Gịnị bụ spermidine? Nduzi dị mfe maka spermidine

Spermidinebụ ụdị polyamine. Polyamines bụ obere, abụba, polycationic (-NH3+). E nwere polyamines anọ bụ́ isi n'ime anụmanụ na-enye nwa ara: spermine, spermidine, putrescine na cadaverine. Spermine bụ nke tetramines, spermidine bụ nke triamines, putrescine na cadaverine bụ nke diamines. Ọnụọgụ dị iche iche nke otu amino na-enye ha ihe dị iche iche gbasara ahụ mmadụ.

Mkpụrụ ndụ spermidine n'ime ụmụ mmadụ

Ọ bụghị naanị na spermidine dị na mmiri ara, kamakwa ọ na-agbasa nke ọma n'anụ ahụ na mkpụrụ ndụ ndị ọzọ dị n'ahụ mmadụ. Njupụta nke spermidine n'ime sel na-adaberekarị n'ihe anọ:

①Njikọta n'ime sel:

Arginine → putrescine → spermidine ← spermine. Arginine bụ isi ihe eji emepụta spermidine n'ime mkpụrụ ndụ. Arginase na-akpali ya iji mepụta ornithine na urea. A na-eji Ornithine emepụta putrescine n'okpuru ọrụ nke ornithine decarboxylase (ODC1). Nke a bụ usoro na-egbochi ọnụego), putrescine na-emepụta spermidine n'okpuru ọrụ nke spermidine synthase (SPDS). Enwere ike ịmepụta spermidine site na mmebi nke spermine.

②Mbute ihe na-esi na mpụga sel pụta:

E kewara ya n'ime nri na njikọta nje bacteria n'ime eriri afọ. Nri ndị bara ụba na spermidine gụnyere wheat germ, natto, soybeans, ero, wdg. A na-amịkọrọ spermine na spermidine a na-eri na nri ngwa ngwa site na eriri afọ ma kesaa ya na-enweghị mmebi, yabụ ntinye nke spermidine n'ọbara. Njupụta dị iche iche. Bakteria probiotic dị na microbiota eriri afọ dịka Bifidobacterium nwekwara ike ịmepụta spermidine.

③Ịdị oke mkparị:

A na-eji nwayọọ nwayọọ gbazee spermine dị n'ime ahụ ka ọ bụrụ spermidine na putrescine site na N1-acetyltransferase (SSAT), polyamine oxidase (PAO) na amine oxidase ndị ọzọ, ebe a na-agbanwe putrescine ka ọ bụrụ aminobutyric acid site na oxidases. N'ikpeazụ, a na-emepụta ma na-ewepụta amine ion na carbon dioxide site na ahụ.

④Afọ:

Ọnụọgụgụ nke spermidine na-agbanwe ka afọ na-aga. Ndị nchọpụta tụrụ nha nke polyamines n'ime anụ ahụ na akụkụ ahụ dị iche iche nke òké dị izu atọ, izu iri na izu iri na izu iri abụọ na isii ma chọpụta na ọ bụ ya ka a na-echekwa n'ime pancreas, ụbụrụ na akpanwa. Mgbanwe n'ime eriri afọ na-ebelata ntakịrị ka afọ na-aga, ma na-ebelata nke ukwuu na thymus, splin, ovary, imeju, afọ, akpa ume, akụrụ, obi na akwara. Ọ naghị esiri anyị ike iche na ihe kpatara mgbanwe a gụnyere mgbanwe nri, mgbanwe n'ụdị flora eriri afọ, mbelata ọrụ nke polyamine synthase, wdg.

Ebumnuche ebumpụta ụwa nke spermidine

Gịnị mere obere molekul dị mfe ji bụrụ ihe dị mkpa maka ahụ mmadụ? Ihe nzuzo dị n'ime ya: Spermidine bụ obere molekul polycationic (-NH3+) nke nwere abụba amine nke dị n'ụdị dị iche iche n'okpuru ọnọdụ pH nke anụ ahụ, yana ion dị mma nke kesara n'ime yinye carbon. Chajị eletriki, nwere ọrụ anụ ahụ siri ike.

