Kedu ihe ịchọrọ ịma gbasara palmitoylethanolamide (PEA)?

Palmitoylethanolamide (PEA) bụ fatty acid amide na-emekarị nke dọtara uche maka uru ahụike ọ nwere. A na-ahụ ogige a na anụ ahụ dị iche iche n'ime ahụ dum, nchọpụta na-egosi na palmitamideethanol (PEA) nwere ike ibelata mbufụt, belata ihe mgbu, ma nwee ike ịkwalite ahụike eriri afọ na igbu oge ịka nká. O nwere ike inwe uru ahụike dị iche iche. Ọdịnaya na-esonụ ga-enyocha uru ahụike nke palmitoylethanolamide (PEA), ka o si arụ ọrụ n'ahụ mmadụ, yana otu esi achọta palmitoylethanolamide dị elu (PEA).

Kedu ihe bụ palmitoylethanolamide (PEA)?

Palmitoylethanolamide (PEA) bụ ihe na-emekarị endocannabinoid-dị ka ogige mara maka analgesic ya na-adịghị ala ala na mgbochi mkpali. Na mgbakwunye na nke ahụ na-emepụta ya, a na-ahụ PEA n'ụdị nri dị iche iche gụnyere: cheese, nkochi ime akwa, anụ, mmiri ara ehi, ahụekere, soy lecithin.

ị maara? Mgbe ahụ na-ezute ihe nrụgide, dị ka mmerụ ahụ ma ọ bụ mbufụt, ọkwa PEA na-agbanwe iji nọgide na-enwe homeostasis cellular.

Kedu ka palmitoylethanolamide si emetụta ahụ mmadụ?

Ndị ọkà mmụta sayensị aghọtabeghị nke ọma usoro palmitoylethanolamide si eme ya. Ka o sina dị, anyị abịala ogologo oge, n'ihi Prọfesọ Rita Levi-Montalcini, onye na 1992-1996 kọwapụtara usoro ọrụ nke palmitoylethanolamide n'ozuzu ya. Kemgbe ahụ, ọ gara n'ihu na-amụ mmetụta palmitoylethanolamide na mgbu neuropathic na allergies.

Palmitoylethanolamide nwere ike iwetara mmadụ uru ahụike anọ:

●Wepụ nzaghachi mkpasu iwe.

● Belata ọrụ cell mast (allergy).

● Kwado ọrụ nke usoro hemp endogenous.

● Mee ka ndị na-anabata ya rụọ ọrụ n'ime ahụ.

Kedu ka PEA si egosipụta mmetụta mgbochi mkpali na analgesic?

Uru ahụike nke PEA gụnyere mmetụta na sel mgbochi na-achịkwa mbufụt, ọkachasị na ụbụrụ. PEA nwere ike inye aka belata mmepụta nke ihe mkpali. Agbanyeghị, PEA na-arụkarị ọrụ na ndị na-anabata ya na sel, nke na-achịkwa akụkụ dị iche iche nke ọrụ cell. A na-akpọ ndị nnata ndị a PPAR. PEA na ogige ndị ọzọ na-enyere aka mee ka PPAR rụọ ọrụ nwere ike ibelata ihe mgbu ma nwee ike ịbawanye metabolism site na abụba na-ere ọkụ, serum triglycerides dị ala, na-abawanye serum HDL cholesterol, melite njikwa shuga ọbara, ma nyere aka belata ibu.

Uru Palmitoylethanolamide

N'ihi mmetụta analgesic na mgbochi mkpali, nchọpụta na-egosi na PEA nwere ike inye aka na ọnọdụ dị iche iche metụtara mgbu, dị ka fibromyalgia, sciatica, na osteoarthritis.

1. Wepụ ihe mgbu na nzaghachi mkpali

Ihe mgbu na-adịghị ala ala bụ nsogbu siri ike nke na-emekpa ndị ọrịa ahụ gburugburu ụwa, na ka ọnụ ọgụgụ ndị mmadụ na-eme agadi, nsogbu a ga-adịwanye njọ. Otu n'ime ọrụ palmitoylethanolamide bụ na ọ nwere ike inye aka belata mgbu na mbufụt. palmitoylethanolamide na-emekọrịta ihe na ndị na-anabata CB1 na CB2, nke bụ akụkụ dị mkpa nke sistemu hemp endogenous. Usoro a na-ahụ maka idobe homeostasis ma ọ bụ nguzozi n'ime ahụ.

