Ka anyị na-aka nká, ịkwado ahụike anyị n'ozuzu na-adịwanye mkpa.Nnyocha ndị metụtara ya na-egosi na nicotinamide riboside, ụdị vitamin B3, nwere ike ịlụso ịka nká ọgụ ma kwalite ịka nká.Nicotinamide Riboside Na mgbakwunye na ịmegharị mkpụrụ ndụ ịka nká, nicotinamide riboside na-egosipụtakwa nkwa na ịkwalite ahụike na ogologo ndụ.Ọmụmụ anụmanụ na-egosi na mgbakwunye NR nwere ike ịgbatị ndụ ndụ ma melite ahụike n'ọtụtụ ọnọdụ metụtara afọ, gụnyere oke ibu, ọrịa obi, na ọrịa neurodegenerative.
Ịka nká bụ usoro okike nke ihe niile dị ndụ na-enweta.Dị ka mmadụ, ahụ anyị na uche anyị na-enwe ọtụtụ mgbanwe ka anyị na-aka nká.
Mgbanwe kachasị pụta ìhè bụ nke akpụkpọ ahụ, na wrinkles, afọ ntụpọ, wdg pụtara.Tụkwasị na nke ahụ, mọzụlụ na-esiwanye ike, ọkpụkpụ na-ebelata njupụta, nkwonkwo na-esiwanye ike, na mmegharị nke onye ọ bụla nwere oke.
Akụkụ ọzọ dị mkpa nke ịka nká bụ ụbara ihe ize ndụ nke ọrịa na-adịghị ala ala dị ka ọrịa obi, ọrịa shuga, na ụfọdụ ụdị ọrịa cancer.Na mgbakwunye, mbelata ọgụgụ isi bụ nsogbu ọzọ a na-ahụkarị.Ọnwụ ncheta, ihe isi ike itinye uche, na mbelata ike echiche nwere ike imetụta ndụ anyị kwa ụbọchị.
Ọtụtụ ndị toworo eto na-enwekwa mmetụta nke owu ọmụma, ịda mbà n'obi, ma ọ bụ nchegbu, karịsịa ma ọ bụrụ na ha na-eche nsogbu ahụ ike ihu ma ọ bụ na onye ha hụrụ n'anya nwụnahụrụ ha.N'ọnọdụ a, ọ dị mkpa ịchọ nkwado mmetụta uche site n'aka ezinụlọ, ndị enyi, na ọbụna ndị ọkachamara.
Ọ bụ ezie na anyị enweghị ike ịkwụsị usoro ịka nká, e nwere ụzọ anyị nwere ike isi mee ka ọ kwụsịlata ma nọgide na-eto eto ruo ogologo oge.Ihe mgbakwunye mgbochi ịka nká bụ otu nhọrọ dị mma.
NAD + bụ coenzyme dị mkpa dị na sel niile dị ndụ.Isi ọrụ ya bụ ịkwalite metabolism cellular site n'inyere nnyefe elektrọn aka n'ọtụtụ usoro ndu dị ka mmepụta ume.Agbanyeghị, ka anyị na-etolite, ọkwa NAD + na ahụ anyị na-agbadata.Ụfọdụ ọmụmụ na-atụ aro na ibelata ọkwa NAD + nwere ike ịbụ ihe na-enye aka na usoro ịka nká.
Otu n'ime ọganihu kacha pụta ìhè na nyocha NAD + bụ nchọpụta nke NAD + precursor molecule akpọrọ nicotinamide riboside (NR).NR bụ ụdị vitamin B3 nke agbanwere ka ọ bụrụ NAD + n'ime sel anyị.Ọtụtụ ọmụmụ anụmanụ egosila nsonaazụ na-ekwe nkwa, na-atụ aro na mgbakwunye NR nwere ike ịbawanye ọkwa NAD + ma nwee ike ịgbanwe ọdịda metụtara afọ.
