Na ụwa nke ihe mgbakwunye nri, magnesium alpha-ketoglutarate ntụ ntụ anatawo nlebara anya zuru oke maka uru ahụike ya. A maara ogige a maka ọrụ ya na mmepụta ume, mgbake anụ ahụ, na ahụike metabolic zuru oke. Ọ bụrụ na ịchọrọ itinye mgbakwunye a n'ime ihe omume gị kwa ụbọchị, ọ dị oke mkpa ịmara ebe ị ga-azụta nnukwu magnesium alpha ketoglutarate ntụ ntụ online.
Alfa-ketoglutarate (AKG) ogologo oge bụ ihe mgbakwunye egwuregwu na-ewu ewu nke a na-ejikarị eme ihe na mpaghara mgbatị ahụ, mana mmasị na molecule a abanyela ugbu a n'ọhịa nke nyocha ịka nká n'ihi ọrụ bụ isi ya na metabolism. AKG bụ metabolite intermediary nke na-apụtakarị nke bụ akụkụ nke okirikiri Krebs, nke pụtara na ahụ anyị na-emepụta ya.
AKG bụ molekul na-etinye aka na ọtụtụ ụzọ metabolic na cellular. Ọ na-arụ ọrụ dị ka onye na-enye ume ike, onye na-ebu ụzọ mepụta amino acid na molekul na-egosi cell, ma bụrụ onye na-achịkwa usoro epigenetic. Ọ bụ molekul dị mkpa na okirikiri Krebs, na-ahazi ọsọ ọsọ nke okirikiri citric acid nke organism. Ọ na-arụ ọrụ n'ụzọ dị iche iche n'ime ahụ iji nyere aka wulite akwara ma nyere aka gwọọ ọnya, nke bụ otu n'ime ihe kpatara ya ji ewu ewu na ụwa mgbatị ahụ. Mgbe ụfọdụ, ndị na-ahụ maka ahụike na-enye alfa-ketoglutarate intravenously iji gbochie mmebi obi nke nsogbu na-erugharị ọbara na-akpata n'oge ịwa ahụ obi na iji gbochie mfu anụ ahụ mgbe ịwachara ahụ ma ọ bụ trauma.
AKG na-arụkwa ọrụ dị ka onye na-ekpochapụ nitrogen, na-egbochi oke nitrogen na igbochi mkpokọta amonia. Ọ bụkwa isi iyi nke glutamate na glutamine, nke na-akpali njikọ protein ma na-egbochi mmebi protein na akwara. Ọzọkwa, ọ na-achịkwa enzymes iri na otu translocation (TET) na-etinye aka na DNA demethylation na ngalaba Jumonji C nwere lysine demethylase, bụ isi histone demethylase Enzymes. N'ụzọ dị otú a, ọ bụ ihe egwuregwu dị mkpa na nhazi usoro na okwu.
【AKG nwere ike igbu oge ịka nká? 】
Enwere ihe akaebe na AKG nwere ike imetụta ịka nká, ọtụtụ nchọpụta na-egosikwa na ọ na-eme ya. Otu nnyocha gosiri na AKG gbatịpụrụ ndụ ndị okenye C. elegans site na ihe dịka 50% site na igbochi ATP synthase na ebumnuche nke rapamycin (TOR). N'ime ọmụmụ ihe a, achọpụtara AKG ọ bụghị naanị ịgbatị ndụ kamakwa ọ na-egbu oge ụfọdụ phenotypes metụtara afọ, dị ka mfu nke mmegharị ahụ a na-ahazi ngwa ngwa na-ahụkarị na ikpuru C. elegans ochie.
【ATP synthase】
Mitochondrial ATP synthase bụ enzyme nke na-etinye aka na metabolism ike n'ọtụtụ sel dị ndụ. ATP bụ enzyme na-ejikọta akpụkpọ ahụ nke na-eje ozi dị ka onye na-ebu ume iji kwalite metabolism ike cellular. Nnyocha na 2014 gosiri na iji gbasaa ndụ nke C. elegans, AKG chọrọ ATP synthase subunit beta ma dabere na TOR dị ala. Ndị nchọpụta chọpụtara na ATP synthase subunit β bụ protein na-ejikọta AKG. Ha chọpụtara na AKG na-egbochi ATP synthase, na-eduga na mbelata nke ATP dịnụ, mbelata oriri oxygen, na mmụba nke autophagy na ma nematode na mkpụrụ ndụ mammalian.
