Taa, ka nkezi ndụ ndị mmadụ gburugburu ụwa na-eji nwayọọ nwayọọ na-abawanye, mgbochi ịka nká aghọwo isiokwu dị oké mkpa. N'oge na-adịbeghị anya, Urolithin A, okwu nke a na-amachaghị n'oge gara aga, ji nwayọọ nwayọọ bata n'ihu ọha. Ọ bụ ihe pụrụ iche metabolized site na microorganisms nke eriri afọ ma nwee njikọ chiri anya na ahụike. Isiokwu a ga-ekpughe ihe omimi nke ihe okike a dị ebube - urolithin A.
Akụkọ ihe mere eme nkeurolitin A (UA)Enwere ike ịchọta ya na 2005. Ọ bụ metabolite nke microorganisms nke eriri afọ na enweghị ike ịgbakwunye ya ozugbo site na ọwa nri. Otú ọ dị, precursor ellagitannins bara ụba na mkpụrụ osisi dị iche iche dị ka pọmigranet na strawberries.
Ọrụ nke urolitin A
Na Machị 25, 2016, otu nnukwu ọmụmụ ihe na magazin bụ "Nature Medicine" dọọrọ uche ndị na-ege ntị na njikọ ya na igbu oge ịka nká mmadụ. Ebe ọ bụ na achọpụtara ya na 2016 na UA nwere ike ịgbatị ogologo ndụ nke C. elegans nke ọma, UA ejirila ya mee ihe na ọkwa niile (sel hematopoietic stem cell, anụ ahụ anụ ahụ, ụbụrụ (akụkụ), usoro ahụ ji alụso ọrịa ọgụ, ogologo ndụ onye ọ bụla) na ụdị dị iche iche. (C. elegans, melanogaster Egosiputa mmetụta mgbochi ịka nká na ijiji mkpụrụ osisi, oke, na ụmụ mmadụ.
(1) Mgbochi ịka nká na ịkwalite ọrụ akwara
Nnwale ụlọ ọgwụ na-enweghị usoro nke e bipụtara na JAMA Network Open, akwụkwọ akụkọ enyemaka nke Journal of the American Medical Association, gosiri na maka ndị agadi ma ọ bụ ndị nwere nsogbu ịkwaga n'ihi ọrịa, ihe mgbakwunye UA nwere ike inye aka mee ka ahụ ike dịkwuo mma ma rụọ ọrụ a chọrọ.
(2) Nyere aka n'ịkwalite ikike mgbochi tumor nke immunotherapy
Na 2022, otu nyocha nke Florian R. Greten sitere na Georg-Speyer-Haus Institute of Tumor Biology and Experimental Therapeutics na Germany chọpụtara na UA nwere ike ime ka mitophagy dị na mkpụrụ ndụ T, kwalite ntọhapụ nke PGAM5, mee ka ụzọ akara Wnt rụọ ọrụ, yana na-akwalite T ebe nchekwa stem cell. nguzobe, si otú ahụ na-akwalite mgbochi tumor.
(3) Weghachite ịka nká nke mkpụrụ ndụ hematopoietic na usoro ahụ ji alụso ọrịa ọgụ
N'ime ọmụmụ 2023, Mahadum Lausanne dị na Switzerland mụrụ mmetụta ya na sistemu hematopoietic site na ikwe ka ụmụ oke dị ọnwa 18 rie nri bara ụba urolithin A maka ọnwa 4 yana nyochaa mgbanwe mkpụrụ ndụ ọbara ha kwa ọnwa. Mmetụta.
Nsonaazụ gosiri na nri UA mụbara ọnụ ọgụgụ nke mkpụrụ ndụ hematopoietic na mkpụrụ ndụ progenitor lymphoid, ma belata ọnụ ọgụgụ nke sel progenitor erythroid. Nchọpụta a na-egosi na nri a nwere ike gbanwee mgbanwe ụfọdụ na usoro hematopoietic metụtara ịka nká.
(4) Mmetụta mgbochi mkpali
Ọrụ mgbochi mkpali nke UA dị ike karị ma nwee ike igbochi ọtụtụ ihe mkpali na-ahụkarị dịka TNF-α. Ọ bụ kpọmkwem n'ihi nke a ka UA na-ekere òkè na ọgwụgwọ mkpali dị iche iche gụnyere ụbụrụ, abụba, obi, eriri afọ na imeju anụ ahụ. Ọ nwere ike belata mbufụt na anụ ahụ dị iche iche.
