Salidroside bụ isi ihe na-arụ ọrụ nke a na-ewepụta na Rhodiola rosea ma nwee ọtụtụ ihe ndị dị ndụ na ọgwụ. Salidroside nwere mmetụta nke iguzogide nrụgide oxidative, igbochi apoptosis nke mkpụrụ ndụ, na ibelata mmeghachi omume mkpali.
Salidroside bụ ihe na-egbochi ọrịa nke sitere n'okike nke na-echebe mkpụrụ ndụ akwara site na iwepụ ROS na igbochi apoptosis nke mkpụrụ ndụ.
Oke calcium dị n'ime sel bụ otu n'ime ihe ndị na-akpata apoptosis neuronal. Rhodiola rosea extract na saldroside nwere ike ibelata mmụba nke ọkwa calcium na-enweghị sel nke nrụgide oxidative na-akpata ma chebe mkpụrụ ndụ cortical mmadụ site na glutamate. Salidroside nwere ike igbochi mkpali microglial nke lipopolysaccharide kpatara, gbochie mmepụta NO, gbochie ọrụ nitric oxide synthase (iNOS) inducible, ma belata ọkwa TNF-α na IL-1β, IL-6.
Salidroside na-egbochi NADPH oxidase 2/ROS/mitogen-activated protein kinase (MAPK) na ihe na-achịkwa nzaghachi nke mmepe na mmebi DNA 1 (REDD1)/ihe mgbaru ọsọ nke rapamycin (mTOR)/p70 ribosome. Ụzọ mgbaama protein S6 kinase na-eme ka usoro mgbaama protein nke dabere na AMP/silent information regulator 1, RAS homologue gene member A/MAPK na PI3K/Akt rụọ ọrụ.
1. Salidroside na-egbochi mmebi radical efu ma na-echebe ahụ
Ahụ mmadụ nwere ike imepụta ụfọdụ mkpụrụ ndụ ihe nketa n'oge usoro ahụike nkịtị, a na-achọkwa obere mkpụrụ ndụ ihe nketa iji nọgide na-arụ ọrụ nkịtị nke ahụ. E nwekwara usoro mwepụ mkpụrụ ndụ ihe nketa n'ime ahụ iji wepụ mkpụrụ ndụ ihe nketa n'efu nke gafere oke mkpụrụ ndụ ihe nketa ka ọ ghara imebi ahụike ahụ.
Agbanyeghị, n'okpuru mmetụta nke ụfọdụ ihe pụrụ iche gbasara gburugburu ebe obibi, ihe ndị na-akpata mmebi nke akụkụ ahụ ga-adị oke oke ma gafere ọsọ nke ihe ndị na-akpata mmebi nke sistemụ ahụ, na-akpata enweghị nguzozi na sistemụ mmepụta nke na-enweghị oxygen, nke na-eduga na mkpokọta nke ihe ndị na-akpata mmebi nke oxygen n'ahụ, si otú a na-akpata mmebi nke akpụkpọ ahụ sel.
Nnyocha egosila na gburugburu ebe obibi hypoxic n'okpuru ọnọdụ dị larịị nwere ike ibute enweghị nguzozi na metabolism radical na-enweghị oxygen, na-agbakọta radicals free intracellular na ịbawanye ngwaahịa lipid peroxidation. Ọmụmụ ihe egosila na saldroside nwere ike ichebe mkpụrụ ndụ anụ ahụ site na iwepụ radicals free n'ahụ.
2. Salidroside na-egbochi hypoxia iji nọgide na-enwe nkwụsi ike nke ọrụ mitochondrial
A na-eji ihe dị ka pasentị 80-90 nke oxygen dị n'ime sel eme ihe maka oxidation bayọlọjik na mitochondria iji mepụta ATP ma mepụta ụdị oxygen reactive ROS iji nọgide na-arụ ọrụ ndụ nkịtị nke mkpụrụ ndụ. Naanị pasentị 10-20 nke oxygen dị n'efu n'èzí mitochondria maka biosynthesis, degeneration, biotransformation (detoxification), wdg. Ọrụ iku ume mitochondrial na-eme ka ọ dịkwuo mma na obere hypoxia ma ọ bụ na mmalite nke hypoxia, nke a na-egosipụta dị ka nzaghachi nkwụghachi nke sistemu iku ume nke ahụ.