Njikọ kpọmkwem nke ATP-2 site na AKG, mgbochi enzyme metụtara, mbelata ọkwa ATP, mbelata oriri oxygen na mgbatị nke ndụ fọrọ nke nta ka ọ bụrụ ndị ahụ mgbe ATP synthase 2 (ATP-2) kwụsịrị ozugbo. Dabere na nchoputa ndị a, ndị nchọpụta kwubiri na AKG nwere ike ịgbatị ndụ site n'ịchọ ATP-2. N'ụzọ bụ isi, ihe na-eme ebe a bụ na a na-egbochi ọrụ mitochondrial, akpan akpan agbụ ụgbọ njem eletrọn, ọ bụkwa ihe mgbochi a na-eme ka ọ dị ogologo ndụ nke C. elegans. Isi ihe bụ ibelata ọrụ mitochondrial zuru oke na-agaghị oke ma ọ bụ na-emerụ ahụ. Ya mere, okwu "na-adị ndụ ngwa ngwa, na-anwụ na-eto eto" bụ nnọọ eziokwu, naanị na nke a, n'ihi na mgbochi nke ATP, ikpuru nwere ike ịdị ndụ ngwa ngwa na-anwụ anwụ.
[Alfa-ketoglutarate na ebumnuche nke rapamycin (TOR)]
Nnyocha dị iche iche egosila na mgbochi nke TOR nwere ike imetụta ịka nká n'ụdị dị iche iche, gụnyere ịkwụsị ịka nká na yist, na-eme ka ịka nká na Caenorhabditis elegans, na-ebelata ịka nká na Drosophila, na ịhazi ndụ ndụ na ụmụ oke. AKG anaghị emekọrịta ihe ozugbo na TOR, ọ bụ ezie na ọ na-emetụta TOR, nke bụ isi site na igbochi ATP synthase. AKG na-adabere, opekata mpe na akụkụ, na protein kinase arụ ọrụ (AMPK) na igbe ndụ ndụ “ọzọ” (FoxO) iji metụta ndụ. AMPK bụ ihe mmetụta ike ekwentị echekwara echekwara n'ọtụtụ ụdị, gụnyere mmadụ. Mgbe oke AMP/ATP dị oke elu, AMPK na-arụ ọrụ, nke na-egbochi mgbaàmà TOR site na ịgbalite phosphorylation nke TOR inhibitor TSC2. Usoro a na-enyere mkpụrụ ndụ aka ịhazi metabolism ha nke ọma ma dozie ọnọdụ ike ha. FoxOs, otu obere ezinụlọ nke ihe ntụgharị forkhead, na-arụ ọrụ dị oke mkpa n'ịhazi mmetụta nke insulin na ihe na-eto eto na ọtụtụ ọrụ, gụnyere mmụba cell, metabolism cell, na apoptosis. Otu nnyocha na-egosi na ịgbatị ndụ site n'ibelata akara ngosi TOR, a chọrọ FoxO transcription factor PHA-4.
【α-ketoglutarate na autophagy】
N'ikpeazụ, autophagy na-arụ ọrụ site na mgbochi caloric na mgbochi kpọmkwem nke TOR na-abawanye ụba na C. elegans nyere AKG ọzọ. Nke a pụtara na mgbochi AKG na TOR na-abawanye ndụ site n'otu ụzọ ahụ ma ọ bụ site n'ụzọ kwụ ọtọ / nke yiri ya na usoro na-emecha na-agbakọta na otu ebumnuche ala. A na-akwado nke a site n'ọmụmụ ihe gbasara yist agụụ na-agụ agụụ na nje bacteria, yana ụmụ mmadụ mgbe mgbatị ahụ gasịrị, nke gosipụtara ọkwa AKG dị elu. A na-eche na mmụba a bụ nzaghachi agụụ, na nke a na-akwụ ụgwọ gluconeogenesis, nke na-eme ka transaminases metụtara glutamate na imeju mepụta carbon sitere na catabolism amino acid.
