Taa, ka ndụ mmadụ n'ụwa niile na-akawanye njọ, ihe mgbochi ịka nká aghọọla isiokwu dị mkpa. N'oge na-adịbeghị anya, okwu Urolithin A, nke a na-amaghị nke ọma n'oge gara aga, aghọọla ihe a na-ahụ anya n'ihu ọha. Ọ bụ ihe pụrụ iche a na-eme ka ọ bụrụ ihe sitere na nje bacteria eriri afọ ma nwee njikọ chiri anya na ahụike. Isiokwu a ga-ekpughe ihe omimi nke ihe okike a dị ebube - urolithin A.
Akụkọ ihe mere eme nkeurolithin A (UA)enwere ike ịchọpụta ya na 2005. Ọ bụ ihe na-eme ka nje bacteria dị n'ime eriri afọ dị iche iche, a pụghịkwa itinye ya ozugbo site na usoro nri. Agbanyeghị, ellagitannins mbụ ya bara ụba na mkpụrụ osisi dị iche iche dịka pomegranate na strọberị.
Ọrụ nke urolithin A
Na Machị 25, 2016, otu nnyocha dị mkpa na magazin "Nature Medicine" dọtara uche ndị na-ege ntị na njikọ ya na igbu oge ịka nká mmadụ. Kemgbe achọpụtara na 2016 na UA nwere ike ịgbatị ndụ C. elegans nke ọma, ejirila UA mee ihe n'ọkwa niile (mkpụrụ ndụ hematopoietic, anụ ahụ akpụkpọ ahụ, ụbụrụ (akụkụ ahụ), sistemu ahụ ji alụso ọrịa ọgụ, ndụ onye ọ bụla) na n'ụdị dị iche iche (C. elegans, melanogaster. Mmetụta mgbochi ịka nká egosila nke ọma na ijiji mkpụrụ osisi, òké, na ụmụ mmadụ.
(1) Mgbochi ịka nká ma melite ọrụ akwara
Nnwale ahụike a na-eme n'enweghị usoro nke e bipụtara na JAMA Network Open, akwụkwọ akụkọ nke Journal of the American Medical Association, gosiri na maka ndị agadi ma ọ bụ ndị nwere nsogbu ịkwaga n'ihi ọrịa, ihe mgbakwunye UA nwere ike inyere aka melite ahụike akwara ma mee mmega ahụ achọrọ.
(2) Inyere aka ịkwalite ikike mgbochi etuto ahụ nke immunotherapy
Na 2022, ndị otu nyocha nke Florian R. Greten sitere na Georg-Speyer-Haus Institute of Tumor Biology and Experimental Therapeutics na Germany chọpụtara na UA nwere ike ịkpalite mitophagy na mkpụrụ ndụ T, kwalite ntọhapụ nke PGAM5, mee ka ụzọ mgbaama Wnt rụọ ọrụ, ma kwalite mmepụta mkpụrụ ndụ T memory stem., si otú a na-akwalite mgbochi ọrịa kansa.
(3) Gbanwee ịka nká nke mkpụrụ ndụ hematopoietic na sistemu ahụ ji alụso ọrịa ọgụ
N'ime nnyocha e mere n'afọ 2023, Mahadum Lausanne dị na Switzerland mụrụ mmetụta ya na sistemụ ọbara site n'ikwe ka òké dị ọnwa 18 rie nri bara ụba na urolithin A ruo ọnwa anọ ma na-enyocha mgbanwe na mkpụrụ ndụ ọbara ha kwa ọnwa. Mmetụta.
Nsonaazụ gosiri na nri UA mụbara ọnụọgụgụ mkpụrụ ndụ hematopoietic na mkpụrụ ndụ lymphoid progenitor, ma belata ọnụọgụgụ mkpụrụ ndụ erythroid progenitor. Nchọpụta a na-egosi na nri a nwere ike ịgbanwe ụfọdụ mgbanwe na sistemụ hematopoietic nke metụtara ịka nká.
(4) Mmetụta mgbochi mkpali
Ọrụ mgbochi mbufụt nke UA dị ike karịa ma nwee ike igbochi ọtụtụ ihe mkpali nkịtị dịka TNF-α. Ọ bụ ya mere UA ji arụ ọrụ n'ọtụtụ ọgwụgwọ mkpali gụnyere ụbụrụ, abụba, obi, eriri afọ na imeju. Ọ nwere ike belata mbufụt n'ime anụ ahụ dị iche iche.
