Urolithin A bụ ogige sitere n'okike bụ ogige metabolite nke nje bacteria na-emepụta na-eme ka ellagitannins mee ka ahụike dịkwuo mma na ọkwa cellular. Urolithin B enwetawo nlebara anya nke ndị nchọpụta maka ikike ya imezi ahụike eriri afọ yana ibelata mbufụt. Urolithin A na urolithin B nwere ihe jikọrọ ya, mana ha nwere ụfọdụ iche iche. Kedu ihe dị iche iche gị, ka anyị chọpụta!
N'ime afọ ndị na-adịbeghị anya, ndị ọkà mmụta sayensị na-amụ banyere uru ahụike nke urolithin, ihe sitere n'okike nke bụ ihe metabolite mepụtara site na ntughari nke ellagitannins site na nje bacteria eriri afọ. Ihe na-ebute ya bụ ellagic acid na ellagitannins, bụ ndị na-emekarị n'ọtụtụ ebe nri dị ka pọmigranet, guava, tii, pecans, nuts, na tomato dị ka strawberries, black raspberries, na blackberries. Tụkwasị na nke ahụ, urolithin A , polyphenol eke, bụ ihe na-adọrọ mmasị dị ka onye na-eme ihe ike na-eme ka ọ bụrụ ihe na-eme ka ọ bụrụ ihe na-eme ka ọ bụrụ ihe na-eme ka ọ bụrụ ihe na-eme ka ọ bụrụ ihe na-eme ka ọ bụrụ onye na-eme ihe ike na-eme ka ahụ dị mma.
Sụlọ akwụkwọ na-enyocha thmmetụta nke UA na ọrụ cellular na ụzọ ndụ egosila na ọ nwere ọtụtụ usoro nke ime ihe. Nnyocha achọpụtawokwa na UA na-arụ ọrụ mitochondrial autophagy, usoro nke na-ewepụ mitochondria mebiri emebi site na cell ma kwalite mmepụta ume. Omume a dị mkpa karịsịa na ọrịa ndị metụtara ịka nká, ebe ọ bụ na mitochondria na-adịghị arụ ọrụ na-eduga na nchịkọta nke nrụgide oxidative na mbufụt. UA na-achịkwa okwu nke mkpụrụ ndụ ihe nketa na-etinye aka na nzaghachi nrụgide oxidative, nrụzi DNA na apoptosis, nke dị mkpa maka ịnọgide na-enwe iguzosi ike n'ezi ihe cell na igbochi ọrịa cancer.
Nke ọzọr na-akpali akụkụ nke UA bụikike ya dị ka onye na-eme ihe nhụsianya nke senescence, nke pụtara na ọ nwere ike ịhọrọ akpalite apoptosis n'ime mkpụrụ ndụ senescent, nke bụ mkpụrụ ndụ mebiri emebi nke na-adịghị ekewa ọzọ ma na-ezobe ihe ndị na-emerụ ahụ na-emerụ sel na anụ ahụ agbata obi. A na-ejikọta mkpụrụ ndụ senescent na ọrịa dị iche iche metụtara ịka nká, dị ka ogbu na nkwonkwo, atherosclerosis na neurodegeneration. Site n'ịhọrọ ikpochapụ mkpụrụ ndụ ndị a, UA nwere ike igbu oge ma ọ bụ gbochie mmalite nke ọrịa ndị a ma melite ahụike zuru oke.
Urolithins bụ klaasị nke ogige mara dị ka ellagitannin metabolites, nke a na-emepụta nke ọma site na eriri afọ microbiota. N'ime ha, ụmụ irighiri ihe abụọ, urolithin A na urolithin B, enwetala nlebara anya dị ukwuu maka uru ahụike ha nwere. A na-ahụ ogige ndị a na mkpụrụ osisi dị iche iche dị ka mkpụrụ pọmigranet, strawberries, na raspberries. Na blọọgụ a, anyị ga-elebakwu anya n'ihe metụtara urolithin A na urolithin B.
Urolithin A bụ molekul kasị ukwuu nke ezinụlọ urolithin, a nyochawokwa ya nke ọma maka ihe ndị na-eme ka ahụ dị ike na-eme ka ahụ ghara ịdị na-egbu ya. Ọzọkwa, ọmụmụ na-atụ aro na UA nwere ike melite ọrụ mitochondrial ma gbochie mmebi ahụ. A makwaara UA maka ihe nwere ike igbochi ọrịa kansa. Nnyocha egosiwo na UA nwere ike igbochi mgbasawanye cell na ịkpata ọnwụ cell n'ime ahịrị mkpụrụ ndụ cancer dị iche iche, gụnyere prostate, ara, na mkpụrụ ndụ cancer colon.
N'aka nke ọzọ, urolithin B enwetala nlebara anya nke ndị nchọpụta maka ikike ya imezi ahụike eriri afọ yana ibelata mbufụt. Nnyocha egosila na UB nwere ike ịkwalite ụdị microbial dị iche iche ma belata cytokines pro-inflammatory, dị ka interleukin-6 na tumor necrosis factor-alpha. Ọzọkwa, a chọpụtakwara na UB nwere ihe ndị nwere ike ime ka neuroprotective, dịka ọmụmụ egosila na ọ nwere ike inye aka gbochie ọrịa neurodegenerative dịka Parkinson na Alzheimer's.