Ọrịa hypoxia siri ike ga-ebu ụzọ metụta mpụta ikuku oxygen nke mitochondria na nsogbu metabolic ọrụ nke ahụ, belata mmepụta nke neurotransmitters, ma mee ka ikike biotransformation ghara ịdị ike, si otú a na-emetụta ọrụ nke anụ ahụ na akụkụ ahụ. Ọmụmụ ihe egosila na saldroside nwere ike ichebe mmezi nke ọrụ mitochondria site na ibelata ọdịnaya ROS na mitochondria sel, ịbawanye ọrụ SOD, na ịbawanye ọnụọgụ mitochondria.
3. Mmetụta nchebe myocardial nke salidroside
Nnyocha egosila na sistemụ obi bụ isi ihe na-agbanwe gburugburu ebe obibi hypoxic. Gburugburu ebe obibi hypoxic ga-eme ka metabolism aerobic nke ahụ ghara ịdị ike ma ghara inwe ike zuru oke, na-ebute ihe mgbaàmà dịka hypoxia, ischemia, na apoptosis nke mkpụrụ ndụ myocardial. Ọmụmụ ihe egosila na saldroside nwere ike ime ka ọrụ obi ka mma ma melite microcirculation site na ịgbasa akwara ọbara na akwara, ime ka ọbara myocardial dịkwuo mma, ịgbanwe hemodynamics nke obi, ibelata ibu obi, na ibelata mmebi ischemic myocardial.
Na nkenke, saldroside nwere ike ime ihe na sistemụ obi site na ọtụtụ usoro, ụzọ, na ebumnuche, chebe apoptosis mkpụrụ ndụ myocardial nke ọtụtụ ihe kpatara ya, ma melite ọnọdụ ischemia na hypoxia nke ahụ. N'ebe hypoxic dị, ntinye aka Rhodiola rosea dị oke mkpa n'ichebe anụ ahụ na akụkụ ahụ yana idobe ọrụ sel kwụsiri ike. Ọ na-arụ ọrụ dị mkpa n'igbochi na ibelata ọrịa elu.
Ọnọdụ mmepụta saldroside ugbu a
1) Na-adaberekarị na mwepụta osisi
Rhodiola rosea bụ ihe ọkụkụ dị na yasalidroside.Dịka ụdị osisi ahịhịa na-adịru ogologo oge, Rhodiola rosea na-etokarị n'ebe nwere oke oyi, anoxia, nkụ, na nnukwu ọdịiche okpomọkụ n'etiti ehihie na abalị n'ogo nke mita 1600-4000. Ọ bụ otu n'ime osisi ọhịa dị larịị. China bụ otu n'ime ebe ndị Rhodiola rosea na-emepụta ihe n'ụwa, mana àgwà ibi ndụ nke Rhodiola rosea pụrụ iche. Ọ bụghị naanị na ọ siri ike ịkọ ihe n'ụzọ aka, kamakwa mmepụta nke ụdị ọhịa dị obere nke ukwuu. Oghere mkpa kwa afọ maka Rhodiola rosea dị elu ruo tọn 2,200.
2) Njikọta kemịkalụ na ịgbakọ mmiri ọgwụ
N'ihi obere ọdịnaya na oke ọnụ ahịa mmepụta ihe dị na osisi, na mgbakwunye na ụzọ mwepụta eke, ụzọ mmepụta saldroside gụnyekwara ụzọ mmepụta kemịkalụ, ụzọ ịgba mmiri ihe dị ndụ, wdg. N'ime ha, ka teknụzụ na-aga n'ihu na-etolite, ịgba mmiri ihe dị ndụ aghọwo ụzọ teknụzụ kachasị maka mmepe na mmepụta nke saldroside. Ugbu a, Suzhou Mailun enwetala nsonaazụ nyocha na mmepe ma nweta mmepụta ụlọ ọrụ mmepụta ihe.
Nkwupụta: Edemede a bụ maka ozi izugbe naanị, ekwesighikwa ịkọwa ya dị ka ndụmọdụ ahụike ọ bụla. Ụfọdụ ozi sitere na blọgụ sitere na ịntanetị, ọ bụghịkwa ọkachamara. Weebụsaịtị a bụ naanị ọrụ maka nhazi, nhazi na idezi akụkọ. Ebumnuche nke izipu ozi ndị ọzọ apụtaghị na ị kwenyere na echiche ya ma ọ bụ kwado eziokwu nke ọdịnaya ya. Gakwuru ọkachamara ahụike mgbe niile tupu i jiri ihe mgbakwunye ọ bụla ma ọ bụ mee mgbanwe na usoro nlekọta ahụike gị.
Oge ozi: Ọgọst-15-2024