Magnesium bụ mineral nke anọ kachasị na ahụ mmadụ ma na-ekere òkè na mmeghachi omume enzymatic 300. Ọ dị mkpa maka mmepụta ume, njikọ protein, mkpụkọ akwara, na ọrụ akwara. Magnesium na-edobekwa ụda obi nkịtị ma na-achịkwa ọbara mgbali.
Ọ bụ ezie na magnesium dị mkpa, ọtụtụ ndị anaghị eri ya nke ọma, na-ebute ụkọ magnesium nke na-emetụta ahụike zuru oke. Isi nri ndị magnesium na-ejikarị na-eri gụnyere akwụkwọ nri akwụkwọ ndụ akwụkwọ ndụ, mkpụrụ, mkpụrụ, ọka na mkpo.
Mmekọrịta dị n'etiti magnesium na alfa-ketoglutarate
1. Mmeghachi omume enzymatic
Ion Magnesium dị mkpa maka ọrụ nke enzymes dị iche iche na-etinye aka na okirikiri Krebs, gụnyere enzyme nke na-agbanwe alfa-ketoglutarate na succinyl-CoA. Ntughari a dị oke mkpa maka ịga n'ihu nke usoro Krebs na mmepụta nke ATP, ego ike cellular.
Enweghị magnesium zuru oke, mmeghachi omume enzymatic ndị a nwere ike imebi, na-eduga n'ịbelata mmepụta ume na ike ịrụ ọrụ nke metabolic. Nke a na-egosi mkpa ọ dị ịnọgide na-enwe ọkwa magnesium zuru oke maka ọrụ cell kacha mma na ike metabolism.
2. Iwu nke ụzọ metabolic
Magnesium na-ekerekwa òkè n'ịhazi ụzọ metabolic metụtara alfa-ketoglutarate. Dịka ọmụmaatụ, magnesium na-emetụta ọrụ nke amino acid metabolism enzymes nwere njikọ chiri anya na AKG. Ntughari nke ụfọdụ amino asịd n'ime α-ketoglutarate bụ isi nzọụkwụ na mmepụta ume na nitrogen metabolism. Na mgbakwunye, egosiri na magnesium na-ahazi ọrụ nke ụzọ mgbaàmà isi, dị ka ụzọ mTOR nke na-etinye aka na uto cell na metabolism. Site na imetụta ụzọ ndị a, magnesium nwere ike imetụta ọkwa na itinye n'ọrụ nke alfa-ketoglutarate n'ime ahụ.
3. Njirimara antioxidant
A maara Alfa-ketoglutarate maka njirimara antioxidant ya, na-enyere aka belata nrụgide oxidative n'ime sel. E gosikwara na Magnesium nwere mmetụta antioxidant. Mgbe magnesium dị na oke zuru oke, ọ na-eme ka ikike antioxidant nke alpha-ketoglutarate dịkwuo elu, na-enye nchebe ọzọ megide mmebi oxidative. Ejikọtala nrụgide oxidative na nsogbu ahụike dị iche iche, gụnyere ọrịa na-adịghị ala ala na ịka nká. Site n'ịkwado ọrụ antioxidant nke alfa-ketoglutarate, magnesium nwere ike inye aka na ahụike cellular na ogologo ndụ.
Magnesium alpha-ketoglutarate bụ ngwakọta nke na-ejikọta magnesium na alpha-ketoglutarate, isi etiti na okirikiri Krebs (nke a makwaara dị ka okirikiri citric acid), nke dị mkpa maka mmepụta ike nke mkpụrụ ndụ dị oke mkpa. A na-ejikarị emeju nri nri n'ihi uru ya nwere ike ime n'ịkwalite arụmọrụ egwuregwu, mgbake na ahụike metabolic zuru oke.
1. kwalite mmepụta ume
Otu n'ime isi uru nke Magnesium Alpha KetoglutarateNtụ ntụ bụ ike ya na-amụba ike ike. AKG na-arụ ọrụ dị mkpa na okirikiri Krebs, nke na-ahụ maka ịtụgharị nri ka ọ bụrụ ike. Site na ịgbakwunye AKG, ị na-akwado usoro mmepụta ume nke ahụ gị. Ọzọkwa, magnesium dị mkpa maka mmepụta nke ATP (adenosine triphosphate), ego ike nke cell.
