Kedu ihe bụ Choline Alfoscerate na kedu ka o si enyere ụbụrụ gị aka?

Dịka ihe dị n'ime ahụ mmadụ, L-α-glycerophosphocholine nwere ike ịbanye n'ime ihe mgbochi ọbara-ụbụrụ ma nwee nnukwu bioavailability. Ọ bụ nri dị elu nke dị mkpa nye ahụ mmadụ. "Ihe mgbochi ọbara-ụbụrụ bụ ihe owuwu dị oke njọ, dị ka 'mgbidi' n'etiti capillary plexuses nke ụbụrụ. L-α-glycerophosphocholine nwere ike ịbanye n'ime ihe mgbochi ọbara-ụbụrụ ngwa ngwa ma rụọ ọrụ n'ime ka ebe nchekwa dịkwuo mma, imeziwanye echiche, ọ nwekwara uru dị na ibelata nchekasị, ime ka ọnọdụ obi sie ike, na ịbawanye ike akwara na ntachi obi. "Mmetụta nri nke L-α-glycerophosphocholine na-egosipụtakarị n'akụkụ ise.

Otu bụ ime ka ọrụ ụbụrụ ka mma. Ka ọnụọgụgụ mkpụrụ ndụ akwara dị n'ụbụrụ na-amụba, otú ahụ ka ike ha si esi ike, otú ha si ebufe ihe mgbaàmà akwara ngwa ngwa, otú ahụ ka ike nhazi ụbụrụ si esi ike. L-α-glycerophosphocholine nwere ike ime ka ọrụ ụbụrụ ka mma nke ọma site n'ime ka ike nke mkpụrụ ndụ akwara na ikike nnyefe nke ihe mgbaàmà akwara dịkwuo mma. N'ihe gbasara ime ka ọrụ akwara cholinergic dịkwuo mma, nnyefe ihe mgbaàmà n'etiti mkpụrụ ndụ akwara na-adabere na nnyefe nke ihe ndị na-eme ka akwara dịkwuo mma, acetylcholine bụkwa ozi kemịkalụ dị mkpa na ihe na-eme ka akwara dịkwuo mma nke na-eme ka echiche na-arụ ọrụ ma na-eme ka ọ dị n'otu n'etiti ụbụrụ na ahụ dum.

Enwere ike ịgbari L-α-glycerophosphocholine ka ọ bụrụ 3-glycerol phosphate na choline n'ụbụrụ, ọ bụkwa ya bụ acetylcholine kachasị arụ ọrụ nke ọma. Ọ nwere ike ime ka ebe nchekwa dịkwuo mma ma melite echiche site n'ịkwalite mmepụta na ntọhapụ nke acetylcholine n'ụbụrụ. N'ihe gbasara ime ka akpụkpọ ahụ dị jụụ na mmiri mmiri dịkwuo mma, L-α-glycerophosphocholine nwere ike ịkwalite mmepụta nke phosphoinositide, si otú a na-eme ka akpụkpọ ahụ dị jụụ na mmiri mmiri dịkwuo mma. Neurons nwere usoro ndị na-adịghị emebi emebi nwere ike izipu ozi nke ọma. Meziwanye ike iche echiche nke ahụ.

Nke abụọ bụ nri na nchekwa akwara. Ihe ndị na-akpata neurotrophic, ihe ndị na-akpata uto nke anụ ahụ akwara, nwere ike ịchịkwa ọdịiche mkpụrụ ndụ ma kwalite nhazi nke njikọ akwara ọhụrụ. L-α-glycerophosphocholine nwere ike ịkwalite mwepụta nke ọtụtụ ihe neurotrophic ma mee ka ụzọ mgbaàmà metụtara ndụ mkpụrụ ndụ rụọ ọrụ, si otú a Ọ na-enwe mmetụta neuroprotective ma na-eme ka ọkwa nghọta nke ahụ ka mma. N'otu oge ahụ, L-α-glycerophosphocholine nwekwara ike ịkwalite mmepụta nke hormone uto ma nọgide na-enwe ahụike ahụ site n'ịbawanye ọkwa hormone uto nke ahụ.

