7,8-Dihydroxyflavone (7,8-DHF) bụ flavonoid sitere n'okike nke na-egosi nkwa na mpaghara ahụike dị iche iche. Ọ bụrụ na ị nwere mmasị na mgbakwunye okike ma ọ bụ ihe oriri na-edozi ahụ nke nwere ike ịkwado ahụike ụbụrụ, ọnọdụ, na ọdịmma zuru oke, 7,8-DHF nwere ike ịba uru ịgagharị. 7,8-Dihydroxyflavone Powder nyere Suzhou Myland nwere nọmba CAS nke 38183-03-8 na ịdị ọcha ruru 98%. Ngwaahịa a emeela njikwa mma siri ike ma na-agbaso ụkpụrụ mba ụwa, na-ahụ na arụmọrụ na nchekwa nke ngwaahịa ahụ. , Kwesịrị ekwesị maka nchọpụta sayensị, mmepe ọgwụ, mmepụta ngwaahịa nlekọta ahụike na mpaghara ndị ọzọ, na-enye gị nhọrọ a pụrụ ịdabere na ya.
7,8-Dihydroxyflavone (7,8-DHF)bụ ngwakọta flavonoid dị ụkọ na-emekarị na okike. Achọpụtala ya na Astragalus pumila, Primula grandifolia na Hubei crabapple. apụtala dị ka ogige nootropic na-ekwe nkwa. Ọ egosipụtala mmetụta dị iche iche nke neuropharmacological na ọmụmụ ihe mbụ,
Flavonoids bụ klaasị nke ogige polyphenolic dị n'ụdị mkpụrụ osisi, akwụkwọ nri, na ihe ọkụkụ ndị ọzọ. N'ime afọ ndị na-adịbeghị anya, ha enwetawo nlebara anya dị ukwuu n'ihi ihe antioxidant ha, mgbochi mkpali, na neuroprotective Njirimara.
E gosipụtara ogige ndị a ka ha nwee mmetụta bara uru na ụbụrụ, gụnyere ịkwalite ọrụ ọgụgụ isi na igbochi ọrịa neurodegenerative. 7,8-DHF bụ otu n'ime ogige polyphenolic a ma ama na-enweta nlebara anya dị ka nootropic. A mụọla ya maka mmetụta ọ nwere na ọnọdụ, ebe nchekwa, mmụta, nchekasị, na ọrụ ọgụgụ isi ndị ọzọ.
A na-eche na mmetụta akwara ozi nke 7,8-DHF na-emekọrịta ihe site na mmekọrịta ya na ndị na-anabata ya. Achọpụtara ya na ọ bụ TrkA, onye na-anabata ya na-egosi ihe na-akpata uto akwara na ihe dị mkpa maka ndụ neuronal na plasticity.
7,8-DHF na-eme site n'ịchịkwa okwu nke ndị nabatara dị iche iche, gụnyere glutamate receptor subunits na BDNF. Ọ na-emetụtakwa nguzobe synapse, ike metabolism, na ntọhapụ nke acetylcholine na ụfọdụ akụkụ ụbụrụ.
Na mgbakwunye, a maara osteoporosis dị ka "onye na-egbu nkịtị" nke ahụ mmadụ, na-eyi ahụike nke ndị agadi na ndị agadi egwu egwu, karịsịa ụmụ nwanyị postmenopausal. N'okpuru ọnọdụ physiological nkịtị, ọkpụkpụ ọkpụkpụ dị n'ọnọdụ kwesịrị ekwesị; ma mgbe enweghi ahaghị nhata n'etiti ọkpụkpụ ọkpụkpụ na-eme ka osteoblast na-eme ka ọkpụkpụ na-eme ka ọkpụkpụ na-eme ka ọkpụkpụ na-eme ka ọkpụkpụ na-eme ka ọkpụkpụ na-eme ka ọkpụkpụ na-eme ka ọ bụrụ nke zuru oke iji gbakwunye ọkpụkpụ na-etinye uche na ya, ọkpụkpụ ọkpụkpụ ga-ebelata. , microstructure nke ọkpụkpụ anụ ahụ na-ebibi, na-eme ka ọkpụkpụ ọkpụkpụ.
