Kedu ihe ị kwesịrị ịma gbasara palmitoylethanolamide (PEA)?

Palmitoylethanolamide (PEA) bụ amide abụba na-esi n'okike apụta nke dọtara uche maka uru ahụike ya. A na-ahụ ihe mejupụtara ya n'ọtụtụ anụ ahụ, nnyocha na-egosikwa na palmitamideethanol (PEA) nwere ike ibelata mbufụt, belata ihe mgbu, ma kwalite ahụike eriri afọ ma mee ka ịka nká ghara ịdị ngwa. Ọ nwere ike inwe ọtụtụ uru ahụike. Ihe ndị a ga-enyocha uru ahụike nke palmitoylethanolamide (PEA), otu o si arụ ọrụ n'ahụ mmadụ, na otu esi achọta palmitoylethanolamide (PEA) dị elu.

Gịnị bụ palmitoylethanolamide (PEA)?

Palmitoylethanolamide (PEA) bụ ihe mejupụtara endocannabinoid nke sitere n'okike nke a maara maka ihe mgbu na-adịghị ala ala na ihe mgbochi mbufụt. Na mgbakwunye na ahụ na-emepụta PEA, a na-ahụ ya n'ọtụtụ nri dị iche iche gụnyere: chiiz, nkochi akwa, anụ, mmiri ara ehi, ahụekere, lecithin soy.

Ị maara? Mgbe ahụ na-enweta nrụgide, dịka mmerụ ahụ ma ọ bụ mbufụt, ọkwa PEA na-agbanwe iji nọgide na-enwe homeostasis nke sel.

Kedu ka palmitoylethanolamide si emetụta ahụ mmadụ?

Ndị ọkà mmụta sayensị aghọtabeghị usoro nke palmitoylethanolamide si arụ ọrụ nke ọma. Agbanyeghị, anyị abịala ogologo ụzọ, ekele dịrị Prọfesọ Rita Levi-Montalcini, onye kọwara usoro nke palmitoylethanolamide n'afọ 1992-1996. Kemgbe ahụ, ọ nọgidere na-amụ mmetụta nke palmitoylethanolamide na-enwe n'ahụ mgbu na allergies.

Palmitoylethanolamide nwere ike iweta uru ahụike anọ dị mkpa nye mmadụ:

●Mee ka mmeghachi omume mkpali belata.

●Belata mkpali nke mkpụrụ ndụ mast (nfụkasị ahụ).

●Mee ka ọrụ nke usoro hemp endogenous sikwuo ike.

● Mee ka ndị na-anabata ihe dị iche iche rụọ ọrụ n'ahụ.

Kedu ka PEA si arụ ọrụ megide mkpali na mgbu?

Uru ahụike nke PEA gụnyere mmetụta na mkpụrụ ndụ ihe nketa nke na-achịkwa mbufụt, ọkachasị n'ụbụrụ. PEA nwere ike inye aka belata mmepụta nke ihe mkpali. Agbanyeghị, PEA na-arụ ọrụ karịsịa na ndị na-anabata ihe na mkpụrụ ndụ, nke na-achịkwa akụkụ dị iche iche nke ọrụ mkpụrụ ndụ. A na-akpọ ndị na-anabata ihe ndị a PPARs. PEA na ihe ndị ọzọ na-enyere aka mee ka PPAR rụọ ọrụ nwere ike ibelata ihe mgbu ma nwee ike ịbawanye metabolism site na ịgba abụba ọkụ, belata triglycerides na serum, mụbaa HDL cholesterol na serum, melite njikwa shuga ọbara, ma nyere aka belata ibu.

Uru nke Palmitoylethanolamide

N'ihi mmetụta mgbu na mgbochi mkpali ya, nchọpụta na-egosi na PEA nwere ike inye aka na ọtụtụ ọnọdụ metụtara mgbu, dịka fibromyalgia, sciatica, na osteoarthritis.