Nke atọ bụ ihe na-egbochi ọrịa kansa. Oxidation na mbufụt bụ isi ihe na-akpata ịka nká na ọnwụ nke mkpụrụ ndụ ụbụrụ. L-α-glycerophosphocholine nwere ike iwepụ ihe ndị na-akpata ọrịa kansa n'ahụ, lụso nrụgide oxidative ọgụ, ma nwee ike ibelata ihe na-akpata nuklia NF-κB, ihe na-akpata tumor necrosis TNF-α, na interleukins. Mwepụta nke ihe ndị na-akpata ọrịa dịka IL-6 na-egbochi mbufụt ụbụrụ, si otú a na-agbanwe ọdịda nke ọrụ nghọta ma na-egbochi mmepe nke ọrịa neurodegenerative.

Mmetụta ndị dị mkpa a enwetala site na mmetụta ahụike. N'ọmụmụ ihe a kpọrọ "Mmetụta nke L-α-glycerophosphocholine na nsogbu ncheta metụtara afọ", e nyere mmadụ anọ placebo, e nyekwara mmadụ ise ndị ọzọ. Mgbe e jiri ọnụ ṅụọ L-α-glycerophosphocholine (1200 mg/ụbọchị) ruo ọnwa atọ, e jiri electrodes 16 dekọọ ebili mmiri ụbụrụ ruo nkeji ise mgbe ndị ahụ tetara ma na-ezu ike. Nsonaazụ gosiri na ma e jiri ya tụnyere placebo, L-alpha-glycerophosphocholine mụbara nke ukwuu nke oke ebili mmiri ụbụrụ kachasị ọsọ ebe ọ na-enwekarị mbelata ugboro ole na-adịghị nwayọ. Nke ahụ bụ, ọ nwere ike ime ka ụbụrụ dị ike nke ndị agadi ma mee ka ahụ dịghachi ndụ.

Nke anọ bụ ịchịkwa mmetụta uche. Dopamine nwere ike ime ka mmadụ nwee obi ụtọ, serotonin na gamma-aminobutyric acid nwekwara ike ịchịkwa ọnọdụ ahụ. L-α-glycerophosphocholine nwere ike ịkwalite mwepụta nke dopamine, melite ngosipụta nke ndị na-ebufe dopamine, melite dopamine neurotransmission na ụbụrụ, ma mụbaa ọkwa serotonin na striatum na prefrontal cortex; ọ nwekwara ike ịkwalite endogenous nke ukwuu. Mwepụta nke γ-aminobutyric acid na anụ ahụ mmekọahụ cortical na-ebelata enweghị ike ihi ụra, si otú a na-egosipụta mmetụta ya na-egbochi ịda mbà n'obi, na-ebelata nchekasị na ime ka ọnọdụ ahụ sie ike.

Nke ise bụ ime ka arụmọrụ egwuregwu ka mma. N'oge mmega ahụ, L-alpha-glycerophosphocholine na-emekwa ka nhazi ahụ dịkwuo mma site n'ịbawanye oke akwara ma melite ọrụ metabolic n'ozuzu ya site n'ịbawanye mmepụta homonụ uto dị elu na mmepụta ike. Na mgbakwunye, L-α-glycerophosphocholine nwekwara ike ime ka nnyefe neurotransmitter dị ngwa ngwa, melite arụmọrụ nke njikọ neuromuscular, mee ka nrụgide na ntachi obi nke akwara ọkpụkpụ dịkwuo elu, si otú a na-eme ka ike mmega ahụ nke ahụ dịkwuo elu, na-egbochi ike ọgwụgwụ, ma na-enwe mmetụta dị mma na uto akwara.

