Urolithin A bụ mkpụrụ ndụ na-akpali akpali na ngalaba nyocha nke mgbochi ịka nká. Ikike ya iweghachi ọrụ cellular na ịkwalite ahụike abụwo ihe na-ekwe nkwa na ọmụmụ anụmanụ. Otú ọ dị, a chọkwuru nyocha iji chọpụta irè ya n'ime ụmụ mmadụ. Ọ bụ ezie na anyị nwere ike ọ gaghị achọpụta isi iyi nke ntorobịa, Urolithin A na-eme ka anyị dịkwuo nso ịghọta ihe nzuzo nke ịka nká na nke nwere ike imeghe isi ihe na-eme ka ndụ dịkwuo ogologo, ahụike.
Urolithin A bụ ihe okike nke enwetala nlebara anya nke ukwuu n'afọ ndị na-adịbeghị anya n'ihi uru ahụike ya nwere ike ime. Nnyocha na-apụta na-egosi na ọ nwere ike ịnwe mgbochi mkpali, mgbochi cancer na mgbochi ịka nká.
●Urolithin A bụ metabolite nke na-emepụta site na nbibi nke ellagitannins, ogige polyphenolic dị na mkpụrụ osisi na mkpụrụ ụfọdụ. Ntughari nke ellagitannins na urolithin A na-eme n'ụzọ bụ isi na eriri afọ n'ihi omume nke ụfọdụ nje bacteria.
●Mkpụrụ pọmigranet bụ otu n'ime ihe ndị kasị baa ọgaranya nke ellagitannins ma si otú ahụ urolithin A. Arils na-acha uhie uhie, ma ọ bụ mkpụrụ osisi, nke pọmigranet nwere nnukwu ellagitannins, nke na-agbanwe na urolithin A n'oge mgbaze. Ihe ọṅụṅụ pọmigranet na mịpụta bụkwa ezigbo isi mmalite nke urolithin A.
●Mkpụrụ ọzọ nwere urolithin A bụ raspberries. Dị ka pọmigranet, raspberries bara ụba na ellagitannins, karịsịa na mkpụrụ ha. Iri raspberries ọhụrụ ma ọ bụ oyi kpọnwụrụ mgbe niile nwere ike ịbawanye ọkwa urolithin A n'ime ahụ.
●Ụfọdụ mkpụrụ, dị ka walnuts na pistachios, nwekwara akara urolithin A. Ọ bụ ezie na a na-ahụ urolithin A na obere ego ma e jiri ya tụnyere mkpụrụ osisi ndị dị ka pọmigranet, gụnyere mkpụrụ ndị a na nri gị nwere ike inye aka ịbawanye ụbara urolithin A.
Ọ bụ ezie na mkpụrụ osisi ọhụrụ na mkpụrụ osisi bụ ezigbo nri nri nke urolithin A, ọ bara uru ịkọwa na mgbakwunye urolithin A dịkwa. Ihe mgbakwunye ndị a nwere ike inye ụzọ dị mma iji bulie urolithin A gị.
Urolithin A bụ ngwakọta sitere na ihe okike a na-akpọ ellagitannin, nke dị na mkpụrụ osisi ụfọdụ dị ka pọmigranet na tomato. Mgbe anyị na-eri mkpụrụ osisi ndị a, nje bacteria na-akụda ellagitannins n'ime urolithin A, na-ekwe ka ahụ anyị rite uru na onyinye a dị ịrịba ama.
Otu n'ime nchọpụta kacha atọ ụtọ gbasara urolithin A bụ ikike ya ime ka mitochondria dịghachi ndụ, ụlọ ike nke mkpụrụ ndụ anyị. Ka anyị na-aka nká, mitochondria anyị na-adịchaghị mma, na-eduga na mbelata mmepụta ike cell. Nnyocha egosila na urolithin A nwere ike ịgbalite usoro a na-akpọ mitophagy, nke na-ekpochapụ mitochondria na-adịghị arụ ọrụ ma na-akpali mmepụta nke ọhụrụ ahụ ike. Usoro a na-eduga n'ịkwalite mmepụta ume na ọrụ cellular n'ozuzu ya.
Ọzọkwa, a chọpụtala urolitin A na-eme ka ahụ ike na ike dịkwuo elu. Ka anyị na-aka nká, anyị na-enwekarị ike ịla n'iyi, na-eduga n'adịghị ike na ibelata njem. Otú ọ dị, nnyocha e mere na ụmụ anụmanụ ndị meworo agadi egosiwo na mgbakwunye na urolithin A na-akwalite uto ahụ ike ma na-egbochi uru ahụ.
Uru ọzọ na-eju anya nke Urolitin A bụ nchebe ya megide ọrịa neurodegenerative dị ka Alzheimer na Parkinson. Ihe e ji mara ọrịa ndị a site na nchịkọta protein na-egbu egbu na ụbụrụ, na-eduga n'ịda mbà n'obi na nsogbu mmegharị. Nnyocha e mere n'oge na-adịbeghị anya egosiwo na urolithin A nwere ike inye aka wepụ protein ndị a na-emerụ ahụ, na-ebelata ihe ize ndụ na ọganihu nke ọrịa ndị a na-adịghị ahụkebe.