2. Meziwanye ọrụ akwara na mgbake
A maara Magnesium maka ọrụ ọ na-arụ na mkpụkọ akwara na izu ike, nke dị mkpa maka ịrụ ọrụ kachasị mma. AKG nwekwara ike inye aka belata mgbu anụ ahụ ma belata oge mgbake mgbe mgbatị ahụ siri ike. Site n'itinye mgbakwunye a n'ime ihe omume gị kwa ụbọchị, ị nwere ike nweta ntachi obi na-abawanye, ike ọgwụgwụ, na mgbake ngwa ngwa, na-enye gị ohere ịkwanye oke gị.
3. Nkwado ọgụgụ isi
Ahụ ike nke ọgụgụ isi bụ nchegbu na-arịwanye elu nye ọtụtụ ndị mmadụ, karịsịa ka anyị na-eme agadi. Nnyocha na-egosi na AKG nwere ike ịnwe akụrụngwa neuroprotective nke nwere ike inye aka kwado ahụike ụbụrụ na ọrụ ọgụgụ isi. Magnesium na-ekerekwa òkè na nhazi nke neurotransmitter, nke dị oke mkpa maka ọnọdụ uche na arụmọrụ. Site na ijikọta ogige abụọ a, magnesium alpha ketoglutarate ntụ ntụ nwere ike inye aka melite nlebara anya, ebe nchekwa, na nghọta zuru oke nke uche.
4. Nkwado ịka nká
Ka anyị na-aka nká, ahụ anyị na-enwe mgbanwe dị iche iche nwere ike imetụta ahụ ike anyị. Ịgbakwunye na magnesium alpha ketoglutarate ntụ ntụ nwere ike inye aka belata ụfọdụ mmetụta ndị a. Ọmụmụ anụmanụ ejirila AKG na-abawanye ogologo ndụ, na ikike ya ịkwado ahụike cellular nwere ike inye aka na usoro ịka nká ka mma. Magnesium, n'aka nke ọzọ, dị mkpa maka ịnọgide na-enwe njupụta ọkpụkpụ na igbochi ọrịa ndị metụtara afọ. Ọnụ, ha nwere ike ịkwalite ndụ ahụike na ume ka anyị na-eme agadi.
5. Kwalite ọrụ mgbochi
Usoro mgbochi ọrịa siri ike dị mkpa maka ahụike zuru oke, ọkachasị n'ụwa taa. Magnesium na-arụ ọrụ dị mkpa na ọrụ mgbochi ọrịa, na-enyere aka ịhazi mbufụt na ịkwado usoro nchebe ahụ. AKG nwekwara ike ịnwe akụrụngwa na-akwalite mgbochi, na-eme ka nchikota a bụrụ njikọ siri ike n'ịkwado nzaghachi mgbochi ahụ dị mma.
Ọ bụ ezie na ihe ndị bụ isi nke alpha-ketoglutarate na magnesium nwere ike ịdị ka ihe mgbakwunye dị iche iche, ọtụtụ ihe nwere ike imetụta ịdị mma na ịdị mma ha. Nke a bụ ụfọdụ isi ihe atụ:
Ụdị 1.Dosage na usoro onunu ogwu
Ọ bụghị ihe mgbakwunye AKG magnesium niile ka emepụtara nhata. Usoro nwere ike ịdị iche iche n'etiti ụdị. Ụfọdụ nwere ike ịnwe ihe ndị ọzọ, dị ka vitamin, mineral, ma ọ bụ mpụta ahịhịa, nke nwere ike ịkwalite ma ọ bụ gbanwee mmetụta nke isi ihe.
2. Bioavailability
Bioavailability na-ezo aka n'ókè na ọnụego nke ihe na-etinye n'ime ọbara. Ụdị ụfọdụ nke magnesium, dị ka magnesium citrate ma ọ bụ magnesium glycinate, na-adị ndụ karịa ụdị magnesium ndị ọzọ, dị ka magnesium oxide. Ụdị magnesium a na-eji na mgbakwunye nwere ike imetụta nke ọma ka ahụ gị si eji ya eme ihe.
N'otu aka ahụ, ụdị alfa-ketoglutarate na-emetụta nnabata ya. Chọọ maka mgbakwunye na-eji ụdị dị elu, ụdị bioavailable nke ogige abụọ ahụ iji hụ na ị nwetara uru kachasị.
