5-amino-1-methylquinolinium iodide CAS No.:42464-96-0 98.0% ịdị ọcha min. | emeju ihe ndị na-emepụta ihe
Ngwa ngwaahịa
| Aha ngwaahịa | 5-amino-1-methylquinolinium iodide |
| Aha ọzọ | NNMTi5-Amino-1-mq iodide 5-amino-1-methylquinolinium iodide 5-AMINO-1-METHYLQUINOLIN-1-IUM IODIDE 5-Amino-1-methylquinolin-1-iumiodide 1-methylquinolin-1-ium-5-amine; iodide 5-Amino-1-methyl-1-quinolinium Iodide |
| CAS Mba. | 42464-96-0 |
| Usoro ihe omimi | C10H11IN2 |
| Ibu molekụla | 286.11 |
| Ịdị ọcha | 98% |
| Ọdịdị | Agba aja aja ruo na-acha uhie uhie siri ike |
| Nkwakọ ngwaahịa | 1kg / akpa, 25kg / gbọmgbọm |
| Ngwa | Ihe mgbakwunye nri nri |
Ntinye ngwaahịa
NNMTi bụ enzyme karịrị akarị n'oge ịka nká na-ejikọta ya na nrụzi nke mmebi ụzọ NAD +, arụrụ ọrụ sirtuin1 dysregulated, yana mmụba nke mkpụrụ ndụ akwara. NNMTi na-akwalite myoblast dị iche iche na vitro ma na-eme ka njikọ na mweghachi nke mkpụrụ ndụ sel anụ ahụ na ụmụ oke agadi. NNMTi bụkwa onye na-egbochi nicotinamide N-methyltransferase (NNMT) (IC50=1.2 μM), na-ahọrọ nke ọma na NNMT na-ejikọta ihe fọdụrụ na saịtị. NNMTi na-akwalite myoblast dị iche iche na vitro ma na-eme ka njikọ na mweghachi nke mkpụrụ ndụ sel anụ ahụ na ụmụ oke agadi. N'ime ha, cytosolic enzyme nicotinamide N-methyltransferase (NNMT) ka achọpụtala ọhụrụ iji mezie ọkwa nke nicotinamide precursors chọrọ maka NAD + biosynthesis, yabụ na-arụ ọrụ dị mkpa n'ịhazi ụzọ ụzọ mgbapụta NAD + na metabolism cellular.
Njirimara
(1) Ịdị ọcha dị elu: NNMTi nwere ike nweta ngwaahịa dị ọcha site na usoro mmepụta ihe a nụchara anụcha. Ịdị ọcha dị elu pụtara bioavailability ka mma.
(2) Ezubere iche: NNMTi na-elekwasị anya kpọmkwem enzyme NNMT ma nwee ike igbochi ọrụ ya nke ọma, si otú ahụ na-emetụta ụzọ metabolic nke nicotinamide.
(3) Nkwụsi ike: NNMTi nwere ezigbo nkwụsi ike ma nwee ike ịnọgide na-arụ ọrụ ya na mmetụta ya n'okpuru ebe dị iche iche na ọnọdụ nchekwa.
(4) Atụmanya mmepe: N'ihi njirimara dị iche iche nke NNMT, mmepe ya enwetala nlebara anya zuru oke ma nwee nnukwu nyocha na atụmanya ngwa.
Ngwa
NNMTi bụ ihe mgbochi nicotinamide N-methyltransferase (NNMT) nke na-akwalite ọdịiche nke myoblast. NNMTi nwekwara ike iji dị ka mgbakwunye iji nyere aka belata ibu na abụba ma melite abụba imeju.
