Ogige ndị e kere eke na-achọsiwanye ike na nyocha sayensị nke taa na ụlọ ọrụ ọgwụ. 7,8-Dihydroxyflavone (7,8-Dihydroxyflavone), dị ka ihe dị mkpa sitere na osisi, adọtala nlebara anya zuru ebe niile n'ihi nnukwu ọrụ ndu ya. Maka ndị na-eme nchọpụta sayensị na ụlọ ọrụ, ọ dị oké mkpa ịchọta ndị na-eweta ndị a pụrụ ịdabere na ya nke 7,8-Dihydroxyflavone Powder. 7,8-Dihydroxyflavone ntụ ntụ nyere Suzhou Myland nwerenọmba CAS nke 38183-03-8 yana ịdị ọcha ruru 98%, na-enye gị nhọrọ kwesịrị ntụkwasị obi.
7,8-Dihydroxyflavone(nke a makwaara dị ka 7,8-DHF ma ọ bụ proflavonoid) bụ molekul sitere n'okike nke sitere na klas flavonoid nke ogige. Achọtara na akwụkwọ nke Godmania aesculifolia, Tridax procumbens na primula.
7,8-DHF bụ organic compound na molekụla usoro C15H10O4. Ọ bụ soluble na organic solvents ma nwee njirimara agba, isi na uto jikọtara ya na flavonoid ogige.
7,8-DHF apụtala dị ka onyinye nootropic na-ekwe nkwa. O gosipụtala mmetụta dị iche iche nke neuropharmacological na ọmụmụ ihe ọmụmụ, gụnyere imeziwanye ebe nchekwa, ịkwalite neurogenesis na igbochi neurodegeneration.
Dị ka onye nwere ike na nhọrọ obere molecule agonist nke tropomyosin receptor kinase B (TrkB), proflavin egosila ịdị irè na ụdị anụmanụ megide ọrịa dị iche iche, gụnyere ọrịa Alzheimer.
Flavonoids bụ klaasị nke ogige polyphenolic dị n'ụdị mkpụrụ osisi, akwụkwọ nri, na ihe ọkụkụ ndị ọzọ. N'ime afọ ndị na-adịbeghị anya, ha enwetawo nlebara anya dị ukwuu n'ihi ihe antioxidant ha, mgbochi mkpali, na neuroprotective Njirimara.
E gosipụtara ogige ndị a ka ha nwee mmetụta bara uru na ụbụrụ, gụnyere ịkwalite ọrụ ọgụgụ isi na igbochi ọrịa neurodegenerative. 7,8-DHF bụ otu n'ime ogige polyphenolic a ma ama na-enweta nlebara anya dị ka nootropic. A mụọla ya maka mmetụta ọ nwere na ọnọdụ, ebe nchekwa, mmụta, nchekasị, na ọrụ ọgụgụ isi ndị ọzọ.
A na-eche na mmetụta akwara ozi nke 7,8-DHF na-emekọrịta ihe site na mmekọrịta ya na ndị na-anabata ya. Achọpụtara ya na ọ bụ TrkA, onye na-anabata ya na-egosi ihe na-akpata uto akwara na ihe dị mkpa maka ndụ neuronal na plasticity.
7,8-DHF na-eme site n'ịchịkwa okwu nke ndị nabatara dị iche iche, gụnyere glutamate receptor subunits na BDNF. Ọ na-emetụtakwa nguzobe synapse, ike metabolism, na ntọhapụ nke acetylcholine na ụfọdụ akụkụ ụbụrụ.
Nnyocha na 7,8-dihydroxyflavone amụbaala n'ime mmetụta ya na ahụike mmadụ, na-eleba anya ka ọ na-eṅomi ọrụ nke ụbụrụ neurotrophic factor (BDNF), protein dị mkpa maka ndụ na ọrụ nke neuronal. nke protein.
N'ihe banyere ojiji ya, 7,8-DHF enyochala maka ngwa ndị nwere ike ịgwọ ọrịa ọrịa akwara n'ihi ike ya ịbanye n'ime ihe mgbochi ụbụrụ ọbara.
7,8-Dihydroxyflavone na-apụtakarị n'ụdị nri osisi dị iche iche, gụnyere:
●Mkpụrụ osisi: apụl, beri, mkpụrụ vaịn na mkpụrụ osisi citrus
● Akwụkwọ nri: eyịm, kale, broccoli na akwụkwọ nri
● ogwu: pasili, thyme na oregano
Na mgbakwunye na isi mmalite ndị a sitere n'okike, 7,8-DHF dịkwa n'ụdị mgbakwunye maka oriri dị mma na atụmatụ.