7,8-Dihydroxyflavone (7,8-DHF) bụ flavonoid sitere na osisi nke nwere ike iṅomi ọrụ nke ụbụrụ neurotrophic nke ụbụrụ na-enweta (BDNF), na-ebute dimerization nke ndị na-anabata TrkB ma mee ka ụmụ irighiri ihe ngosi ya dị ala. Nnyocha egosiwo na BDNF nwere ike ịkwalite ọdịiche osteoblast na ịkwaga ma mee ka ọgwụgwọ mgbawa dị ngwa ngwa.
7,8-DHF nwere ike ịkwalite mgbasawanye na ọdịiche dị iche iche nke osteoblasts site na iji TrkB na-emekọrịta ihe ma na-eme ka ụzọ akara Wnt / β-catenin, ma nwee ike igbochi ọgbọ nke osteoclasts site n'iwetu ihe odide transcription c-fos; na mgbakwunye, 7,8-DHF nwere ike melite osteoporosis phenotype na oke ovariectomized.
Ọdịdị chemical na Njirimara nke 7,8-dihydroxyflavone
O nwere otu hydroxyl abụọ na mgbanaka benzene na otu hydroxyl na mgbanaka pyrrolone. Ka anyị lebakwuo anya na usoro kemịkal nke 7,8-dihydroxyflavone:
Usoro ihe omimi nke 7,8-DHF bụ C15H10O5, na-egosi na ọ nwere 15 carbon carbon, 10 hydrogen atom, na 5 atom oxygen.
7,8-Dihydroxyflavone bụ kristal na-acha odo odo siri ike nke nwere ịdị arọ nke 286.24 g/mol. Ọ na-agbaze ntakịrị na mmiri n'ihi ọtụtụ hydroxyl dị iche iche nwere ike jikọta hydrogen na ụmụ irighiri mmiri.
7,8-DHF usoro nke omume: BDNF ụkpụrụ na Trkb nnabata nnabata
N'ihe gbasara usoro ihe omume, a maara 7,8-DHF iji kwalite mmepụta nke BDNF (ụbụrụ neurotrophic ihe na-akpata ụbụrụ) site na ijikọ na ịgbalite ya TrkB. Na-enweghị oke teknụzụ, nke a na-eduga n'ọtụtụ ọrụ cellular nke bara uru n'ịkwado ọrụ neuronal kwesịrị ekwesị na ịkwalite neurogenesis.
Ka anyị lebakwuo anya na usoro omume 7,8-DHF dị n'okpuru.
Ihe na-akpata ụbụrụ neurotrophic (BDNF) na ọrụ ya na neuroplasticity
N'ịchọpụta na ụbụrụ ụbụrụ na-enweta neurotrophic factor (BDNF) na-ebelata na ọrịa neurodegenerative, karịsịa ọrịa Alzheimer (AD), mkpa ya n'ịkwado na ịkwalite ahụike ụbụrụ na-apụtawanye ìhè. .
BDNF dị oke egwu maka ọrụ neuronal dị iche iche ka ọ na-akwalite nnyefe synapti, synaptogenesis, na plasticity synapti site na iji akara ndị na-anabata TrkB. Nke a na-eme ka ụzọ akara BDNF-TrkB bụrụ ebumnuche na-ekwe nkwa maka mmepe nke usoro ọgwụgwọ iji lụso ọrịa neurodegenerative ọgụ.
Nnyocha e mere n'oge na-adịbeghị anya abanyela na uru nke obere molecule TrkB agonist 7,8-dihydroxyflavone (7,8-DHF) na ibelata mmetụta mmalite nke pathology metụtara AD. N'ime nyocha nke ụdị òké 5xFAD nke AD, a na-emeso ụmụ oke na 7,8-DHF maka ọnwa abụọ malite na otu ọnwa.
Nsonaazụ nke nyocha a na-ekpughe ikike ọgwụgwọ nke 7,8-DHF n'ịgbasa mgbanwe neurochemical metụtara AD na akara nrịbama. N'ụzọ doro anya, ọgwụgwọ 7,8-DHF mere ka mbelata cortical Aβ plaque deposition, bụ isi njirimara nke AD.
Ọzọkwa, ọ na-echebe neurons cortical site na mbelata nke dendritic arbor complexity, na-enyere aka ịnọgide na-enwe n'ozuzu neuronal nhazi. Otú ọ dị, ọ dịghị emetụta njupụta nke spine dendritic.
