Onye na-emepụta ntụ ntụ Galantamine Hydrobromide CAS Nọmba: 1953-04-4 98% ịdị ọcha nkeji maka ihe mgbakwunye
Usoro Ngwaahịa
| Aha ngwaahịa | Galantamine Hydrobromide |
| Aha ọzọ | Galanthamine hydrobromide; Galantamine HBr; Galanthamine HBr; (4aS,6R,8aS) -4a,5,9,10,11,12-hexahydro-3-methoxy-11-methyl-6H-Benzofuro [3a,3,2-ef] [2] benzazepin-6-ol, Hydrobromide |
| Nọmba CAS | 1953-04-4 |
| Usoro molekụla | C17H21NO3.HBr |
| Ibu molekụla | 368.27 |
| Ịdị ọcha | 98.0% |
| Ọdịdị | ntụ ntụ ọcha ruo na ntụ ọcha na-acha ọcha |
| Nkwakọ ngwaahịa | 1kg/akpa 10kgs, 25kgs/mgba |
| Ngwa | nootropics |
Okwu mmeghe ngwaahịa
Galantamine hydrobromide bụ benzazepine sitere na bọlbụ na okooko osisi nke narcissus, osmanthus, ma ọ bụ canna. Ọ bụkwa ihe na-egbochi cholinesterase n'ọnụ. Dịka ligand maka ndị na-anabata nicotinic acetylcholine, ejirila ya mee ihe nke ukwuu iji melite ọrụ neurocognitive. Ọrụ ya bụ igbochi acetylcholinesterase n'ụzọ asọmpi na nke na-agbanwe agbanwe, si otú a na-eme ka acetylcholine dịkwuo elu. Mgbe a na-etinye ya n'ọbara, galantamine hydrobromide na-abanye ngwa ngwa n'akụkụ dị iche iche nke ahụ, gụnyere ụbụrụ. Ọ na-ejikọ na ndị na-anabata nicotinic acetylcholine, na-akpata mgbanwe nhazi na mmụba nke ntọhapụ acetylcholine. Ọ na-arụkwa ọrụ site n'ịsọ mpi na ịtụgharị mmetụta nke ndị na-egbochi cholinesterase. Site na igbochi cholinesterase, ọ na-egbochi mmebi nke acetylcholine, si otú a na-amụba ọkwa na ogologo oge nke neurotransmitter dị ike a. Galantamine nwekwara ike imeziwanye mmụta na ncheta, gbochie mbufụt ụbụrụ, ma nọgide na-enwe ọkwa dị elu nke neurotransmitter site na ịnọgide na-eguzosi ike n'ezi ihe nke neurons na synapses.
atụmatụ
(1) Ịdị ọcha dị elu: Galantamine hydrobromide nwere ike ịbụ ngwaahịa dị ọcha dị elu site na usoro mmepụta dị mma. Ịdị ọcha dị elu pụtara nnweta bioavailability ka mma na obere mmeghachi omume ọjọọ.
(2) Nchekwa: A chọpụtala na Galantamine hydrobromide dị mma maka ahụ mmadụ.
(3) Ịkwụsi ike: Galantamine hydrobromide nwere ezigbo nkwụsi ike ma nwee ike ịnọgide na-arụ ọrụ na mmetụta ya n'okpuru gburugburu ebe obibi na ọnọdụ nchekwa dị iche iche.
Ngwa
Dịka ihe mgbakwunye nri, galantamine hydrobromide nwere ike ime ka ebe nchekwa, uche, na ikike ịrụ ọrụ kwa ụbọchị ka mma. Ọ na-arụ ọrụ site n'iweghachi nguzozi nke ụfọdụ ihe ndị sitere n'okike (ndị na-ahụ maka akwara ozi) n'ụbụrụ, nke na-eme ka ọsọ nke nhazi ebe nchekwa dịkwuo elu ma na-eme ka nkọwa na eziokwu dịkwuo mma. Na mgbakwunye, galantamine hydrobromide na-emetụta neuroplasticity ozugbo ma ọ bụ n'ụzọ na-apụtaghị ìhè. Ọ na-akpali synaptic plasticity site n'ịrụ ọrụ microglia na astrocytes. Galantamine na-enye nchebe antioxidant megide nrụgide oxidative nke sitere na free radicals.