1. Rie nri bara ụba na ellagitannins: Iji na-abawanye ọkwa urolithin, iri nri nwere ellagitannins bụ isi. Mkpụrụ pọmigranet, strawberries, raspberries na blackberries bụ ezigbo isi mmalite nke ellagitannins. Tinyere mkpụrụ osisi ndị a na nri gị nwere ike ịkwalite mmepụta urolithin na eriri afọ gị.
2. Na-eme ka ahụike gut dịkwuo mma: Inwe microbiota eriri afọ dị mma dị oke mkpa maka mmepụta urolithin. Iji kwado microbiome eriri afọ dị iche iche ma kwụzie ọtọ, tinye nri esiri esi dị ka yogọt, kefir, sauerkraut, na kimchi na nri gị. Ihe oriri ndị a na-ewebata ezigbo nje bacteria na eriri afọ gị, nke na-akwalite mmepụta urolithin.
3. Were ihe mgbakwunye urolithin: Na mgbakwunye na isi nri nri, mgbakwunye urolithin dịkwa n'ahịa. Ihe mgbakwunye ndị a na-enye doses nke urolithins gbadoro anya, nke nwere ike ịba uru maka ndị ọ na-esiri ike iri nri zuru oke nke ellagitannin bara ụba mgbe niile ma ọ bụ ndị nwere nsogbu ahụ ike.
4. Jikọta ellagitannins na isi iyi abụba: ellagitannins na-adị mfe itinye n'ahụ ahụ mgbe ejiri isi abụba dị mma rie ya. Tụlee ịgbakwụnye ụfọdụ mkpụrụ, mkpụrụ, ma ọ bụ ntakịrị mmanụ oliv n'ime mkpụrụ osisi ahụ iji mee ka mmịnye nke ellagitannins dịkwuo elu ma mụbaa mmepụta urolithin.
Oge ọ na-ewe maka urolitin A na-arụ ọrụ dịgasị iche iche n'ọtụtụ ihe. Ihe kacha mkpa bụ metabolism nke onwe. Ahụ onye ọ bụla na-ahazi ihe dị iche iche, nke na-emetụtakwa ngwa ngwa ahụ na-amịkọrọ ma jiri urolithin A. Na mgbakwunye, dose na ụdị nke urolithin A na-eri nwekwara ike imetụta oge mmalite ya.
Nnyocha e mere egosiwo na iri ụdị urolithin A, dị ka ihe ọṅụṅụ pọmigranet ma ọ bụ ụfọdụ mkpụrụ osisi, nwere ike ịmepụta ọkwa nke ihe mejupụtara ọbara n'ime ọbara n'ime awa ole na ole. Otú ọ dị, mmetụta nke urolithin A nwere ike ọ gaghị apụta ozugbo, n'ihi na omume nke ogige ahụ na-elekwasị anya na uru ahụike ogologo oge.
Ọ dị mkpa iburu n'obi na urolithin A abụghị ngwa ngwa maka ọnọdụ ahụike ọ bụla. Kama nke ahụ, a na-eche na ọ ga-arụ ọrụ ya site n'ịgbalite usoro imegharị mkpụrụ ndụ ahụ a na-akpọ autophagy. Usoro a gụnyere imebi na iwepu sel na protein ndị mebiri emebi, nke nwere ike inwe mmetụta dị ogologo oge na ahụike na ọdịmma zuru oke. Nnyocha ka na-aga n'ihu maka ogologo oge ọ ga-ewe iji chọpụta uru urolithin A nwere ike ime.
Nchoputa banyere mmetụta urolithin A ka dị ntakịrị, n'ihi na ọ bụ mpaghara nyocha ọhụrụ dị ọhụrụ. Ọtụtụ nnyocha e mere ruo taa lekwasịrị anya na mmetụta ya dị mma karịa mmetụta ọjọọ ọ bụla. Ka o sina dị, ọ dị mkpa iji nlezianya gaa n'ihu ma ghọta ihe egwu nwere ike ime.
Nsogbu enwere ike na iji urolitin A bụ na ọ nwere ike imekọrịta ihe na ọgwụ ụfọdụ. Dị ka ihe mgbakwunye nri, ọ nwere ike ịmekọrịta ọgwụ na-emepụta site na otu enzymes imeju metabolized. Nke a nwere ike ịgbanwe ka ọgwụ ndị a si dị irè ma ọ bụ dị mma. Ya mere, ọ dị mkpa ịkpọtụrụ onye ọkachamara ahụike tupu ị were urolithin A ma ọ bụrụ na ị na-aṅụ ọgwụ ọ bụla ọzọ.
Akụkụ ọzọ ị ga-atụle bụ usoro ọgwụgwọ urolithin A. Ugbu a, ọ dịghị ihe oriri a na-atụ aro kwa ụbọchị ma ọ bụ ntụziaka usoro ọgwụgwọ kpọmkwem maka ogige a. Ya mere, ọ na-esiri ike ikpebi ma enwere ọgwụ kachasị mma, ma ọ bụ ọ bụrụ na enwere mmetụta ọ bụla nwere ike ịkpata ya na oke doses. A na-atụ aro ka ị soro ntuziaka dị na akara ngwaahịa ma ọ bụ kpọtụrụ onye na-ahụ maka ahụike ka ị chọpụta usoro ọgwụgwọ kwesịrị ekwesị.
Oge nzipu: Jun-21-2023