Dị ka Aytan, Nurgul na ndị ọzọ si kwuo, ọgwụgwọ ahụ gosikwara mmetụta neuroprotective na hippocampus, na-egbochi ọkwa dị elu nke ogige choline nwere na ibelata ọnwụ glutamate.
Tropomyosin receptor kinase B (Trkb) ụzọ mgbama nnabata
Na 2010, otu Prọfesọ Ye Keqiang nke Mahadum Emory kọrọ maka oge mbụ na Usoro nke National Academy of Sciences (PNAS) na 7,8-DHF nwere ike iji dị ka obere molecule agonist nke tropomyosin receptor kinase B ( TrkB), nke nwere ike ịmegharị Ọrụ nke ụbụrụ na-enweta neurotrophic factor (BDNF) na-eme ka ụzọ mgbaàmà na-agbada na TrkB, dị ka MAPK/ERK, PI3K/Akt na PKC. Ọzọkwa, ọmụmụ ndị sochirinụ chọpụtara na 7,8-DHF nwere ike belata oke abụba na-akpata oke ibu na ụmụ oke site na ịgbalite akwara skeletal TrkB, na-egosi ọdịiche dị n'etiti nwoke na nwanyị.
Ihe na-akpata neurotrophic nke ụbụrụ (BDNF) nwere ike ịkwalite ọdịiche osteoblast, ọpụpụ na ọgwụgwọ mgbaji. BDNF bụ onye otu ezinụlọ na-akpata neurotrophic ma na-achịkwa usoro dị iche iche nke usoro ndu site na ijikọ na transmembrane receptor tyrosine kinase B (TrkB). Ka o sina dị, akara TrkB nke BDNF mere ka ọ na-adịru nwa oge na 10 min wee gbagoo na 60 min. Agbanyeghị, BDNF nwere obere ndụ ọkara ma enweghị ike ịgafe mgbochi ụbụrụ ọbara n'ụzọ dị mfe.
7,8-dihydroxyflavone (7,8-DHF) bụ flavonoid sitere na osisi nke nwere ike imeri njedebe ndị dị n'elu nke BDNF ma chọpụta ya dị ka mimetic BDNF na-arụ ọrụ ma na-eji ya ugbu a na usoro biochemical na cellular dị iche iche A kwadoro na ọ nwere ike ịkpalite TrkB dimerization ma mee ka ụmụ irighiri ihe ngosi ya dị ala.
Onye na-anabata tropomyosin kinase B (TrkB) na-arụ ọrụ dị oke mkpa n'ịgbazi mmetụta nke BDNF na neurons. Dị ka onye na-anabata tyrosine kinase transmembrane, TrkB bụ onye na-anabata BDNF ma na-ebute ihe ngosi nke intracellular na-ejikọta na ihe ndị na-ahụ maka neurotrophic.
BDNF na-arụ ọrụ TrkB iji kpalite ọtụtụ ụzọ intracellular isi, gụnyere phosphatidylinositol 3-kinase (PI3K) -Akt, protein kinase mitogen-activated (MAPK) -extracellular signal-regulated kinase (ERK), na phospholipase Cγ (PLCγ) -protein kinase C ( PKC) ụzọ. Nke ọ bụla n'ime ụzọ ndị a na-enye aka n'akụkụ dị iche iche nke ọrụ neuronal na ọdịmma.
Ụzọ PI3K-Akt dị oke mkpa maka ịkwalite ndụ neuronal na igbochi apoptosis. Ngosipụta BDNF-TrkB na-eme ka ụzọ a dịkwuo ndụ ndụ site na igbochi ihe pro-apoptotic na-akpali akpali ihe mgbochi apoptotic, si otú ahụ hụ na nchekwa nke neurons dị mma.
N'aka nke ọzọ, ụzọ MAPK-ERK na-arụ ọrụ dị mkpa n'ichepụta neuronal na mmụba. Ngosipụta BDNF-TrkB na-akwalite ịgbalite ụzọ MAPK-ERK, nke n'aka nke ya na-akwado maturation neuronal na ọdịiche na ntinye ha na netwọkụ neuronal dị ugbu a.
Ụzọ PLCγ-PKC dị oke mkpa maka ịhazi plastik synapti, bụ isi usoro mmụta na ebe nchekwa. Ngosipụta BDNF-TrkB na-agbanwe ọrụ nke ụzọ a, n'ikpeazụ na-eduga na mgbanwe na ike synapti na njikọta.
