Kedu amino acid ka spermine si na ya gbanwe? Gịnị bụ ọrụ ya?

spambụ ihe dị mkpa polyamine nke dị n'ọtụtụ ebe n'ime ihe ndị dị ndụ, karịsịa na-ekere òkè dị mkpa na mmụba cell na uto. A na-agbanwe spermine site na amino acid arginine na ornithine. Isiokwu a ga-enyocha isi iyi, ọrụ na mkpa spermine dị n'ime ihe ndị dị ndụ.

Isi mmalite nke spermine

Njikọ nke spermine tumadi dabere na metabolism nke amino acids. Nke mbụ, ornithine bụ ihe mmalite nke njikọ spermine, nke nwere ike ịmepụta site na mmeghachi omume decarboxylation nke arginine. Usoro a kapịrị ọnụ bụ nke a:

Arginine na-agbanwe ka ọ bụrụ ornithine: N'okpuru catalysis nke enzymes, arginine na-decarboxylated iji mepụta ornithine.
Ntughari nke ornithine ka ọ bụrụ spermine: Ornithine na-ejikọta ya na amino acid (na-emekarị amino acid alanine) na, site na usoro mmeghachi omume enzymatic, n'ikpeazụ na-etolite spermine.
Usoro ntụgharị a abụghị naanị na-agụnye metabolism nke amino acid, kamakwa ọ na-emetụta uto cell, nkewa na nrụzi.

Mmetụta ndu nke spermine

Spermine nwere ọtụtụ ọrụ dị mkpa dị ndụ n'ime ihe ndị dị ndụ, ọkachasị gụnyere akụkụ ndị a:

Mmụba cell na uto: Spermine na-arụ ọrụ dị mkpa na nhazi nke okirikiri cell. Nnyocha e mere egosiwo na spermine nwere ike ịkwalite mmụba cell, karịsịa n'ime usoro nrụzi anụ ahụ na ịmaliteghachi. Ọ na-akwalite nkewa na uto cell site n'ịchịkwa okwu nke protein ndị metụtara okirikiri cell.

Mmetụta Antioxidant: Spermine nwere akụrụngwa antioxidant, nke nwere ike wepu radicals n'efu n'ime ahụ wee belata mmebi nke mkpụrụ ndụ nke nrụgide oxidative kpatara. Ihe onwunwe a na-eme ka spermine nwee uru ngwa ngwa n'igbu oge ịka nká na igbochi ọrịa ndị metụtara afọ.

Ịchịkwa okwu mkpụrụ ndụ ihe nketa: Spermine nwere ike ịhazi okwu mkpụrụ ndụ site na ijikọ na DNA na RNA. Mmetụta nchịkwa a dị oké mkpa maka ọrụ cell na ọnọdụ physiological, karịsịa na nzaghachi nke mkpali na nrụgide mpụga.

Na-akwalite apoptosis: N'ọnọdụ ụfọdụ, spermine nwekwara ike ịkwalite apoptosis (ọnwụ cell emepụtara), nke dị mkpa maka ịnọgide na-enwe homeostasis cellular na ahụ ike anụ ahụ.

Immunomodulation: Spermine na-arụkwa ọrụ dị mkpa na usoro ahụ ji alụso ọrịa ọgụ. Ọ nwere ike ịkwalite ọrụ nke mkpụrụ ndụ na-alụso ọrịa ọgụ ma melite nguzogide ahụ na ọrịa na ọrịa.

Spamine na ahụike

Ka nyocha gbasara spermine na-abawanye, ihe akaebe na-egosi na spermine nwere njikọ chiri anya na nsogbu ahụike dị iche iche. Dịka ọmụmaatụ, ọkwa spermine nwere njikọ chiri anya na ọnọdụ na mmepe nke ọrịa dị iche iche dị ka ịka nká, ọrịa obi, na ọrịa cancer.

Ịka nká: Nnyocha achọpụtala na ọkwa spam na-eji nwayọọ nwayọọ na-ebelata n'oge usoro ịka nká, na mgbakwunye spermine nwere ike inye aka mee ka usoro ịka nká kwụsịlata ma melite ahụike nke ndị toro eto.

Ahụike obi: Spermine na-arụ ọrụ nchebe na usoro obi, na-eme ka ọrụ endothelial dịkwuo mma ma na-ebelata ihe ize ndụ nke ọrịa obi.

na ngwụcha

Dị ka ihe dị mkpa dị ndụ molekul, spermine bụ tumadi sitere na metabolism nke amino asịd, karịsịa ntughari nke arginine na ornithine. Spermine na-arụ ọrụ dị mkpa na mmụba cell, mgbochi oxidation, usoro okwu mkpụrụ ndụ ihe nketa, wdg, ma dị mkpa maka ịnọgide na-enwe ahụike na ọrụ nke ihe ndị dị ndụ. Site na nyocha miri emi nke spermine, enwere ike ịchọta ozi ndị ọzọ gbasara ọrụ ya na ahụike na ọrịa n'ọdịnihu, na-enye echiche na ụzọ ọhụrụ maka igbochi na ọgwụgwọ ọrịa ndị metụtara ya.

Site n'ịghọta mmalite na ọrụ nke spermine, anyị nwere ike ịghọta nke ọma mkpa ọ dị na ọrụ ndụ ma nye ihe ndabere sayensị maka ịkwalite ahụike na igbu oge ịka nká. A na-atụ anya na nyocha n'ọdịnihu ga-ekpughere ngwa ngwa nke spermine ma na-enye nnukwu onyinye na ahụike mmadụ.

Disclaimer: Weebụsaịtị a na-ebipụta ma ọ bụ degharịa akụkọ a naanị maka ebumnobi na ikesa ozi ndị ọzọ, ọ pụtaghị na ọ kwenyere n'echiche ya ma ọ bụ kwado nkọwa ya. Ọ bụrụ na enwere mperi na akara isi mmalite ma ọ bụ mebie ikike iwu gị, biko kpọtụrụ webụsaịtị a na akaebe nke nwe, anyị ga-edozi ma ọ bụ hichapụ ya n'oge. Daalụ.