Kedu ihe bụ spermidine? Ntuziaka dị mfe maka spermidine

Spermidinebụ ụdị polyamine. Polyamines bụ obere, abụba, polycationic (-NH3+) biomolecules. Enwere polyamines anọ dị na mammals: spermine, spermidine, putrescine na cadaverine. Spermine bụ nke tetramines, spermidine bụ nke triamines, putrescine na cadaverine bụ nke diamines. Ọnụọgụ dị iche iche nke amino dị iche iche na-enye ha njirimara physiological dị iche iche.

Spermidine n'ime ahụ mmadụ

Ọ bụghị naanị na Spermidine dị na semen, kamakwa ọ na-ekesa na anụ ahụ na sel ndị ọzọ nke ahụ mmadụ. Ntinye uche intracellular spermidine dabere na ihe anọ:

① njikọ intracellular:

Arginine → putrescine → spermidine ← spermine. Arginine bụ isi akụrụngwa maka njikọ nke spermidine na sel. A na-eme ya site na arginase iji mepụta ornithine na urea. A na-eji Ornithine mepụta putrescine n'okpuru ọrụ ornithine decarboxylase (ODC1). Nke a bụ nzọụkwụ na-ebelata ọnụego), putrescine na-emepụta spermidine n'okpuru ọrụ spermidine synthase (SPDS). A pụkwara imepụta Spermidine site na mmebi nke spermine.

② Ịnweta mkpụrụ ndụ ọzọ:

Kewara n'ime nri nri na njikọ microbial nke eriri afọ. Nri bara ụba na spermidine gụnyere ọka wit, natto, soybeans, mushrooms, wdg. Spermine na spermidine ingested si nri na-etinye obi gị dum ngwa ngwa site na eriri afọ ma kesaa n'enweghị mmebi, ya mere ntinye nke spermidine n'ime ọbara bụ Concentrations dị iche iche. Nje bacteria probiotic dị na microbiota intestinal dị ka Bifidobacterium nwekwara ike ịmepụta spermidine.

Ihe na-akpata catabolism:

A na-eji nwayọọ nwayọọ ree spermine n'ime ahụ na spermidine na putrescine site na N1-acetyltransferase (SSAT), polyamine oxidase (PAO) na amine oxidases ndị ọzọ, ebe putrescine na-agbanwekwa ghọọ aminobutyric acid site oxidases. N'ikpeazụ, a na-emepụta ion amine na carbon dioxide ma na-esi na ahụ pụta.

Afọ:

Ntinye uche nke spermidine na-agbanwe na afọ. Ndị na-eme nchọpụta tụlere mkpokọta polyamines n'ime anụ ahụ dị iche iche na akụkụ nke ụmụ oke izu 3, izu iri na izu iri abụọ na isii wee chọpụta na a na-echekwa ya na pancreas, ụbụrụ na akpanwa. Mgbanwe na eriri afọ na-ebelata ntakịrị ka afọ, na ibelata nke ukwuu na thymus, splin, ovary, imeju, afo, akpa ume, akụrụ, obi na uru ahụ. Ọ naghị esiri anyị ike ịkọ na ihe kpatara mgbanwe a gụnyere mgbanwe nri, mgbanwe n'ụdị flora intestinal, mbelata ọrụ nke polyamine synthase, wdg.

Ebumnuche ebumpụta ụwa nke spermidine

Kedu ihe kpatara obere molekul dị mfe dị otú ahụ ji bụrụ isi ihe dị mkpa maka ahụ mmadụ? Ihe nzuzo dị n'ezie na nhazi ya: Spermidine bụ polycationic (-NH3+) fatty amine obere molecule nke dị n'ụdị protonated dị iche iche n'okpuru ọnọdụ pH physiological, yana ion dị mma kesara n'okirikiri carbon. Ụgwọ eletrik, nwere ọrụ physiological siri ike.

Ya mere, ma ọ bụ nucleic acid, phospholipids, protein acidic nwere acidic residues, pectic polysaccharides nwere carboxyl otu na sulfates, ma ọ bụ neurotransmitters na hormones (dopamine, epinephrine, serotonin, thyroid hormone, wdg) nwere ihe owuwu ndị yiri ya, nwere ike ịbụ ebumnuche maka spermidine. njide. Ndị kachasị mkpa bụ:

Nucleic acid:

Nnyocha achọpụtala na ọtụtụ polyamines dị n'ụdị polyamine-RNA complexes n'ime sel, yana 1-4 nhata nke polyamine na-ejikọta kwa 100 nhata nke ogige phosphate. Ya mere, isi ọrụ nke spermidine metụtara mgbanwe nhazi na nsụgharị nke RNA, dị ka imetụta ọkwa dị iche iche nke njikọ protein site na-emetụta usoro nke abụọ nke mRNA, tRNA na rRNA. Spermidine nwekwara ike ịmepụta "àkwà mmiri" kwụsiri ike n'etiti eriri DNA abụọ nwere helical, na-ebelata ohere nke radicals free ma ọ bụ ihe ndị ọzọ na-emebi DNA, na ichekwa DNA site na denaturation thermal na X-ray radieshon.

② Protein:

Spermidine nwere ike jikọta na protein na-ebu nnukwu ebubo na-adịghị mma ma gbanwee ngbanwe oghere nke protein ahụ, si otú ahụ na-emetụta ọrụ physiological ya. Ihe atụ gụnyere protein kinases / phosphatases (njikọ dị mkpa na ọtụtụ ụzọ ntụgharị mgbaàmà), enzymes na-etinye aka na histone methylation na acetylation (na-emetụta okwu mkpụrụ ndụ site n'ịgbanwe epigenetics), acetylcholinesterase (ihe dị mkpa nke ọrịa neurodegenerative). otu n'ime ọgwụ ọgwụgwọ), ndị na-anabata ọwa ion (dị ka AMPA, ndị na-anabata AMDA), wdg.

Suzhou Myland bụ onye nrụpụta ndebanye aha FDA na-enye ntụ ntụ sppermidine dị elu na ịdị ọcha.

Na Suzhou Myland, anyị na-agba mbọ ịnye ngwaahịa kachasị mma na ọnụ ahịa kacha mma. A na-anwale ntụ ntụ Spermidine anyị nke ọma maka ịdị ọcha na ike, na-eme ka ị nweta mgbakwunye dị elu ị nwere ike ịtụkwasị obi. Ma ịchọrọ ịkwado ahụike cellular, mee ka usoro ahụ ji alụso ọrịa ọgụ dịkwuo elu ma ọ bụ kwalite ahụike zuru oke, Spermidine ntụ ntụ bụ nhọrọ zuru oke.

Site na ahụmịhe afọ 30 na teknụzụ dị elu na atụmatụ R&D kachasị mma, Spermidine ewepụtala ngwaahịa dị iche iche nke asọmpi ka ọ bụrụ mgbakwunye sayensị ndụ ọhụụ, njikọta omenala na ụlọ ọrụ nrụpụta.

Na mgbakwunye, Suzhou Myland bụkwa onye nrụpụta FDA debanyere aha. Akụrụngwa R&D nke ụlọ ọrụ ahụ, akụrụngwa mmepụta na ngwa nyocha bụ nke ọgbara ọhụrụ yana ọtụtụ ọrụ, ma nwee ike imepụta kemịkalụ site na milligrams ruo tọn n'ọ̀tụ̀tụ̀, ma na-agbaso ụkpụrụ ISO 9001 na nkọwapụta GMP.