Mụta maka flavonoids
Flavonoids bụ ogige polyphenolic nke na-arụ ọrụ dị mkpa na pigmentation osisi, nzacha UV, na nguzogide ọrịa. A na-ekewa ha n'ọtụtụ subcategories, gụnyere flavonols, flavones, isoflavones, flavanones, na anthocyanins. Subclass nke ọ bụla nwere usoro kemịkalụ dị iche iche na ihe omume ndu, na-ebute uru ahụike dị iche iche.
Kedu ihe bụ 7,8-dihydroxyflavone?
7,8-Dihydroxyflavone bụ ụdị flavonoid pụrụ iche bụ nke subclass flavonoid. Ọdịdị kemịkal ya nwere otu hydroxyl abụọ na ọnọdụ 7 na 8 nke ọkpụkpụ azụ flavonoid, bụ nke na-ahụ maka ihe pụrụ iche ya. A na-achọta ogige a n'ụzọ bụ isi na osisi ndị dị ka dioscorea (yam) ma mụọ ya maka mmetụta neuroprotective nwere ike ime, ihe mgbochi mkpali, na nkwalite ọgụgụ isi.
Isi ọdịiche dị n'etiti 7,8-DHF na Flavonoids ndị ọzọ
1. Chemical Ọdịdị
Ọdịiche pụtara ìhè n'etiti 7,8-DHF na flavonoids ndị ọzọ bụ usoro kemịkal ya. Ọ bụ ezie na ọtụtụ flavonoids na-ekekọrịta ọkpụkpụ azụ, ọnụnọ nke otu hydroxyl n'ọnọdụ ụfọdụ nwere ike imetụta ọrụ ndụ ha nke ukwuu. Dịka ọmụmaatụ, quercetin, flavonol a ma ama, nwere nhazi dị iche iche nke otu hydroxyl, nke na-emetụta ike ya na mmekọrịta ya na ebumnuche ndu.
2. Ọrụ ndu
7,8-DHF egosila na ọ nwere ọrụ ndụ pụrụ iche ma e jiri ya tụnyere flavonoids ndị ọzọ. Nnyocha na-egosi na ọ na-eme ka ụbụrụ ụbụrụ na-enweta neurotrophic factor (BDNF), nke dị oke mkpa maka ndụ neuron, uto na ọdịiche. Usoro a dị mkpa karịsịa n'ihe gbasara ọrịa neurodegenerative na ịda mbà n'obi.
N'ụzọ dị iche, flavonoids ndị ọzọ dị ka catechins (nke a na-achọta na tii akwụkwọ ndụ akwụkwọ ndụ) na anthocyanins (dị na tomato) na-arụ ọrụ bụ isi site na ọrụ antioxidant, na-ekpochapụ radicals free na ibelata nrụgide oxidative. Ọ bụ ezie na ihe ndị a bara uru, ha nwere ike ọ gaghị emetụta ihe ndị neurotrophic ozugbo n'otu ụzọ ahụ 7,8-DHF si eme.
3. Bioavailability
Bioavailability na-ezo aka n'ókè na ọnụego nke etinyere ihe na-arụ ọrụ ma ọ bụ ihe na-arụ ọrụ wee dị na saịtị ahụ. 7,8-DHF egosila ezigbo bioavailability na ọmụmụ anụmanụ, na-egosi na ọ nwere ike ịgafe ihe mgbochi ụbụrụ ọbara nke ọma, nke dị oke mkpa maka mmetụta neuroprotective ya.
N'ụzọ dị iche, bioavailability nke flavonoids ndị ọzọ nwere ike ịdị iche iche. Dịka ọmụmaatụ, ọ bụ ezie na a na-eri quercetin n'ọtụtụ ebe, a na-ejikarị absorption ya dị oke n'ihi metabolism ngwa ngwa. Ọdịiche a dị na bioavailability na-emetụta ịdị irè nke ogige ndị a iji nweta nsonaazụ ahụike achọrọ.
7,8-DHF usoro nke omume: BDNF ụkpụrụ na Trkb nnabata nnabata
N'ihe gbasara usoro ihe omume, a maara 7,8-DHF iji kwalite mmepụta nke BDNF (ụbụrụ neurotrophic ihe na-akpata ụbụrụ) site na ijikọ na ịgbalite ya TrkB. Na-enweghị oke teknụzụ, nke a na-eduga n'ọtụtụ ọrụ cellular nke bara uru n'ịkwado ọrụ neuronal kwesịrị ekwesị na ịkwalite neurogenesis.