Mgbe mmerụ ahụ ma ọ bụ nzaghachi mkpali mere, ahụ na-ewepụta ogige hemp endogenous iji nyere aka ịchịkwa nzaghachi mgbochi ahụ. palmitoylethanolamide nwere ike inye aka ịbawanye ọkwa hemp endogenous n'ime ahụ, si otú ahụ na-ebelata mgbu na mbufụt.

Na mgbakwunye, palmitoylethanolamide nwere ike ibelata ntọhapụ nke kemịkalụ mkpali ma belata nzaghachi mkpali akwara n'ozuzu ya. Mmetụta ndị a na-eme palmitoylethanolamide ngwá ọrụ nwere ike inyere aka ịchịkwa mgbu na nzaghachi mkpali. Nnyocha na-egosi na palmitoylethanolamide nwekwara ike ịdị irè maka mgbu sciatica na ọrịa ọwara carpal.

2. Fibromyalgia

Ọtụtụ nchọpụta na-egosi na PEA nwere ike inye aka belata mgbaàmà nke fibromyalgia, ọrịa na-adịghị ala ala nke na-akpata mgbu zuru oke. Mgbe ejiri ya dị ka ihe mgbakwunye na ọgwụgwọ ọdịnala, ntinye PEA na-ebelata ihe mgbu ma mee ka ndụ dịkwuo mma n'oge. Dị ka otu nnyocha si kwuo, ịṅụ PEA maka ọnwa atọ na-ebelata ihe mgbu na ndị nwere fibromyalgia.

3. Ihe mgbu azụ

Nnyocha mbụ na-egosi na PEA nwere ike ime maka mgbu azụ. Nnyocha nyocha nke 2017 gosiri na PEA na-ebelata mgbu mgbu na ndị ọrịa nwere ọrịa ịwa ahụ dara ada.

Ndị mmadụ na-ata ahụhụ site na sciatica, ihe mgbu na-esi na azụ azụ gbadaa otu ma ọ bụ ụkwụ abụọ, nwekwara ike nweta ahụ efe mgbe ha nwụsịrị PEA. Nnwale a na-achịkwaghị achịkwa, nke kpuru ìsì abụọ, ebe a na-achịkwa placebo mụrụ mmetụta nke PEA dị elu na nke dị ala karịa placebo. A na-ebelata ihe mgbu karịa 50% n'ime ìgwè dị elu. Ọ bụ ezie na obere dose PEA enwetaghị otu ogo ahụ mgbu mgbu dị ka oke dose, ma doses abụọ ahụ dị irè karịa placebo.

4. Osteoarthritis

PEA nwere ike ịba uru maka ndị nwere ọrịa ogbu na nkwonkwo, ọrịa nke e ji mbelata nke cartilage nkwonkwo na ọkpụkpụ mara. Ndị sonyere na otu ọmụmụ ndị natara PEA nwere ọganihu dị ukwuu na Western Ontario na McMaster Universities Osteoarthritis Index (WOMAC) ma e jiri ya tụnyere ndị otu placebo. WOMAC bụ ajụjụ e mere iji nyochaa ọnọdụ na akara ngosi (dịka ọmụmaatụ, mgbu, isi ike, ọrụ anụ ahụ) n'ime ndị ọrịa nwere ikpere na hip osteoarthritis.

Nnyocha ọzọ metụtara ndị ọrịa nwere ọrịa ogbu na nkwonkwo temporomandibular (TMJ) jikọtara ya na ọrịa ogbu na nkwonkwo gosiri na mgbakwunye PEA mere ka ihe mgbu dịkwuo mma mgbe ụbọchị 14 gasịrị ma e jiri ya tụnyere ibuprofen. Otu a nyere PEA maka ụbọchị 14 gosipụtara mmụba dị ukwuu na oghere ọnụ ọnụ (ihe enyemaka mgbu) karịa otu ibuprofen.

