Dị ka ihe endogenous n'ime ahụ mmadụ. L-a-glycerophosphocholine nwere ike banye n'ime mgbochi ụbụrụ ọbara ma nwee nnukwu bioavailability dị oke elu. Ọ bụ nri dị elu nke dị mkpa maka ahụ mmadụ. "Ihe mgbochi ụbụrụ nke ọbara bụ ihe dị mgbagwoju anya, 'mgbidi' dị ka ihe dị n'etiti capillary plexuses nke ụbụrụ. L-α-glycerophosphocholine nwere ike ịbanye n'ime ọbara-ụbụrụ ihe mgbochi ma na-ekere òkè n'ịkwalite ebe nchekwa, na-emeziwanye echiche, na Ọ. nwere uru bara uru n'ibelata nchekasị, ime ka ọnọdụ kwụsie ike, na ịba ụba ike na ntachi obi nke anụ ahụ "Mmetụta nri L-α-glycerophosphocholine na-apụtakarị na akụkụ ise.
Otu bụ imeziwanye ọrụ ụbụrụ. Ka ọnụ ọgụgụ mkpụrụ ndụ akwara dị n'ụbụrụ na-abawanye, ka ike ha na-esikwu ike, ka ha na-ebufe akara akwara ngwa ngwa, na ike nhazi ụbụrụ na-esiwanye ike. L-a-glycerophosphocholine nwere ike imeziwanye ọrụ ụbụrụ nke ọma site n'ịkwalite ịdị ndụ nke mkpụrụ ndụ akwara yana ikike nnyefe nke akara akwara. N'ihe gbasara ịkwalite neurotransmission cholinergic, nnyefe mgbaàmà n'etiti mkpụrụ ndụ akwara na-adabere na nnyefe nke ndị na-ahụ maka ụbụrụ, na acetylcholine bụ onye ozi kemịkalụ bụ isi na neurotransmitter nke na-eme ka echiche na-arụ ọrụ na-arụ ọrụ ma na-akwado nhazi n'etiti ụbụrụ na ahụ dum.
Enwere ike imebi L-α-glycerophosphocholine n'ime 3-glycerol phosphate na choline n'ime ụbụrụ ma bụrụ ihe kacha arụ ọrụ nke acetylcholine. Ọ nwere ike ịkwalite ebe nchekwa ma melite echiche site n'ịkwalite njikọ na ntọhapụ nke acetylcholine na ụbụrụ. N'ihe banyere ime ka nkwụsi ike na mmiri dị na cell membranes, L-a-glycerophosphocholine nwere ike ịkwalite njikọ nke phosphoinotide, si otú ahụ na-eme ka nkwụsi ike na mmiri nke membranes cell dịkwuo elu. Neuron ndị nwere ihe arụrụghị arụ nwere ike ibunye ozi karịa. Mee ka ikike iche echiche nke ahụ dịkwuo mma.
Nke abụọ bụ nri na-edozi ahụ na nchebe akwara. Ihe na-akpata Neurotrophic, ihe na-eto eto nke anụ ahụ ụjọ, nwere ike ịhazi ọdịiche dị na sel stem ma kwalite njikọ ọhụrụ nke akwara. L-a-glycerophosphocholine nwere ike ịkwalite nzuzo nke ihe dị iche iche nke neurotrophic ma mee ka ụzọ mgbaàmà dị iche iche metụtara ndụ cell, si otú ahụ na-eme ka mmetụta neuroprotective na-eme ka ahụ dịkwuo mma. N'otu oge ahụ, L-α-glycerophosphocholine nwekwara ike ịkwalite mmepụta nke hormone na-eto eto ma nọgide na-ahụ ahụ ike site n'ịba ụba nke hormone na-eto eto.
Nke atọ bụ antioxidant. Oxidation na mbufụt bụ isi ihe na-akpata ịka nká na ọnwụ nke mkpụrụ ndụ ụbụrụ. L-α-glycerophosphocholine nwere ike imebi radicals n'efu n'ime ahụ, lụso nrụgide oxidative ọgụ, ma nwee ike belata ihe NF-κB nke nuklia, ụbụrụ necrosis factor TNF-α, na interleukins. Ntọhapụ nke ihe ndị na-egbuke egbuke dị ka IL-6 na-eme ka ụbụrụ ụbụrụ dịkwuo mma, si otú ahụ na-atụgharị nke ọma n'ọdịda nke ọrụ ọgụgụ isi na igbochi ihe omume na mmepe nke ọrịa neurodegenerative.
A kwadoro mmetụta ndị dị mkpa site na mmetụta ụlọ ọgwụ. N'ime ọmụmụ ihe "Mmetụta nke L-α-glycerophosphocholine na nsogbu ncheta afọ metụtara afọ", 4 isiokwu e nyere placebo, na ndị ọzọ 5 isiokwu e nyere mgbe ha were L-α-glycerophosphocholine (1200 mg / ụbọchị) ọnụ maka ọnwa 3. , A na-eji 16 electrodes na-edekọ ebili mmiri ụbụrụ maka nkeji 5 ka ihe ndị ahụ na-amụ anya ma na-ezu ike. Nsonaazụ gosiri na ma e jiri ya tụnyere placebo, L-alpha-glycerophosphocholine mụbara oke nke ebili mmiri ụbụrụ kachasị ngwa ngwa ebe ọ na-enwe mmasị ibelata ugboro ole na-adị nwayọọ. Ya bụ, ọ nwere ike ime ka ụbụrụ ndị dị n'etiti ahụ dịkwuo ike ma na-egbu oge ịka nká nke ahụ.