7,8-DHF isi ụdị omume:
(1) Ihe na-akpata ụbụrụ neurotrophic (BDNF) na ọrụ ya na neuroplasticity
N'ịchọpụta na ụbụrụ ụbụrụ na-enweta neurotrophic factor (BDNF) na-ebelata na ọrịa neurodegenerative, karịsịa ọrịa Alzheimer (AD), mkpa ya n'ịkwado na ịkwalite ahụike ụbụrụ na-apụtawanye ìhè.
BDNF dị oke egwu maka ọrụ neuronal dị iche iche ka ọ na-akwalite nnyefe synapti, synaptogenesis, na plasticity synapti site na iji akara ndị na-anabata TrkB. Nke a na-eme ka ụzọ akara BDNF-TrkB bụrụ ebumnuche na-ekwe nkwa maka mmepe nke usoro ọgwụgwọ iji lụso ọrịa neurodegenerative ọgụ.
(2) Tropomyosin receptor kinase B (Trkb) ụzọ mgbaàmà nnabata
Onye na-anabata tropomyosin kinase B (TrkB) na-arụ ọrụ dị oke mkpa n'ịgbazi mmetụta nke BDNF na neurons. Dị ka onye na-anabata tyrosine kinase transmembrane, TrkB bụ onye na-anabata BDNF ma na-ebute ihe ngosi nke intracellular na-ejikọta na ihe ndị na-ahụ maka neurotrophic.
BDNF na-arụ ọrụ TrkB iji kpalite ọtụtụ ụzọ intracellular isi, gụnyere phosphatidylinositol 3-kinase (PI3K) -Akt, protein kinase mitogen-activated (MAPK) -extracellular signal-regulated kinase (ERK), na phospholipase Cγ (PLCγ) -protein kinase C ( PKC) ụzọ. Nke ọ bụla n'ime ụzọ ndị a na-enye aka n'akụkụ dị iche iche nke ọrụ neuronal na ọdịmma.
Ụzọ PI3K-Akt dị oke mkpa maka ịkwalite ndụ neuronal na igbochi apoptosis. Ngosipụta BDNF-TrkB na-eme ka ụzọ a dịkwuo ndụ ndụ site na igbochi ihe pro-apoptotic na-akpali akpali ihe mgbochi apoptotic, si otú ahụ hụ na nchekwa nke neurons dị mma.
N'aka nke ọzọ, ụzọ MAPK-ERK na-arụ ọrụ dị mkpa n'ichepụta neuronal na mmụba. Ngosipụta BDNF-TrkB na-akwalite ịgbalite ụzọ MAPK-ERK, nke n'aka nke ya na-akwado maturation neuronal na ọdịiche na ntinye ha na netwọkụ neuronal dị ugbu a.
Ụzọ PLCγ-PKC dị oke mkpa maka ịhazi plastik synapti, bụ isi usoro mmụta na ebe nchekwa. Ngosipụta BDNF-TrkB na-agbanwe ọrụ nke ụzọ a, n'ikpeazụ na-eduga na mgbanwe na ike synapti na njikọta.
Mgbanwe a na-akwalite mmegharị na nhazigharị nke sekit akwara na nzaghachi na ahụmahụ ọhụrụ na mkpali gburugburu ebe obibi.
Site n'ime ihe dị ka agonist TrkB, 7,8-DHF na-arụ ọrụ nootropic ya karịsịa site n'ịhazi ụzọ mgbaàmà metụtara BDNF, si otú ahụ na-akwalite neurogenesis na ịkwalite plasticity synapti.
Site na iṅomi mmetụta nke BDNF, 7,8-DHF na-enyere aka ichebe neurons site na mmebi, na-akwalite ndụ ha, ma na-akwalite uto na mmezi nke njikọ neuronal ọhụrụ. Ikike a iji kwalite neuroplasticity, melite ọrụ ọgụgụ isi, na ịkwụsị mgbaàmà nke ọrịa akwara na-eme ka 7,8-DHF bụrụ onye na-ekwe nkwa maka mmepe ọgwụ na nyocha ọzọ.
7,8-DHF Nootropic Uru: Mmalite Nghọta na Neuroprotection
Banyere uru nootropic ya, 7,8-DHF na-arụ ọrụ site na usoro isi anọ:
Nchekwa ebe nchekwa na iweghachite: ọrụ dabere hippocampus
Achọpụtara 7,8-DHF iji kwalite nkwado nchekwa na iweghachite n'ọtụtụ mmụta mmụta dabere na hippocampus na ebe nchekwa na ụdị òké. Nchọpụta ndị a na-egosi na 7,8-DHF nwere ike ịbụ nootropic na-ekwe nkwa, Enwere ike iji mee ka ọrụ nchekwa dịkwuo mma na ndị nwere ahụike na ndị nwere nsogbu ncheta.