3. Ịdị ọcha na Ogo
Ịdị ọcha na ịdị mma nke ihe eji eme ihe na mgbakwunye dị oke mkpa maka ịdị irè na nchekwa ya. Ụfọdụ ngwaahịa nwere ike ịnwe ihe ndochi, ihe mgbakwunye, ma ọ bụ ihe mmetọ nwere ike ibelata ịdị irè ha ma ọ bụ nwee ihe egwu ahụike. Mgbe ị na-ahọrọ ihe mgbakwunye AKG magnesium, chọọ ngwaahịa ndị ọzọ nwalere maka ịdị ọcha na ịdị mma. Asambodo sitere na otu dị ka NSF International ma ọ bụ United States Pharmacopeia na-ahụ na ngwaahịa na-emezu ụkpụrụ dị elu.
4. Aha aha ika
Aha aha ika na-arụkwa ọrụ dị mkpa n'ịdị mma nke mgbakwunye. Ụdị ndị a ma ama nke nwere akụkọ ihe mere eme nke ịmepụta ngwaahịa dị elu na-abụkarị ndị a pụrụ ịdabere na ya karịa ụlọ ọrụ ọhụrụ ma ọ bụ ndị a ma ama. Nyochaa nlebanya na ọkwa ndị ahịa iji chọpụta ịdị irè na ntụkwasị obi nke ngwaahịa ika gị.
5. Ezubere iji
Mgbe ị na-ahọrọ mgbakwunye magnesium AKG, tụlee ebumnuche ahụike gị akọwapụtara. Ị na-achọ ịkwalite arụmọrụ egwuregwu, na-akwado mgbake ahụ ike ma ọ bụ melite ahụike zuru oke? Usoro dị iche iche nwere ike ịka mma maka ebumnuche dị iche iche.
N'ihe oriri nke oge a na nyocha nke biomedical, α-ketoglutarate magnesium ntụ ntụ adọtalakwu anya dị ka ihe mgbakwunye nri dị mkpa. Ọ bụghị naanị na ọ na-ekere òkè dị mkpa na metabolism ike, a na-eche na ọ nwere mmetụta dị mma na uto cell, nrụzi na mgbochi ịka nká. Iji gboo mkpa nke nyocha sayensị na ahịa mgbakwunye ahụike, ọ dị mkpa karịsịa ịhọrọ Alpha Ketoglutarate Magnesium Powder dị elu.
Suzhou Myland bụ ụlọ ọrụ ọkachamara na nyocha, mmepe na mmepụta nke ngwa mgbakwunye nri. Ọ na-agba mbọ inye ndị ahịa ihe dị ọcha α-ketoglutarate magnesium ntụ ntụ. Nọmba CAS nke ngwaahịa a bụ 42083-41-0, ịdị ọcha ya dịkwa elu dị ka 98%, na-eme ka ntụkwasị obi ya na ịdị irè ya na nnwale na ngwa dị iche iche.
Atụmatụ
Ịdị ọcha dị elu: Ịdị ọcha nke Suzhou Myland α-ketoglutarate magnesium ntụ ntụ ruru 98%, nke pụtara na ndị ọrụ nwere ike nweta nsonaazụ nnwale ziri ezi na nke na-agbanwe agbanwe n'oge eji. Ngwaahịa dị oke ọcha nwere ike belata nnyonye anya nke adịghị ọcha na nnwale ma hụ na nyocha siri ike.
Nkwa mma: Dị ka ụlọ ọrụ biotechnology nwere ahụmahụ bara ụba, Suzhou Myland na-agbaso ụkpụrụ mba ụwa maka mmepụta na njikwa mma. A na-enweta ogbe ngwaahịa ọ bụla siri ike iji hụ na ọ ruru ụkpụrụ ịdị mma dị mkpa. Ndị ahịa nwere ike iji ya jiri obi ike wee belata ihe egwu kpatara nsogbu ịdịmma ngwaahịa.
Ọrụ dị iche iche: Magnesium α-ketoglutarate ntụ ntụ ọ bụghị nanị na-arụ ọrụ dị mkpa na metabolism ume, ma a na-ejikwa ya na nri egwuregwu, mgbochi ịka nká, nchebe cell na ubi ndị ọzọ. Nnyocha na-egosi na AKG nwere ike ịkwalite njikọ nke amino acids, kwalite ike mgbake akwara, na-egbu oge usoro ịka nká ruo n'ókè ụfọdụ.
