Calcium Alpha ketoglutarate (AKG) bụ metabolite nke etiti nke tricarboxylic acid okirikiri ma na-ekere òkè na njikọ nke amino acid, vitamin na acid organic na metabolism ume. Enwere ike iji ya dị ka mgbakwunye nri ma nwee atụmanya ngwa sara mbara. Na mgbakwunye na ọrụ ndụ ya na ahụ mmadụ, a na-ejikwa calcium alpha-ketoglutarate n'ọtụtụ ebe na mpaghara ọgwụ ma ghọọ akụkụ dị mkpa nke ọtụtụ ngwaahịa ahụike na ngwọta ahụike.
Kedu ihe bụ alfa-ketoglutarate?
AKG bụ metabolite intermediary nke na-apụtakarị nke bụ akụkụ nke okirikiri Krebs, nke pụtara na ahụ anyị na-emepụta ya. Ụlọ ọrụ mgbakwụnye na-emepụtakwa ụdị sịntetik nke yiri kemịkalụ na AKG emepụtara n'onwe ya.
Kedu ihe AKG na-eme?
AKG bụ molekul na-etinye aka na ọtụtụ ụzọ metabolic na cellular. Ọ na-eje ozi dị ka onye na-enye ume, onye na-ebu ụzọ mepụta amino acid na mkpụrụ ndụ ihe nrịbama cell, ma bụrụ onye na-emegharị usoro epigenetic. Ọ bụ molekul dị mkpa na okirikiri Krebs, na-ahazi ọsọ ọsọ nke okirikiri citric acid nke organism. Ọ na-arụ ọrụ n'ụzọ dị iche iche n'ime ahụ iji nyere aka wulite ahụ ike ma nyere aka n'ịgwọ ọnya, nke bụ otu n'ime ihe kpatara ya ji ewu ewu na ụwa na-ewu ahụ.
AKG na-arụkwa ọrụ dị ka onye na-ekpochapụ nitrogen, na-egbochi oke nitrogen na igbochi mmụba nke amonia. Ọ bụkwa nnukwu isi iyi nke glutamate na glutamine, nke na-akpali njikọ protein na akwara ma na-egbochi mmebi protein.
Na mgbakwunye, ọ na-achịkwa 10-11 translocation (TET) enzyme na-etinye aka na DNA demethylation na ngalaba Jumonji C nke nwere lysine demethylase, nke bụ isi histone demethylase. N'ụzọ dị otú a, ọ bụ ihe egwuregwu dị mkpa na nhazi usoro na okwu.
AKG nwere ike igbu oge ịka nká?
Enwere ihe akaebe na AKG nwere ike imetụta ịka nká, ọtụtụ nchọpụta na-egosikwa na nke a bụ ikpe. Nnyocha ọmụmụ 2014 gosiri na AKG gbatịpụrụ ndụ ndị okenye C. elegans site na ihe dịka 50% site na igbochi ATP synthase na ebumnuche nke rapamycin (TOR).
N'ime ọmụmụ ihe a, anyị chọpụtara na AKG ọ bụghị nanị na-agbatị ndụ ndụ kamakwa ọ na-egbu oge ụfọdụ phenotypes metụtara afọ, dị ka mfu nke mmegharị ahụ na-ahazi ngwa ngwa na-emekarị na C. elegans agadi. Iji ghọta otú AKG si emetụta ịka nká, anyị ga-akọwa usoro nke AKG na-egbochi ATP synthase na TOR iji gbasaa ndụ na C. elegans na ikekwe ụdị ndị ọzọ.
Kedu ka calcium alfa-ketoglutarate si arụ ọrụ
Nke mbụ, calcium alpha-ketoglutarate na-arụ ọrụ dị mkpa na metabolism ike. Dị ka ngwaahịa etiti nke tricarboxylic acid cycle (TCAcycle), calcium α-ketoglutarate na-ekere òkè na mmepụta ume intracellular. Site na okirikiri TCA, nri ndị dị ka carbohydrates, abụba, na protein na-eme ka oxidized wee mebie iji mepụta ATP (adenosine triphosphate) iji nye ike maka mkpụrụ ndụ. Dị ka ihe dị mkpa n'etiti TCA okirikiri, calcium α-ketoglutarate nwere ike kwalite cell ume metabolism, mee ka ahụ ike larịị, nyere aka welie ike anụ ahụ na ntachi obi, na melite anụ ahụ ike ọgwụgwụ.
