Ihe mgbakwunye nri - Ihe ọhụrụ maka ịdị ogologo ndụ na mgbochi ịka nká: Calcium Alpha-ketoglutarate

Ketoglutarate Calcium Alpha (AKG) bụ metabolite etiti nke usoro tricarboxylic acid ma na-esonye na mmepụta amino acid, vitamin, na organic acid na metabolism ike. Enwere ike iji ya dị ka mgbakwunye nri ma nwee ohere itinye ya n'ọrụ sara mbara. Na mgbakwunye na ọrụ bayoloji ya n'ahụ mmadụ, a na-ejikwa calcium alpha-ketoglutarate nke ukwuu n'ọhịa ọgwụ ma aghọọla akụkụ dị mkpa nke ọtụtụ ngwaahịa ahụike na ngwọta ọgwụ.

Kedu ka calcium alpha-ketoglutarate si arụ ọrụ

Nke mbụ,calcium alpha-ketoglutaratena-arụ ọrụ dị mkpa na metabolism ike. Dịka ihe dị n'etiti nke usoro tricarboxylic acid (TCA cycle), calcium α-ketoglutarate na-esonye na usoro mmepụta ike intracellular. Site na usoro TCA, a na-eme ka nri dị ka carbohydrates, abụba, na protein dị ka oxidized ma gbazee iji mepụta ATP (adenosine triphosphate) iji nye ike maka mkpụrụ ndụ. Dịka ihe dị mkpa na usoro TCA, calcium α-ketoglutarate nwere ike ịkwalite metabolism ike sel, mee ka ọkwa ike nke ahụ dịkwuo elu, nyere aka mee ka ike anụ ahụ na ntachi obi dịkwuo mma, ma melite ike ọgwụgwụ anụ ahụ.

Nke abụọ, calcium α-ketoglutarate na-arụ ọrụ dị mkpa na metabolism amino acid. Amino acid bụ isi ihe dị na protein, calcium α-ketoglutarate na-etinye aka na mgbanwe na metabolism nke amino acid. N'usoro ịtụgharị amino acid ka ọ bụrụ metabolites ndị ọzọ, calcium α-ketoglutarate na-agbanwe na amino acid iji mepụta amino acid ọhụrụ ma ọ bụ α-keto acid, si otú a na-achịkwa nguzozi na ojiji nke amino acid. Na mgbakwunye, calcium α-ketoglutarate nwekwara ike ije ozi dị ka ihe nnọchi oxidation maka amino acid, sonyere na metabolism oxidative nke amino acid, ma mepụta ike na carbon dioxide. Ya mere, calcium α-ketoglutarate dị oke mkpa n'ịnọgide na-enwe homeostasis nke amino acid na metabolism protein n'ahụ.

Tinyere nke ahụ, calcium alpha-ketoglutarate na-arụ ọrụ dị ka ihe na-egbochi ọrịa nke na-ewepụ ihe ndị na-emebi emebi ma na-echebe mkpụrụ ndụ site na mmebi oxidative. N'otu oge ahụ, calcium α-ketoglutarate nwekwara ike ịchịkwa ọrụ nke sistemu ahụ ji alụso ọrịa ọgụ, kwalite mkpali na mmụba nke mkpụrụ ndụ ji alụso ọrịa ọgụ, ma melite iguzogide ọrịa na ọrịa. Ya mere, calcium α-ketoglutarate dị oke mkpa n'ịnọgide na-enwe nguzozi nke ahụ ji alụso ọrịa ọgụ na iguzogide ọrịa.

Nnyocha gbasara mmetụta nke ịka nká

Ịka nká na-emetụta anyị niile ma bụrụ ihe nwere ike ibute ọtụtụ ọrịa, dịka ọnụọgụgụ ndị ọrụ Medicare si kwuo, ohere nke ịmalite ọrịa na-abawanye ka afọ na-aga. Iji belata ịka nká ma belata ihe ize ndụ nke ọrịa nke ọma, nchọpụta achọpụtala ihe dị nchebe ma na-arụ ọrụ nke nwere ike imetụta ịka nká - calcium alpha-ketoglutarate.

Calcium alpha-ketoglutarate bụ ihe dị mkpa n'ahụ anyị, nke a maara maka ọrụ nke sel na okirikiri Krebs, okirikiri dị mkpa maka oxidation nke abụba asịd na amino asịd, na-enye mitochondria ohere imepụta ATP (ATP bụ isi iyi ike nke mkpụrụ ndụ).

Nke a gụnyere ibu nke usoro calcium alpha-ketoglutarate, yabụ enwere ike ịgbanwe calcium alpha-ketoglutarate ka ọ bụrụ glutamate wee bụrụ glutamine, nke nwere ike inye aka kpalite njikọ nke protein na collagen (collagen bụ protein fibrous nke na-eme 1/3 nke protein niile dị n'ahụ ma na-enyere aka ịkwado ahụike ọkpụkpụ, akpụkpọ ahụ na akwara).

Ponce De Leon Health, Inc., ụlọ ọrụ nyocha ogologo ndụ nke lekwasịrị anya n'ịgbanwe ịka nká mkpụrụ ndụ ihe nketa, mere nnyocha a na-achịkwa nke ọtụtụ afọ nke calcium alpha-ketoglutarate na òké ndị dị afọ etiti wee chọpụta na ndụ òké ndị nọ n'ìgwè nnwale ahụ mụbara site na 12%. Ihe kachasị mkpa bụ na adịghị ike belatara site na 46% ebe ndụ ahụike mụbara site na 41%. Ihe akaebe na-egosi na mgbakwunye alpha-ketoglutarate nwere ike ọ bụghị naanị ịgbatị ndụ kamakwa ịgbatị oge ahụike n'ozuzu ya.

Calcium α-ketoglutarate, dị ka ihe mgbakwunye nri dị iche iche, nwere ohere sara mbara maka ojiji na ngwaahịa nlekọta ahụike. Ọrụ ya dị iche iche dịka antioxidant, mgbochi ịka nká, njikwa ahụ ji alụso ọrịa ọgụ na metabolism amino acid na-eme ka ọ bụrụ ngwaọrụ dị ike iji melite ahụike mmadụ. Site na mmụba nke mmata gbasara nlekọta ahụike na mmụba nke nyocha sayensị, a kwenyere na itinye calcium α-ketoglutarate n'ọrụ na ngwaahịa nlekọta ahụike ga-enweta nlebara anya na mmepe ka ukwuu.