Mgbanwe a na-akwalite mmegharị na nhazigharị nke sekit akwara na nzaghachi na ahụmahụ ọhụrụ na mkpali gburugburu ebe obibi.
Njirimara neuroprotective
Nnyocha na-egosi na flavonoid a na-echebe neurons pụọ na nrụgide oxidative na apoptosis (ọnwụ cell emepụtara). Nchegbu oxidative bụ ihe dị mkpa na ọrịa neurodegenerative dị ka Alzheimer na ọrịa Parkinson. Site n'ịchụpụ radicals efu na ibelata mmebi oxidative, 7,8-DHF nwere ike inye aka chebe iguzosi ike n'ezi ihe na ọrụ neuronal.
Na ọmụmụ anụmanụ, 7,8-DHF egosipụtara iji meziwanye ọrụ ọgụgụ isi na ebe nchekwa. Dịka ọmụmaatụ, n'ụdị ọrịa Alzheimer, 7,8-DHF egosipụtara iji kwalite plasticity synapti, nke dị oke mkpa maka mmụta na ebe nchekwa. Usoro nke ime ihe
Mmetụta mgbochi mkpali
Na mgbakwunye na akụrụngwa neuroprotective ya, 7,8-dihydroxyflavone nwekwara mmetụta mgbochi mkpali. Ọrịa na-adịghị ala ala bụ ihe a na-ahụkarị nke ọtụtụ ọrịa, gụnyere ọrịa neurodegenerative. Site n'ịgbanwe ụzọ mkpali, 7,8-DHF nwere ike inye aka belata neuroinflammation, nke a na-ejikọtakarị na mbelata ọgụgụ isi.
Njirimara Antioxidant: ROS scavenging na lipid peroxidation
7,8-DHF nwere akụrụngwa antioxidant dị ka egosipụtara site n'ikike ya ịchụpụ ụdị oxygen na-emeghachi omume (ROS) ma belata peroxidation lipid. Mmetụta ndị a na-enye aka na mmetụta neuroprotective ya site na ibelata nrụgide oxidative na-akpata mmebi neuronal na arụ ọrụ.
Nnyocha egosiwo na 7,8-DHF na-egbochi mmepụta nke cytokines pro-inflammatory ma na-ebelata ọrụ nke microglia, mkpụrụ ndụ na-alụso ọrịa ọgụ na usoro nhụjuanya nke etiti. Mmetụta mgbochi a na-egbochi ọ bụghị nanị na-echebe neurons kamakwa ọ na-emepụta ebe dị mma karịa maka ọrụ ọgụgụ isi.
N'inye mmetụta bara uru na ahụike ụbụrụ, 7,8-dihydroxyflavone nwere ike itinye aka na mpaghara dị iche iche nke ahụike na ọgwụ. Ụfọdụ ngwa ndị ama ama gụnyere:
Nchekwata na iweghachite
Achọpụtara 7,8-DHF iji welie nkwado nchekwa na iweghachite na mmụta dị iche iche dabere na hippocampal na ọrụ ebe nchekwa na ụdị òké. Nchọpụta ndị a na-egosi na 7,8-DHF nwere ike ịbụ nootropic na-ekwe nkwa maka imeziwanye ọrụ ebe nchekwa na ma ndị nwere ahụike na ndị nwere nsogbu ncheta.
Synaptic plasticity: ike ogologo oge na ịda mbà n'obi
Dị ka e kwuru na mbụ, 7,8-DHF egosila na ọ na-emezi plasticity synaptic site n'ịkwalite LTP na ibelata LTD na hippocampus. A na-eche na mmetụta ndị a bụ onye ogbugbo site n'ikike ya ime ka ndị na-anabata TrkB rụọ ọrụ ma mechaa welie ụzọ akara BDNF.
Mgbanwe a nke synapti plasticity na-enye aka na mmelite nke ọrụ ọgụgụ isi a hụrụ na-esote nchịkwa 7,8-DHF.
nkwalite ọgụgụ isi
Dịka e kwuru na mbụ, 7,8-DHF na-egosi ikike ịkwalite ọrụ ọgụgụ isi na ebe nchekwa. Nke a na-eme ka ọ bụrụ onye ndoro-ndoro maka mgbakwunye iji kwalite arụmọrụ nke uche, karịsịa na ndị agadi ma ọ bụ ndị nwere ọgụgụ isi.
