Onye na-emepụta ntụ ntụ YDL223C (HBT1) Nọmba CAS: 489408-02-8 99% ịdị ọcha nkeji maka ihe mgbakwunye

HBT1 na-ejikọ na ligand-binding domain nke α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPA-R) n'ụzọ dabere na glutamate. Nke a pụtara na HBT1 bụ molekul nke nwere ike ijikọ naanị na saịtị kpọmkwem na protein AMPA-R mgbe glutamate dị, njikọ a na-enyekwa aka ịchịkwa ọrụ nke protein ahụ. A na-egosipụta ndị na-anabata AMPA n'ofe sistemụ akwara etiti ma na-arụ ọrụ dị mkpa na nkwukọrịta akwara, nhazi mmetụta uche, mmụta, ebe nchekwa, na plasticity synaptic. Ndị na-anabata AMPA bụ ndị na-enye aka na neurotransmission excitatory, na-eme ka mkpali ngwa ngwa, na-ebelata mmetụta ngwa ngwa na ọtụtụ synapses, ma na-etinye aka na nzaghachi mbụ na glutamate na mpaghara synaptic. A na-egosipụtakarị ndị na-anabata AMPA na ndị na-anabata NMDA na synapses, ha na-akwalitekwa usoro plasticity synaptic nke metụtara mmụta, ncheta, excitotoxicity, na neuroprotection. Ihe na-akpata neurotrophic nke ụbụrụ (BDNF) bụ ihe na-akpata neurotrophic nke na-arụ ọrụ dị mkpa n'ịdozi na ịgbasa nke akwara ozi ma nwee mmetụta dị ike na ọtụtụ mmetụta na mmụba, ọdịiche, ndụ na ọnwụ nke mkpụrụ ndụ neuronal na ndị na-abụghị neuronal. , ihe na-eme ka neurotransmitter na-arụ ọrụ nke na-enye aka na plasticity neuronal na mmụta na ebe nchekwa. Ya mere, ọ dị mkpa maka ahụike na ọdịmma nke sistemụ akwara ozi.