwekwara ike ịjụ anyị maka ozi ngwaahịa site na email, anyị ga-azakwa gị ozugbo enwere ike.
Na ngwụcha
Dịka ihe dị mkpa nwere ọtụtụ ihe ndị dị ndụ, 7,8-Dihydroxyflavone na-aghọ ihe dị mkpa na nyocha sayensị na ngwa ụlọ ọrụ mmepụta ihe. Ntụ ntụ 7,8-Dihydroxyflavone dị elu nke Suzhou Myland nyere ga-enye nkwado siri ike maka nyocha na mmepe ngwaahịa gị site na ịdị mma ya dị mma na ọrụ a pụrụ ịtụkwasị obi. Anyị na-atụ anya ịrụ ọrụ na gị iji chọpụta ikike itinye 7,8-Dihydroxyflavone n'ọrụ ndị ọzọ.
Ajụjụ: Gịnị bụ 7,8-dihydroxyflavone?
A:7,8-Dihydroxyflavone bụ flavonoid sitere n'okike nke a maara maka ikike ya nwere ike igbochi akwara ozi, a na-amụkwa ya maka mmetụta ya na ọrụ nghọta na mmụba ọnọdụ uche.
Ajụjụ: Kedu uru 7,8-dihydroxyflavone nwere ike ịba?
A: Nnyocha gosiri na 7,8-dihydroxyflavone nwere ike inyere aka melite ebe nchekwa, belata nchekasị, ma gbochie ọrịa neurodegenerative. Njirimara antioxidant ya nwekwara ike ịkwalite ahụike zuru oke site n'ịlụso nrụgide oxidative ọgụ.
Ajụjụ: Kedu ihe bụ bioavailability nke 7,8-DHF?
A: N'ọmụmụ anụmanụ, 7,8-dihydroxyflavone (7,8-DHF) nwere ike ịdị ihe dị ka 5% (n'ime òké) n'ihi na ọ naghị agbaze nke ọma ma na-agbanwe agbanwe ngwa ngwa. N'agbanyeghị obere ihe dị ndụ, 7,8-DHF ka nwere ike ịgafe ihe mgbochi ọbara-ụbụrụ ma metụta ụbụrụ. A chọrọ nnyocha ọzọ iji chọpụta otú o si adị ndụ n'ime ụmụ mmadụ ma chọpụta ụzọ isi mee ka ọ dịkwuo mma.
A: Kedu ka 7,8-DHF si eme ka ị nwee mmetụta?
A: Dịka nootropic, 7,8-dihydroxyflavone (7,8-DHF) nwere mmetụta dị mma na ọrụ nghọta na ọnọdụ uche. Ndị mmadụ na-enweta ncheta ka mma, itinye uche n'ihe, na ikike mmụta ka mma.
Nkwupụta: Edemede a bụ maka ozi izugbe naanị, ekwesighikwa ịkọwa ya dị ka ndụmọdụ ahụike ọ bụla. Ụfọdụ ozi sitere na blọgụ sitere na ịntanetị, ọ bụghịkwa ọkachamara. Weebụsaịtị a bụ naanị ọrụ maka nhazi, nhazi na idezi akụkọ. Ebumnuche nke izipu ozi ndị ọzọ apụtaghị na ị kwenyere na echiche ya ma ọ bụ kwado eziokwu nke ọdịnaya ya. Gakwuru ọkachamara ahụike mgbe niile tupu i jiri ihe mgbakwunye ọ bụla ma ọ bụ mee mgbanwe na usoro nlekọta ahụike gị.
Oge ozi: Ọktoba-14-2024