Synaptic plasticity: ike ogologo oge na ịda mbà n'obi
7,8-DHF egosila na ọ na-achịkwa plasticity synaptic site n'ịkwalite LTP na ibelata LTD na hippocampus. A na-eche na mmetụta ndị a bụ onye ogbugbo site n'ikike ya ime ka ndị na-anabata TrkB rụọ ọrụ ma mechaa welie ụzọ akara BDNF. Mgbanwe a nke synapti plasticity na-enye aka na mmelite nke ọrụ ọgụgụ isi a hụrụ na-esote nchịkwa 7,8-DHF.
Njirimara Antioxidant: ROS scavenging na lipid peroxidation
7,8-DHF nwere akụrụngwa antioxidant dị ka egosipụtara site n'ikike ya ịchụpụ ụdị oxygen na-emeghachi omume (ROS) ma belata peroxidation lipid. Mmetụta ndị a na-enye aka na mmetụta neuroprotective ya site na ibelata nrụgide oxidative na-akpata mmebi neuronal na arụ ọrụ.
Mmetụta mgbochi mkpali: na-achịkwa ọrụ microglial na mmepụta cytokine
Na mgbakwunye na akụrụngwa antioxidant ya, achọpụtara 7,8-DHF ka ọ na-egosipụta mmetụta mgbochi mkpali site n'ịgbanwe ọrụ microglial na ibelata mmepụta nke cytokines pro-inflammatory dị ka TNF-a na IL-1β. Nke a na-enye aka na mmetụta neuroprotective na nootropic site n'igbochi mmerụ ahụ na-ebute mbufụt.
Mgbe ị na-achọ onye na-ebubata ya7,8-DihydroxyflavoneNtụ ntụ, ị nwere ike ịtụle akụkụ ndị a:
1. Aha onye na-eweta ya
Ịhọrọ onye na-eweta ngwaahịa nwere aha ọma dị oke mkpa. Ị nwere ike nweta mmetụta nke aha onye na-ebubata ya site na ịlele nyocha ndị ahịa, akụkọ ụlọ ọrụ na nnọkọ ọkachamara. Suzhou Myland nwere aha ọma na ụlọ ọrụ ahụ, yana nzaghachi ndị ahịa dị mma yana àgwà ngwaahịa a ma ama.
2. Ogo ngwaahịa
Gbaa mbọ hụ na ngwaahịa sitere n'aka ndị na-ebubata ya na-agbaso ụkpụrụ mba ụwa na njikwa mma chọrọ. Suzhou Myland 7,8-Dihydroxyflavone ntụ ntụ emeela nyocha nke ọma ma nwee ịdị ọcha nke ruru 98%, na-eme ka arụmọrụ na nchekwa nke ngwaahịa ahụ sie ike.
3. Asambodo na nnabata
Ịhọrọ onye na-ebubata ya na GMP (Ezigbo Nrụpụta Omume) na Asambodo ISO na-eme ka usoro mmepụta ya na-agbaso ụkpụrụ mba ụwa. Suzhou Myland na-agbaso ụkpụrụ ndị a iji hụ na nkwụsi ike na nkwụsi ike nke ngwaahịa ọ bụla.
4. Nkwado teknụzụ na ọrụ
Onye na-eweta ntụkwasị obi kwesịrị inye nkwado teknụzụ ọkachamara na ọrụ ndị ahịa. Suzhou Myland nwere ọkachamara teknuzu otu nke nwere ike inye ndị ahịa na ngwaahịa ojiji aro na teknuzu nduzi na-enyere ndị ahịa nweta mma pụta na nnyocha na ngwa.
5. Ọnụ ego na oge nnyefe
Ọnụ ahịa na oge nnyefe bụkwa ihe dị mkpa mgbe ị na-ahọrọ onye na-ebubata ya. Ị nwere ike ịrịọ nhota n'aka ọtụtụ ndị na-ebubata ma tulee ọnụ ahịa ha na oge nnyefe ka ịchọta nhọrọ kacha dabara adaba. Suzhou Myland
na-enye ọnụ ahịa asọmpi na oge nnyefe na-agbanwe agbanwe ma na-ahụ na ngwaahịa dị mma.
Otu esi enweta ntụ ntụ 7,8-Dihydroxyflavone
Ọ bụrụ na ị na-achọ 7,8-Dihydroxyflavone ntụ ntụ dị elu, Suzhou Myland bụ ezigbo nhọrọ gị. Ị nwere ike ịkpọtụrụ anyị site na:
Weebụsaịtị gọọmentị: Gaa na yawebụsaịtị gọọmentị nke Suzhou Mylandịmụtakwu banyere ozi ngwaahịa na nkwado teknụzụ.