Nke abuo, calcium α-ketoglutarate na-arụ ọrụ dị mkpa na amino acid metabolism. Amino acid bụ akụkụ bụ isi nke protein, na calcium α-ketoglutarate na-etinye aka na ntụgharị na metabolism nke amino acids. N'ime usoro ịtụgharị amino acid ka ọ bụrụ metabolites ndị ọzọ, calcium α-ketoglutarate na-ebugharị na amino acid iji mepụta amino acid ọhụrụ ma ọ bụ acid α-keto, si otú a na-ahazi nguzozi na itinye n'ọrụ nke amino acid. Na mgbakwunye, calcium α-ketoglutarate nwekwara ike ije ozi dị ka mkpụrụ oxidation nke amino asịd, na-ekere òkè na metabolism oxidative nke amino acid, ma mepụta ume na carbon dioxide. Ya mere, calcium α-ketoglutarate dị oke mkpa n'ịkwado homeostasis nke amino acid na protein metabolism n'ime ahụ.
Na mgbakwunye, calcium alpha-ketoglutarate na-arụ ọrụ dị ka antioxidant nke na-ekpochapụ radicals free ma na-echebe mkpụrụ ndụ site na mmebi oxidative. N'otu oge ahụ, calcium α-ketoglutarate nwekwara ike ịhazi ọrụ nke usoro ahụ ji alụso ọrịa ọgụ, kwalite ọrụ na mmụba nke mkpụrụ ndụ na-alụso ọrịa ọgụ, ma welie ahụ ahụ na-eguzogide ọrịa na ọrịa. Ya mere, calcium α-ketoglutarate dị oke mkpa n'ịkwado nguzozi nke ahụ na iguzogide ọrịa.
Nnyocha na mmetụta calcium α-ketoglutarate na ịka nká
Ịka nká na-emetụta anyị niile ma bụrụ ihe dị ize ndụ maka ọtụtụ ọrịa, na dị ka usoro mgbasa ozi nke ụlọ ọrụ Medicare si kwuo, ohere nke ịrịa ọrịa na-abawanye na afọ.
Calcium alpha-ketoglutarate bụ ihe dị mkpa metabolite na ahụ anyị, mara maka ọrụ cell na Krebs okirikiri, okirikiri dị mkpa maka oxidation nke ọdụdụ asịd na amino asịd, ikwe mitochondria imepụta ATP (ATP bụ ike isi iyi nke mkpụrụ ndụ).
Nke na-agụnye ntinye nke calcium alpha-ketoglutarate usoro, ya mere, calcium alpha-ketoglutarate nwekwara ike ghọọ glutamate wee ghọọ glutamine, nke nwere ike inye aka kpalie njikọ nke protein na collagen (collagen bụ protein fibrous nke na-eme 1/3). nke protein niile dị na ahụ ma na-enyere aka ịkwado ahụike ọkpụkpụ, akpụkpọ ahụ na anụ ahụ).
Calcium α-ketoglutarate, dị ka ihe mgbakwunye nri na-edozi ọtụtụ ọrụ, nwere atụmanya ngwa sara mbara na ngwaahịa nlekọta ahụike. Ọrụ ya dị iche iche dị ndụ dị ka antioxidant, mgbochi ịka nká, usoro mgbochi na amino acid metabolism na-eme ka ọ bụrụ ngwá ọrụ dị ike iji meziwanye ahụike mmadụ. N'ịbawanye mmata nke nlekọta ahụike na mmụba nke nchọpụta sayensị, a kwenyere na ntinye nke calcium α-ketoglutarate n'ọhịa nke ngwaahịa nlekọta ahụike ga-enweta nlebara anya na mmepe.
Disclaimer: Edemede a bụ naanị maka ozi izugbe na e kwesịghị ịkọwa ya dị ka ndụmọdụ ahụike ọ bụla. Ụfọdụ ozi biputere blọọgụ na-abịa site na ịntanetị na ọ bụghị ọkachamara. Webụsaịtị a na-ahụ maka nhazi, nhazi na idezi akụkọ. Ebumnuche nke ibuga ozi ndị ọzọ apụtaghị na ị kwenyere n'echiche ya ma ọ bụ kwado na ọdịnaya ya bụ eziokwu. Gakwuru onye ọkachamara ahụike mgbe niile tupu i jiri mgbakwunye ọ bụla ma ọ bụ mee mgbanwe na usoro nlekọta ahụike gị.
Oge nzipu: Ọktoba 15-2024
