Kedu ihe bụ 7,8-Dihydroxyflavone na gịnị kpatara ị ga-eji lekọta?

7,8-Dihydroxyflavone (7,8-DHF)bụ flavonoid sitere n'okike, ngwakọta polyphenolic dị n'ụdị osisi dị iche iche. A maara Flavonoids maka akụrụngwa antioxidant ha ma na-arụ ọrụ dị mkpa na usoro nchekwa osisi. A na-ahụ 7,8-Dihydroxyflavone karịsịa na osisi ndị dị ka Godmania aesculifolia na Tridax procumbens.

7,8-Dihydroxyflavone dị iche na flavonoids ndị ọzọ na ikike ya iṅomi ọrụ nke ụbụrụ neurotrophic factor (BDNF). BDNF bụ protein nke na-akwado ndụ, mmepe, na ọrụ nke neurons na ụbụrụ. Ọ na-arụ ọrụ dị mkpa na neuroplasticity, ikike ụbụrụ ịhazi onwe ya site n'ịmepụta njikọ akwara ọhụrụ. Ihe onwunwe a nke 7,8-DHF na-emepe ọtụtụ ụzọ nyocha, karịsịa na ngalaba nke neuroscience.

Usoro nke ime ihe

Usoro bụ isi nke 7,8-Dihydroxyflavone na-arụ ọrụ ya bụ ịgbalite TrkB (tropomyosin receptor kinase B). TrkB bụ nnabata dị elu maka BDNF. Mgbe 7,8-Dihydroxyflavone na-ejikọta na TrkB, ọ na-ebute usoro nke ụzọ mgbaàmà intracellular nke na-akwalite ndụ neuronal, uto, na ọdịiche.

Ọmụmụ ihe ọmụmụ egosila na 7,8-dihydroxyflavone nwere ike iṅomi BDNF (ụbụrụ neurotrophic ihe na-akpata ụbụrụ) ma mee ka nkwupụta ya na ọkwa ya dị na hippocampus. N'ụdị anụmanụ, ọ nwere ike ọgwụgwọ maka ọtụtụ ọrịa akwara ozi ma ọ bụ ọgbaghara, ya bụ ọrịa strok, ịda mbà n'obi, na ọrịa Parkinson. N'ime ọmụmụ ihe abụọ dị iche iche, 7,8-dihydroxyflavone egosila na ọ ga-agafe ihe mgbochi ụbụrụ ụbụrụ (BBB). N'ihi na ọ na-arụ ọrụ n'okporo ụzọ mgbaàmà nitric oxide ma rụọ ọrụ TrkB receptor (tropomyosin receptor kinase B)

Ihe na-akpata neurotrophic BDNF na-ebunye nrịbama site na ijikọta ndị na-anabata ya, si otú ahụ na-emetụta usoro physiological nke neurons. Ọ bụ ezie na 7,8-DHF nwere ike ịme ka mmetụta nke BDNF neurotrophic factor, isi ihe dị na usoro mmekọrịta ya na onye na-anabata BDNF. Nnyocha egosiwo na 7,8-DHF nwere ike jikọta na BDNF onye na-anabata TrkB ma mee ka ụzọ akara ngosi dị ala.

Kpọmkwem, mgbe 7,8-DHF na-ejikọta na TrkB, ọ na-akpalite usoro ntụgharị mgbaàmà intracellular. Nke a gụnyere ịgbalite kinase protein dị ka ụzọ PI3K/Akt na MAPK/ERK. Ịgbalite ụzọ ndị a dị oke mkpa maka ịkwalite nlanarị neuronal, uto, na plasticity synapti. Site na ịmegharị ntinye nke ụzọ ndị a site na BDNF, 7,8-DHF na-enyere aka ịkwalite ngbanwe nke neuronal na iguzogide nrụgide mpụga.

7,8-DHF na-achịkwa okwu mkpụrụ ndụ n'ime neurons. Ọ nwere ike imetụta nsụgharị nke mkpụrụ ndụ ihe nketa metụtara neurodevelopment, neuroprotection na nhazi synapse, si otú a na-eṅomi mmetụta nke BDNF na ọkwa molekul. Mgbanwe a nke okwu mkpụrụ ndụ ihe nketa na-akwado ọrụ 7,8-DHF n'ịkwalite ahụike akwara ozi.

7,8-Dihydroxyflavone (7,8-DHF) bụ flavonoid monophenolic nwere ọtụtụ mmetụta. Ọ na-eme dị ka agonist maka neurotrophic tyrosine kinase receptor TrkB (Kd=320nM) ma na-echebe TrkB-na-egosipụta neurons si apoptosis. Ihe na-akpata neurotrophic nke ụbụrụ (BDNF) bụ protein nwere mmetụta neurotrophic nke dị mkpa maka nhazi ụbụrụ, mmụta na ebe nchekwa.