1. Belata ihe mgbu na mmeghachi omume mkpali

Mgbu na-adịghị ala ala bụ nsogbu siri ike nke na-emetụta ndị ọrịa gburugburu ụwa, ka ndị mmadụ na-aka nká, nsogbu a ga-akawanye njọ. Otu n'ime ọrụ nke palmitoylethanolamide bụ na ọ nwere ike inye aka belata ihe mgbu na mbufụt. palmitoylethanolamide na-emekọrịta ihe na ndị nnata CB1 na CB2, nke bụ akụkụ dị mkpa nke sistemụ hemp endogenous. Sistemụ a bụ ọrụ maka ịnọgide na-enwe homeostasis ma ọ bụ nguzozi n'ahụ.

Mgbe mmerụ ahụ ma ọ bụ mmeghachi omume mkpali mere, ahụ na-ewepụta ihe ndị dị n'ime hemp iji nyere aka ijikwa mmeghachi omume ahụ ji alụso ọrịa ọgụ. palmitoylethanolamide nwere ike inye aka mee ka ọkwa hemp dị n'ime ahụ dịkwuo elu, si otú a na-ebelata ihe mgbu na mbufụt.

Ọzọkwa, palmitoylethanolamide nwere ike ibelata mwepụta nke kemịkalụ mkpali ma belata nzaghachi mkpali akwara niile. Mmetụta ndị a na-eme ka palmitoylethanolamide bụrụ ngwaọrụ nwere ike inyere aka ijikwa mgbu na nzaghachi mkpali. Ọmụmụ ihe na-egosi na palmitoylethanolamide nwekwara ike ịdị irè maka mgbu sciatica na ọrịa ọwara carpal.

2. Ọrịa Fibromyalgia

Ọtụtụ nnyocha na-egosi na PEA nwere ike inye aka belata ihe mgbaàmà nke fibromyalgia, ọrịa akwara na-adịghị ala ala nke na-akpata mgbu zuru ebe niile. Mgbe ejiri ya dị ka ihe mgbakwunye na ọgwụgwọ ọdịnala, ịṅụ PEA na-ebelata ike mgbu ma na-eme ka ndụ dịkwuo mma ka oge na-aga. Dịka otu nnyocha si kwuo, ịṅụ PEA ruo ọnwa atọ belatara ihe mgbu na ndị nwere fibromyalgia nke ukwuu.

3. Mgbu azụ

Nnyocha mbụ gosiri na PEA nwere ike ime maka mgbu azụ. Nnyocha e mere na 2017 gosiri na PEA belatara oke ihe mgbu n'ime ndị ọrịa nwere ọrịa ịwa ahụ azụ dara ada.

Ndị na-arịa sciatica, mgbu nke na-esi n'azụ ala gbadaa otu ma ọ bụ ụkwụ abụọ, nwekwara ike inweta ahụ efe mgbe ha ṅụchara PEA. Nnwale a na-achịkwa nke ọma, nke a na-achịkwa nke ọma, nyochachara mmetụta nke PEA dị elu na nke dị ala ma e jiri ya tụnyere placebo. Mgbu ahụ belatara ihe karịrị 50% n'ime otu ndị a na-aṅụ ọgwụ dị elu. Ọ bụ ezie na obere PEA enwetaghị otu ọkwa nke mgbu ahụ dị ka nnukwu dose, ọgwụ abụọ ahụ dị irè nke ukwuu karịa placebo.

4. Ọrịa ogbu na nkwonkwo

PEA nwere ike ịba uru nye ndị nwere osteoarthritis, ọrịa nke a na-akpọ ọrịa nkwonkwo na ọkpụkpụ. Ndị sonyere n'otu nnyocha e mere nke natara PEA nwetara mmụba dị ukwuu na akara Osteoarthritis Index (WOMAC) nke Western Ontario na McMaster Universitys ma e jiri ya tụnyere otu placebo. WOMAC bụ ajụjụ e mere iji nyochaa ọnọdụ na ihe mgbaàmà (dịka ọmụmaatụ, ihe mgbu, isi ike, ọrụ anụ ahụ) na ndị ọrịa nwere osteoarthritis ikpere na úkwù.

Nnyocha ọzọ metụtara ndị nwere mgbu temporomandibular arthritic (TMJ) nke metụtara osteoarthritis gosiri na mgbakwunye PEA mere ka ike mgbu dịkwuo mma nke ukwuu mgbe ụbọchị 14 gasịrị ma e jiri ya tụnyere ibuprofen. Ndị otu ahụ nyere PEA ruo ụbọchị 14 gosiri mmụba dị ukwuu na imepe ọnụ kachasị (ihe na-ebelata ihe mgbu) karịa otu ibuprofen.

