Ndị ọkà mmụta sayensị achọpụtala na ka anyị na-aka nká, mitochondria anyị ji nwayọọ nwayọọ na-ada ma na-emepụta obere ume. Nke a nwere ike ibute ọrịa ndị metụtara afọ dịka ọrịa neurodegenerative, ọrịa obi, na ndị ọzọ.
Urolitin A
Urolitin A bụ metabolite eke nwere antioxidant na mmetụta antiproliferative. Ndị ọkachamara n'ihe banyere nri na Mahadum Nova Southeast dị na United States achọpụtala na iji urolithin A dị ka nri nri nwere ike igbu oge ịka nká ma gbochie mmepe nke ọrịa ndị metụtara afọ.
Urolithin A (UA) bụ nje bacteria anyị na-emepụta mgbe anyị risịrị polyphenols dị na nri dị ka pọmigranet, strawberries, na walnuts. Mgbakwunye UA na ụmụ oke ndị agadi na-eme ka sirtuins rụọ ọrụ ma na-abawanye NAD + na ọkwa ike cell. N'ụzọ dị mkpa, egosiri UA iji kpochapụ mitochondria mebiri emebi site na mọzụlụ mmadụ, si otú ahụ na-emewanye ike, ike ọgwụgwụ, na ịrụ ọrụ egwuregwu. Ya mere, mgbakwunye UA nwere ike ịgbatị ndụ site n'ịkwụsị ịka nká ahụ.
Urolithin A anaghị abịa ozugbo site na nri, mana ogige ndị dị ka ellagic acid na ellagitannins dị na mkpụrụ, pọmigranet, mkpụrụ vaịn na mkpụrụ osisi ndị ọzọ ga-emepụta urolithin A mgbe ha mebere ya site na microorganisms intestinal.
Spermidine
Spermidine bụ ụdị okike nke polyamine nke enwetara nlebara anya n'afọ ndị na-adịbeghị anya maka ikike ya ịgbatị ndụ yana ịbawanye ogologo ahụike. Dị ka NAD + na CoQ10, spermidine bụ molekul na-emekarị nke na-ebelata na afọ. Dị ka UA, spermidine na-emepụta site na nje bacteria anyị na-ebute mitophagy - mwepụ nke mitochondria na-adịghị mma, mebiri emebi. Ọmụmụ òké na-egosi na mgbakwunye spermidine nwere ike ichebe ọrịa obi na ịka nká nke nwanyị. Na mgbakwunye, spermidine nri (nke a na-achọta n'ụdị nri dị iche iche gụnyere soy na ọka) mere ka ebe nchekwa dị na oke. Achọkwuru nyocha iji chọpụta ma nchoputa ndị a nwere ike imegharị n'ime mmadụ.
Usoro ịka nká nkịtị na-ebelata mkpokọta ụdị spermidine n'ime ahụ, dịka nchọpụta e bipụtara na Scientific Reports nke ndị nchọpụta na Kyoto Prefectural University of Medicine na Japan si kwuo. Otú ọ dị, a hụbeghị ihe a na narị afọ;
Spermidine nwere ike ịkwalite autophagy.
Nri nwere nnukwu spermidine gụnyere: nri ọka wit dum, kelp, mushrooms shiitake, nuts, bracken, purslane, wdg.
curcumin
Curcumin bụ ihe na-arụ ọrụ na turmeric nke nwere mgbochi mkpali na antioxidant Njirimara.
Ndị ọkà mmụta sayensị na-eme nchọpụta sitere na Polish Academy of Sciences achọpụtala na curcumin nwere ike ibelata mgbaàmà nke ịka nká ma na-egbu oge ọganihu nke ọrịa ndị metụtara afọ nke mkpụrụ ndụ ụbụrụ na-etinye aka na ya, si otú ahụ na-agbatị ndụ.
Na mgbakwunye na turmeric, nri ndị nwere curcumin na-agụnye: ginger, galik, eyịm, ose ojii, mọstad na curry.
Ihe mgbakwunye NAD+
N'ebe enwere mitochondria, enwere NAD + (nicotinamide adenine dinucleotide), molecule dị mkpa maka ịbawanye mmepụta ume. NAD + na-agbada n'ụzọ nkịtị na afọ, nke yiri ka ọ dabara na mbelata afọ metụtara ọrụ mitochondrial. Nke a bụ otu n'ime ihe kpatara eji mepụta NAD + boosters dị ka NR (Nicotinamide Ribose) iji weghachi ọkwa NAD +.
Nnyocha na-egosi na site n'ịkwalite NAD +, NR nwere ike ịkwalite mmepụta ume mitochondrial ma gbochie nrụgide metụtara afọ. Ihe mgbakwunye NAD + nwere ike imeziwanye ọrụ akwara, ahụike ụbụrụ, na metabolism ebe enwere ike ịlụso ọrịa neurodegenerative ọgụ. Na mgbakwunye, ha na-ebelata oke ibu, na-eme ka mmetụta insulin dịkwuo mma, na-edozi ọkwa nke lipid, dị ka ibelata LDL cholesterol.
Oge nzipu: Jul-24-2024
