Kedu ihe bụ 7,8-Dihydroxyflavone, gịnịkwa mere i ji kwesị ichebara ya echiche?

7,8-Dihydroxyflavone (7,8-DHF)bụ flavonoid nke sitere n'okike, ihe mejupụtara polyphenolic nke dị n'ọtụtụ osisi. A maara flavonoids maka ihe ndị na-egbochi antioxidant ha ma na-arụ ọrụ dị mkpa na usoro nchekwa osisi. A na-ahụ 7,8-Dihydroxyflavone karịsịa na osisi dịka Godmania aesculifolia na Tridax procumbens.

7,8-Dihydroxyflavone dị iche na flavonoids ndị ọzọ n'ike ya iṅomi ọrụ nke ihe na-akpata neurotrophic nke ụbụrụ (BDNF). BDNF bụ protein nke na-akwado ndụ, mmepe, na ọrụ nke neurons n'ụbụrụ. Ọ na-arụ ọrụ dị mkpa na neuroplasticity, ikike ụbụrụ ịhazi onwe ya site na ịmepụta njikọ akwara ọhụrụ. Njirimara a nke 7,8-DHF na-emepe ọtụtụ ụzọ nyocha, karịsịa n'ọhịa nke neuroscience.

Usoro ihe omume

Isi ihe 7,8-Dihydroxyflavone ji arụ ọrụ bụ ịgbalite onye nnata TrkB (tropomyosin receptor kinase B). TrkB bụ onye nnata nwere njikọ dị elu maka BDNF. Mgbe 7,8-Dihydroxyflavone jikọtara na TrkB, ọ na-akpali usoro ụzọ mgbaàmà dị iche iche nke na-akwalite ndụ neuronal, uto, na ọdịiche.

Ọmụmụ ihe tupu oge eruo egosila na 7,8-dihydroxyflavone nwere ike iṅomi BDNF (ihe na-akpata neurotrophic nke sitere na ụbụrụ) ma mee ka ngosipụta na ọkwa ya dịkwuo elu na hippocampus. N'ihe atụ anụmanụ, ọ nwere ike ịgwọ ọrịa ma ọ bụ nsogbu akwara dị iche iche, ya bụ, strok, ịda mbà n'obi, na ọrịa Parkinson. N'ọmụmụ ihe abụọ dị iche iche, 7,8-dihydroxyflavone egosila na ọ dị oke mkpa ịnweta ihe dị ndụ n'ọnụ ma achọpụtara na ọ gafere ihe mgbochi ụbụrụ-ọbara (BBB). N'ihi na ọ na-arụ ọrụ na ụzọ signaling nitric oxide ma na-arụ ọrụ na onye nnata TrkB (tropomyosin receptor kinase B)

Ihe na-akpata neurotrophic BDNF na-ebufekarị akara site na ijikọ na ndị na-anabata ya kpọmkwem, si otú a na-emetụta usoro physiological nke neurons. Ọ bụ ezie na 7,8-DHF nwere ike ime ka mmetụta nke neurotrophic factor BDNF dị ka ihe na-akpata neurotrophic, isi ihe dị na usoro mmekọrịta ya na onye na-anabata BDNF. Ọmụmụ ihe egosila na 7,8-DHF nwere ike ijikọ na onye na-anabata BDNF TrkB ma mee ka ụzọ mgbaama dị n'okpuru rụọ ọrụ.

N'ụzọ pụrụ iche, mgbe 7,8-DHF jikọtara na TrkB, ọ na-akpali usoro ihe omume transduction nke mgbaàmà dị n'ime sel. Nke a gụnyere ịgbalite protein kinases dịka ụzọ PI3K/Akt na MAPK/ERK. Ịgbalite ụzọ ndị a dị oke mkpa maka ịkwalite ndụ neuronal, uto, na ike synaptic. Site n'iṅomi mkpali nke ụzọ ndị a site na BDNF, 7,8-DHF na-enyere aka ime ka neuronal dịkwuo mma ma na-eguzogide nrụgide mpụga.

7,8-DHF na-achịkwakwa ngosipụta mkpụrụ ndụ ihe nketa n'ime akwara ozi. Ọ nwere ike imetụta ntụgharị mkpụrụ ndụ ihe nketa metụtara mmepe akwara ozi, nchebe akwara ozi na nhazi synapse, si otú a na-eṅomi mmetụta nke BDNF na ọkwa molekul. Mgbanwe a nke ngosipụta mkpụrụ ndụ ihe nketa na-akwadokwa ọrụ nke 7,8-DHF n'ịkwalite ahụike akwara ozi.

7,8-Dihydroxyflavone (7,8-DHF) bụ flavonoid monophenolic nwere ọtụtụ mmetụta. Ọ na-arụ ọrụ dị ka agonist maka neurotrophic tyrosine kinase receptor TrkB (Kd=320nM) ma na-echebe akwara ndị na-egosipụta TrkB site na apoptosis. Ihe na-akpata neurotrophic nke sitere na ụbụrụ (BDNF) bụ protein nwere mmetụta neurotrophic nke dị mkpa maka nhazi ụbụrụ, mmụta na ncheta.