5. Neuropathic mgbu

Ọmụmụ ihe mbụ na nyocha anụmanụ na-atụ aro na PEA nwere ike inye aka na nhụjuanya neuropathic (nke kpatara mmebi nke irighiri akwara na-ebu ozi n'etiti ụbụrụ na ọkpụkpụ azụ), karịsịa na ndị nwere ọrịa ọwara carpal, ọrịa shuga neuropathy, chemotherapy Ndị mmadụ nwere neuropathy peripheral, na-adịghị ala ala. mgbu pelvic, na mgbu metụtara ọrịa strok na otutu sclerosis. Ọnwụnwa ndị ọzọ na-agwọ ọrịa dị mkpa iji chọpụta irè nke PEA na-edozi ihe mgbu neuropathic.

6. Ike ịka nká

Ịkwụsị usoro ịka nká bụ ihe mgbaru ọsọ bara uru nke ọtụtụ ndị ọkà mmụta sayensị gburugburu ụwa na-agbaso. A na-ewere Palmitoylethanolamide dịka mgbakwunye mgbochi ịka nká nke nwere ike inye aka chebe mkpụrụ ndụ site na mmebi oxidative, nke bụ isi ihe na-akpata ịka nká.

Mgbe mkpụrụ ndụ na-ekpughere oke ọrụ radical n'efu, mmeghachi omume oxidative nwere ike ime, na-eduga na ọnwụ cell akabeghị aka. Iri oriri na-adịghị mma, ise siga, na ihe ndị ọzọ na-ahụ maka gburugburu ebe obibi dị ka mmetọ ikuku na-abawanye mmebi nke oxidative.Palmitoylethanolamide nwere ike igbochi mmebi a site n'iwepụ ihe ndị na-akpata free radicals na ibelata mkpokọta mkpali n'ime ahụ.

Na mgbakwunye, egosipụtara palmitoylethanolamide ethanol nwere ike ịkpalite mmepụta nke collagen na protein anụ ahụ ndị ọzọ dị mkpa. Ya mere, ọ nwere ike ibelata ọdịdị wrinkles na ahịrị dị mma, na-eme ihe dị ka ihe nchebe site n'ime sel.

Suzhou Myland Pharm & Nutrition Inc. bụ onye na-emepụta aha FDA nke na-enye ntụ ntụ Palmitoylethanolamide (PEA) dị elu na nke dị elu.

Na Suzhou Myland Pharm anyị na-agba mbọ ịnye ngwaahịa kachasị mma na ọnụ ahịa kacha mma. A na-anwale ntụ ntụ Palmitoylethanolamide (PEA) nke ọma maka ịdị ọcha na ike, na-eme ka ị nweta mgbakwunye dị elu ị nwere ike ịtụkwasị obi. Ma ịchọrọ ịkwado ahụike cellular, kwalite usoro ahụ ji alụso ọrịa ọgụ, ma ọ bụ kwalite ahụike zuru oke, Palmitoylethanolamide (PEA) ntụ ntụ bụ nhọrọ zuru oke.

Site na ahụmịhe afọ 30 na teknụzụ dị elu na atụmatụ R&D kachasị mma, Suzhou Myland Pharm ewepụtala ngwaahịa dị iche iche nke asọmpi wee bụrụ mgbakwunye sayensị ndụ ọhụrụ, njikọta omenala na ụlọ ọrụ nrụpụta.

Na mgbakwunye, Suzhou Myland Pharm bụkwa onye nrụpụta FDA debanyere aha. Akụrụngwa R&D nke ụlọ ọrụ ahụ, akụrụngwa nrụpụta na ngwa nyocha bụ nke ọgbara ọhụrụ yana ọtụtụ arụ ọrụ, ma nwee ike imepụta kemịkalụ site na milligrams ruo tọn n'ọ̀tụ̀tụ̀, ma na-agbaso ụkpụrụ ISO 9001 na nkọwapụta GMP.