Absorption, Distribution, Metabolism, and Excretion (ADME): 7,8-DHF na-egosiputa ihe ndị dị mma nke pharmacokinetic, gụnyere ntinye ngwa ngwa, nkesa sara mbara, na ntinye ụbụrụ nke ọma. A na-ebutekarị ya site na imeju, nke na-ewepụ ọtụtụ n'ime ihe ndị ahụ n'ime nsị na ntakịrị ntakịrị na-esi na mmamịrị.
Mgbochi ụbụrụ nke ọbara-ụbụrụ na ikike nke anụ ahụ ụbụrụ. Otu n'ime isi njirimara nke 7,8-DHFbụ ikike ya ịgafe ihe mgbochi ụbụrụ ọbara (BBB) na banye n'ime ụbụrụ ụbụrụ, nke dị oke mkpa maka ịdị irè ya dị ka nootropic.
Profaịlụ nchekwa nchekwa Preclinical - Nnukwu na ọmụmụ ihe na-egbu egbu na-adịghị ala ala: Nnyocha nchekwa nke preclinical gosipụtara na 7,8-DHF nwere profaịlụ nchekwa dị mma, na-enweghị mmetụta ọjọọ dị egwu hụrụ na nnukwu ihe ọmụmụ nsi na-adịghị ala ala na òké. Agbanyeghị, nyocha nchekwa ọzọ, gụnyere ọmụmụ na anụmanụ dị elu na isiokwu mmadụ, achọrọ iji chọpụta nchekwa ya maka ojiji ụlọ ọgwụ.
Ọ bụ ezie na ọmụmụ ihe izizi egosila na 7,8-DHF nwere profaịlụ nchekwa dị mma, mmetụta ndị nwere ike ịdị na isiokwu mmadụ ka amabeghị. Dị ka ọ dị n'akwụkwọ ọhụrụ ọ bụla, a ga-akpachapụ anya wee nyochaa mmetụta ọjọọ ndị nwere ike ime mgbe a na-enyocha ojiji ya na mmadụ.
Dabere na usoro 7,8-DHF nke omume na mmetụta na ndị na-anabata TrkB, ụfọdụ mmetụta ndị nwere ike ijikọ na 7,8-DHF nwere ike ịgụnye:
Isi ọwụwa: BDNF na TrkB nnabata nnabata na-achịkwa ọrụ neuronal na excitability; nchịkwa nke 7,8-DHF nwere ike ime ka isi ọwụwa na ụfọdụ ndị mmadụ.
Ehighị ụra nke ọma: Mmụba ọrụ neuronal na plastik synapti nwere ike imetụta usoro ihi ụra, nwere ike ibute ehighị ụra nke ọma ma ọ bụ ihi ụra.
Nsogbu eriri afọ: Dị ka ọtụtụ ogige bioactive, 7,8-DHF nwere ike ịkpata mmetụta nke eriri afọ, dị ka ọgbụgbọ, vomiting, ma ọ bụ afọ ọsịsa na ụfọdụ ndị mmadụ.
Ọ dị mkpa iburu n'obi na a ga-amụrịrị ihe ndị a nwere ike ime na ule ụlọ ọgwụ. N'inye ikike ya ịmegharị akara ngosi BDNF na ntinye aka nke TrkB, ekwesịrị ịkpachara anya mgbe ị na-ejikọta 7,8-DHF na ọgwụ ndị ọzọ na-elekwasị anya n'ụzọ ndị a ma ọ bụ nwee usoro ọrụ yiri ya.
Dị ka onyinye dị mkpa, 7,8-Dihydroxyflavone adọtala mmasị dị ukwuu n'ihi ọrụ ndụ ya pụrụ iche. Maka ndị na-eme nchọpụta sayensị na ụlọ ọrụ, ọ dị oké mkpa ịchọta 7,8-Dihydroxyflavone ntụ ntụ. 7,8-Dihydroxyflavone Powder nyere Suzhou Myland nwere nọmba CAS nke 38183-03-8 na ịdị ọcha ruru 98%. Ngwaahịa a emeela njikwa mma siri ike ma na-agbaso ụkpụrụ mba ụwa, na-ahụ na arụmọrụ na nchekwa nke ngwaahịa ahụ. , Kwesịrị ekwesị maka nchọpụta sayensị, mmepe ọgwụ, mmepụta ngwaahịa nlekọta ahụike na mpaghara ndị ọzọ, na-enye gị nhọrọ a pụrụ ịdabere na ya.
