Mitochondria dị ezigbo mkpa dị ka ụlọ ike nke mkpụrụ ndụ ahụ anyị, na-enye ike dị egwu iji mee ka obi anyị na-akụ, ume ume anyị na ahụ anyị na-arụ ọrụ site na mmeghari ohuru kwa ụbọchị. Agbanyeghị, ka oge na-aga, yana afọ, ihe nrụpụta ike anyị, mitochondria, na-enwe ike imebi ma tufuo ikike ịrụ ọrụ nke ọma. Mitochondria na-arụ ọrụ nke ọma dị mkpa na ndụ mmadụ. Agbanyeghị, mitochondria na-enwekwa ike imebi ya site na isi mmalite dị iche iche, gụnyere nrụgide oxidative, mbufụt, na nsị gburugburu ebe obibi. Ihe ndị a nwere ike imebi DNA mitochondrial, na-emebi ikike ha ịmepụta ATP na ogige ndị ọzọ dị mkpa.
Ọ dabara nke ọma, ahụ anyị na-ahọrọ nke ọma na-ewepụ mitochondria mebiri emebi na nke na-adịghị arụ ọrụ site na sel anyị site na mitochondrial autophagy iji nọgide na-enwe ahụike ka mma na izere ụfọdụ mmetụta ọjọọ nke mitochondria ndị a mebiri emebi, dị ka nchọpụta ndị na-egosi na usoro nke mitochondrial autophagy nwere ọrụ na mgbochi. ịka nká. Ka anyị ghọta njikọ dị n'etiti mitochondria na mgbochi ịka nká!
Kedu ọrụ nke mitochondria?
Mitochondria bụ akụkụ dị mkpa nke na-emepụta ike n'ime sel anyị. Isi ọrụ ha bụ imepụta adenosine triphosphate (ATP), nke bụ ego ike nke mkpụrụ ndụ anyị. Ka mitochondria anyị nwere, otú ahụ ka ATP anyị nwere ike ịmepụta, nke na-eduga n'ịbawanye ike na ike ọgwụgwụ. N'ime ọrụ ndị bụ isi ọ na-arụ bụ:
(1)inye ume na metabolic intermediates na ahụ
(2)Mitochondrial autophagy na-amata mitochondria mebiri emebi wee họrọ ya wepụ ha, na mwepụ nke mitochondria ndị a mebiri emebi na-akwalite biosynthesis nke mitochondria ọhụrụ.
(3)Ọ nwere ike ịrụ ọrụ na igbochi ọnwụ cell site na iwepu mitochondria
(4)Ejikọtala ya na mmepe nke nsogbu ahụike dị iche iche, gụnyere ọrịa obi, ọrịa neurodegenerative na ọbụna ụdị ụfọdụ nke ọrịa cancer.
Kedu njikọ dị n'etiti mitochondria na mgbochi ịka nká?
Nnyocha egosiwo na ka anyị na-eme agadi, nkwụsị site na mitochondrial autophagy bụ dysregulated, nke pụtara na mkpụrụ ndụ mitochondrial adịghị enwe ike ikpochapụ ọrụ ha. Na-enweghị usoro njikwa mma kachasị dị ka mitochondrial autophagy, enwere ike ịbawanye mmebi cellular.
N'ime ọmụmụ anụmanụ, a hụwo ogologo ndụ ogologo oge mgbe e gosipụtara mkpụrụ ndụ ihe nketa na-achịkwa mitochondrial autophagy, na-atụ aro na mitochondrial autophagy na ogologo ndụ na-ejikọta. Tụkwasị na nke ahụ, a na-ahụkarị autophagy mitochondrial na-adịghị mma n'ọtụtụ ọrịa ndị metụtara afọ, gụnyere ọrịa Parkinson na ọrịa Alzheimer, ọrịa obi, na ọrịa cancer, na-atụ aro na ntinye aka na-ezubere iche maka mitochondrial autophagy nwere ike itinye aka na mgbochi ọrịa na ọgwụgwọ. N'ikpeazụ, isi ihe na-eme ka ịka nká n'ụzọ amara dabere na nghọta na ịkwado usoro dị mgbagwoju anya nke na-eme ka ahụ na-arụ ọrụ. Site n'ịrụ ọrụ iji kwalite mitochondrial autophagy ahụike yana ime nhọrọ ndụ nke na-ebute ọdịmma anyị ụzọ, anyị nwere ike imeghe ihe nzuzo na ndụ ogologo na ahụike!
Otu esi abawanye autophagy mitochondrial
(1)Tụlee ibu ọnụ na-agba ọsọ na mgbochi kalori
Nnyocha e mere egosiwo na a pụrụ ịkpali mitochondrial autophagy site n'ụdị ụzọ ndụ dị iche iche. Dịka ọmụmaatụ, egosipụtara na mmega ahụ na-abawanye autophagy mitochondrial, si otú ahụ na-eme ka ọrụ mitochondrial dịkwuo mma. Na mgbakwunye, mmemme nri dị ka ibu ọnụ na-adịte aka ma ọ bụ mmachi kalori nwekwara ike kpalite autophagy mitochondrial, na-eme ka mitochondria dịkwuo mma.