• Neuroprotection: 7,8-DHF bụ neuroprotective na ụdị anụmanụ nke ọrịa ọrịa Parkinson, na-akwado mmụta mmetụta uche na ụmụ oke na reverse deficits ebe nchekwa na òké ụdị ọrịa Alzheimer, na nwekwara ike melite moto ọrụ na ogologo huntingtin lanarị oge nke ọrịa anụmanụ ụdị. BDNF nwere ike imeziwanye neuroplasticity na ndụ neuron, nyere ụbụrụ aka ịmepụta njikọ akwara ọhụrụ, rụkwaa mkpụrụ ndụ ụbụrụ na-ada ada, ma chebe mkpụrụ ndụ ụbụrụ dị mma. Ọ dị mkpa maka nhazi ụbụrụ, mmụta na ebe nchekwa, ma nwee ike ichebe ụbụrụ site na nhụsianya metụtara afọ. Ibelata ikike ọgụgụ isi ma chebe megide ọrịa neurodegenerative dị ka ọrịa Alzheimer na ọrịa Parkinson.

• Na-achịkwa nlanarị nke neuronal: 7,8-DHF nwere ike jikọta na TrkB ma mee ka ụzọ akara ngosi nke ala, dị ka ụzọ PI3K / Akt na MAPK / ERK. Ịkwalite ụzọ ndị a dị oke mkpa maka ịkwalite ndụ neuronal, uto na plasticity synapti. mkpa. BDNF bụkwa ihe na-akpata neurotrophic nke nwere ike ime ka ụzọ mgbaàmà intracellular rụọ ọrụ site na ijikọta ndị na-anabata TrkB ma kwalite ndụ na uto nke neurons.

• Kwalite plasticity synapti: 7,8-DHF nwere ike ịkwalite nhazi na ike nke synapses site n'ịkwalite ndị na-anabata TrkB, si otú ahụ na-eme ka arụmọrụ nke nnyefe synaptik dịkwuo mma. A na-eche na BDNF na-akwalite nhazi na ike nke synapses, si otú ahụ na-amụba arụmọrụ nke mgbasa ozi synapti ma si otú ahụ kwalite ikike mmụta na ebe nchekwa.

• Mmetụta na mmụta na ebe nchekwa: 7,8-DHF nwere ike melite mmụta na ikike ncheta na ụmụ oke, nke nwere ike jikọta ya na mmetụta ya na ndụ neuronal na synaptic plasticity. BDNF na-arụkwa ọrụ dị mkpa n'ịmụ ihe na usoro nchekwa site n'ịkwalite ndụ nke neurons na nhazi nke synapses, si otú ahụ na-emeziwanye ikike mmụta na ebe nchekwa.

• Mgbanwe ọnọdụ: 7,8-DHF nwere mmetụta na-eme ka ọnọdụ uche, nke nwere ike jikọta na mmetụta ya na ndụ neuronal na synaptic plasticity. A na-eche na BDNF na-ekere òkè na nhazi mmetụta uche site n'ịchịkwa ndụ nke neurons na nhazi nke synapses, si otú ahụ na-emetụta nkwupụta mmetụta uche.

Na nchịkọta, 7,8-DHF na BDNF nwere usoro ọrụ yiri nke ahụ na neuroprotection, na-achịkwa ndụ neuronal, na-akwalite plasticity synapti, na-emetụta mmụta na ebe nchekwa, na ịchịkwa mmetụta uche.

Suzhou Myland Pharm & Nutrition Inc. bụ ụlọ ọrụ FDA debanyere aha na-enye 7,8-Dihydroxyflavone dị elu na ịdị ọcha dị elu.

Na Suzhou Myland Pharm anyị na-agba mbọ ịnye ngwaahịa kachasị mma na ọnụ ahịa kacha mma. A na-anwale 7,8-Dihydroxyflavone anyị nke ọma maka ịdị ọcha na ike, na-eme ka ị nweta mgbakwunye dị elu ị nwere ike ịtụkwasị obi. Ma ịchọrọ ịkwado ahụike cellular, kwalite usoro ahụ ji alụso ọrịa ọgụ ma ọ bụ kwalite ahụike zuru oke, 7,8-Dihydroxyflavone anyị bụ nhọrọ zuru oke.

Site na ahụmịhe afọ 30 na teknụzụ dị elu na atụmatụ R&D kachasị mma, Suzhou Myland Pharm ewepụtala ngwaahịa dị iche iche nke asọmpi wee bụrụ mgbakwunye sayensị ndụ ọhụrụ, njikọta omenala na ụlọ ọrụ nrụpụta.

Na mgbakwunye, Suzhou Myland Pharm bụkwa onye nrụpụta FDA debanyere aha. Akụrụngwa R&D nke ụlọ ọrụ ahụ, akụrụngwa nrụpụta na ngwa nyocha bụ nke ọgbara ọhụrụ yana ọtụtụ ọrụ, ma nwee ike imepụta kemịkalụ site na milligrams ruo tọn n'ọ̀tụ̀tụ̀, ma na-agbaso ụkpụrụ ISO 9001 na nkọwapụta GMP.