Alfa GPC nwere ike imeziwanye elekwasị anya gị? Nke a bụ ihe ị kwesịrị ịma

A bịa n'ịkwalite ebe nchekwa na mmụta, nchọpụta na nso nso a na-egosi na alfa GPC nwere ike ịba uru nke ukwuu. Nke a bụ n'ihi na A-GPC na-ebufe choline na ụbụrụ, na-akpali neurotransmitter dị mkpa nke na-akwalite ahụike uche.

Nnyocha na-egosi alfa GPC bụ otu n'ime ihe mgbakwunye ụbụrụ nootropic kacha mma na ahịa. Ọ bụ ụbụrụ na-eme ka ụbụrụ dịkwuo elu nke egosiri na ọ dị mma ma na-anabata ya nke ọma site n'aka ndị ọrịa meworo agadi na-achọ imeziwanye ihe mgbaàmà nke nkwarụ, yana ndị na-eto eto na-eme egwuregwu na-achọ imeziwanye ntachi obi na ike ha.
Yiri mmetụta ụbụrụ na-ebuli elu nke phosphatidylserine, a-GPC nwere ike bụrụ ọgwụgwọ ebumpụta ụwa maka ọrịa Alzheimer ma nwee ike belata mbelata ọgụgụ isi metụtara afọ.

Kedu ihe bụ Alpha GPC?

Ọnụ ego nke Alfa GPC ma ọ bụ alfa glycerylphosphorylcholine bụ molekul nke na-arụ ọrụ dị ka isi iyi nke choline. Ọ bụ acid fatty achọtara na lecithin soy na osisi ndị ọzọ ma ejiri ya na mgbakwunye ahụike nke uche yana wulite ike akwara.
Alfa GPC, nke a makwaara dị ka choline alfoscerate, bara uru maka ikike ya ibufe choline na ụbụrụ ma nyere ahụ aka ịmepụta neurotransmitter acetylcholine, nke na-ahụ maka ọtụtụ uru ahụike choline. Ejikọtara Acetylcholine na mmụta na ebe nchekwa, ọ bụkwa otu n'ime ihe ndị na-eme ka akwara dị mkpa maka mkpụkọ akwara.
N'adịghị ka choline bitartrate, ihe mgbakwunye choline ọzọ na-ewu ewu na ahịa, A-GPC nwere ike ịgafe mgbochi ụbụrụ ọbara. Nke a bụ ya mere o ji enwe mmetụta dị mma na ụbụrụ yana ihe kpatara eji agwọ ọrịa dementia, gụnyere ọrịa Alzheimer.

Alfa GPC bara uru na ojiji ya

1. Meziwanye nsogbu ebe nchekwa

A na-eji Alfa GPC kwalite ebe nchekwa, mmụta na ikike iche echiche. Ọ na-eme nke a site na ịba ụba acetylcholine na ụbụrụ, kemịkalụ nke na-arụ ọrụ dị mkpa na ebe nchekwa na ọrụ mmụta. Ndị nchọpụta ahụ kwuru na alfa GPC nwere ikike imeziwanye mgbaàmà mgbaama metụtara ọrịa Alzheimer na dementia.
Nnwale kpuru ìsì abụọ, nke a na-achịkwaghị nke ọma, ebe a na-achịkwa placebo nke e bipụtara na Clinical Therapeutics na 2003 tụlere ịdị irè na nnabata nke alfa GPC n'ịgwọ ọrịa nhụsianya nke ọrịa Alzheimer dị nro na nke na-adịghị ala ala.
Ndị ọrịa were 400 mg a-GPC capsules ma ọ bụ placebo capsules ugboro atọ kwa ụbọchị maka ụbọchị 180. A na-enyocha ndị ọrịa niile na mmalite nke ikpe ahụ, mgbe 90 ụbọchị ọgwụgwọ gasịrị, na na njedebe nke ikpe 180 ụbọchị mgbe e mesịrị.
N'ime otu alfa GPC, ihe niile enyochala, gụnyere ọgụgụ isi na omume Alzheimer's Assessment Assessment Scale na Mini-Mental State Examination, nọgidere na-akawanye mma mgbe 90 na 180 ụbọchị ọgwụgwọ gasịrị, ebe na placebo otu ha nọgidere na-agbanweghị agbanwe. gbanwee ma ọ bụ ka njọ.
Ndị nchọpụta ahụ kwubiri na a-GPC bara uru na ụlọ ọgwụ na-anabata ya nke ọma n'ịgwọ mgbaàmà uche nke dementia ma nwee ike dị ka ọgwụgwọ ebumpụta ụwa maka ọrịa Alzheimer.