(5) Nchekwa Neuro
Ụfọdụ ndị ọkà mmụta ekwenyela na UA nwere ike igbochi ụzọ apoptosis metụtara mitochondria ma mezie ụzọ akara p-38 MAPK, si otú ahụ na-egbochi oxidative nrụgide-akpata apoptosis. Dịka ọmụmaatụ, UA nwere ike imeziwanye ọnụọgụ ndụ nke neurons na-akpali site na nrụgide oxidative ma nwee ezigbo ọrụ neuroprotective.
(6) Mmetụta abụba
UA nwere ike imetụta metabolism lipid cell na lipogenesis. Nnyocha egosiwo na UA nwere ike ịmalite ịmalite abụba agba aja aja na agba aja aja nke abụba ọcha, ebe ọ na-egbochi nchịkọta abụba sitere na nri.
(7) meziwanye oke ibu
UA nwekwara ike ibelata mkpokọta abụba na adipocytes na mkpụrụ ndụ imeju emebere na vitro ma na-abawanye oxidation abụba. Ọ nwere ike ịtụgharị T4 na-adịghị arụ ọrụ na thyroxine ka ọ bụrụ T3 na-arụsi ọrụ ike karị, na-eme ka ọnụọgụ metabolic na mmepụta okpomọkụ site na nrịbama thyroxine. , si otú a na-ekere òkè n'ịchịkwa oke ibu.
(8) Chebe anya
The mitophagy inducer UA nwere ike ibelata nrụgide oxidative na retina merela agadi; ọ na-ebelata ọkwa cGAS cytosolic ma na-ebelata ọrụ glial cell na retina merela agadi.
(9) Nlekọta anụ ahụ
N'ime ihe niile achọpụtara metabolites eriri afọ mammalian, UA nwere ọrụ antioxidant kachasị ike, nke abụọ bụ proanthocyanidin oligomers, catechins, epicatechin na 3,4-dihydroxyphenylacetic acid. chere.
Urolithin A ngwa ndapụta
Na 2018, US Food and Drug Administration họpụtara UA ka ọ bụrụ ihe oriri "nke a na-ahụkarị dị ka nchekwa" ma enwere ike ịgbakwunye ya na nhịahụ protein, ihe ọṅụṅụ nnọchi nri, oatmeal ozugbo, mmanya protein na-edozi ahụ na ihe ọṅụṅụ mmiri ara ehi (ruo 500 mg). / ije ozi)), yogọt Greek, yogọt protein dị elu na mmiri ara ehi (ruo 1000 mg / na-eje ozi).
Enwere ike ịgbakwunye UA na ngwaahịa nlekọta anụ ahụ, gụnyere ude ụbọchị, ude abalị na ngwakọta serum, nke e mere iji kwalite hydration akpụkpọ ahụ ma belata wrinkles nke ukwuu, melite ọdịdị akpụkpọ ahụ site n'ime, na ịlụso ihe ịrịba ama a na-ahụ anya nke ịka nká ọgụ. , na-enyere akpụkpọ ahụ aka ịnọgide na-eto eto.
Urolitin A usoro mmepụta
(1) Usoro ịgba ụka
A na-ebu ụzọ nweta mmepụta azụmahịa nke UA site na teknụzụ gbaa ụka, bụ nke a na-esi na peels pọmigranet fermented na-enwekwa urolithin A karịa 10%.
(2) Usoro njikọ kemịkalụ
Na-aga n'ihu ọhụrụ ọhụrụ na mmepe nke nnyocha, chemical njikọ bụ ụzọ dị mkpa nke mmepụta mmepụta nke urolithin A. Suzhou Myland Pharm bụ ihe ọhụrụ ndụ sayensị emeju, omenala njikọ na n'ichepụta ọrụ ụlọ ọrụ nke nwere ike inye High-ọcha, nnukwu-olu urolithin A. ntụ ntụ ntụ ihe.
Disclaimer: Edemede a bụ naanị maka ozi izugbe na e kwesịghị ịkọwa ya dị ka ndụmọdụ ahụike ọ bụla. Ụfọdụ ozi biputere blọọgụ na-abịa site na ịntanetị na ọ bụghị ọkachamara. Webụsaịtị a na-ahụ maka nhazi, nhazi na idezi akụkọ. Ebumnuche nke ibuga ozi ndị ọzọ apụtaghị na ị kwenyere n'echiche ya ma ọ bụ kwado na ọdịnaya ya bụ eziokwu. Gakwuru onye ọkachamara ahụike mgbe niile tupu i jiri mgbakwunye ọ bụla ma ọ bụ mee mgbanwe na usoro nlekọta ahụike gị.
Oge nzipu: Ọgọst-23-2024
