Na-ekpughe usoro kachasị ọhụrụ na mgbakwunye Alfa GPC maka 2024

Choline Alfoscerate,nke a makwaara dị ka Alpha-GPC, bụ ihe a na-ewepụta na lecithin osisi, mana ọ bụghị phospholipid, kama ọ bụ phospholipid sitere na ihe ndị nwere abụba abụba lipophilic. Alfa-GPC bụ nri na-arụ ọtụtụ ọrụ a na-ahụ n'ime sel niile anụ mammalian. N'ihi na ọ dị oke hydrophilic, a na-etinye ya ngwa ngwa mgbe nchịkwa ọnụ gasịrị. GPC bụ precursor nke acetylcholine (ACh) ma na-ekwe nkwa dị ukwuu na choline dysfunction.

GPC na-agafe ngwa ngwa mgbochi ọbara-ụbụrụ ma na-enye isi iyi nke choline maka biosynthesis nke ACh na phosphatidylcholine. Phospholipids na acetylcholine, mgbe a na-enweta ya na ọkwa kachasị mma, na-akwalite ahụike uche, nke uche na nke cerebrovascular. Na mgbakwunye, itinye uche ziri ezi nke Alfa-GPC na Ach nwere ike ịkwalite usoro physiological ma melite arụmọrụ anụ ahụ. ACh na-ekere òkè na mkpụkọ akwara na bụ isi neurotransmitter nke na-achịkwa nzaghachi anụ ahụ maka mmega ahụ.

Ebe ọ bụ na mmegharị ahụ niile metụtara mkpụkọ, yana nkwekọrịta metụtara mkpokọta ACh cellular dị, ịbawanye ọkwa ACh na-ebuli arụmọrụ ahụ ike. Tụnyere ndị ọzọ na-emekarị choline precursors, Alpha-GPC n'enweghị nsogbu na-abawanye choline etoju na ọbara na ụbụrụ. Ọtụtụ nchọpụta ekwenyela na uru dị iche iche nke Alpha-GPC na-atụ aro na mgbakwunye ọnụ nwere ike ịrụ ọrụ dị mkpa n'ịkwalite ọrụ akwara ozi, ịrụ ọrụ anụ ahụ, na imeziwanye ebe nchekwa.

Ịrụ ọrụ Alpha-GPC

Mee ka ụbụrụ nwee ike

Ka ọnụ ọgụgụ mkpụrụ ndụ akwara dị n'ụbụrụ na-abawanye, ka ike ha na-esikwu ike, ka ha na-ebufe akara akwara ngwa ngwa, na ike nhazi ụbụrụ na-esiwanye ike. Alfa-GPC nwere ike imeziwanye ọrụ ụbụrụ n'ụzọ zuru ezu site n'ịkwalite ike nke mkpụrụ ndụ akwara yana ikike nnyefe nke akara akwara. N'ihe gbasara ịkwalite neurotransmission cholinergic, nnyefe mgbaàmà n'etiti mkpụrụ ndụ akwara na-adabere na nnyefe nke ndị na-ahụ maka ụbụrụ, na acetylcholine bụ onye ozi kemịkalụ bụ isi na neurotransmitter nke na-eme ka echiche na-arụ ọrụ na-arụ ọrụ ma na-akwado nhazi n'etiti ụbụrụ na ahụ dum. Enwere ike imebi Alfa-GPC n'ime 3-glycerol phosphate na choline na ụbụrụ ma bụrụ ihe kacha arụ ọrụ nke acetylcholine. Ọ nwere ike ịkwalite ebe nchekwa ma melite echiche site n'ịkwalite njikọ na ntọhapụ nke acetylcholine na ụbụrụ. N'ihe gbasara ịkwalite nkwụsi ike na mmiri mmiri nke cell membranes, Alpha-GPC nwere ike ịkwalite njikọ nke phosphoinotide, si otú ahụ na-eme ka nkwụsi ike na mmiri nke membranes cell dịkwuo elu. Neurons nwere usoro zuru oke nwere ike ịnye ozi karịa ma melite ike iche echiche nke ahụ. Mefuo.

Chebe irighiri akwara

Ihe ndị na-eto eto nke anụ ahụ ụjọ, ya bụ neurotrophic, nwere ike ịhazi ọdịiche dị n'etiti mkpụrụ ndụ stem ma kwalite nguzobe nke njikọ akwara ọhụrụ. Alpha-GPC nwere ike ịkwalite nzuzo nke ihe dị iche iche nke neurotrophic ma mee ka ụzọ mgbaàmà na-emetụta ndụ ndụ cell, si otú a na-eme ka ọ bụrụ ihe na-adịghị mma. Melite ogo ọgụgụ isi nke ahụ. N'otu oge ahụ, Alfa-GPC nwekwara ike ịkwalite nzuzo nke hormone na-eto eto ma nọgide na-ahụ ahụ ike site n'ịba ụba nke hormone na-eto eto.