• Nchedo Neuro: 7,8-DHF na-echebe akwara ozi n'ụdị anụmanụ nke ọrịa Parkinson, na-akwado mmụta mmetụta uche n'ime òké ma na-agbanwe obere ncheta na ụdị òké nke ọrịa Alzheimer, ma nwee ike imeziwanye ọrụ moto ma na-agbatị oge ndụ anụ ọhịa nke ụdị anụmanụ nwere ọrịa huntingtin. BDNF nwere ike imeziwanye neuroplasticity na ndụ neuron, nyere ụbụrụ aka ịmepụta njikọ akwara ọhụrụ, rụzie mkpụrụ ndụ ụbụrụ na-ada ada, ma chebe mkpụrụ ndụ ụbụrụ dị mma. Ọ dị mkpa maka nhazi ụbụrụ, mmụta na ebe nchekwa, ma nwee ike ichebe ụbụrụ pụọ na nkwarụ nghọta nke afọ. Ịda na ikike nghọta ma chebe megide ọrịa neurodegenerative dị ka ọrịa Alzheimer na ọrịa Parkinson.

• Na-achịkwa ndụ akwara ozi: 7,8-DHF nwere ike ijikọ na TrkB ma mee ka ụzọ mgbaàmà dị n'okpuru ala rụọ ọrụ, dịka ụzọ PI3K/Akt na MAPK/ERK. Ịrụ ọrụ nke ụzọ ndị a dị oke mkpa maka ịkwalite ndụ akwara ozi, uto na ike synaptic. dị mkpa. BDNF bụkwa ihe na-akpata neurotrophic nke nwere ike ime ka ụzọ mgbaàmà dị n'ime sel rụọ ọrụ site na ijikọ na ndị na-anabata TrkB ma kwalite ndụ na uto nke neurons.

• Na-akwalite ike synaptic plasticity: 7,8-DHF nwere ike ịkwalite nhazi na ime ka synaptics sie ike site n'ịkwalite ndị na-anabata TrkB, si otú a na-eme ka arụmọrụ nke nnyefe synaptic dịkwuo mma. A na-echekwa na BDNF na-akwalite nhazi na ime ka synaptics sie ike, si otú a na-eme ka arụmọrụ nke nnyefe synaptic dịkwuo mma ma si otú a na-eme ka ikike mmụta na ncheta dịkwuo mma.

• Mmetụta dị na mmụta na ebe nchekwa: 7,8-DHF nwere ike imeziwanye ikike mmụta na ebe nchekwa n'ime òké, nke nwere ike ịbụ njikọ na mmetụta ya na ndụ neuronal na ike synaptic. BDNF na-arụkwa ọrụ dị mkpa na usoro mmụta na ebe nchekwa site n'ịkwalite ndụ nke neurons na ịmepụta synapses, si otú a na-eme ka ikike mmụta na ebe nchekwa dịkwuo mma.

• Na-agbanwe ọnọdụ uche: 7,8-DHF nwere mmetụta na-agbanwe ọnọdụ uche, nke nwere ike ịbụ njikọ na mmetụta ya na ndụ akwara ozi na ike synaptic. A na-echekwa na BDNF na-arụ ọrụ na nhazi mmetụta uche site n'ịchịkwa ndụ nke neurons na ịmepụta synapses, si otú a na-emetụta ngosipụta nke mmetụta uche.

Na nchịkọta, 7,8-DHF na BDNF nwere usoro yiri nke ahụ nke ime ihe n'ihe gbasara nchekwa akwara ozi, na-achịkwa ndụ akwara ozi, na-akwalite ike synaptic, na-emetụta mmụta na ebe nchekwa, na-achịkwa mmetụta uche.

Suzhou Myland Pharm & Nutrition Inc. bụ ụlọ ọrụ mmepụta ihe nke FDA debanyere aha ya, nke na-enye 7,8-Dihydroxyflavone dị elu ma dị ọcha.

Na Suzhou Myland Pharm, anyị na-agba mbọ inye ngwaahịa kachasị mma na ọnụ ahịa kacha mma. A na-anwale 7,8-Dihydroxyflavone anyị nke ọma maka ịdị ọcha na ike, na-eme ka ị nweta mgbakwunye dị elu ị nwere ike ịtụkwasị obi. Ma ịchọrọ ịkwado ahụike sel, ịkwalite sistemu ahụ ji alụso ọrịa ọgụ gị ma ọ bụ melite ahụike zuru oke, 7,8-Dihydroxyflavone anyị bụ nhọrọ zuru oke.

Site na ahụmịhe afọ iri atọ nke teknụzụ dị elu na atụmatụ R&D kachasị mma, Suzhou Myland Pharm emepụtala ọtụtụ ngwaahịa asọmpi ma bụrụ ụlọ ọrụ mgbakwunye sayensị ndụ ọhụrụ, mmepụta omenala na ọrụ mmepụta.

Tinyere nke ahụ, Suzhou Myland Pharm bụkwa onye nrụpụta nke FDA debanyere aha ya. Akụrụngwa nyocha na mmepe nke ụlọ ọrụ ahụ, ebe mmepụta, na ngwa nyocha ya bụ nke ọgbara ọhụrụ ma na-arụ ọrụ nke ọma, ha nwekwara ike imepụta kemịkalụ site na milligram ruo tọn n'ọkwa, ma rube isi n'ụkpụrụ ISO 9001 na nkọwapụta mmepụta GMP.