Calcium Alpha ketoglutarate (AKG) bụ metabolite etiti nke usoro tricarboxylic acid ma na-esonye na mmepụta nke amino acid, vitamin na organic acid na metabolism ike. Enwere ike iji ya dị ka mgbakwunye nri ma nwee ohere sara mbara maka ojiji. Na mgbakwunye na ọrụ bayoloji ya n'ahụ mmadụ, a na-ejikwa calcium alpha-ketoglutarate nke ukwuu n'ọhịa ọgwụ ma aghọọla akụkụ dị mkpa nke ọtụtụ ngwaahịa ahụike na ngwọta ọgwụ.
Kedu ihe bụ alpha-ketoglutarate?
AKG bụ metabolite dị n'ime ahụ nke na-eme n'onwe ya nke bụ akụkụ nke usoro Krebs, nke pụtara na ahụ anyị na-emepụta ya. Ụlọ ọrụ mgbakwunye ahụ na-emepụtakwa ụdị sịntetik nke yiri nke AKG e mepụtara n'onwe ya.
Kedu ihe AKG na-eme?
AKG bụ molekul nke na-arụ ọrụ n'ọtụtụ ụzọ metabolic na cell. Ọ na-eje ozi dị ka onye na-enye ike, ihe na-ebute mmepụta amino acid na molekul mgbaàmà cell, ọ bụkwa ihe na-eme ka usoro epigenetic dị. Ọ bụ molekul dị mkpa na okirikiri Krebs, na-achịkwa ọsọ zuru oke nke okirikiri citric acid nke ihe ahụ. Ọ na-arụ ọrụ n'ọtụtụ ụzọ dị iche iche n'ahụ iji nyere aka wulite akwara ma nyere aka na ọgwụgwọ ọnya, nke bụ otu n'ime ihe kpatara ya ji ewu ewu n'ụwa nke na-ahụ maka ahụ.
AKG na-arụkwa ọrụ dị ka ihe na-ekpochapụ nitrogen, na-egbochi oke nitrogen ma na-egbochi mkpokọta ammonia gabigara ókè. Ọ bụkwa ezigbo isi iyi nke glutamate na glutamine, nke na-akpali njikọ protein n'ime akwara ma na-egbochi mmebi protein.
Tinyere nke ahụ, ọ na-achịkwa enzyme 10-11 translocation (TET) nke metụtara DNA demethylation na lysine demethylase nke nwere Jumonji C domain, nke bụ isi histone demethylase. N'ụzọ dị otu a, ọ bụ ihe dị mkpa na nhazi mkpụrụ ndụ ihe nketa na ngosipụta.
AKG nwere ike igbu oge ịka nká?
E nwere ihe akaebe na AKG nwere ike imetụta ịka nká, ọtụtụ nnyocha na-egosikwa na nke a bụ eziokwu. Nnyocha nke afọ 2014 gosiri na AKG gbatịkwuru ndụ C. elegans toro eto site na ihe dị ka 50% site na igbochi ATP synthase na ihe mgbaru ọsọ nke rapamycin (TOR).
N'ọmụmụ ihe a, anyị chọpụtara na AKG anaghị agbatị ndụ naanị kamakwa ọ na-egbu oge ụfọdụ ụdị ihe ndị metụtara afọ, dịka mfu nke mmegharị ahụ ngwa ngwa a na-ahụkarị na C. elegans ndị agadi. Iji ghọta otu AKG si emetụta ịka nká, anyị ga-akọwa usoro AKG si egbochi ATP synthase na TOR ịgbatị ndụ na C. elegans na ikekwe ụdị ndị ọzọ.
Kedu ka calcium alpha-ketoglutarate si arụ ọrụ
Nke mbụ, calcium alpha-ketoglutarate na-arụ ọrụ dị mkpa na metabolism ike. Dịka ihe dị n'etiti nke tricarboxylic acid cycle (TCA cycle), calcium α-ketoglutarate na-esonye na usoro mmepụta ike intracellular. Site na okirikiri TCA, a na-eme ka nri dị ka carbohydrates, abụba, na protein dị ka oxidized ma gbazee iji mepụta ATP (adenosine triphosphate) iji nye ike maka mkpụrụ ndụ. Dịka ihe dị mkpa na okirikiri TCA, calcium α-ketoglutarate nwere ike ịkwalite metabolism ike sel, mee ka ọkwa ike nke ahụ dịkwuo elu, nyere aka mee ka ike anụ ahụ na ntachi obi dịkwuo mma, ma melite ike ọgwụgwụ anụ ahụ.