N'agbanyeghị ihe ndị metụtara ya, UA na UB nwere ụfọdụ ọdịiche pụtara ìhè. Dịka ọmụmaatụ, egosiri UA ka ọ dị ike dị ka onye na-egbochi mkpali na antioxidant karịa UB. N'aka nke ọzọ, a chọpụtala na UB na-arụ ọrụ nke ọma n'igbochi nsogbu ndị metụtara oke ibu, dịka nkwụsị insulin na ọdịiche adipocyte. Na mgbakwunye, n'adịghị ka UA, UB amụbeghị nke ukwuu dị ka onye na-egbochi ọrịa kansa.
Usoro nke ime ihe maka UA na UB dịkwa iche. UA na-arụ ọrụ Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) ụzọ, nke na-arụ ọrụ na mitochondrial biogenesis, ebe UB na-eme ka ụzọ AMP-activated protein kinase (AMPK), nke na-etinye aka na homeostasis ike. Ụzọ ndị a na-enye aka na mmetụta bara uru nke ogige ndị a na ahụike.
N'agbanyeghị uru na-akpali akpali nke UA na UB, a ka nwere njedebe na ojiji ha. Dịka ọmụmaatụ, bioavailability nke ogige ndị a ka dị ntakịrị, na pharmacokinetics ha aghọtachaghị nke ọma. Ọzọkwa, mmetụta nke ogige ndị a na ụmụ mmadụ ka akọwapụtabeghị nke ọma, ebe ọ bụ na a na-eme ọtụtụ ọmụmụ na vitro ma ọ bụ ụdị anụmanụ. Ka o sina dị, nchọpụta dị ugbu a na-egosi na UA na UB nwere ike ịbụ ndị na-ekwe nkwa maka ịmepụta nri ma ọ bụ ihe mgbakwunye iji kwado ahụike zuru oke na igbochi ọrịa.
Urolithin A. Obere molekul a na-ahụ n'onwe ya na mkpụrụ osisi na mkpụrụ osisi na-ewu ewu n'ihi ike a na-ekwu na ọ na-eme ka ihe niile dị mma site na uto akwara ruo n'ịrụ ọrụ ụbụrụ. Urolitin A bụ metabolite, nke pụtara na ọ bụ ihe sitere na ogige ndị ọzọ na ahụ. Kpọmkwem, a na-emepụta ya mgbe nje nje eriri afọ na-akụda ellagitannins, nke a na-ahụ na nri ụfọdụ dị ka pọmigranet, strawberries na walnuts. Ma ebe a bụ akụkụ na-adọrọ mmasị: ọ bụghị onye ọ bụla nwere nje bacteria dị mkpa iji mepụta urolithin A. N'ezie, nchọpụta egosila na ọ bụ naanị ihe dịka 30-50% nke ndị mmadụ nwere ike ịmepụta molekul a n'ụzọ nkịtị. Nke a bụ ebe ihe mgbakwunye na-abara uru.
Yabụ, gịnị bụuru nke urolitin A? Ọfọn, otu n'ime ihe ndị kasị ukwuu na-ekwu bụ na ọ nwere ike inye aka melite ahụ ike muscle. Nnyocha e bipụtara na akwụkwọ akụkọ Nature Medicine chọpụtara na mgbe e nyere oke urolithin A, ha nwere mmụba 42% na ntachi obi na mmụba 70% na oke ahụ. Ọ bụ ezie na nsonaazụ ndị a na-adọrọ mmasị n'ezie, ọ dị mkpa iburu n'obi na nke a bụ ntakịrị ihe ọmụmụ na a chọkwuru nyocha iji kwado nchoputa ndị a n'ime mmadụ.
Mana nke ahụ abụghị ihe a na-ekwu na urolithin A na-eme. E gosikwara na ọ na-emeziwanye ọrụ mitochondrial. Mitochondria bụ n'ezie osisi ike nke mkpụrụ ndụ, na-ahụ maka imepụta ike nke ahụ nwere ike iji. Ka anyị na-aka nká, ọrụ mitochondrial anyị na-amalite ịda, nke nwere ike ịkpata ọtụtụ nsogbu ahụike. Otú ọ dị, nchọpụta mbụ na-egosi na urolithin A nwere ike inye aka belata ọdịda a, nwere ike ime ka ahụike zuru ezu dịkwuo elu na ịgbatị ndụ ndụ.
Dị ka a ga-asị na nke ahụ ezughi oke, urolithin A gosikwara na ọ nwere uru ọgụgụ isi. Nnyocha e bipụtara na magazin bụ Scientific Reports chọpụtara na mgbe a na-enye oke urolithin A, ikike ncheta na ikike mmụta ha na-akawanye mma. Ndị nchọpụta kwenyere na nke a nwere ike ịbụ n'ihi mmetụta mgbochi mkpali nke molecule, nke na-enyere aka chebe mkpụrụ ndụ ụbụrụ pụọ na mmebi.