5. Mgbu akwara

Ọmụmụ ihe mbụ na nnwale anụmanụ na-egosi na PEA nwere ike inye aka na mgbu neuropathic (nke mmebi akwara ndị na-ebu ozi n'etiti ụbụrụ na eriri azụ kpatara), ọkachasị na ndị nwere ọrịa carpal tunnel syndrome, ọrịa neuropathy nke ọrịa shuga, chemotherapy Ndị nwere neuropathy akụkụ, ihe mgbu pelvic na-adịghị ala ala, na ihe mgbu metụtara strok na multiple sclerosis. A chọrọ nnwale ahụike ọzọ iji chọpụta irè nke PEA n'ịgwọ mgbu neuropathic.

6. Ịka nká nke ọma

Ịkwụsị ịka nká bụ ihe mgbaru ọsọ bara uru nke ọtụtụ ndị ọkà mmụta sayensị gburugburu ụwa na-achụ. A na-ewere Palmitoylethanolamide dị ka ihe mgbakwunye na-egbochi ịka nká nke nwere ike inye aka chebe mkpụrụ ndụ site na mmebi oxidative, nke bụ isi ihe na-akpata ịka nká.

Mgbe mkpụrụ ndụ na-enwe oke ọrụ free radicals, mmeghachi omume oxidative nwere ike ime, nke na-ebute ọnwụ mkpụrụ ndụ tupu oge eruo. Iri nri na-adịghị mma, ise siga, na ihe ndị ọzọ metụtara gburugburu ebe obibi dịka mmetọ ikuku na-emekwa ka mmebi oxidative dịkwuo elu. Palmitoylethanolamide nwere ike igbochi mmebi a site na iwepụ free radicals na ibelata nzaghachi mbufụt n'ahụ.

Ọzọkwa, egosila na palmitoylethanolamide ethanol nwere ike ịkpalite mmepụta nke collagen na protein ndị ọzọ dị mkpa maka akpụkpọ ahụ. Ya mere, ọ nwere ike ibelata ọdịdị nke wrinkles na ahịrị dị nro, na-arụ ọrụ dị ka ihe nchebe pụọ ​​n'ime sel.

Suzhou Myland Pharm & Nutrition Inc. bụ ụlọ ọrụ mmepụta ihe nke FDA debanyere aha ya, nke na-enye ntụ ntụ Palmitoylethanolamide (PEA) dị elu ma dị ọcha.

Na Suzhou Myland Pharm, anyị na-agba mbọ inye ngwaahịa kachasị mma na ọnụ ahịa kacha mma. A na-anwale ntụ ntụ Palmitoylethanolamide (PEA) anyị nke ọma maka ịdị ọcha na ike, na-eme ka ị nweta mgbakwunye dị elu ị nwere ike ịtụkwasị obi. Ma ịchọrọ ịkwado ahụike sel, ịkwalite sistemu ahụ ji alụso ọrịa ọgụ gị, ma ọ bụ melite ahụike zuru oke, ntụ ntụ Palmitoylethanolamide (PEA) anyị bụ nhọrọ zuru oke.

Site na ahụmịhe afọ iri atọ nke teknụzụ dị elu na atụmatụ R&D kachasị mma, Suzhou Myland Pharm emepụtala ọtụtụ ngwaahịa asọmpi ma bụrụ ụlọ ọrụ mgbakwunye sayensị ndụ ọhụrụ, mmepụta omenala na ọrụ mmepụta.

Tinyere nke ahụ, Suzhou Myland Pharm bụkwa onye nrụpụta nke FDA debanyere aha ya. Akụrụngwa nyocha na mmepe nke ụlọ ọrụ ahụ, ebe mmepụta, na ngwa nyocha ya bụ nke ọgbara ọhụrụ ma na-arụ ọrụ nke ọma, ha nwekwara ike imepụta kemịkalụ site na milligram ruo tọn n'ọkwa, ma na-agbaso ụkpụrụ ISO 9001 na nkọwapụta mmepụta GMP.