Salidroside: ikpughe nzuzo nke Rhodiola rosea si antioxidant Njirimara

Salidroside bụ antioxidant eke na-echebe mkpụrụ ndụ akwara site n'ịkpachapụ ROS na igbochi apoptosis cell.

Ibubiga calcium intracellular bụ otu n'ime isi ihe na-ebute apoptosis neuronal. Mwepụta Rhodiola rosea na salidroside nwere ike belata mmụba nke ọkwa calcium n'efu intracellular nke nrụgide oxidative kpatara ma chebe mkpụrụ ndụ cortical mmadụ site na glutamate. Salidroside nwere ike igbochi lipopolysaccharide na-eme ka microglial rụọ ọrụ, na-egbochi mmepụta NO, na-egbochi ọrụ nitric oxide synthase (iNOS), ma belata TNF-α na IL-1β, IL-6 ọkwa.

Salidroside na-egbochi NADPH oxidase 2 / ROS / mitogen-activated protein kinase (MAPK) na nzaghachi nzaghachi nke mmepe na DNA mmebi 1 (REDD1) / mammalian target of rapamycin (mTOR) / p70 ribosome protein S6 kinase akara ụzọ na-eme ka AMP-adabere. protein kinase/onye na-ahụ maka ozi nzuzo 1, RAS homologous gene onye otu ezinụlọ A/MAPK na PI3K/Akt ụzọ akara.

1. Salidroside na-emegide mmebi radical free ma na-echebe ahụ

Ahụ nwere ike mepụta ụfọdụ ego nke endogenous free radicals n'oge nkịtị physiological Filiks, na a ụfọdụ physiological dose nke free radicals dị mkpa iji nọgide na-enwe ahụ nkịtị physiological omume. Enwekwara usoro nchacha n'efu n'ime ahụ iji wepụ radicals free nke gafere doses physiological ka ọ ghara imerụ ahụ ike nke ahụ.

Otú ọ dị, n'okpuru mmetụta nke ụfọdụ ihe pụrụ iche gburugburu ebe obibi, ndị endogenous free radicals ga-abụ nke ukwuu ma gafere usoro nke free radical scavenging ọnụego, na-eme ka ahaghị nhata n'ime ahụ oxygen free radical mmepụta-scavenging usoro, na-eduga na mkpokọta nke oxygen free radicals. n'ime ahụ, si otú ahụ na-akpata mmebi cell membrane. mmebi.

Nnyocha na-egosi na gburugburu ọnọdụ hypoxic dị n'okpuru ọnọdụ ala dị larịị nwere ike ime ka adịghị mma na metabolism na-enweghị oxygen, na-achịkọta radicals free intracellular na ịba ụba ngwaahịa peroxidation lipid. Nnyocha e mere egosiwo na salidroside nwere ike ichekwa mkpụrụ ndụ anụ ahụ site n'iwepụ radicals n'efu n'ime ahụ.

2. Salidroside na-emegide hypoxia iji jikwaa nkwụsi ike nke ọrụ mitochondrial

Ihe dị ka 80-90% nke oxygen intracellular ka a na-eji maka oxidation bayoloji na mitochondria iji mepụta ATP ma mepụta ụdị oxygen na-arụ ọrụ ROS iji nọgide na-arụ ọrụ ndụ nkịtị nke mkpụrụ ndụ. Naanị 10-20% oxygen nwere onwe ya n'èzí mitochondria maka biosynthesis, mmebi, biotransformation (detoxification), wdg. Mitochondrial iku ume ọrụ na-akwalite na obere hypoxia ma ọ bụ na mmalite ogbo nke hypoxia, nke na-egosipụta dị ka nkwụghachi ụgwọ nke usoro iku ume nke ahụ.

Nnukwu hypoxia ga-ebu ụzọ metụta ikuku oxygenation nke mitochondria na ọrịa metabolic na-arụ ọrụ nke ahụ, belata mmepụta nke neurotransmitters, na-ebelata ikike biotransformation, si otú ahụ na-emetụta ọrụ nke anụ ahụ na akụkụ ahụ. Nnyocha e mere egosiwo na salidroside nwere ike ichebe ọrụ nke mitochondrial site na ibelata ọdịnaya ROS na cell mitochondria, ịba ụba ọrụ SOD, na ịba ụba nke mitochondria.

3. Mmetụta nchebe myocardial nke salidroside

Nnyocha egosiwo na usoro obi obi bụ isi usoro nke na-agbanwe ọnọdụ hypoxic. Gburugburu ebe obibi hypoxic ga-eme ka metabolism aerobic nke anụ ahụ kwụsịlata na enweghị ike zuru oke, na-eduga na mgbaàmà dị ka hypoxia, ischemia, na apoptosis nke mkpụrụ ndụ myocardial. Nnyocha egosiwo na salidroside nwere ike ịkwalite ọrụ obi yana melite microcirculation site n'ịgbasa arịa ọbara na venous, na-eme ka myocardial perfusion dị mma, na-agbanwe hemodynamics nke obi, na-ebelata ibu obi, na ibelata mmebi ischemic myocardial.
Na nkenke, salidroside nwere ike ịrụ ọrụ na sistem obi obi site na ọtụtụ usoro, ụzọ, na ebumnuche, na-echebe apoptosis cell myocardial nke ọtụtụ ihe kpatara ya, ma melite ọnọdụ ischemia na ọnọdụ hypoxia nke anụ ahụ. N'ime ọnọdụ hypoxic, ntinye aka nke Rhodiola rosea dị oke mkpa n'ichekwa anụ ahụ na akụkụ ahụ na idowe nkwụsi ike nke ọrụ cell. Ọ na-ekere òkè dị mkpa n'igbochi na ibelata ọrịa elu.
Ọnọdụ mmepụta salidroside ugbu a

1) tumadi ịdabere na osisi mmịpụta

Rhodiola rosea bụ ihe eji eme ihesalidroside.Dị ka ụdị osisi herbaceous perennial, Rhodiola rosea na-etolite na mpaghara oyi na-atụ, anoxia, nkụ, na nnukwu ọdịiche dị n'etiti ehihie na abalị na elu 1600-4000 mita. Ọ bụ otu n'ime osisi ala dị larịị. China bụ otu n'ime mpaghara na-emepụta Rhodiola rosea n'ụwa, mana àgwà ndụ nke Rhodiola rosea bụ ihe pụrụ iche. Ọ bụghị naanị na ọ siri ike ịzụlite artificially, ma mkpụrụ nke ụdị ọhịa dị oke ala. Ọdịiche a na-achọ kwa afọ maka Rhodiola rosea ruru tọn 2,200.

2) Chemical njikọ na ndu gbaa ụka

N'ihi ọdịnaya dị ala na ọnụ ahịa mmepụta ihe dị elu na osisi, na mgbakwunye na ụzọ mmepụta eke, usoro mmepụta salidroside na-agụnyekwa usoro njikọ kemịkalụ, usoro ịgba ụka ndu, wdg. N'ime ha, ka nkà na ụzụ na-aga n'ihu na-eto eto, ihe ọkụkụ nke ndu aghọwo ihe bụ isi. ụzọ teknụzụ maka mmepe nyocha na mmepụta nke salidroside. Ka ọ dị ugbu a, Suzhou Mailun enwetala nsonaazụ nyocha na mmepe wee nweta mmepụta ihe.