Ọ dị mfe ịnweta: Dị ka ịnweta mineral dị mkpa, magnesium dị mkpa maka ọtụtụ ọrụ physiological nke ahụ mmadụ. Mgbe ejikọtara ya na alfa-ketoglutarate, bioavailability nke magnesium na-abawanye, na-enye ndị ọrụ ohere ịgbakwunye magnesium ka ha na-enwetakwa ọtụtụ uru nke AKG.
Ọwa ịzụta
Suzhou Myland na-enye ọwa ịzụrụ n'ịntanetị dị mma. Ndị ahịa nwere ike nweta nghọta zuru oke site na webụsaịtị gọọmentị. Na mgbakwunye, otu ọkachamara nke ụlọ ọrụ ahụ ga-enyekwa ndị ahịa nkwado teknụzụ na ọrụ ndụmọdụ iji nyere ndị ahịa aka ịghọta nke ọma ma jiri ngwaahịa ahụ.
Mgbe ị na-achọ nnukwu magnesium alpha-ketoglutarate ntụ ntụ, Suzhou Myland bụ ihe ịrụ ụka adịghị ya na nhọrọ a pụrụ ịtụkwasị obi. Site na ịdị ọcha ya dị elu, njikwa mma siri ike na atụmanya ngwa ngwa, ngwaahịa Suzhou Myland nwere ike gboo mkpa dị iche iche nke ndị nyocha sayensị na ụlọ ọrụ. Ma ị na-eme nchọpụta bụ isi ma ọ bụ na-emepụta ngwaahịa ọhụrụ, ị nwere ike nweta nchebe dị elu na nkwado site na ịhọrọ Suzhou Myland magnesium alpha-ketoglutarate ntụ ntụ.
Q: Gịnị bụ Magnesium Alpha-Ketoglutarate ntụ ntụ?
A: Magnesium Alpha-Ketoglutarate Powder bụ ihe mgbakwunye nri nke na-ejikọta magnesium na alpha-ketoglutarate, nke na-etinye aka na okirikiri Krebs, nke dị mkpa maka mmepụta ume n'ime ahụ. A na-ejikarị ihe mgbakwunye a na-akwado ahụike metabolic, kwalite arụmọrụ egwuregwu, na ịkwalite ọdịmma zuru oke.
Ajụjụ: Gịnị bụ uru nke na-ewere Magnesium Alpha-Ketoglutarate ntụ ntụ?
A: Ụfọdụ uru nke Magnesium Alpha-Ketoglutarate ntụ ntụ gụnyere:
● Mmepụta ike na-emewanyewanye: Na-akwado okirikiri Krebs, na-enyere aka na ntughari nke ihe oriri n'ime ike.
●Mgbake akwara: Ọ nwere ike inye aka belata mgbu akwara ma melite oge mgbake mgbe mgbatị ahụ gasịrị.
● Ahụ́ Ike Ọkpụkpụ: Magnesium dị oké mkpa maka ime ka ọkpụkpụ na-adị mma, ọ pụkwara inye aka gbochie ọkpụkpụ ọkpụkpụ.
Ọrụ ọgụgụ isi: Ụfọdụ ọmụmụ na-egosi na ọ nwere ike ịkwado ahụike ụbụrụ na ọrụ ọgụgụ isi.
● Nkwado Metabolic: Nwere ike inye aka n'ịhazi usoro metabolic ma nwee ike inye aka na njikwa ibu.
Disclaimer: Edemede a bụ naanị maka ozi izugbe na e kwesịghị ịkọwa ya dị ka ndụmọdụ ahụike ọ bụla. Ụfọdụ ozi biputere blọọgụ na-abịa site na ịntanetị na ọ bụghị ọkachamara. Webụsaịtị a na-ahụ maka nhazi, nhazi na idezi akụkọ. Ebumnuche nke ibuga ozi ndị ọzọ apụtaghị na ị kwenyere n'echiche ya ma ọ bụ kwado na ọdịnaya ya bụ eziokwu. Gakwuru onye ọkachamara ahụike mgbe niile tupu i jiri mgbakwunye ọ bụla ma ọ bụ mee mgbanwe na usoro nlekọta ahụike gị.
Oge nzipu: Ọktoba 12-2024