Ya mere, ebee ka ndị mmadụ ga-esi nweta ihe oriri a nwere ọtụtụ uru dị na ya? N'ezie, L-α-glycerophosphocholine dị n'ọtụtụ nri dịka àkwá, ọkụkọ, na trout egwurugwu, mana ihe dị na ya dị obere. Dịka "Mbipụta nke Abụọ nke US General Food Choline Content Database" nke United States Department of Agriculture bipụtara si kwuo, ihe dị na L-α-glycerophosphocholine na ngụkọta nri 630 na ụdị 22 gosiri na L-α-glycerophosphocholine kwa gram 100 nke nri. Ọdịnaya nke glycerophosphocholine dị site na 0 ruo 190 mg. Ya mere, iji mezuo mkpa nke uto, mmepe na metabolism nke ahụ mmadụ, enwere ike ime mgbakwunye ndị ọzọ nke ọma.

Njikọta kemịkalụ bụ otu n'ime ụzọ isi emepụta L-α-glycerophosphocholine. Site na iji polyphosphoric acid, choline chloride, R-3-chloro-1,2-propanediol, sodium hydroxide na mmiri dị ka ihe eji emepụta ihe, mgbe emechara ka ọ gbazee agba, wepụ ihe na-adịghị ọcha, tinye ya n'ime ihe, nụchaa ya ma kpọọ nkụ. Enwere ike itinye L-α-glycerophosphocholine nke usoro ndị ọzọ mepụtara na ihe ọṅụṅụ dị nro, ihe ọṅụṅụ egwuregwu, kọfị, gummies, oatmeal energy bars, wdg, ma nwee ike itinye mmetụta nri ya n'ụzọ ezubere iche iji gboo mkpa nri dị iche iche nke ndị ahịa.

Na mba United States, Japan, Canada na mba ndị ọzọ, a na-eji L-α-glycerophosphocholine eme ihe nke ukwuu n'ihe gbasara nri. Ngwaahịa ndị metụtara ya na-ekpuchi ihe mgbakwunye nri, ihe ọṅụṅụ, gummies na ụdị ndị ọzọ, ngwaahịa ọ bụla nwekwara ọrụ doro anya, usoro akwadoro na otu akwadoro.

Suzhou Myland Pharm & Nutrition Inc. bụ ụlọ ọrụ mmepụta ihe nke FDA debanyere aha ya nke na-enye ntụ ntụ Alpha GPC dị elu ma dị ọcha.

Na Suzhou Myland Pharm, anyị na-agba mbọ inye ngwaahịa kachasị mma na ọnụ ahịa kacha mma. A na-anwale ntụ ntụ Alpha GPC anyị nke ọma maka ịdị ọcha na ike, na-eme ka ị nweta mgbakwunye dị elu ị nwere ike ịtụkwasị obi. Ma ịchọrọ ịkwado ahụike sel, ịkwalite sistemu ahụ ji alụso ọrịa ọgụ gị ma ọ bụ melite ahụike zuru oke, ntụ ntụ Alpha GPC anyị bụ nhọrọ zuru oke.

Site na ahụmịhe afọ iri atọ nke teknụzụ dị elu na atụmatụ R&D kachasị mma, Suzhou Myland Pharm emepụtala ọtụtụ ngwaahịa asọmpi ma bụrụ ụlọ ọrụ mgbakwunye sayensị ndụ ọhụrụ, mmepụta omenala na ọrụ mmepụta.

Tinyere nke ahụ, Suzhou Myland Pharm bụkwa onye nrụpụta nke FDA debanyere aha ya. Akụrụngwa nyocha na mmepe nke ụlọ ọrụ ahụ, ebe mmepụta, na ngwa nyocha ya bụ nke ọgbara ọhụrụ ma na-arụ ọrụ nke ọma, ha nwekwara ike imepụta kemịkalụ site na milligram ruo tọn n'ọkwa, ma rube isi n'ụkpụrụ ISO 9001 na nkọwapụta mmepụta GMP.