(5) Nchedo akwara
Ụfọdụ ndị ọkà mmụta ekwenyela na UA nwere ike igbochi ụzọ apoptosis metụtara mitochondria ma chịkwaa ụzọ mgbaàmà p-38 MAPK, si otú a gbochie apoptosis nke nrụgide oxidative kpatara. Dịka ọmụmaatụ, UA nwere ike imeziwanye ọnụego ndụ nke neurons nke nrụgide oxidative kpaliri ma nwee ọrụ nchebe dị mma.
(6) Mmetụta nke abụba
UA nwere ike imetụta metabolism nke abụba lipid na lipogenesis nke sel. Ọmụmụ ihe egosila na UA nwere ike ịkpalite mkpali nke abụba aja aja na ịgba aja aja nke abụba ọcha, ebe ọ na-egbochi mkpokọta abụba nke nri na-akpata.
(7) Meziwanye oke ibu
UA nwekwara ike ibelata mkpokọta abụba na adipocytes na mkpụrụ ndụ imeju a na-akọ n'ime vitro ma mee ka abụba ghara ịdị oke njọ. Ọ nwere ike ịgbanwe T4 na-adịghị arụ ọrụ nke ọma na thyroxine ka ọ bụrụ T3 na-arụ ọrụ nke ọma, na-eme ka ọnụego metabolic na mmepụta okpomọkụ dịkwuo elu site na mgbaàmà thyroxine., si otú a na-arụ ọrụ n'ịchịkwa oke ibu.
(8) Chebe anya
UA nke na-akpali mitophagy nwere ike ibelata nrụgide oxidative na retina ochie; ọ na-ebelata ọkwa nke cytosolic cGAS ma na-ebelata ọrụ mkpụrụ ndụ glial na retina ochie.
(9) Nlekọta akpụkpọ ahụ
N'ime ihe niile dị na mmiri ara ehi a na-ahụ maka eriri afọ, UA nwere ọrụ antioxidant kachasị ike, nke abụọ bụ naanị proanthocyanidin oligomers, catechins, epicatechin na 3,4-dihydroxyphenylacetic acid. Chere.
Mmetụta nke ngwa Urolithin A
Na 2018, US Food and Drug Administration ahọpụtala UA dị ka ihe a na-eri "nke a na-ahụkarị dị ka ihe dị mma" ma enwere ike itinye ya na ihe ọṅụṅụ protein, ihe ọṅụṅụ nnọchi nri, oatmeal ozugbo, ihe oriri protein na ihe ọṅụṅụ mmiri ara ehi (ruo 500 mg/nri)), yogọt Gris, yogọt protein dị elu na ihe ọṅụṅụ protein mmiri ara ehi (ruo 1000 mg/nri).
Enwere ike itinye UA na ngwaahịa nlekọta akpụkpọ ahụ, gụnyere ude ehihie, ude abalị na ngwakọta serum, nke e mere iji mee ka mmiri akpụkpọ ahụ dị ọcha ma belata wrinkles nke ukwuu, melite udidi akpụkpọ ahụ site n'ime gaa n'èzí, ma lụso ihe ịrịba ama a na-ahụ anya nke ịka nká ọgụ nke ọma. , na-enyere akpụkpọ ahụ aka ịnọgide na-eto eto.
Usoro mmepụta Urolithin A
(1) Usoro ịgba mmiri
A na-ebu ụzọ nweta mmepụta azụmaahịa nke UA site na teknụzụ ịgbakọ agba, nke a na-esi na mkpụrụ pọmigranet agbakọ ma nwee urolithin A nke karịrị 10%.
(2) Usoro mmepụta kemịkalụ
Site na mmepe na mmepe nke nyocha na-aga n'ihu, mmepụta kemịkalụ bụ ụzọ dị mkpa isi mepụta urolithin A. Suzhou Myland Pharm bụ ụlọ ọrụ mgbakwunye sayensị ndụ ọhụrụ, mmepụta omenala na ọrụ mmepụta nke nwere ike inye ihe eji emepụta urolithin A dị ọcha nke ukwuu, nke nwere nnukwu olu.
Nkwupụta: Edemede a bụ maka ozi izugbe naanị, ekwesighikwa ịkọwa ya dị ka ndụmọdụ ahụike ọ bụla. Ụfọdụ ozi sitere na blọgụ sitere na ịntanetị, ọ bụghịkwa ọkachamara. Weebụsaịtị a bụ naanị ọrụ maka nhazi, nhazi na idezi akụkọ. Ebumnuche nke izipu ozi ndị ọzọ apụtaghị na ị kwenyere na echiche ya ma ọ bụ kwado eziokwu nke ọdịnaya ya. Gakwuru ọkachamara ahụike mgbe niile tupu i jiri ihe mgbakwunye ọ bụla ma ọ bụ mee mgbanwe na usoro nlekọta ahụike gị.
Oge ozi: Ọgọst-23-2024