Nke abụọ, calcium α-ketoglutarate na-arụ ọrụ dị mkpa na metabolism amino acid. Amino acid bụ isi ihe dị na protein, calcium α-ketoglutarate na-etinye aka na mgbanwe na metabolism nke amino acid. N'usoro ịtụgharị amino acid ka ọ bụrụ metabolites ndị ọzọ, calcium α-ketoglutarate na-agbanwe na amino acid iji mepụta amino acid ọhụrụ ma ọ bụ α-keto acid, si otú a na-achịkwa nguzozi na ojiji nke amino acid. Na mgbakwunye, calcium α-ketoglutarate nwekwara ike ije ozi dị ka ihe nnọchi oxidation maka amino acid, sonyere na metabolism oxidative nke amino acid, ma mepụta ike na carbon dioxide. Ya mere, calcium α-ketoglutarate dị oke mkpa n'ịnọgide na-enwe homeostasis nke amino acid na metabolism protein n'ahụ.
Tinyere nke ahụ, calcium alpha-ketoglutarate na-arụ ọrụ dị ka ihe na-egbochi ọrịa nke na-ewepụ ihe ndị na-emebi emebi ma na-echebe mkpụrụ ndụ site na mmebi oxidative. N'otu oge ahụ, calcium α-ketoglutarate nwekwara ike ịchịkwa ọrụ nke sistemu ahụ ji alụso ọrịa ọgụ, kwalite mkpali na mmụba nke mkpụrụ ndụ ji alụso ọrịa ọgụ, ma melite iguzogide ọrịa na ọrịa. Ya mere, calcium α-ketoglutarate dị oke mkpa n'ịnọgide na-enwe nguzozi nke ahụ ji alụso ọrịa ọgụ na iguzogide ọrịa.
Nnyocha na mmetụta nke calcium α-ketoglutarate na ịka nká
Ịka nká na-emetụta anyị niile ma bụrụ ihe nwere ike ibute ọtụtụ ọrịa, dịka ọnụọgụgụ ndị ọrụ Medicare si kwuo, ohere nke ịrịa ọrịa na-abawanye ka afọ na-aga.
Calcium alpha-ketoglutarate bụ ihe dị mkpa n'ahụ anyị, nke a maara maka ọrụ nke sel na okirikiri Krebs, okirikiri dị mkpa maka oxidation nke abụba asịd na amino asịd, na-enye mitochondria ohere imepụta ATP (ATP bụ isi iyi ike nke mkpụrụ ndụ).
Nke a gụnyere ibu nke usoro calcium alpha-ketoglutarate, yabụ enwere ike ịgbanwe calcium alpha-ketoglutarate ka ọ bụrụ glutamate wee bụrụ glutamine, nke nwere ike inye aka kpalite njikọ nke protein na collagen (collagen bụ protein A nke na-eme 1/3 nke protein niile dị n'ahụ ma na-enyere aka ịkwado ahụike ọkpụkpụ, akpụkpọ ahụ na akwara).
Calcium α-ketoglutarate, dị ka ihe mgbakwunye nri dị iche iche, nwere ohere sara mbara maka ojiji na ngwaahịa nlekọta ahụike. Ọrụ ya dị iche iche dịka antioxidant, mgbochi ịka nká, njikwa ahụ ji alụso ọrịa ọgụ na metabolism amino acid na-eme ka ọ bụrụ ngwaọrụ dị ike iji melite ahụike mmadụ. Site na mmụba nke mmata gbasara nlekọta ahụike na mmụba nke nyocha sayensị, a kwenyere na itinye calcium α-ketoglutarate n'ọrụ na ngwaahịa nlekọta ahụike ga-enweta nlebara anya na mmepe ka ukwuu.
Nkwupụta: Edemede a bụ maka ozi izugbe naanị, ekwesighikwa ịkọwa ya dị ka ndụmọdụ ahụike ọ bụla. Ụfọdụ ozi sitere na blọgụ sitere na ịntanetị, ọ bụghịkwa ọkachamara. Weebụsaịtị a bụ naanị ọrụ maka nhazi, nhazi na idezi akụkọ. Ebumnuche nke izipu ozi ndị ọzọ apụtaghị na ị kwenyere na echiche ya ma ọ bụ kwado eziokwu nke ọdịnaya ya. Gakwuru ọkachamara ahụike mgbe niile tupu i jiri ihe mgbakwunye ọ bụla ma ọ bụ mee mgbanwe na usoro nlekọta ahụike gị.
Oge ozi: Ọktoba-15-2024
