Gịnị bụ telomerase activator-cycloastraganol achọpụtara ugbu a?

Na 1985, Greider et al. Achọpụtara telomerase nke mbụ, na enzyme a achọpụtara ọhụrụ nwere ike ịgbakwunye DNA na-emegharị na nsọtụ chromosomes iji nọgide na-enwe ogologo telomere. Telomerase bụ ihe mgbagwoju anya ribonucleoprotein nke isi catalytic gụnyere TERT na TERC, nke TERT bụ isi ihe na-achịkwa ọrụ telomerase. Ogologo Telomere na-aga n'ihu na-ebelata ka mkpụrụ ndụ na-ekewa. Mgbe ọ na-erute uru dị oke mkpa, ọ na-ebute mgbaàmà mmebi DNA, na-eduga na mkpirisi cell cell na usoro ọrịa ọdịda anụ ahụ nke e ji mkpụmkpụ telomeres mara.

Na 2010, ụlọ ọrụ America Geron jikọrọ aka na Mahadum Sayensị na Teknụzụ Hong Kong na ọrụ nyocha iji nyochaa telomerase activators. A chọpụtara nacycloastraganolnwere ike ịgbalite ọrụ telomerase ma mee ka ndọtị telomere rụọ ọrụ. Nchọpụta a na-akwalite mmepe nke telomerase activators. Ọganihu nyocha na mmepe ngwaahịa metụtara mmanya astragalus. Cycloastragenol (CAG) bụ naanị telomerase activator a na-akọ ugbu a n'etiti ngwaahịa eke. Ọ nwere ike ịlụso mkpụmkpụ nke telomere ọgụ nke ọma ma nwee mgbochi ịka nká, mgbochi apoptosis, mgbochi fibrosis, usoro mgbochi ọrịa, nkwalite mgbasawanye cell na ọgwụgwọ ọnya, wdg. Mmetụta ọgwụ ọgwụ, si otú ahụ nwee mmetụta ọgwụgwọ na ọrịa ndị metụtara telomere dysfunction.

Cycloastragenol na ịka nká

telomeres
Telomeres bụ ihe owuwu pụrụ iche na nsọtụ chromosomes na-echebe chromosomes ma jiri mkpụkọ chromosome na nkewa sel belata. Selụ na-akakwa ka telomeres na-ebelata.

telomerase
Telomerase nwere ike ịmepụta telomeres iji mee ka ogologo na nhazi nke telomeres guzosie ike, si otú ahụ chebe chromosomes na igbu oge ịka nká.

Mgbochi ịka nká: Onye na-arụ ọrụ telomerase, nke na-eme mmetụta mgbochi ịka nká site n'ịbawanye telomerase ma si otú ahụ na-egbu oge nkwụsị nke telomeres.

Telomeres bụ okpu nke dị na nsọtụ chromosomes cell na-echebe ha pụọ ​​​​na mmebi n'oge nkewa sel. Ka mkpụrụ ndụ na-aga n'ihu na-ekewa, telomeres na-aga n'ihu na-ebelata, na-eru ebe dị egwu ebe mkpụrụ ndụ ga-aka nká ma ọ bụ nwụọ. Telomerase nwere ike ịgbatị ogologo telomeres, na ndụ nke mkpụrụ ndụ ga-abawanye na ya.

Ịka nká bụ akụkụ a na-apụghị izere ezere nke ndụ; Otú ọ dị, ndị nchọpụta na-amụ ụdị ọgwụgwọ dịgasị iche iche iji gbalịa izere ụfọdụ mmetụta nke ịka nká, gụnyere ịmụ ihe senolytics. Senolytics bụ ogige ndị na-ewepụ mkpụrụ ndụ senescent (ịka nká) ma gosipụta ya iji belata mmetụta nke ịka nká. Nnyocha ọhụrụ na-egosi na cycloastraganol nwere mmetụta mgbochi ịka nká.

Ọmụmụ ihe a sitere na China ma bipụta ya na International Journal of Molecular Sciences, lekwasịrị anya na mkpụrụ ndụ mmadụ na ụmụ oke nwere senescence na-akpata radieshon. Cycloastragenol na-ebelata mkpụrụ ndụ senescent na-emetụtaghị sel ndị na-abụghị nke anụ ahụ. Ọgwụgwọ Cycloastragenol na-ebelatakwa protein ndị dị n'ime sel sesescent nke achọrọ maka uto cell na nlanarị. Na mgbakwunye, ọ na-egbochi mmegharị sel jikọtara ya na sel na usoro mkpali metụtara afọ. Achọpụtara ụmụ oke ndị merela agadi ejiri cycloastraganol mee ka ha nwere obere mkpụrụ ndụ anụ ahụ yana arụrụ ọrụ ahụ metụtara afọ ka mma.