Ọtụtụ ọrịa ndị metụtara afọ, dị ka ọrịa neurodegenerative na arụrụ ọrụ nke metabolic, na-ejikọta ya na ọrụ mitochondrial na-adịghị mma.Mitochondria bụ ụlọ ike nke mkpụrụ ndụ anyị, na-ahụ maka imepụta ike.NAD + na-arụ ọrụ dị mkpa n'ịkwado ọrụ mitochondrial kacha mma.Site na ichekwa ahụike mitochondrial, NAD + nwere ike ibelata ihe ize ndụ nke ọrịa ndị metụtara afọ yana ịgbatị ndụ.
Na mgbakwunye, NAD + na-etinye aka na ọrụ sirtuins, ezinụlọ nke protein jikọtara ya na ogologo ndụ.Sirtuins na-ahazi usoro usoro ndu dị iche iche, gụnyere nrụzi DNA, nzaghachi nrụgide cellular, na mbufụt.NAD + dị mkpa maka ọrụ Sirtuin, na-eje ozi dị ka coenzyme na-eme ka ọrụ enzymatic ya rụọ ọrụ.Site na ịgbakwunye NAD + na ịkwalite ọrụ Sirtuin, anyị nwere ike ịla oge ịka nká ma kwalite ahụike na ogologo ndụ.
Ọtụtụ nchọpụta egosila na mgbakwunye NAD + nwere mmetụta dị mma na ụdị anụmanụ.Dịka ọmụmaatụ, otu nnyocha e mere na ụmụ oke gosiri na ịgbakwunye NR na-eme ka ọrụ ahụ dịkwuo mma na ntachi obi.Nnyocha ndị ọzọ egosila na mgbakwunye NR nwere ike ịkwalite ọrụ metabolic na oke oke, na-eme ka ọ dị ka nke ụmụ oke.Nchọpụta ndị a na-egosi na mgbakwunye NAD + nwere ike inwe mmetụta yiri nke ahụ na ụmụ mmadụ, n'agbanyeghị na ọ dị mkpa nyocha ọzọ.
Nicotinamide riboside(nke a makwaara dị ka niagen) bụ ụdị ọzọ nke niacin (nke a makwaara dị ka vitamin B3) a na-ahụkwa ya na obere ntakịrị na mmiri ara ehi na nri ndị ọzọ.Enwere ike ịtụgharị ya ka ọ bụrụNAD+ n'ime sel.Dị ka ihe mbụ, NR na-abanye ngwa ngwa ma bufee ya na sel, ebe a na-atụgharị ya na NAD + site na usoro mmeghachi omume enzymatic.
Ọmụmụ ihe mgbakwunye NR na ọmụmụ anụmanụ na nke mmadụ egosila nsonaazụ dị mma.N'ime ụmụ oke, achọpụtara mgbakwunye NR na-abawanye ọkwa NAD + na anụ ahụ dị iche iche ma melite ọrụ metabolic na mitochondrial.
NAD + na-etinye aka na usoro cellular dị iche iche nke na-ada na afọ, gụnyere nrụzi DNA, mmepụta ume, na nhazi nke okwu mkpụrụ ndụ ihe nketa.A na-eche na iji NR mejupụta ọkwa NAD + nwere ike iweghachi ọrụ cellular, si otú ahụ meziwanye ahụike yana ịgbatị ndụ.
Na mgbakwunye, n'ime ọmụmụ banyere oke ibu na oke ibu, mgbakwunye NR mụbara ọkwa NAD +, si otú a na-emeziwanye mmetụta insulin na ọrụ mitochondrial.Nchọpụta ndị a na-egosi na mgbakwunye NR nwere ike ịnwe ngwa ngwa n'ịgbasa ọrịa metabolic dị ka ụdị ọrịa shuga 2 na oke ibu.
1. Ihe oriri sitere n'okike nke nicotinamide riboside
Otu ebe enwere ike nweta NR bụ ngwaahịa mmiri ara ehi.Ụfọdụ ọmụmụ egosila na ngwaahịa mmiri ara ehi nwere ọnụọgụ NR, ọkachasị mmiri ara ehi ejiri NR gbasie ike.Agbanyeghị, ọdịnaya NR dị na ngwaahịa ndị a dị obere ma nweta ego zuru oke site na iri nri naanị nwere ike bụrụ ihe ịma aka.
