Spermidine bụ polyamine dị mkpa nke dị n'ọtụtụ ebe n'ime ihe ndị dị ndụ ma na-ekere òkè na usoro ndu dị iche iche dị ka mmụba cell, ọdịiche na apoptosis. Enwere ụzọ dị iche iche nke usoro njikọta spam: biosynthesis, njikọ kemịkalụ na njikọ enzymatic. Usoro ọ bụla nwere uru na ọghọm ya pụrụ iche yana ndapụta ngwa.
Biosynthesis bụ ụzọ bụ isi maka njikọ spermine, nke a na-emekarị site na usoro mmeghachi omume enzymatic na sel. Biosynthesis nke spermine tumadi dabere na metabolism nke amino asịd, karịsịa lysine na arginine. Nke mbụ, a na-atụgharị lysine ka ọ bụrụ aminobutyric acid (Putrescine) site na lysine decarboxylase, mgbe ahụ aminobutyric acid na-ejikọta ya na amino acid n'okpuru ọrụ nke spermine synthase na-emecha ghọọ spermine. Na mgbakwunye, njikọ nke spermine na-agụnyekwa metabolism nke polyamines ndị ọzọ, dị ka putrescine (Cadaverine) na spermine (Spermine). Mgbanwe na ntinye nke polyamines ndị a na sel ga-emetụta njikọ nke spermine.
Ngwakọta kemịkalụ bụ usoro a na-ejikarị emepụta spermine na ụlọ nyocha. A na-atụgharịkarị ogige organic dị mfe ka ọ bụrụ spermine site na mmeghachi omume kemịkal. Ụzọ njikọ kemịkalụ a na-ahụkarị na-amalite site na amino acids wee nweta spermine site na usoro nke esterification, mbelata na mmeghachi omume amination. Uru nke usoro a bụ na enwere ike ime ya n'okpuru ọnọdụ a na-achịkwa, ịdị ọcha ngwaahịa dị elu, ọ dịkwa mma maka nyocha ụlọ nyocha nke obere. Otú ọ dị, njikọ kemịkal na-achọkarị iji ihe ndị na-emepụta ihe na-emepụta ihe na-emepụta ihe, nke nwere ike inwe mmetụta ụfọdụ na gburugburu ebe obibi.
Njikọ Enzymatic bụ usoro njikọ ọhụrụ emepụtara n'afọ ndị na-adịbeghị anya, nke na-eji mmeghachi omume enzyme-catalyzed kpọmkwem na-emepụta spermine. Uru nke usoro a bụ ọnọdụ mmeghachi omume dị nro, nhọrọ dị elu, na enyi na gburugburu ebe obibi. Site na teknụzụ injinịa mkpụrụ ndụ ihe nketa, enwere ike nweta spermine synthase nke ọma, si otú a na-emeziwanye arụmọrụ nke njikọ ahụ. Njikọ Enzymatic nwere atụmanya ngwa sara mbara na mmepụta ụlọ ọrụ, ọkachasị n'ọhịa nke biomedicine na mgbakwunye nri.
Akụkụ bụ isi nke spermine bụ ogige polyamine, gụnyere spermine, putrescine na triamine. Ọdịdị molekụla nke spermine nwere ọtụtụ amino na imino, ma nwee ọrụ ndụ siri ike. Nnyocha e mere egosiwo na spermine na-ekere òkè dị mkpa na mmụba cell, mgbochi oxidation, na mgbochi ịka nká. N'afọ ndị na-adịbeghị anya, ọtụtụ nchọpụta achọpụtala na spermine nwekwara njikọ chiri anya na omume na mmepe nke ọrịa dị iche iche, dị ka ọrịa cancer, ọrịa obi, na ọrịa neurodegenerative. Ya mere, njikọ na ntinye nke spermine adọtala uche zuru oke.
N'ime ngwa bara uru, enwere ike iji spam mee ihe ọ bụghị naanị dị ka reagent maka nyocha nke ndu, kamakwa dị ka ihe mgbakwunye nri na ngwa ngwaahịa ahụike. Ka ndị mmadụ na-etinyekwu uche na ahụike, ahịa ahịa spermine na-eji nwayọọ nwayọọ na-abawanye. Site n'ịkwalite usoro njikọ nke spermine, mkpụrụ ya na ịdị ọcha nwere ike ịba ụba, na ọnụ ahịa mmepụta ihe nwere ike ibelata, si otú ahụ kwalite ngwa ya na mpaghara dị iche iche.
N'ozuzu, usoro njikọ nke spam na-agụnye biosynthesis, njikọ kemịkalụ na njikọ enzymatic. Usoro ọ bụla nwere uru pụrụ iche yana ọnọdụ ndapụta. Nnyocha n'ọdịnihu nwere ike ilekwasị anya n'ịkwalite mmepụta mmepụta ihe, ibelata mmetụta gburugburu ebe obibi na ịgbasa mpaghara ngwa. Site na ọganihu sayensị na teknụzụ na-aga n'ihu, njikọ na ntinye nke spermine ga-ebute ohere mmepe ọhụrụ.
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Oge nzipu: Dec-12-2024