2. Kwalite mmụta na itinye uche

Enwere otutu nyocha nke na-akwado abamuru nke alfa GPC maka ndi mmadu nwere nsogbu uche, mana kedu ka o si di irè maka ndi mmadu na-enweghi mgbaka? Nnyocha na-egosi na Alpha GPC nwekwara ike imeziwanye nlebara anya, ebe nchekwa na ikike mmụta na ndị na-eto eto nwere ahụike.
Akwụkwọ akụkọ American Journal of Clinical Nutrition bipụtara otu ọmụmụ ihe gbasara ndị sonyere na-enweghị mgbaka ma chọpụta na oriri choline dị elu jikọtara ya na ịrụ ọrụ ọgụgụ isi ka mma. Ngalaba ọgụgụ isi enyochara gụnyere ebe nchekwa okwu, ebe nchekwa anya, mmụta okwu, na ọrụ onye isi.
Otu nnyocha e bipụtara na Journal of the International Society of Sports Nutrition chọpụtara na mgbe ndị na-eto eto na-eji ihe mgbakwunye alfa GPC mee ihe, ọ bara uru na ụfọdụ ọrụ arụ ọrụ anụ ahụ na nke uche. Ndị natara 400 mg nke a-GPC nwetara 18% ngwa ngwa na ule mwepu serial karịa ndị natara 200 mg nke caffeine. Na mgbakwunye, otu ndị na-eri caffeine gbagoro nke ukwuu na neuroticism ma e jiri ya tụnyere otu alfa GPC.

3. Melite arụmọrụ egwuregwu

Nchọcha na-akwado njirimara synergistic nke alfa GPC. N'ihi nke a, ndị na-eme egwuregwu na-enwewanye mmasị na a-GPC n'ihi ikike ọ nwere ime ka ntachi obi dịkwuo mma, mmepụta ike, na ike anụ ahụ. Mgbakwunye na a-GPC mara na ọ na-enyere aka ịbawanye ike anụ ahụ, na-akwalite mmepụta nke anụ ahụ siri ike, yana belata oge mgbake mgbe mgbatị ahụ gasịrị.
Nnyocha na-egosi na alfa GPC na-amụba hormone uto mmadụ, nke na-ekere òkè na mmụgharị cell, uto na mmezi nke anụ ahụ mmadụ dị mma. A maara hormone na-eto eto maka ikike ya ịkwalite ikike anụ ahụ yana ịrụ ọrụ egwuregwu.
Enweela ọtụtụ ọmụmụ na-enyocha ịdị irè nke alfa GPC na ntachi obi anụ ahụ na ike. Ọmụmụ ihe ọmụmụ nke 2008, nke a na-achịkwa, ebebo, nke crossover gụnyere ụmụ nwoke asaa nwere ahụmahụ ọzụzụ nguzogide gosiri na a-GPC na-emetụta ọkwa hormone na-eto eto. Enyere ndị sonyere na otu nnwale 600 mg nke alpha GPC nkeji 90 tupu mmega ahụ nguzogide.
Ndị nchọpụta ahụ chọpụtara na e jiri ya tụnyere ntọala, ọkwa hormone na-eto eto mụbara okpukpu 44 na alfa GPC na 2.6-fold na placebo. Iji A-GPC abawanyela ike anụ ahụ, yana ike pịa bench na-abawanye site na 14% ma e jiri ya tụnyere placebo.
Na mgbakwunye na ịba ụba ike na ume anụ ahụ, hormone na-eto eto nwere ike ịkwalite ịbelata ibu, mee ka ọkpụkpụ sie ike, mee ka ọnọdụ dịkwuo mma, ma melite ogo ụra.