(2)Mmega ahụ oge niile
Mmega ahụ bụ nke kachasị mfe na nke kachasị mfe ịgbaso. Ọ nwere ike ịkwalite ahụike na ịdị ogologo ndụ yana melite ọrụ mitochondrial yana ime ka ọkpụkpụ mitochondrial autophagy, ya mere mmega ahụ nwere ike ịhazi ya nke ọma na ike ụfọdụ, aerobic na ntachi obi na-amụba mitochondrial autophagy.
(3)Urolithin A bụ molekul na-ebute autophagy mitochondrial
Urolithin A bụ ihe metabolite na-emepụta site na ntughari nke tannins ellagic site na nje bacteria eriri afọ. Ihe na-ebute ya bụ ellagic acid na ellagitannin, nke a pụrụ ịchọta n'ọtụtụ osisi oriri, dị ka pọmigranet, strawberries, raspberries, walnuts, wdg, ma ọ bụghị na ọ dị na nri, n'ihi na ọ bụ naanị nje bacteria nwere ike ime ka ellagitannin ghọọ urolithin. Na urolithin A, ihe na-emepụta ihe na-emepụta site na precursors nri, bụ ihe egosiri na ọ na-akpalite autophagy mitochondrial.
Mkpa nke mitochondrial autophagy
Mitochondrial autophagy bụ ihe okike na usoro dị mkpa nke na-enyere aka ịnọgide na-enwe mitochondria dị mma n'ime sel anyị. Usoro a na-agụnye ịchọpụta mitochondria mebiri emebi ma ọ bụ nke na-adịghị arụ ọrụ ma họrọ wepụ ha na cell iji mee ụzọ maka mitochondria ọhụrụ, nke nwere ike dochie ha. N'otu oge ahụ, usoro nke mitochondrial autophagy na-enyere aka hụ na ike ahụ anyị na-akwụsi ike nakwa na mkpụrụ ndụ na anụ ahụ anyị na-anọgide na-adị mma ma na-arụ ọrụ.
N'ikpeazụ, ịnọgide na-enwe ahụ ike mitochondria dị oke mkpa maka ahụ ike na ọdịmma anyị n'ozuzu ya, na mkpụrụ ndụ anyị ewepụtala usoro a na-akpọ mitochondrial autophagy iji hụ na anyị na-enweta mitochondria ahụike na-aga n'ihu. Otú ọ dị, usoro ndụ ndụ (dị ka mmega ahụ) na ihe oriri (dị ka nri ketogenic) na iji ihe mgbakwunye nwere ike ịkwado ọrụ mitochondrial ma nyere aka gbochie ọrịa ndị metụtara afọ. Site n'ilekọta mitochondria anyị, anyị nwere ike hụ na anyị nwere ume na ume anyị chọrọ iji bie ndụ zuru oke.
Na mgbakwunye, anyị nwere ike mara nke ọma njikọ dị n'etiti mitochondria na mgbochi ịka nká, ka anyị na-eme agadi, usoro mitochondrial autophagy na-emebi, ya bụ, ọ na-eduga n'ịgbakọta mitochondria na sel, nke na-ebu ọnụ, ihe mgbochi calorie, urolithin A. , wdg nwere ike ịkpalite autophagy mitochondrial ma nwee ike melite ahụike na mgbochi ịka nká, ebe ma NAD + na urolithin A na-enye aka na mmepụta nke mitochondria ọhụrụ site na usoro a na-akpọ usoro biogenesis nke a na-akpọ biogenesis; Otú ọ dị, urolithin A nwere ọrụ ọzọ dị mkpa. Ọ na-ebuli usoro a na-akpọ mitochondrial autophagy, nke a na-ewepụ mitochondria mebiri emebi ma megharịa ya ka ọ bụrụ mitochondria ọhụrụ, na-arụ ọrụ nke ọma. Ọtụtụ ndị mmadụ na ndụ anyị nwere ike ha agaghị enwe ike ịkwado mmega ahụ ruo ogologo oge, mana ngwaahịa egosipụtara anyị na-enye, Urolithin A, nwere ike inye ahụike kacha mma.
Ajụjụ: Enwere nri ụfọdụ na ndụ gị nke nwere ike inye aka gbochie ịka nká?
A: Ee, ụfọdụ nri bara ụba na antioxidants, vitamin na mineral nwere ike inye aka kwalite akpụkpọ ahụ dị mma ma belata usoro ịka nká. Ọmụmatụ gụnyere mkpụrụ osisi, akwụkwọ nri, protein ndị na-esighị ike na abụba dị mma.
Oge nzipu: Jun-01-2023