Cycloastragenol na-ebelata sel nke anụ ahụ

Senescence bụ ihe ama ama nke ịka nká, mana ndị nchọpụta achọpụtala na ikpochapụ mkpụrụ ndụ senescent na ụmụ irighiri ihe na-egosi na ha nwere ike inye aka gbochie ọrịa ndị metụtara afọ na ọbụna gbanwee ha n'ọnọdụ ụfọdụ. N'ebe a, ndị nchọpụta na-emeso mkpụrụ ndụ mmadụ na cycloastraganol ma chọpụta na ọ na-ekpochapụ mkpụrụ ndụ senescent nke ọma na-enweghị emetụta mkpụrụ ndụ ndị na-adịghị ahụkebe. Tụkwasị na nke ahụ, a na-ebelata ihe nrịbama cellular nke mkpụrụ ndụ senescent mgbe ọgwụgwọ cycloastraganol gasịrị.

Nnyocha ndị gara aga egosila na ụzọ PI3K / AKT / mTOR-ụzọ akara aka na-etinye aka na uto cell na ndụ-na-etinye aka na usoro mkpali na-ebute site na mkpụrụ ndụ senescent, na-enyere aka ịkwalite senescence na sel ndị gbara ya gburugburu. Ndị nchọpụta ahụ chọpụtara na cycloastragenol nyere aka belata protein na ụzọ a, na-atụ aro na ogige ahụ nwere ike ịrụ ọrụ site na igbochi ụzọ PI3K / AKT / mTOR iji nyere aka gbochie ịka nká. Ọzọkwa, e gosipụtara cycloastragenol iji belata ikike nke mkpụrụ ndụ senescent iji kwalite ịdị ndụ site na ntọhapụ nke ụmụ irighiri ihe na-egbuke egbuke, ihe ndị na-eto eto, na immunomodulators, kwekọrọ na aro ndị na-ebelata PI3K, AKT, na mTOR mgbaàmà nwere ike ibelata mmetụta na-akwalite mmepụta n'etiti sel ndị gbara ya gburugburu. .

Cycloastragenol bụ nke triterpene saponins ma na-enweta ya site na hydrolysis nke astragaloside IV. Ọ nwere obere arọ molekụla dị ntakịrị na lipophilicity siri ike, nke bara uru na ntinye biofilm na ntinye eriri afọ iji nweta bioavailability ka mma. Mmetụta nke cycloastragalinol
1. Ọgwụgwọ mmebi ụbụrụ
2. Meziwanye fibrosis imeju
3. Ọgwụgwọ osteoporosis
4. Mgbochi ịka nká mmetụta
5. Na-egbu oge ịka nká cell

Gịnị mere ọ dị mkpa iji synthesize cycloastraganol?

① Cycloastraganol nwere mmetụta ọgwụ dị iche iche dị ka igbochi apoptosis ụbụrụ ụbụrụ na neuroinflammation n'oge ischemia cerebral na idowe ihe mgbochi ụbụrụ ọbara.
② Cycloastragenol bụ naanị obere terpenoid molekul nwere ọrụ telomerase achọpụtara ugbu a ma nwee ike ịgwọ ọrịa neurodegenerative.
③ Ọ nwere mmetụta nke igbochi fibrosis myocardial na ịkwalite mgbochi tumor. Ọ bụ molekul na-ewu ewu na nyocha na mmepe nke ọgwụ mgbochi ịka nká.

Nsogbu ndị dị adị

Ọdịnaya nke cycloastraganol na Astragalus membranaceus dị obere ma ọ siri ike ịnweta ya ozugbo. Usoro mmepụta cycloastraganol dị adị na-adabere na mmịpụta ọgwụ ndị China ọdịnala, nke a na-enwetakarị site n'ịgbanwe astragaloside IV na Astragalus membranaceus. Nke ahụ bụ, a na-enweta astragaloside IV site na astragalus akuku na nkà na ụzụ omenala anụ ahụ, mgbe ahụ, astragaloside IV gbanwere na cycloastragaloside site na iji acidolysis, Smith deradaration, enzyme na microbial hydrolysis. Otú ọ dị, ụzọ nkwadebe ndị a dị oké ọnụ ahịa, dị mfe ime ka mmetọ gburugburu ebe obibi, sie ike ikewapụ na ime ka ọ dị ọcha, na-adịghịkwa mma maka ngwa na nkwalite. Ya mere, ndị mmadụ atụgharịala uche ha na njikọ artificial nke cycloastraganol.

Olee otú iji sịntetik bayoloji synthesize? ---Synthetic Biology

Biology sịntetik na-ezo aka n'ichepụta ezubere iche, mgbanwe, na ọbụna okike nke "ndụ mmadụ" nwere ọrụ na-ekwekọghị n'okike n'okpuru nduzi nke echiche injinia, ya bụ, injinia nke bayoloji. N'ikwu okwu n'ozuzu, a na-eji usoro ndu eme ya.