Ndụmọdụ n'ịntanetị: Kpọtụrụ ndị otu ndị ahịa anyị ozi ozugbo site na ọrụ nyocha n'ịntanetị nke webụsaịtị ahụ na-enye iji nweta ozi ngwaahịa na nhota ndị ịchọrọ.
Kọntaktị ekwentị: Kpọọ nọmba kọntaktị anyị ka gị na ndị ọrụ ahịa ọkachamara kparịta ụka wee nweta ozi ngwaahịa zuru ezu na aro ịzụrụ.
Ajụjụ email: Ị nwekwara ike ịjụ anyị maka ozi ngwaahịa site na email, anyị ga-aza gị ozugbo enwere ike.
Ịchọta 7,8-Dihydroxyflavone Powder suppliers a pụrụ ịdabere na ya adịghị mfe, ma site n'ịṅa ntị na aha onye na-eweta ya, àgwà ngwaahịa, asambodo na nnabata, nkwado teknụzụ na ọrụ, yana ọnụahịa na oge nnyefe, ị nwere ike ime mkpebi amamihe dị na ya. họrọ. Suzhou Myland bụ ezigbo onye mmekọ gị na 7,8-Dihydroxyflavone ntụ ntụ dị ọcha yana ezigbo ọrụ ndị ahịa. Anyị na-atụ anya ka gị na ha rụkọọ ọrụ iji chọpụta ike ngwa nke 7,8-Dihydroxyflavone.
Ajụjụ: proflavin nwere ike imeziwanye ikike mmụta?
A: Ee, egosiri proflavin iji kwalite ikike mmụta na ọmụmụ anụmanụ site n'ịkwalite neurogenesis na njikọ synapti. Ọ na-achịkwa sistemu neurotransmitter nke dị oke mkpa na usoro mmụta, ọkachasị na hippocampus, mpaghara isi ụbụrụ maka mmụta.
Ajụjụ: 7,8-DHF ọ na-enyere aka mgbake mgbake mgbe mmerụ ahụ gasịrị?
A: Ee, ọmụmụ ihe ọmụmụ na-egosi na 7,8-DHF nwere ike inye aka mgbake mgbake mgbe ụbụrụ ụbụrụ gasịrị site n'ịkwalite neuroprotection na neuroregeneration. Ọ na-ebelata ọnwụ neuronal ma na-akwado uto nke neurons ọhụrụ, nwere ike imeziwanye ọrụ ọgụgụ isi nke trauma ma ọ bụ mmerụ ahụ ischemic mebiri.
Ajụjụ: Kedu ọrụ 7,8-dihydroxyflavone na-arụ na mbelata ọgụgụ isi metụtara ịka nká?
A: Nnyocha na-apụta na-egosi na 7,8-DHF nwere ike ime ka ọ ghara ịdị na-eche echiche nke metụtara ịka nká site n'ichebe nrụgide oxidative na mbufụt, ihe ndị na-emekarị na ọrịa ụbụrụ metụtara afọ.
Site n'ịkwalite ọkwa BDNF na ntinye aka nke TrkB, ọ na-enyere aka ịnọgide na-enwe ike ngbanwe nke uche, ọ bụ ezie na a chọkwuru ọmụmụ mmadụ iji nyochaa mmetụta ndị a nke ọma.
Q: 7,8-DHF nwere ike melite nlebara anya na ọrụ isi?
A: Ọmụmụ anụmanụ mbụ na-atụ aro na 7,8-DHF nwere ike imeziwanye nlebara anya na ọrụ nchịkwa site n'ịkwalite ụkpụrụ neurotransmitter na njikọ akwara na mpaghara ụbụrụ na-etinye aka na usoro ndị a.
Disclaimer: Edemede a bụ naanị maka ozi izugbe na e kwesịghị ịkọwa ya dị ka ndụmọdụ ahụike ọ bụla. Ụfọdụ ozi biputere blọọgụ na-abịa site na ịntanetị na ọ bụghị ọkachamara. Webụsaịtị a na-ahụ maka nhazi, nhazi na idezi akụkọ. Ebumnuche nke ibuga ozi ndị ọzọ apụtaghị na ị kwenyere n'echiche ya ma ọ bụ kwado na ọdịnaya ya bụ eziokwu. Gakwuru onye ọkachamara ahụike mgbe niile tupu i jiri mgbakwunye ọ bụla ma ọ bụ mee mgbanwe na usoro nlekọta ahụike gị.
Oge nzipu: Ọktoba 16-2024