Na mgbakwunye na isi mmalite nri, ihe mgbakwunye NR dị na capsule ma ọ bụ ntụ ntụ.A na-enwetakarị ihe mgbakwunye ndị a site na isi mmalite ndị dị ka yist ma ọ bụ gbaa ụka.A na-ewerekarị NR nke yiast enwetara dị ka ebe a pụrụ ịdabere na ya na nke na-adigide n'ihi na enwere ike imepụta ya n'ọtụtụ buru ibu na-adabereghị na isi anụmanụ.NR nke emepụtara na nje bacteria bụ nhọrọ ọzọ, nke a na-enwetakarị site na ụdị nje bacteria na-emepụta NR na-emekarị.
2. Mgbakwunye nicotinamide riboside
Isi iyi nke nicotinamide riboside kachasị na nke a pụrụ ịdabere na ya bụ site na mgbakwunye nri.Ihe mgbakwunye NR na-enye ụzọ dị mma ma dị irè iji hụ na oriri kacha mma nke ogige a dị mkpa.Mgbe ị na-ahọrọ mgbakwunye NR kacha mma, ọ dị mkpa ịtụle ihe ndị a:
a) Nkwenye nke ọma: Chọọ ihe mgbakwunye nke ụlọ ọrụ ndị a ma ama na-eme ma na-agbaso ụkpụrụ njikwa mma siri ike.Nke a ga-eme ka ị nweta ngwaahịa dị elu nke adịghị ọcha ma ọ bụ mmetọ.
b) Bioavailability: NR supplements na-eji usoro nnyefe dị elu dị ka encapsulation ma ọ bụ teknụzụ liposome iji welie bioavailability nke NR ka ọ bụrụ nke ọma na-etinye ya n'ahụ ma jiri ya mee ihe.Họrọ ụdị mgbakwunye a iji bulie uru ị nwetara na NR.
c) Ịdị ọcha: Gbaa mbọ hụ na mgbakwunye NR ị họọrọ dị ọcha na enweghị mgbakwunye na-enweghị isi, ihe ndochi ma ọ bụ ihe nchekwa.Ịgụ akara na ịghọta ihe ndị mejupụtara nwere ike inyere gị aka ime mkpebi ziri ezi.
1. Mee ka mmepụta ike cell dịkwuo elu
NR na-arụ ọrụ dị mkpa na mmepụta nke molekul dị mkpa nicotinamide adenine dinucleotide (NAD+).NAD + na-etinye aka na usoro cellular dị iche iche, gụnyere ike metabolism.Ka anyị na-aka nká, ọkwa NAD + na ahụ anyị na-ebelata, na-eme ka mmepụta ike belata.Site n'ịkwalite njikọ nke NAD +, NR na-enyere aka ịmaliteghachi mkpụrụ ndụ ma mee ka mmepụta ike dị mma.Nke a na-eme ka ike cellular na-abawanye ume, na-eme ka arụ ọrụ anụ ahụ dịkwuo mma, ma na-ebelata ike ọgwụgwụ.
2. Mgbochi ịka nká na nrụzi DNA
Mbelata ọkwa NAD + jikọtara ya na ịka nká na ọrịa ndị metụtara afọ.NR nwere ike ịbawanye ọkwa NAD + n'ime ahụ, na-eme ka ọ bụrụ ihe na-egbochi ịka nká.NAD + na-etinye aka na usoro nrụzi DNA, na-ahụ na iguzosi ike n'ezi ihe nke mkpụrụ ndụ ihe nketa anyị.Site n'ịkwalite nrụzi DNA, NR nwere ike inye aka gbochie mmebi DNA metụtara afọ yana ịkwado ịka nká.Na mgbakwunye, ọrụ NR n'ịgbalite sirtuins, klaasị nke protein a maara iji chịkwaa ahụike na ndụ cellular, na-abawanye ikike mgbochi ịka nká.