Antioxidant

Oxidation na mbufụt bụ isi ihe na-akpata ịka nká na ọnwụ. Alfa-GPC nwere ike imebi radicals n'efu n'ime ahụ, lụso nrụgide oxidative ọgụ, ma nwee ike belata mbufụt dị ka NF-κB, tumor necrosis factor TNF-α, na interleukin IL-6. Ntọhapụ nke ihe na-egbochi mbufụt nke ụbụrụ, si otú ahụ na-atụgharị nke ọma n'ịbelata ọrụ ọgụgụ isi na igbochi ihe omume na mmepe nke ọrịa neurodegenerative. A kwadoro mmetụta ndị dị mkpa site na mmetụta ụlọ ọgwụ.

Na ọmụmụ "Mmetụta nke Alpha-GPC na Age-metụtara Mmebi Nchekwa", 4 isiokwu e nyere placebo, na ndị ọzọ 5 isiokwu e nyere Alpha-GPC (1200 mg / ụbọchị), mgbe na-aga n'ihu ọnụ nchịkwa maka ọnwa 3, 16. A na-eji electrodes dekọọ ebili mmiri ụbụrụ maka nkeji ise ka ihe ndị ahụ nọ na-amụ anya ma na-ezu ike. Nsonaazụ gosiri na atụnyere placebo, Alpha-GPC nwere ike ịbawanye oke nke ebili mmiri ụbụrụ kachasị ọsọ, ebe ọ na-enwe ọchịchọ ibelata ugboro ole na-adị nwayọọ. Ya bụ, ọ nwere ike ime ka ụbụrụ ndị dị n'etiti ahụ dịkwuo ike ma na-egbu oge ịka nká nke ahụ.

Hazie mmetụta uche

Dopamine nwere ike ime ka ndị mmadụ nwee obi ụtọ, na serotonin na gamma-aminobutyric acid nwere ike ịhazi ọnọdụ ahụ. Alfa-GPC nwere ike ịkwalite ntọhapụ nke dopamine, na-achịkwa okwu nke ndị na-ebugharị dopamine, melite dopamine neurotransmission na ụbụrụ, na ịbawanye ọkwa nke serotonin na striatum na prefrontal cortex; ọ nwekwara ike kwalite nke ọma γ- Ntọhapụ nke aminobutyric acid na-ebelata ehighị ụra nke ọma, si otú ahụ na-eme ihe na-egbochi ịda mbà n'obi, na-ebelata nchekasị na mmetụta na-eme ka ọnọdụ ahụ guzosie ike.

Na mgbakwunye, Alpha-GPC na-egosikwa na ọ ga-enwe ike ịkwalite nnabata nke ígwè na-abụghị heme na nri, dị ka mmetụta vitamin C na 2: 1 ruru na ígwè, ya mere a na-ewere Alpha-GPC dị ka, ma ọ bụ na opekempe na-enye aka na, nkwalite nke ngwaahịa anụ. Mmetụta nke absorption ígwè na-abụghị heme. Ọzọkwa, supplementing na Alpha-GPC nwekwara ike inyere abụba ọkụ usoro na-akwado lipid metabolism. Nke a bụ n'ihi ọrụ choline dị ka nri lipophilic. Ọkwa dị mma nke nri a na-ahụ na acid fatty dị na mitochondria cell, nke nwere ike ime ka abụba ndị a ghọọ ATP ma ọ bụ ike.

Mmelite usoro iwu

A na-eji Alfa GPC ihe karịrị afọ 10. Ugbu a, Alpha GPC bụ ihe oriri ọhụrụ na Japan ma na-ejikarị emepụta ihe oriri na-arụ ọrụ. Na mgbakwunye, United States, Canada, Switzerland na mba ndị ọzọ ejirila nke ọma kwado ma ọ bụ kwe ka agbakwunye Alpha GPC na nri mgbe Japan gasịrị. Na United States, a na-ahazi Alpha GPC dị ka ihe a na-amatakarị dị ka Nchekwa (GRAS). Na Canada, akwadoro Alpha GPC dị ka ngwaahịa ahụike eke.

Ngwa ahịa na usoro ngwaahịa

N'ihi data ezughị ezu na nchekwa nke Alpha GPC na ụmụ ọhụrụ, ụmụ nwanyị dị ime, na ụmụ nwanyị na-enye nwa ara, dabere na ụkpụrụ nke igbochi ihe ize ndụ, ndị dị n'elu ekwesịghị iri ya, akara na ntụziaka kwesịrị igosi otu na-adịghị mma. Na United States, Japan, Canada na obodo ndị ọzọ, Alpha GPC ejirila nri mee ihe n'ọtụtụ ebe. Ngwaahịa ndị emetụtara na-ekpuchi mgbakwunye nri, ihe ọ drinksụ ,ụ, gummies na ụdị ndị ọzọ, na ngwaahịa ọ bụla nwere ọrụ doro anya yana ojiji akwadoro.