Urolithin B, nke a na-achọta na mkpụrụ osisi dị iche iche na pọmigranet, mara maka uru ọ nwere n'ịkwalite ahụike metabolic na ịgbatị ndụ. Nnyocha e mere n'oge na-adịbeghị anya egosila na urolitin B nwere ihe mgbochi mkpali na antioxidant nke nwere ike inye aka gbochie ọrịa na-adịghị ala ala ma melite ahụike zuru oke.
1. Njirimara mgbochi mkpali
Ọrịa na-adịghị ala ala bụ isi ihe na-akpata ọtụtụ ọrịa, gụnyere ọrịa obi, ọrịa shuga na ọrịa kansa. Urolithin B nwere ihe mgbochi mkpali nke na-enyere aka belata mbufụt n'ime ahụ, si otú ahụ belata ohere nke ọrịa na-adịghị ala ala. Otu nnyocha chọpụtara na urolithin B na-ebelata mbufụt nke ụmụ oke nwere ọrịa afọ ọzịza, na-atụ aro ka ọ dị irè n'ịgwọ ụmụ mmadụ nwere ọrịa ndị yiri ya.
2. Njirimara antioxidant
Urolitin B bụ antioxidant siri ike, nke pụtara na ọ nwere ike inye aka chebe ahụ pụọ na nrụgide oxidative, usoro na-emebi mkpụrụ ndụ ma na-akwalite usoro ịka nká. Urolitin B na-enyere aka igbochi mmebi oxidative site n'iwepụ radicals free, nke nwere ike ime ka mmebi cellular na-ebute ọrịa na-adịghị ala ala. Otu nnyocha chọpụtara na urolithin B belatara nrụgide oxidative na òké, na-akwadokwa ikike ya dị ka mgbakwunye mgbochi ịka nká.
3. Na-akwalite ahụ ike akwara
Urolithin B egosila na ọ na-akpali mitochondrial autophagy, usoro cellular nke na-enyere aka iwepụ mitochondria mebiri emebi site na sel. Usoro a na-enyere aka imeziwanye ahụ ike na ọrụ anụ ahụ n'ozuzu ya, na-eme ka ọ bụrụ ihe mgbakwunye nwere ike ime ka ndị na-achọ imeziwanye arụmọrụ anụ ahụ. Otu nnyocha chọpụtara na urolithin B kwalitere ọrụ akwara na ike na ụmụ oke na ụmụ mmadụ.
4. Na-akwado ahụike uche
E gosipụtara Urolithin B iji kwado ahụike ahụike site n'ịkwalite neuroplasticity, usoro na-enyere ụbụrụ aka ime mgbanwe na ozi ọhụrụ ma nwee ike imeziwanye ọrụ ọgụgụ isi. Otu nnyocha chọpụtara na urolithin B na-eme ka ọrụ ọgụgụ isi dịkwuo mma na ebe nchekwa dị na oke.
5. Enwere ike ịba uru ogologo ndụ
Nnyocha e mere n'oge na-adịbeghị anya egosila na urolithin B nwere ikike ịkwalite ogologo ndụ site n'ịkwalite ahụike nke metabolic, ibelata mbufụt, na ichebe nrụgide oxidative. Otu nnyocha chọpụtara na urolithin B mụbara ogologo ndụ na C. elegans, ụdị nke nematode worm, na-akwado uru ọ nwere maka ịkwalite ogologo ndụ.
1. pọmigranet
Mkpụrụ pọmigranet bụ otu n'ime isi mmalite nke urolithin. Ndị nchọpụta achọpụtala na ihe ọṅụṅụ pọmigranet nwere ike ịbawanye ọkwa ọbara nke urolithins A na B. Tụkwasị na nke ahụ, mkpụrụ pọmigranet nwere uru ahụike ndị ọzọ, gụnyere mgbochi mkpali na antioxidant Njirimara.
2. Tomato
Tomato dị ka strawberries, raspberries na blackberries bụkwa ezigbo isi mmalite nke urolithin. Nnyocha egosiwo na iri beri nwere ike ịbawanye ọkwa urolithin A na B n'ọbara.
3. Akụ
Walnuts na pecans na mkpụrụ ndị ọzọ bụkwa ezigbo isi iyi nke urolithin. Nnyocha e mere gosiri na iri mkpụrụ ga-eme ka urolitin A na B dị n'ọbara dịkwuo elu.
Urolithin A na B bụ ogige eke dị na ụfọdụ nri, ha nwere ọtụtụ uru ahụike. Ogige ndị a nwere ihe mgbochi mkpali, meziwanye ahụike mitochondrial na muscle, ma kwalite ahụike uche. Mkpụrụ pọmigranet, mkpụrụ osisi, mkpụrụ na ihe mgbakwunye ellagitannin bụ ụfọdụ n'ime ebe nri kacha mma nwere ike inye urolitins. Ịtinye nri ndị a na nri gị nwere ike inyere gị aka imeghe uru nke urolithins A na B ma kwalite ịka nká.
Oge nzipu: Jun-05-2023