Ntụkwasị obi ịdị mma
Anyị maara na àgwà ngwaahịa anyị na-emetụta nyocha nke ndị ahịa anyị ozugbo na nsonaazụ ngwa. Ya mere, Suzhou Myland na-agbaso GMP (Good Manufacturing Practice) na ụkpụrụ asambodo ISO n'oge usoro mmepụta iji hụ na nkwụsi ike na nkwụsi ike nke ngwaahịa ọ bụla. Na mgbakwunye, ndị otu R&D anyị na-aga n'ihu na-eme ihe ọhụrụ teknụzụ ma na-agba mbọ ka ha na-emeziwanye ogo ngwaahịa na arụmọrụ.
Ndị ọrụ nlekọta ndị ahịa
Suzhou Myland ọ bụghị naanị na-enye ngwaahịa dị elu, kamakwa ọ na-elebara mkpa ndị ahịa anya. Anyị nwere ndị ọkachamara ọkachamara na-akwado nkwado nke nwere ike inye ndị ahịa aro ojiji ngwaahịa na nduzi teknụzụ iji nyere ndị ahịa aka nweta nsonaazụ kacha mma na nyocha na ngwa. Ma ọ bụ obere nnwale ma ọ bụ nnukwu mmepụta ihe, anyị nwere ike ịnye ngwọta na-agbanwe agbanwe iji gboo mkpa nke ndị ahịa dị iche iche.
Otu esi enweta ntụ ntụ 7,8-Dihydroxyflavone
Ọ bụrụ na ị na-achọ 7,8-Dihydroxyflavone ntụ ntụ dị elu, Suzhou Myland bụ ezigbo nhọrọ gị. Ị nwere ike ịkpọtụrụ anyị site na:
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Na ngwụcha
Dị ka ihe dị mkpa ogige na a dịgasị iche iche nke ndu ihe omume, 7,8-Dihydroxyflavone ji nwayọọ nwayọọ na-aghọ ihe dị mkpa akụrụngwa na nkà mmụta sayensị nnyocha na ulo oru ngwa. Ihe dị elu 7,8-Dihydroxyflavone ntụ ntụ nke Suzhou Myland na-enye ga-enye nkwado siri ike maka nyocha gị na mmepe ngwaahịa na ọrụ ya dị mma na nke a pụrụ ịdabere na ya. Anyị na-atụ anya ka gị na ha rụkọọ ọrụ iji chọpụta ike ngwa nke 7,8-Dihydroxyflavone.
Q: Gịnị bụ 7,8-dihydroxyflavone?
A: 7,8-Dihydroxyflavone bụ flavonoid sitere n'okike mara maka njirimara neuroprotective nwere ike ime ma a na-amụ ya maka mmetụta ya na ọrụ ọgụgụ isi na nkwalite ọnọdụ.
Q: Gịnị bụ uru nke 7,8-dihydroxyflavone?
A: Nnyocha na-egosi na 7,8-dihydroxyflavone nwere ike inye aka melite ebe nchekwa, belata nchekasị, ma gbochie ọrịa neurodegenerative. Njirimara antioxidant ya nwekwara ike ịkwalite ahụike n'ozuzu ya site n'ịlụso nrụgide oxidative ọgụ.
Q: Gịnị bụ bioavailability nke 7,8-DHF?
A: The bioavailability nke 7,8-dihydroxyflavone (7,8-DHF) na anụmanụ ọmụmụ bụ ihe dị ka 5% (na ụmụ oke) n'ihi na ya adịghị mma solubility na ngwa ngwa metabolism. N'agbanyeghị obere bioavailability ya, 7,8-DHF ka nwere ike ịgafe mgbochi ụbụrụ ọbara ma na-emetụta ụbụrụ. Achọrọ nyocha ọzọ iji chọpụta bioavailability ya n'ime mmadụ yana nyochaa ụzọ isi kwalite ya.
Q: Kedu ka 7,8-DHF si eme gị?
A: Dị ka nootropic, 7,8-dihydroxyflavone (7,8-DHF) nwere mmetụta dị mma na ọrụ ọgụgụ isi na ọnọdụ. Ndị mmadụ n'otu n'otu na-enwetakwa ebe nchekwa ka mma, itinye uche dị elu, na enwekwukwa ikike mmụta.
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Oge nzipu: Ọktoba 14-2024