Ọnụọgụ na otu ndị akwadoro. Dị ka ihe atụ, na United States, e nwere ihe karịrị 300 dietary Mmeju maka Alfa GPC naanị, na-ekwu mmetụta gụnyere melite ebe nchekwa na cognitive ọrụ, rụọ moto ọrụ, wdg The kwa ụbọchị onunu ogwu bụ 300-1200 mg.
Ọnọdụ teknụzụ mmepụta ugbu a

Nnyocha na-egosi na njikọ kemịkal bụ otu n'ime ụzọ mmepụta nke Alpha GPC. Iji polyphosphoric acid, choline chloride, R-3-chloro-1,2-propanediol, sodium hydroxide na mmiri dị ka akụrụngwa, mgbe condensation na esterification mmeghachi omume, ọ na-decolorized, adịghị ọcha wepụrụ, lekwasị, nụchara anụcha na akpọnwụwo. enwere ike nweta usoro ndị ọzọ. Agbanyeghị, njikọ kemịkalụ ọdịnala, hydrolysis kemịkalụ, kemịkalụ kemịkalụ na ụzọ ndị ọzọ niile na-eche nsogbu dị ka mmetọ gburugburu ebe obibi, ọnụ ahịa dị elu na usoro nkwadebe siri ike.

N'ime afọ ndị na-adịbeghị anya, nkwadebe nke Alpha GPC site na usoro bioenzymatic enwetawo nlebara anya karị. Usoro enzymatic nke mmiri-phase, usoro enzymatic na-abụghị mmiri-phase, wdg apụtala n'otu n'otu. E jiri ya tụnyere usoro kemịkalụ, nkwadebe nke Alpha GPC site na usoro bioenzymatic nwere ọnọdụ mmeghachi omume dị nro na usoro dị mfe. , elu catalytic arụmọrụ na adabara nnukwu-ọnụ ọgụgụ azụmahịa mmepụta.

Suzhou Myland Pharm & Nutrition Inc. bụ onye na-emepụta aha FDA nke na-enye ntụ ntụ ntụ ntụ GPC dị elu na nke dị elu.

Na Suzhou Myland Pharm anyị na-agba mbọ ịnye ngwaahịa kachasị mma na ọnụ ahịa kacha mma. A na-anwale ntụ ntụ Alfa GPC anyị nke ọma maka ịdị ọcha na ike, na-ahụ na ị nweta mgbakwunye dị elu ị nwere ike ịtụkwasị obi. Ma ịchọrọ ịkwado ahụike cellular, kwalite usoro ahụ ji alụso ọrịa ọgụ ma ọ bụ kwalite ahụike zuru oke, ntụ ntụ ntụ ntụ nke Alpha GPC bụ nhọrọ zuru oke.

Site na ahụmịhe afọ 30 na teknụzụ dị elu na atụmatụ R&D kachasị mma, Suzhou Myland Pharm ewepụtala ngwaahịa dị iche iche nke asọmpi wee bụrụ mgbakwunye sayensị ndụ ọhụrụ, njikọta omenala na ụlọ ọrụ nrụpụta.

Na mgbakwunye, Suzhou Myland Pharm bụkwa onye nrụpụta FDA debanyere aha. Akụrụngwa R&D nke ụlọ ọrụ ahụ, akụrụngwa nrụpụta na ngwa nyocha bụ nke ọgbara ọhụrụ yana ọtụtụ ọrụ, ma nwee ike imepụta kemịkalụ site na milligrams ruo tọn n'ọ̀tụ̀tụ̀, ma na-agbaso ụkpụrụ ISO 9001 na nkọwapụta GMP.

A maara Alfa GPC dị ka hygroscopic, nke pụtara na ọ na-amịkọrọ mmiri sitere na ikuku gbara ya gburugburu. N'ihi nke a, ọ dị mkpa ka a na-echekwa ihe mgbakwunye n'ime akpa ikuku na-adịghị na ya ma ghara ikpughe na ikuku ruo ogologo oge.

Echiche ikpeazụ

A na-eji Alfa GPC na-ebuga choline n'ụbụrụ n'ofe mgbochi ụbụrụ ọbara. Ọ bụ ihe mmalite maka acetylcholine, neurotransmitter nke na-akwalite ahụike uche. Enwere ike iji ihe mgbakwunye Alfa GPC mee ka ahụike uche gị dịkwuo mma site na imeziwanye ebe nchekwa, mmụta, na itinye uche. Nnyocha na-egosikwa na Alfa GPC na-enyere aka ịbawanye ike anụ ahụ na ike anụ ahụ.