3. Ahụike obi
Ịnọgide na-enwe usoro ahụike obi dị mma dị mkpa maka ahụike zuru oke.Nicotinamide riboside egosila mmetụta dị mma na ahụike obi.Ọ na-akwado ọrụ nke mkpụrụ ndụ endothelial vaskụla, na-akwalite mmụba ọbara ma belata mbufụt.NR na-emekwa ka ọrụ mitochondrial dị na mkpụrụ ndụ obi, na-egbochi nrụgide oxidative na ịkwalite mmepụta ume.Mmetụta ndị a nwere ike inye aka belata ihe ize ndụ nke ọrịa obi dị ka atherosclerosis na nkụda obi.
4. Neuroprotection na ọrụ ọgụgụ isi
Egosiputara NR ka o nwere ihe ndi na-adighi nma, na-eme ka o nwee ike inye aka n'idebe ahu ike nke ụbụrụ.Ọ nwere ike inwe mmetụta dị mma na ọrụ neuronal ma chebe onwe ya pụọ na mbelata ọgụgụ isi metụtara afọ.Site n'ịbawanye ọkwa NAD +, NR na-akwado ọrụ mitochondrial na ụbụrụ ụbụrụ, na-akwalite mmepụta ume ma na-akwalite nrụzi cellular.Imelite ọrụ mitochondrial nwere ike ịkwalite ikike ọgụgụ isi dị ka ebe nchekwa, itinye uche, na nghọta zuru oke nke uche.
5. Njikwa ibu na ahụike metabolic
Ịkwado ịdị arọ dị mma yana nguzozi nke metabolic dị mkpa maka ahụike anyị dum.Ejikọtara NR na mmetụta bara uru na metabolism, na-eme ka ọ bụrụ ihe enyemaka na njikwa ibu.NR na-arụ ọrụ protein a na-akpọ Sirtuin 1 (SIRT1), nke na-achịkwa usoro metabolic dị ka glucose metabolism na nchekwa abụba.Site na ịgbalite SIRT1, NR nwere ike inye aka belata ibu ma melite ahụike metabolic, si otú ahụ belata ihe ize ndụ nke ọrịa dị ka oke ibu na ụdị ọrịa shuga 2.
Ajụjụ: Gịnị bụ Nicotinamide Riboside (NR)?
A: Nicotinamide Riboside (NR) bụ ihe mbido Nicotinamide Adenine Dinucleotide (NAD +), coenzyme nke na-arụ ọrụ dị mkpa na usoro ndu dị iche iche, gụnyere mmepụta ume na nhazi nke ọrụ metabolic na cellular.
Ajụjụ: Nicotinamide Riboside (NR) nwere ike irite uru metabolism?
A: Ee, achọpụtala Nicotinamide Riboside (NR) na-erite uru metabolism.Site na ịbawanye ọkwa NAD +, NR nwere ike mee ka ụfọdụ enzymes na-etinye aka na metabolism, dị ka sirtuins.Nke a na-arụ ọrụ nwere ike ịkwalite arụmọrụ metabolic, meziwanye mmetụta insulin, ma kwado njikwa ibu dị mma.
Disclaimer: Edemede a bụ naanị maka ozi izugbe na e kwesịghị ịkọwa ya dị ka ndụmọdụ ahụike ọ bụla.Ụfọdụ ozi biputere blọọgụ na-abịa site na ịntanetị na ọ bụghị ọkachamara.Webụsaịtị a na-ahụ maka nhazi, nhazi na idezi akụkọ.Ebumnuche nke ibuga ozi ndị ọzọ apụtaghị na ị kwenyere n'echiche ya ma ọ bụ kwado na ọdịnaya ya bụ eziokwu.Gakwuru onye ọkachamara ahụike mgbe niile tupu i jiri mgbakwunye ọ bụla ma ọ bụ mee mgbanwe na usoro nlekọta ahụike gị.
Oge nzipu: Nov-13-2023