Ya mere, ma ọ bụ nucleic acid, phospholipids, protein acidic nwere ihe fọdụrụ acidic, pectic polysaccharides nwere carboxyl groups na sulfates, ma ọ bụ neurotransmitters na hormones (dopamine, epinephrine, serotonin, thyroid hormone, wdg) nwere nhazi yiri nke ahụ, O nwere ike ịbụ ihe mgbaru ọsọ maka njikọ spermidine. Ndị kacha dị oke mkpa bụ:

1. Asịd Nuklia:

Nnyocha achọpụtala na ọtụtụ polyamines dị n'ụdị polyamine-RNA complexes n'ime sel, yana nha nhata 1-4 nke polyamine jikọtara kwa 100 nha nhata nke phosphate compounds. Ya mere, ọrụ bụ isi nke spermidine metụtara mgbanwe nhazi na ntụgharị nke RNA, dịka imetụta ọkwa dị iche iche nke njikọ protein site na imetụta nhazi nke abụọ nke mRNA, tRNA na rRNA. Spermidine nwekwara ike ịmepụta "àkwà mmiri" kwụsiri ike n'etiti eriri DNA abụọ-helical, na-ebelata ohere nke free radicals ma ọ bụ ihe ndị ọzọ na-emebi DNA, yana ichebe DNA site na denaturation okpomọkụ na radieshon X-ray.

②Protein:

Spermidine nwere ike ijikọ na protein ndị nwere nnukwu ụgwọ na-adịghị mma ma gbanwee nhazi oghere nke protein ahụ, si otú a na-emetụta ọrụ ya. Ihe atụ gụnyere protein kinases/phosphatases (njikọ dị mkpa na ọtụtụ ụzọ mgbanwe mgbaàmà), enzymes ndị metụtara histone methylation na acetylation (na-emetụta ngosipụta mkpụrụ ndụ ihe nketa site na ịgbanwe epigenetics), acetylcholinesterase (ihe dị mkpa nke ọrịa neurodegenerative). otu n'ime ọgwụ ọgwụgwọ), ndị na-anabata ion channel (dịka AMPA, ndị na-anabata AMDA), wdg.

Suzhou Myland bụ ụlọ ọrụ mmepụta ihe nke FDA edebanyere aha ya nke na-enye ntụ ntụ Spermidine dị elu ma dị ọcha.

Na Suzhou Myland, anyị na-agba mbọ inye ngwaahịa kacha mma na ọnụ ahịa kacha mma. A na-anwale ntụ ntụ Spermidine anyị nke ọma maka ịdị ọcha na ike, na-eme ka ị nweta mgbakwunye dị elu ị nwere ike ịtụkwasị obi. Ma ịchọrọ ịkwado ahụike sel, ịkwalite sistemu ahụ ji alụso ọrịa ọgụ gị ma ọ bụ melite ahụike zuru oke, ntụ Spermidine anyị bụ nhọrọ zuru oke.

Site na ahụmịhe afọ iri atọ nke teknụzụ dị elu na atụmatụ R&D kachasị mma, Spermidine emepụtala ọtụtụ ngwaahịa asọmpi iji bụrụ ụlọ ọrụ mgbakwunye sayensị ndụ ọhụrụ, mmepụta omenala na ọrụ mmepụta.

Tinyere nke ahụ, Suzhou Myland bụkwa onye nrụpụta nke FDA debanyere aha ya. Akụrụngwa nyocha na mmepe nke ụlọ ọrụ ahụ, ebe mmepụta, na ngwa nyocha ya bụ nke ọgbara ọhụrụ ma na-arụ ọrụ nke ọma, ha nwekwara ike imepụta kemịkalụ site na milligram ruo tọn n'ọkwa, ma na-agbaso ụkpụrụ ISO 9001 na nkọwapụta mmepụta GMP.