Nke anọ bụ ịchịkwa mmetụta uche. Dopamine nwere ike ime ka ndị mmadụ nwee obi ụtọ, na serotonin na gamma-aminobutyric acid nwere ike ịhazi ọnọdụ ahụ. L-a-glycerophosphocholine nwere ike ịkwalite ntọhapụ nke dopamine, na-edozi okwu nke ndị na-ebugharị dopamine, melite dopamine neurotransmission na ụbụrụ, na ịbawanye ọkwa nke serotonin na striatum na prefrontal cortex; ọ nwekwara ike ịkwalite endogenous nke ukwuu Mwepụta nke γ-aminobutyric acid na anụ ahụ cortical mmekọahụ na-ebelata ehighị ụra nke ọma, si otú a na-eme ihe na-egbochi ịda mbà n'obi, na-ebelata nchekasị na mmetụta na-eme ka ọnọdụ ahụ guzosie ike.
Nke ise bụ ịkwalite arụmọrụ egwuregwu. N'oge mmega ahụ, L-alpha-glycerophosphocholine na-emekwa ka ihe mejupụtara ahụ dịkwuo mma site n'ịba ụba nke anụ ahụ ma na-emeziwanye ọrụ metabolic n'ozuzu site n'ịba ụba mmepụta nke homonụ na mmepụta ike. Na mgbakwunye, L-α-glycerophosphocholine nwekwara ike mee ka nnyefe neurotransmitter dị ngwa, melite arụmọrụ nke njikọ neuromuscular, mụbaa nkwekọrịta na ntachi obi nke akwara skeletal, si otú ahụ na-eme ka mgbatị ahụ dịkwuo elu, mgbochi ike ọgwụgwụ, na-enwe mmetụta dị mma na uto muscle. . mmetụta.
Yabụ kedu ebe ndị mmadụ nwere ike nweta nri a nwere ọtụtụ uru nwere ike ime? N'ezie, L-α-glycerophosphocholine dị n'ọtụtụ nri dị ka àkwá, ọkụkọ, na trout egwurugwu, mana ọdịnaya dị obere. Dị ka "Ụdị nke Abụọ nke US General Food Choline Content Database" nke Ngalaba Ọrụ Ugbo nke United States bipụtara, ọdịnaya nke L-α-glycerophosphocholine na ngụkọta nke nri 630 na ụdị 22 gosiri na L-α-glycerophosphocholine kwa 100. gram nri Ọdịnaya nke glycerophosphocholine sitere na 0 ruo 190 mg. Ya mere, iji gboo mkpa nke uto ahụ mmadụ, mmepe na metabolism, enwere ike ịmekwu ihe mgbakwunye n'ụzọ kwesịrị ekwesị.
Ngwakọta kemịkalụ bụ otu n'ime ụzọ mmepụta nke L-α-glycerophosphocholine. Iji polyphosphoric acid, choline chloride, R-3-chloro-1,2-propanediol, sodium hydroxide na mmiri dị ka akụrụngwa, mgbe condensation na esterification mmeghachi omume, ọ na-decolorized, adịghị ọcha wepụrụ, lekwasị, nụchara anụcha na akpọnwụwo. Enwere ike ịgbakwunye L-α-glycerophosphocholine nke usoro ndị ọzọ na-eme na ihe ọṅụṅụ dị nro, ihe ọṅụṅụ egwuregwu, kọfị, gummies, oatmeal energy bars, wdg, ma nwee ike ịmepụta mmetụta nri ya n'ụzọ ezubere iche iji zute ahụike nri dị iche iche nke ndị na-azụ ahịa. mkpa.
Na United States, Japan, Canada na mba ndị ọzọ, a na-eji L-α-glycerophosphocholine mee ihe na nri. Ngwaahịa ndị emetụtara na-ekpuchi mgbakwunye nri, ihe ọ drinksụ ,ụ, gummies na ụdị ndị ọzọ, na ngwaahịa ọ bụla nwere ọrụ doro anya, usoro ọgwụgwọ akwadoro na otu akwadoro.
Suzhou Myland Pharm & Nutrition Inc. bụ onye na-emepụta aha FDA nke na-enye ntụ ntụ Alpha GPC dị elu na nke dị elu.
Na Suzhou Myland Pharm anyị na-agba mbọ ịnye ngwaahịa kachasị mma na ọnụ ahịa kacha mma. A na-anwale ntụ ntụ Alpha GPC anyị nke ọma maka ịdị ọcha na ike, na-eme ka ị nweta mgbakwunye dị elu ị nwere ike ịtụkwasị obi. Ma ịchọrọ ịkwado ahụike cellular, kwalite usoro ahụ ji alụso ọrịa ọgụ ma ọ bụ kwalite ahụike zuru oke, ntụ ntụ Alpha GPC anyị bụ nhọrọ zuru oke.
Site na ahụmịhe afọ 30 na teknụzụ dị elu na atụmatụ R&D kachasị mma, Suzhou Myland Pharm ewepụtala ngwaahịa dị iche iche nke asọmpi wee bụrụ mgbakwunye sayensị ndụ ọhụrụ, njikọta omenala na ụlọ ọrụ nrụpụta.
Na mgbakwunye, Suzhou Myland Pharm bụkwa onye nrụpụta ndebanye aha FDA. Akụrụngwa R&D nke ụlọ ọrụ ahụ, akụrụngwa nrụpụta na ngwa nyocha bụ nke ọgbara ọhụrụ yana ọtụtụ ọrụ, ma nwee ike imepụta kemịkalụ site na milligrams ruo tọn n'ọ̀tụ̀tụ̀, ma na-agbaso ụkpụrụ ISO 9001 na nkọwapụta GMP.
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Oge nzipu: Sep-25-2024