4. Mma mgbake ọrịa strok

Nnyocha mbụ na-egosi na a-GPC nwere ike ịbara ndị ọrịa nwere ọrịa strok ma ọ bụ ọgụ ischemic na-agafe agafe, nke a maara dị ka "obere-stroke." Nke a bụ n'ihi ikike alfa GPC ime ihe dị ka neuroprotectant na ịkwado neuroplasticity site na ndị na-anabata ihe uto akwara.
N'ime nnyocha 1994, ndị nchọpụta Ịtali chọpụtara na alfa GPC kwalitere mgbake uche na ndị ọrịa nwere nnukwu ọrịa strok ma ọ bụ obere. Mgbe ọrịa strok gasịrị, ndị ọrịa natara 1,000 mg nke alfa GPC site na ịgba ọgwụ mgbochi ụbọchị 28, na-esote 400 mg ọnụ ugboro atọ kwa ụbọchị maka ọnwa 5 na-esote.
Na njedebe nke ikpe ahụ, 71% nke ndị ọrịa egosighi mbelata ma ọ bụ amnesia, ndị nchọpụta ahụ kọrọ. Na mgbakwunye, akara ndị onye ọrịa na ule Mini-Mental State abawanyela nke ukwuu. Na mgbakwunye na nchoputa ndị a, pasentị nke ihe ọjọọ na-eso iji alfa GPC dị ala ma ndị nyocha ahụ kwadoro nkwado ya dị mma.

5. Nwere ike ịbara ndị nwere ọrịa akwụkwụ uru

Nnyocha anụmanụ nke e bipụtara na Brain Research na 2017 bụ iji nyochaa mmetụta nke ọgwụgwọ alfa GPC na nkwarụ ọgụgụ isi mgbe ọdịdọ epileptic gasịrị. Ndị nchọpụta ahụ chọpụtara na mgbe a na-agbanye oke na a-GPC izu atọ mgbe a nwụsịrị ọdịdọ, ihe ahụ na-eme ka ọrụ ụbụrụ dịkwuo mma na ụbara neurogenesis, uto nke anụ ahụ akwara.
Ọmụmụ ihe a na-egosi na alfa GPC nwere ike ịba uru na ndị ọrịa Akwụkwụ na-adọ n'ihi mmetụta neuroprotective ya ma nwee ike imeziwanye nkwarụ na-akpata ọrịa epilepsy na mmebi ụbụrụ.

Alfa GPC na Choline

Choline bụ ihe dị mkpa micronutrient chọrọ maka ọtụtụ usoro ahụ, ọkachasị ọrụ ụbụrụ. A na-achọrọ maka ịrụ ọrụ kwesịrị ekwesị nke isi neurotransmitter acetylcholine, nke na-arụ ọrụ dị ka onye na-egbochi ịka nká ma na-enyere akwara anyị aka ikwurịta okwu.
Ọ bụ ezie na ahụ na-eme obere choline n'onwe ya, anyị ga-enweta ihe na-edozi ahụ site na nri. Ụfọdụ nri nwere choline gụnyere imeju beef, salmon, chickpeas, àkwá, na ara ọkụkọ. Agbanyeghị, akụkọ ụfọdụ na-ekwu na choline sitere na nri anaghị etinye ahụ nke ọma nke ọma, nke mere ụfọdụ ndị ji enwe ụkọ choline. Nke a bụ n'ihi na a na-edozi choline n'ime imeju, na ndị nwere nsogbu imeju agaghị enwe ike ịmịnye ya.
Nke a bụ ebe mgbakwunye alfa GPC na-abata. Ụfọdụ ndị ọkachamara na-akwado iji ihe mgbakwunye choline, dị ka a-GPC, iji kwalite ọrụ ụbụrụ yana nyere aka n'icheta nchekwa. A na-eche na Alpha GPC na CDP choline bụ ndị kacha baa uru na ahụ n'ihi na ha yiri nnọọ ka choline si eme na nri. Dị ka choline nke a na-etinye n'ụzọ nkịtị site na nri anyị na-eri, a maara alfa GPC maka ikike ya ịgafe ihe mgbochi ụbụrụ ọbara mgbe a na-etinye ya, na-enyere ahụ aka ịgbanwe choline n'ime ihe dị mkpa neurotransmitter acetylcholine.
Alfa GPC bụ ụdị choline nwere ike. Otu 1,000 mg nke a-GPC bụ ihe ruru 400 mg nke choline nri. Ma ọ bụ, n'ikwu ya n'ụzọ ọzọ, alfa GPC bụ ihe dịka 40% choline site na ibu.

