Ihe mgbakwunye nri-Ihe ọhụrụ maka ogologo ndụ na mgbochi ịka nká: Calcium Alpha-ketoglutarate

Calcium Alpha ketoglutarate (AKG) bụ metabolite etiti nke usoro tricarboxylic acid ma na-ekere òkè n'ịmepụta amino acid, vitamin na acid organic na metabolism ume. Enwere ike iji ya dị ka mgbakwunye nri ma nwee atụmanya ngwa sara mbara. Na mgbakwunye na ọrụ ndụ ya na ahụ mmadụ, a na-ejikwa calcium alpha-ketoglutarate n'ọtụtụ ebe na mpaghara ọgwụ ma ghọọ akụkụ dị mkpa nke ọtụtụ ngwaahịa ahụike na ngwọta ahụike.

Kedu ka calcium alfa-ketoglutarate si arụ ọrụ

Nke mbụ,cAlcium alfa-ketoglutaratena-arụ ọrụ dị mkpa na metabolism ume. Dị ka ngwaahịa etiti nke tricarboxylic acid cycle (TCAcycle), calcium α-ketoglutarate na-ekere òkè na mmepụta ume intracellular. Site na okirikiri TCA, nri ndị dị ka carbohydrates, abụba, na protein na-eme ka oxidized wee mebie iji mepụta ATP (adenosine triphosphate) iji nye ike maka mkpụrụ ndụ. Dị ka ihe dị mkpa n'etiti TCA okirikiri, calcium α-ketoglutarate nwere ike kwalite cell ume metabolism, mee ka ahụ ike larịị, nyere aka welie ike anụ ahụ na ntachi obi, na melite anụ ahụ ike ọgwụgwụ.

Nke abuo, calcium α-ketoglutarate na-arụ ọrụ dị mkpa na amino acid metabolism. Amino acid bụ akụkụ bụ isi nke protein, na calcium α-ketoglutarate na-etinye aka na ntụgharị na metabolism nke amino acids. N'ime usoro ịtụgharị amino acid ka ọ bụrụ metabolites ndị ọzọ, calcium α-ketoglutarate na-ebugharị na amino acid iji mepụta amino acid ọhụrụ ma ọ bụ acid α-keto, si otú a na-ahazi nguzozi na itinye n'ọrụ nke amino acid. Na mgbakwunye, calcium α-ketoglutarate nwekwara ike ije ozi dị ka mkpụrụ oxidation nke amino asịd, na-ekere òkè na metabolism oxidative nke amino acid, ma mepụta ume na carbon dioxide. Ya mere, calcium α-ketoglutarate dị oke mkpa n'ịkwado homeostasis nke amino acid na protein metabolism n'ime ahụ.

Na mgbakwunye, calcium alpha-ketoglutarate na-arụ ọrụ dị ka antioxidant nke na-ekpochapụ radicals free ma na-echebe mkpụrụ ndụ site na mmebi oxidative. N'otu oge ahụ, calcium α-ketoglutarate nwekwara ike ịhazi ọrụ nke usoro ahụ ji alụso ọrịa ọgụ, kwalite ọrụ na mmụba nke mkpụrụ ndụ na-alụso ọrịa ọgụ, ma welie ahụ ahụ na-eguzogide ọrịa na ọrịa. Ya mere, calcium α-ketoglutarate dị oke mkpa n'ịkwado nguzozi nke ahụ na iguzogide ọrịa.

Nyocha banyere mmetụta ịka nká

Ịka nká na-emetụta anyị niile ma bụrụ ihe dị ize ndụ maka ọtụtụ ọrịa, na dị ka usoro mgbasa ozi ụlọ ọrụ Medicare si kwuo, ohere nke ịmalite ọrịa na-abawanye na afọ. Iji belata ịka nká ma belata ihe ize ndụ nke ọrịa n'ụzọ dị irè, nchọpụta achọpụtala ihe dị mma na nke nwere ike imetụta ịka nká - calcium alpha-ketoglutarate.

Calcium alpha-ketoglutarate bụ ihe dị mkpa metabolite na ahụ anyị, mara maka ọrụ cell na Krebs okirikiri, okirikiri dị mkpa maka oxidation nke ọdụdụ asịd na amino asịd, na-ekwe ka mitochondria mepụta ATP (ATP bụ ike nke mkpụrụ ndụ).

Nke a na-agụnye ntinye nke calcium alpha-ketoglutarate usoro, ya mere, calcium alpha-ketoglutarate nwekwara ike ghọọ glutamate wee ghọọ glutamine, nke nwere ike inye aka kpalie njikọ nke protein na collagen (collagen bụ A fibrous protein na-eme ka 1/3 nke). protein niile dị n'ime ahụ ma na-enyere aka ịkwado ahụike ọkpụkpụ, akpụkpọ ahụ na anụ ahụ).

Ponce De Leon Health, Inc., ụlọ ọrụ nyocha ogologo ndụ lekwasịrị anya n'ịgbanwe ịka nká nke mkpụrụ ndụ ihe nketa, mere nyocha nke ọtụtụ afọ na-achịkwa calcium alpha-ketoglutarate na ụmụ oke ndị nọ n'etiti ma chọpụta na ogologo ndụ nke ụmụ oke na otu nnwale mụbara site na. 12% Nke ka mkpa, Kedu ihe ọzọ, e belatara adịghị ike site na 46% yana ogologo ndụ ahụike mụbara site na 41%. Ihe akaebe na-egosi na mgbakwunye alfa-ketoglutarate nwere ike ọ bụghị naanị ịgbatị ndụ mana ọ gbatịkwuo ogologo ahụike.

Calcium α-ketoglutarate, dị ka ihe mgbakwunye nri na-edozi ọtụtụ ọrụ, nwere atụmanya ngwa sara mbara na ngwaahịa nlekọta ahụike. Ọrụ ya dị iche iche dị ndụ dị ka antioxidant, mgbochi ịka nká, usoro mgbochi na amino acid metabolism na-eme ka ọ bụrụ ngwá ọrụ dị ike iji meziwanye ahụike mmadụ. N'ịbawanye mmata nke nlekọta ahụike na mmụba nke nchọpụta sayensị, a kwenyere na ntinye nke calcium α-ketoglutarate n'ọhịa nke ngwaahịa nlekọta ahụike ga-enweta nlebara anya na mmepe.