A-GPC na CDP Choline

CDP Choline, nke a makwaara dị ka cytidine diphosphate choline na citicoline, bụ ihe mejupụtara choline na cytidine. A maara CDP Choline maka ikike ya inye aka bufee dopamine na ụbụrụ. Dị ka alfa GPC, a na-eji Citicoline kpọrọ ihe maka ikike ya ịgafe ihe mgbochi ụbụrụ ụbụrụ mgbe ọ na-etinye ya, na-enye ya mmetụta na-ebuli ebe nchekwa na mmetụta uche.
Ebe alfa GPC nwere ihe dị ka 40% choline site n'ịdị arọ, CDP choline nwere ihe dịka 18% choline. Ma CDP choline nwekwara cytidine, ihe na-ebute nucleotide uridine. N'ịbụ nke a maara maka ikike ọ na-amụba njikọ nke akpụkpọ ahụ cell, uridine nwekwara ihe na-eme ka ọgụgụ isi dịkwuo elu.
Ma a-GPC na CDP choline mara maka uru ọgụgụ isi ha, gụnyere ọrụ ha na-akwado ebe nchekwa, ịrụ ọrụ uche, na itinye uche.

Ebe ịchọta na otu esi eji

A na-ejikarị mgbakwunye A-GPC iji kwalite ebe nchekwa na ikike ọgụgụ isi. A pụkwara iji ya mee ka ntachi obi na ịrụ ọrụ dịkwuo mma. Alfa GPC dị ka mgbakwunye nri ọnụ. Ihe mgbakwunye Alfa GPC dị mfe ịchọta n'ịntanetị ma ọ bụ n'aka ndị na-ebubata ya. Ị ga-ahụ ya n'ụdị capsule na ntụ ntụ. Ọtụtụ ngwaahịa nwere a-GPC na-atụ aro ka ị were mgbakwunye nri iji mee ka ọ dị irè.
Suzhou Myland Pharm & Nutrition Inc. bụ onye na-emepụta aha FDA nke na-enye ntụ ntụ alfa GPC dị elu na nke dị elu.

Na Suzhou Myland Pharm anyị na-agba mbọ ịnye ngwaahịa kachasị mma na ọnụ ahịa kacha mma. A na-anwale ntụ ntụ alfa GPC anyị nke ọma maka ịdị ọcha na ike, na-ahụ na ị nweta mgbakwunye mma ị nwere ike ịtụkwasị obi. Ma ịchọrọ ịkwado ahụike cellular, kwalite usoro ahụ ji alụso ọrịa ọgụ ma ọ bụ kwalite ahụike zuru oke, ntụ ntụ GPC anyị bụ nhọrọ zuru oke.

Site na ahụmịhe afọ 30 na teknụzụ dị elu na atụmatụ R&D kachasị mma, Suzhou Myland Pharm ewepụtala ngwaahịa dị iche iche nke asọmpi wee bụrụ mgbakwunye sayensị ndụ ọhụrụ, njikọta omenala na ụlọ ọrụ nrụpụta.

Na mgbakwunye, Suzhou Myland Pharm bụkwa onye nrụpụta FDA debanyere aha. Akụrụngwa R&D nke ụlọ ọrụ ahụ, akụrụngwa nrụpụta na ngwa nyocha bụ nke ọgbara ọhụrụ yana ọtụtụ ọrụ, ma nwee ike imepụta kemịkalụ site na milligrams ruo tọn n'ọ̀tụ̀tụ̀, ma na-agbaso ụkpụrụ ISO 9001 na nkọwapụta GMP.
A maara A-GPC dị ka hygroscopic, nke pụtara na ọ na-amịkọrọ mmiri sitere na ikuku gbara ya gburugburu. N'ihi nke a, ọ dị mkpa ka a na-echekwa ihe mgbakwunye n'ime akpa ikuku na-adịghị na ya ma ghara ikpughe na ikuku ruo ogologo oge.

Echiche ikpeazụ

A na-eji Alfa GPC na-ebuga choline n'ụbụrụ n'ofe mgbochi ụbụrụ ọbara. Ọ bụ ihe mmalite maka acetylcholine, neurotransmitter nke na-akwalite ahụike uche. Enwere ike iji ihe mgbakwunye Alfa GPC mee ka ahụike uche gị dịkwuo mma site na imeziwanye ebe nchekwa, mmụta, na itinye uche. Nnyocha na-egosikwa na a-GPC na-enyere aka ịbawanye ike anụ ahụ na ike anụ ahụ.